Welcome to the homepage of the Heilemann Group!

Gruppe2022

We develop tools for optical structural cell biology and study the molecular organization of cells.

We advance super-resolution fluorescence microscopy into an "optical omics" technology for structural cell biology. For this purpose, we integrate orthogonal protein labeling tools that allow monitoring multiple proteins simultaneously and image analysis tools that report quantitative molecular information on protein assemblies.


Homepage 04 banner2022

____________________** News Ticker **____________________

Please feel free to visit our group on Twitter: https://twitter.com/HeilemannLab

Feb 28th 2024: Annabelle joined the group for her Master thesis -- Welcome!!

Feb 6th 2024: Philipp joined the group for his Master thesis -- Welcome!!

Jan 2024: Catarina joined the group as a postdoctoral researcher and Alexandra come to us for her PhD thesis -- Both are Welcome!!

Dez 15th 2023: A new articel “Single-molecule imaging reveals nano-clustering of ER-phagy receptors" in Nature Communications with a contribution from Ashwin and Marius now online.

Okt 04th 2023: Marko joined the group for his Master thesis -- Welcome!!

Sep 26th 2023: “Soo, Yunqing and Ashwin are presenting their work at the 28th Single Molecule Spectroscopy and Super-resolution Microscopy in Berlin (link)

Aug 15th 2023: Our new articel "Self-quenched Fluorophore Dimers for DNA-PAINT and STED Microscopy" has been published in Wiley Online Library

August 2023: Congratulations to Tanja for winning a "Poster-Prize" on the EBSA Stockholm.

Jul 31st 2023: EBSA Meeting Stockholm: Soohyen, Dongni, Tanja and Mike are presenting latest results at the EBSA 2023 Meeting in Stockholm

Jul 2023: Congratulations to our colleagues in Yoav Shechtman lab developing fast live-cell single-molecule super-resolution microscopy with contributions from Soohyen Jang

May 22th 2023: A new articel "Biased activation of the receptor tyrosine kinase HER2" has been published in Cellular and Molecular Life Sciences, Springer Nature Content Sharing Initiative

May 2023: Maximilian joined the group for his Master thesis -- Welcome!!

Feb 2023: A collaborative effort to evaluate cluster analysis for single-molecule super-resolution microscopy now published                    

Jan 2023: We contributed to an article reporting protein labelling with exchangeable fluorophores for multi-modal super-resolution microscopy

Oct 1st 2022: Sinem joined the group for her Master thesis -- Welcome!!

Oct 2022: Two new articles published, reporting weak-affinity labels for multi-color STED microscopy and dynamic confinement in receptor signaling                        

Sep 2022: Our articel "Fast DNA-PAINT imaging using a deep neural network" has been published in Nature Communications
                   
Aug 2022: You can find us at the SMLMS in Paris (29.08. to 31.08.22), where some group members will present their work.
                         

Aug 05th 2022: Paresh joined the group for his PhD thesis -- Welcome!!

Jul 2022: Our work on DeepLearning analysis of bacterial image data is published in Communications Biology.                    

Mar 14th 2022: Jin joined the group for his Master thesis -- Welcome!!

Mar 2nd 2022: Claudia and Johanna presented at the SPIE conference in San Francisco

Feb 23rd 2022: "Congratulations to Kaarjel for winning the third prize at the 2022 Art of Science Image Contest at the
                          66th Biophysical Sociatey Annual Meeting!"
                          https://twitter.com/HeilemannLab/status/1496301791193214978

Feb 17th 2022: Ashwin joined the group as a postdoctoral researcher -- Welcome!!

Feb 1st 2022: Christian joined the group for his PhD thesis -- Welcome!!

Jan 1st 2022: Tanja and Soohyen have joined the group for their PhD thesis - welcome to both of them!!

Dez 20th 2021: Mark successfully defended his PhD thesis -- Congratulations!!

Nov 25th 2021: Johanna won an IFI fellowship from DAAD for a 4 months research stay at the Chan-Zuckerberg Biohub
                       -- Congratulations, Johanna!

Okt 7th 2021: Dongni joined the group for her PhD thesis -- Welcome!!

Okt 1st 2021: Laurell joined the group for his PhD thesis -- Welcome!!

May 5th 2021: We are recruiting! If you are interested to work in the emerging and exciting field of optical structural biology,
                      please apply and see you also our other "open positions"

May 1st 2021: Mengjin joined the group for her Master thesis -- Welcome!!

Feb 4th 2021: Thao joined the group for her PhD thesis -- Welcome!!

Jan 2nd 2021: Claudia joined the group for her PhD thesis -- Welcome!!

Nov 19th 2020: Mathilda successfully defended her PhD thesis -- Congratulations!!

Sep 24th 2020: Nina successfully defended her PhD thesis -- Congratulations!!

Aug 3rd 2020: Kaarjel has  joined the group as associated researcher. -- Welcome!!

Apr 18th 2020: Our article "Single-Molecule Super-Resolution Microscopy Reveals Heteromeric Complexes of MET and EGFR upon Ligand Activation" has been published in IJMS as part of the Special Issue 'Tyrosine Kinases in Health and Disease'

Mar 5th 2020: Marie-Lena successfully defended her PhD thesis -- Congratulations!!

Jan 15th 2020: University press release of our study published in Science Signaling which illustrates the molecular structures of TNF receptors in cell membranes. (see publications)

Jan 2nd 2020: Marius joined the group as a postdoctoral researcher -- Welcome!!

Jan 2nd 2020: Johanna joined the group for her PhD thesis -- Welcome!!

Dec 18th: Christoph has won an EMBO Short Term Felloswhip! -- Congratulations!!!

Nov 28th 2019: Christos successfully defended his PhD thesis -- Congratulations!!

Nov 2019: two manuscripts we published recently : a first one by Marina which studies how fluorophore labels affect binding affinities (Nano Letters), and a second one by Chris showing STED microscopy with exchangeable DNA labels (Angewandte Chemie).

Nov 1st 2019: We have an open PhD position on the topic of "Structural biology with high-resolution microscopy" -- if you are interested to join our team, please apply! Advertisement in 'nature careers'

Oct 12th 2019: We received a poster prize at the Seeing is Believing at the EMBL in Heidelberg!

Sep 30th 2019: Laurel joined the group for his Master thesis -- Welcome!!

Sep 2nd 2019: Ann-Christin joined the group for her PhD thesis -- Welcome!!

July 5th 2019: We are presenting our work at a number of conferences in the upcoming weeks. Nina will give a talk on FRET PAINT at the EBSA meeting in Madrid; Christoph will speak about STED with exchangeable dyes at the PicoQuant Meeting in Berlin; Mike will present stoichiometry imaging of membrane receptors at the MAF in La Jolla. We have poster presentations at the EBSA meeting (Mark, Mathilda), the EMBL microbiology meeting in Heidelberg (Mathilda), the SMLMS in Delft (Tim and Klara) and at the Seeing is Believing in Heidelberg (Christoph, Mike).

July 1st 2019: After being a single-molecule enthusiast for many years, Sebastian now moves on to his new research field in the Data Science Group of the Clinical Pharmacology at the University Hospital of the Goethe-University. We wish Sebastian all the best for his future!

June 11th 2019:  Dirk joined the group for his Master thesis -- Welcome!!

May 6th 2019: Daniel joined the group for his Master thesis -- Welcome!!

Apr 17th 2019: Klara joined the group for her PhD thesis -- Welcome!!

Mar 11th 2019: Jan joined the group for his Master thesis -- Welcome!!

Mar 3rd 2019: Yujie joined the group for her Master thesis -- Welcome!!

Jan 15th 2019: Johanna joined the group for her Master thesis -- Welcome!!

Jan 7th 2019: We developed STED/confocal microscopy that is not affected by fluorophore bleaching, using fluorophores that rapidly exchange to and from their target (see here)

Oct 3rd 2018: Just in time on his birthday, Christophs latest paper together with Mathilda, came out: A toolbox for multiplexed super-resolution imaging of the E. coli nucleoid and membrane using novel PAINT labels. Scientific Reports 2018, 8, 14768.

Sep 27th 2018: As part of the celebration of the 10,000th doctorate at the Goethe University, Christoph gave a Science Slam lecture intitled:" Eins nach dem Anderen - wie man mit einzelnen Molekülen höchstaufgelöste Bilder erstellt"

Sep 17th 2018: Florian joined the group for his Master thesis -- Welcome!!

Sep 3rd 2018: Klara joined the group for her Master thesis -- Welcome!!

July 16th to July 18th: Our group retreat took place at the Kurhaus Trifels. For this inspiring event we gratfully acknowledge support by the Wilhelm and Else Heraeus Foundation!

June 26th 2018: Manuscript online in Nano Letters: Correlative Single-Molecule FRET and DNA-PAINT Imaging (see publications)

May 22nd 2018: Manuscript online in mBio: The Pearling Transition Provides Evidence of Force-Driven Endosomal Tubulation during Salmonella Infection (see publications)

May 22nd 2018: Manuscript online in BiophysJ: SPT and Imaging FCS Provide Complementary Information on the Dynamics of Plasma Membrane Molecules (see publications)

Apr 1st 2018: Marina joined the group for her Master thesis -- Welcome!!

Jan 15th 2018: Sarah Sophia joined the group for her Master thesis -- Welcome!!

Dec 21st 2017: Anika successfully defended her PhD thesis -- Congratulations!!

Dec 11th 2017: Carmen successfully defended her PhD thesis -- Congratulations!!

Oct 16th 2017: Christoph successfully defended his PhD thesis -- Congratulations!!

Oct 1st 2017: Mark joined the group for his PhD thesis -- Welcome!!

August 9th 2017: Our new share-server is up and running! See: share.smb.uni-frankfurt.de

July 1st 2017: Steffi Wegner joined the group as our new secretary. -- Welcome!!

June 30th 2017: After so many enjoyable years we want to thank Renate Gregori for her commitment and kindness and wish her all the best for the future!

May 8th 2017: Press release of a study on how bacteria defend themselves against salmonella bacteria in actual topics in science and research at Goethe University. (see publications)

Apr 18th 2017: Tim joined the group for his PhD thesis -- Welcome!!

Apr 10th 2017: Our group chat is up and running! See: chat.smb.uni-frankfurt.de

Mar 1st 2017: Marie-Lena has been awarded a travel grant from Boehringer Ingelheim to perform FCCS and Imaging FCS studies in Thorsten Wohlands lab at the NU Singapore.

Feb 1st 2017: Mara joined the group for her Master thesis -- Welcome!!

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