Publikationen Prof. Abdelhaq Rami

Original und Übersichtsarbeiten | Buchartikel

2011 - 2019

Halbe L, Rami A (2019) Trehalase localization in the cerebral cortex, hippocampus and cerebellum of mouse brains. J Adv Res, 18: 71-79

Halbe L, Rami A. Inhibition of Autophagy Potentiated Hippocampal Cell Death Induced by Endoplasmic Reticulum Stress and its Activation by Trehalose Failed to be Neuroprotective. Curr Neurovasc Res. doi: 10.2174/1567202616666190131155834

Jilg A, Bechstein P, Saade A, Dick M, Li TX, Tosini G, Rami A, Zemmar A, Stehle JH (2019) Melatonin modulates daytime-dependent synaptic plasticity and learning efficiency. J Pineal Res, 66:e12553

Rami A, Niquet J, Konoplew A (2018) Early Aberrant Growth of Mossy Fibers after Status Epilepticus in the Immature Rat Brain. Mol Neurobiol, doi: 10.1007/s12035-018-1432-y. [Epub ahead of print]

Rami A, Benz A (2018) Exclusive Activation of Caspase-3 in Mossy Fibers and Altered Dynamics of Autophagy Markers in the Mice Hippocampus upon Status Epilepticus Induced by Kainic Acid. Mol Neurobiol, 55: 4492-4503

Rami A, Fekadu J, Rawashdeh O (2017) The Hippocampal Autophagic Machinery is Depressed in the Absence of the Circadian Clock Protein PER1 that may Lead to Vulnerability During Cerebral Ischemia. Curr Neurovasc Res, 14: 207-214

Fekadu J, Rami A (2015) Beclin-1 Deficiency Alters Autophagosome Formation, Lysosome Biogenesis and Enhances Neuronal Vulnerability of HT22 Hippocampal Cells. Mol Neurobiol [Epub ahead of print]

Rami A, Benz AP, Niquet J, Langhagen A (2015) Axonal Accumulation of Lysosomal-Associated Membrane Protein 1 (LAMP1) Accompanying Alterations of Autophagy Dynamics in the Rat Hippocampus Upon Seizure-Induced Injury. Neurochem  Res [Epub ahead of print]

Milosch N, Tanriöver G, Kundu A, Rami A, François JC, Baumkötter F, Weyer SW,  Samanta A, Jäschke A, Brod F, Buchholz CJ, Kins S, Behl C, Müller UC, Kögel D (2014) Holo-APP and G-protein-mediated signaling are required for sAPPα-induced activation of the Akt survival pathway. Cell Death Dis

Benz AP, Niquet J, Wasterlain CG, Rami A (2014) Status epilepticus in the immature rodent brain alters the dynamics of autophagy. Curr Neurovasc Res, 11: 125-135

Kim M, Fekadu J, Maronde E, Rami A (2013) Alleviation of autophagy by knockdown of Beclin-1 enhances susceptibility of hippocampal neurons to proapoptotic signals induced by amino acid starvation. Histochem Cell Biol, 139: 99-108

Wiebking N, Maronde E, Rami A (2013) Increased neuronal injury in clock gene Per-1 deficient-mice after cerebral ischemia. Curr Neurovasc Res, 10: 112-125

2006 - 2010

Rami A, Kim M, Niquet J (2010) Translocation of the serine protease Omi/HtrA2 from mitochondria into the cytosol upon seizure-induced hippocampal injury in the neonatal rat brain. Neurochem Res, 35: 2199-2207

Seidel K, Schöls L, Nuber S, Petrasch-Parwez E, Gierga K, Wszolek Z, Dickson D, Gai WP, Bornemann A, Riess O, Rami A, Den Dunnen WF, Deller T, Rüb U, Krüger R (2010) First appraisal of brain pathology owing to A30P mutant alpha-synuclein. Ann Neurol, 67: 684-689

Steiger-Barraissoul S, Rami A (2009) Serum deprivation induced autophagy and predominantly an AIF-dependent apoptosis in hippocampal HT22 neurons. Apoptosis 14: 1274–1288

Rami A (2009) Review: autophagy in neurodegeneration: firefighter and/or incendiarist? Neuropathol Appl Neurobiol, 35: 449-461

Siegelin MD, Siegelin Y, Habel A, Rami A, Gaiser T (2009) KAAD-cyclopamine augmented TRAIL-mediated apoptosis in malignant glioma cells by modulating the intrinsic and extrinsic apoptotic pathway. Neurobiol Dis, 34: 259-266

Siegelin MD, Reuss DE, Habel A, Rami A, von Deimling A (2009) Quercetin promotes degradation of survivin and thereby enhances death-receptor-mediated apoptosis in glioma cells. Neuro Oncol, 11: 122-131

Czech B, Pfeilschifter W, Mazaheri-Omrani N, Strobel MA, Kahles T, Neumann-Haefelin T, Rami A, Huwiler A, Pfeilschifter J  (2009) The immunomodulatory sphingosine 1-phosphate analog FTY720 reduces lesion size and improves neurological outcome in a mouse model of cerebral ischemia. Biochem Biophys Res Commun, 389: 251-256

Rotarska-Jagiela A, Oertel-Knoechel V, Demartino F, van de Ven V, Formisano E, Roebroeck A, Rami A, Schoenmeyer R, Haenschel C, Hendler T, Maurer K, Vogeley K, Linden DE (2009) Anatomical brain connectivity and positive symptoms of schizophrenia: A diffusion tensor imaging study. Psychiatry Res,174: 9-16

Gaiser T, Becker MR, Habel A, Reuss DE, Ehemann V, Rami A, Siegelin MD. (2008) TRAIL-mediated apoptosis in malignant glioma cells is augmented by celecoxib through proteasomal degradation of survivin. Neurosci Lett 442: 109-113

Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS, Baba M, Baehrecke EH, Bahr BA, Ballabio A, Bamber BA, Bassham DC, Bergamini E, Bi X, Biard-Piechaczyk M, Blum JS, Bredesen DE, Brodsky JL, Brumell JH, Brunk UT, Bursch W, Camougrand N, Cebollero E, Cecconi F, Chen Y, Chin LS, Choi A, Chu CT, Chung J, Clarke PG, Clark RS, Clarke SG, Clave C, Cleveland JL, Codogno P, Colombo MI, Coto-Montes A, Cregg JM, Cuervo AM, Debnath J, Demarchi F, Dennis PB, Dennis PA, Deretic V, Devenish RJ, Di Sano F, Dice JF, Difiglia M, Dinesh-Kumar S, Distelhorst CW, Djavaheri-Mergny M, Dorsey FC, Droge W, Dron M, Dunn WA, Jr., Duszenko M, Eissa NT, Elazar Z, Esclatine A, Eskelinen EL, Fesus L, Finley KD, Fuentes JM, Fueyo J, Fujisaki K, Galliot B, Gao FB, Gewirtz DA, Gibson SB, Gohla A, Goldberg AL, Gonzalez R, Gonzalez-Estevez C, Gorski S, Gottlieb RA, Haussinger D, He YW, Heidenreich K, Hill JA, Hoyer-Hansen M, Hu X, Huang WP, Iwasaki A, Jaattela M, Jackson WT, Jiang X, Jin S, Johansen T, Jung JU, Kadowaki M, Kang C, Kelekar A, Kessel DH, Kiel JA, Kim HP, Kimchi A, Kinsella TJ, Kiselyov K, Kitamoto K, Knecht E, Komatsu M, Kominami E, Kondo S, Kovacs AL, Kroemer G, Kuan CY, Kumar R, Kundu M, Landry J, Laporte M, Le W, Lei HY, Lenardo MJ, Levine B, Lieberman A, Lim KL, Lin FC, Liou W, Liu LF, Lopez-Berestein G, Lopez-Otin C, Lu B, Macleod KF, Malorni W, Martinet W, Matsuoka K, Mautner J, Meijer AJ, Melendez A, Michels P, Miotto G, Mistiaen WP, Mizushima N, Mograbi B, Monastyrska I, Moore MN, Moreira PI, Moriyasu Y, Motyl T, Munz C, Murphy LO, Naqvi NI, Neufeld TP, Nishino I, Nixon RA, Noda T, Nurnberg B, Ogawa M, Oleinick NL, Olsen LJ, Ozpolat B, Paglin S, Palmer GE, Papassideri I, Parkes M, Perlmutter DH, Perry G, Piacentini M, Pinkas-Kramarski R, Prescott M, Proikas-Cezanne T, Raben N, Rami A, Reggiori F, Rohrer B, Rubinsztein DC, Ryan KM, Sadoshima J, Sakagami H, Sakai Y, Sandri M, Sasakawa C, Sass M, Schneider C, Seglen PO, Seleverstov O, Settleman J, Shacka JJ, Shapiro IM, Sibirny A, Silva-Zacarin EC, Simon HU, Simone C, Simonsen A, Smith MA, Spanel-Borowski K, Srinivas V, Steeves M, Stenmark H, Stromhaug PE, Subauste CS, Sugimoto S, Sulzer D, Suzuki T, Swanson MS, Tabas I, Takeshita F, Talbot NJ, Talloczy Z, Tanaka K, Tanaka K, Tanida I, Taylor GS, Taylor JP, Terman A, Tettamanti G, Thompson CB, Thumm M, Tolkovsky AM, Tooze SA, Truant R, Tumanovska LV, Uchiyama Y, Ueno T, Uzcategui NL, van dK, I, Vaquero EC, Vellai T, Vogel MW, Wang HG, Webster P, Wiley JW, Xi Z, Xiao G, Yahalom J, Yang JM, Yap G, Yin XM, Yoshimori T, Yu L, Yue Z, Yuzaki M, Zabirnyk O, Zheng X, Zhu X, Deter RL (2008) Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy, 4: 151-175

Rami A, Bechmann I, Stehle JH (2008) Exploiting endogenous anti-apoptotic proteins for novel therapeutic strategies in cerebral ischemia. Prog Neurobiol, 85: 273-296

Rami A, Kögel D (2008) Apoptosis meets autophagy-like cell death in the ischemic penumbra:Two sides of the same coin? Autophagy  4: 1-5

Rami A, Langhagen A, Steiger S (2008) Focal cerebral ischemia induces up-regulation of Beclin 1 and autophagy-like cell death. Neurobiology of Disease 29: 132-41

Rami A (2008) Upregulation of Beclin 1 in the ischemic penumbra. Autophagy 4: 227-229

Spahn A, Blondeau N, Heurteaux C, Dehghani F, Rami A (2008) Concomitant transitory up-regulation of X-linked inhibitor of apoptosis protein (XIAP) and the heterogeneous nuclear ribonucleoprotein C1-C2 in surviving cells during neuronal apoptosis. Neurochemical Research  33: 1859-1868

Althaus J, Siegelin MD, Dehghani F, Cilenti L, Zervos AS, Rami A (2007) The serine protease Omi/HtrA2 is involved in XIAP cleavage and in neuronal cell death following focal cerebral ischemia/reperfusion. Neurochem Int 50: 172-180

Rami A, Agarwal R, Spahn A (2007) Synergetic Effects of Caspase 3 and mu-Calpain in XIAP-Breakdown upon Focal Cerebral Ischemia. Neurochem Res 32: 2072-2079

Althaus J, Bernaudin M, Petit E, Toutain J, Touzani O, Rami A (2006) Expression of the gene encoding the pro-apoptotic BNIP3 protein and stimulation of hypoxia-inducible factor-1alpha (HIF-1alpha) protein following focal cerebral ischemia in rats. Neurochemistry International 48: 687-695

2000 - 2005

Siegelin M, Touzani O, Toutain J, Liston P, Rami A (2005) Induction and redistribution of the XAF1, antagonist of XIAP in the rat brain after transient  Focal ischemia. Neurobiology of Disease 20: 509-518

Zekri L, Chebli K, Tourrière H,  Nielsen FC,  Hansen TV,  Itier JM,  Tremp G, Rami A, Tazi J (2005) Control of foetal growth and neonatal survival by the RasGAP Associated Endoribonuclease G3BP. Molecular Cell Biology 25: 8703-8716

Kahles T, Foerch C, Sitzer M, Schroeter M,  Steinmetz H, Rami A, Neumann-Haefelin T (2005) Tissue plasminogen activator – mediated blood-brain-barrier damage in transient focal cerebral ischemia in rats: Relevance of interactions between thrombotic material and thrombolytic agent. Vascular Pharmacology 43: 254-259 IF: 2.6

König HG, Kögel D, Rami A, Prehn JHM (2005) TGF-ß1 activates two distinct type I receptors in neurons: implications for neuronal NF-kB signaling. Journal of Cell Biology 168: 1077-1086

Siegelin MD, Kossatz LS, Winckler J, Rami A (2005) Regulation of  XIAP and  Smac/DIABLO  in the rat hippocampus following transient forebrain ischemia. Neurochemistry International 46: 41-51

Thees S, Hubbard GB, Winckler J, Schultz C, Rami A (2005) Specific alteration of the Bax/Bcl2 ratio and cytochrome c without execution of apoptosis in the hippocampus of aged baboons. Restorative Neurology and Neuroscience 23: 1-9

Rami A. Calpain and caspase in cerebral ischemia and neuronal apoptosis (2003) the “calpain-calpastatin-caspase-hypothesis” Neurobiology of Disease 13: 75-88

Rami A, T. Volkmann, R. Agarwal, S. Schoninger,  F. Nürnberger, TC Saido , J. Winckler (2003) ß2-adrenergic receptor responsiveness of the calpain-calpastatin system  and attenuation of neuronal death in rat hippocampus after transient global ischemia. Neuroscience Research 47: 373-82

Agarwal R and Rami A (2003) Redistribution of glucose-6-phosphate dehydrogenase in response to cerebral ischemia in rat brain.Indian Journal of ClinicalBiochemistry 18: 64-70

Reinmetz C, Kögel D, Rami A, Chittenden T, and Prehn JHM (2003) “Gene Expression during ER Stress-Induced Apoptosis in Neurons: Induction of the BH3-Only Protein Bbc3/PUMA and Activation of the Mitochondrial Apoptosis Pathway“ Journal of Cell Biology“ 162: 587-597

Rami A, Jansen J, Giesser I, Winckler J (2003) Post-ischemic activation of caspase-3 in the rat hippocampus: Evidence of an axonal and dendritic localisation.  Neurochemistry International 43: 211-223

Rami A,  Sims J, Botez G, Winckler J (2003) Spatial resolution of  phospholipid scramblase 1 (PLSCR1), caspase-3 activation and DNA-fragmentation in the human hippocampus after cerebral ischemia. Neurochemistry International 43: 79-87

Rami A. Calpain and caspase in cerebral ischemia and neuronal apoptosis (2003) the “calpain-calpastatin-caspase-hypothesis” Neurobiology of Disease 13: 75-88

Agarwal R and Rami A (2002) istochemical localisation of glucose-6- Phosphate dehydrogenase activity in rat brain. Indian  Journal of Medical  Biochemistry  6: 19-23

Botez G and Rami A (2001) Immunoreactivity for bcl-2 and c-jun/AP1 in hippocampal corpora amylacea after ischaemia in human. Neuropathology and Applied Neurobiology 27: 474-480

Rami A, Volkmann T, Winckler J (2001) Effective reduction of neuronal death by inhibiting gap junctional intercellular communication in a rodent model of global transient cerebral ischemia.  Experimental Neurology 170: 297-304

Rami A, R. Agarwal, G. Botez and J. Winckler (2000) µ-Calpain Activation, DNA-Fragmentation, and synergistic effects of caspase- and calpain-inhibitors in protecting hippocampal neurons from ischemic damage. Brain Reserach 866: 299-312

Zhu Y, Roth-Eichhorn S, Braun N, Culmsee C, Rami A, Krieglstein J. (2000) The expression of transforming growth factor-beta1 (TGF-beta1) in hippocampal neurons: a temporary upregulated protein level after transient forebrain ischemia in the rat. Brain Reserach 866: 286-98

1986 - 1999

Rami A and Krieglstein J (1998) Scopolamine rescues hippocampal neurons from glutamate neurotoxicity. Brain Research 788: 323-326

Rami A, Rabié and Winckler J (1998) Synergy between chronic corticosterone treatment and cerebral ischemia in producing damage in non-calbindinergic neurons. Experimental Neurology 149: 439-446

Rami A, Ausmeier F, Krieglstein J, and Winckler J (1997) Differential effects of scopolamine on neuronal survival in cerebral ischemia and glutamate-induced neurotoxicity: Relationships to the excessive vulnerability of the dorsoseptal hippocampus. Journal of Chemical Neuroanatomy 13: 201-208

Rami A, Ferger D, and Kreiglstein J (1997) Blocakde of proteolytic activity rescues neurons from glutamate excitotoxicity. Neuroscience Research 27: 93-97

Semkova I, Schilling M, Henrich-Noack P, Rami A, and Krieglstein J (1996) Clenbuterol protects mouse cerebral cortex and rat hippocampus from ischemic damage and attenuates glutamate neurotoxicity in cultured hippocampal neurons by induction of NGF. Brain Research 717: 44-54

Rami A and Krieglstein J (1994) Neuronal protective effects of calcium antagonists in cerebral ischemia. Life Science 55: 2205-2113

Rami A and Krieglstein J (1993) Protective effects of calpain inhibitors against neuronal damage caused by cytotoxic hypoxia in vitro and ischemia in vivo. Brain Research 609: 67-70

Nikolov R, Rami A, and Krieglstein J (1993) Endothelin-1 exacerbates focal cerebral ischemia without exerting neurotoxic action in vitro. European  Journal of Pharmacology 248: 205-208

Rami A and Krieglstein J (1993) Brain damage caused by ischemia: pathophysiological and pahrmacological aspects. Dementia 4: 21-31

Rischke R, Rami A, Bachmann U, Rabié A, and Krieglstein J (1992) Activated astrocytes, but not pyramidal cells, increase glucose utilization in rat hippocampal CA1 subfield after ischemia. Pharmacology 45: 142-153

Rami A and Krieglstein J (1992) Thyroxine attenuates hippocampal neuronal damage caused by ischemia in the rat. Life Science 50: 645-650

Rami A, Rabié A, Thomasset M, and Krieglstein J (1992) Calbindin-D28k and ischemic damage of pyramidal cells in rat hippocampus. Journal of Neuroscience Research 31: 89-95

Faivre-Sarrailh C, Rami A, Fages C, and Tardy M (1991) Effect of  thyroid deficiency on glial fibrillary acidic protein (GFAP) and GFAP-mRNA in the cerebellum and hippocampal formation of the developing rat. Glia 4: 276-284

Rami A and Rabié A (1990) Delayed synaptogenesis in the dentate gyrus of the thyroid-deficient developing rat. Developmental Neuroscience 12: 398-405

Rami A, Barberis C, and Clos J (1989) Effects of hypothyroidism on high affinity vasopressin binding sites in developing hippocamapal synaptosomes. Synapse 3: 200-204

Rami A, Clos J, and Rabié A (1989) Time course of hippocampal cholinergic innervation in the developing hypothyroid rat. A combined histochemical and biochemical study of acetylcholinesterase activity. International Journal of Developmental Neuroscience 7: 301-308

Rami A, Lomri N, Bréhier T, Thomasset M, and Rabié A (1989) Effects of altered thyroid states and undernutrition on the calbindin-D 28k content of the hippocampal formation in the developing rat. Brain Research 485: 20-28

Rami A and Rabié A (1987) Effects of thyroid deficiency on the development of glia in the hippocampal formation of the rat: an imminocytochemical study. Glia 1: 337-345

Rami A, Bréhier, Thomasset M, and Rabié A (1987) Cholecalcin (28 kDa calcium-binding protein) in the rat hippocampus: development in normal animals and in altered thyroid states. An immunocytochemical study. Developmental Biology 124: 228-238

Rami A, Brehier A, Thomasset M, Rabie A (1987) The comparative immunocytochemical distribution of 28 kDa cholecalcin (CaBP) in the hippocampus of rat, guinea pig and hedgehog. Brain Research 422:149-153

Rami A, Rabié A, and Patel AJ (1986) Thyroid hormone and development of the rat hippocampus: cell acquisition in the dentate gyrus. Neuroscience 19: 1207-1216

Rami A, Patel AJ, and Rabié A (1986) Thyroid hormone and development of the hippocampus: Morphological alterations in granule and pyramidal cells. Neuroscience 19: 1217-1226


Artikel und Bücher

Buchartikel

Rami A, Winckler J, and Rabié A (1997) Corticosterone Upregulates hippocampal Calbindin-D28K in region specific manner and  Exacerbates Ischemic Damage exclusively in non-calbindinergic neurons. Neuroendocrinology-Retrospect and Perspectives. Korf-Usadel, Eds. pp 193-205

Semkova I, Rami A, and Krieglstein J (1994) Neuroprotective activity of clenbuterol  against excitotoxic neuronal damage. In: Pharmacology of Cerebral Ischemia (Hrsg. J. Krieglstein and H. Oberpichler-Schwenk), Wiss Verlagges, Stuttgart, pp 397-406

Rami A and Krieglstein J (1993) Inhibition of proteolysis prevents neuronal damage caused by cytotoxic hypoxia or ischemia. In: Pharmacology of Cerebral Ischemia (Hrsg. J. Krieglstein and H. Oberpichler), Wiss Verlagsges, Stuttgart, pp 301-307

Rami A, Rabié A, Thomasset M, and Krieglstein J (1990) Calbindin-D28k and delayed neuronal death in the rat hippocampus after cerebral ischemia. In: Pharmacology of Cerebral Ischemia (Hrsg. J. Krieglstein, H. Oberpichler), Wiss Verlagsges-Stuttgart, pp 123-128

Rischke R, Rami A, Bachmann U, Rabié A, and Krieglstein J (1990) Different vulnerability to ischemia of pre- and postsynaptic terminals in rat hippocampus. In: Pharmacology of Cerebral Ischemia (Hrsg. J. Krieglstein, H. Oberpichler), Wiss. Verlagsges. Stuttgart, pp 129-13

Rami A, Rabié A, Thomasset M, and Krieglstein J (1990) Calbindin-D28k and delayed neuronal death in the rat hippocampus after cerebral ischemia. In: Pharmacology of Cerebral Ischemia (Hrsg. J. Krieglstein, H. Oberpichler), Wiss. Verlagsges. Stuttgart, pp 123-128