Faculty of Biochemistry, Chemistry, Pharmacy
Fachbereich Biochemie, Chemie und Pharmazie

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2.5 Millionen Euro für die Erforschung der Immunabwehr in der Zelle

ERC-Advanced Investigator Grant des Europäischen Forschungsrats geht an den Biochemikern Prof. Robert Tampé, der damit die verschlungenen Pfade des Immunsystems innerhalb der Zelle aufklären will. „Mein Ziel ist es, den Mechanismus der Antigen-Prozessierung im Detail zu untersuchen. Mit dieser Forschung begeben wir uns auf einen der dornenreichsten Pfade der Lebenswissenschaften, weil wir es mit großen, unterschiedlich gebauten Molekülen zu tun haben, die außerdem noch relativ selten in interzellulären Membranen vorkommen“, erklärt Tampé das Forschungsvorhaben.

Research Highlights

Halogen‐aromatic pi-interactions modulate inhibitor residence time

The team provides a detailed mechanistic characterization of the halogen‐aromatic pi interactions in the haspin‐inhibitor complexes by means of kinetic, thermodynamic, and structural measurements along with binding energy calculations.

Heroven C, Georgi V, Ganotra GK, Brennan PE, Wolfreys F, Wade RC, Fernandez-Montalvan AE, Chaikuad A*, Knapp S*: Angewandte Chemie International Edition, 2018, DOI: 10.1038/s41594-018-0035-7

Research Highlights


Successful Joint Sino-German Research Funding Applications by two PIs of the Department

Matthias Wagner, Inorganic Chemistry, and Clemens Glaubitz, Biophysical Chemistry, succeeded in a highly competitive bilateral funding initiative by the Deutsche Forschungsgemeinschaft (DFG) and the National Natural Science Foundation of China (NSFC).
The Glaubitz lab will collaborate with Prof. Xiao He at the East China Normal University, Shanghai. The aim of the project is to link high-end solid-state NMR experiments with novel quantum chemical computations and MD simulations in order to link structural, functional and optical properties of membrane-bound photoreceptors.
The Wagner lab is concerned with the development of boron-containing polycyclic aromatic hydrocarbons as next-generation materials for organic light-emitting diodes (OLEDs) and organic photovoltaic devices. The research will be conducted jointly with Profs. Todd Marder (Julius-Maximilians-Universität Würzburg), Suning Wang (Beijing Institute of Technology), and Jun Liu (Chinese Academy of Science, Changchun).

The Faculty

In the faculty of Biochemistry, Chemistry and Pharmacy, 33 professors are involved in research and teaching. They are supported by 440 permanent members of staff and teach more than 2.000 undergraduate and 500 PhD students and postdoctoral fellows in three different disciplines: Pharmacy, Chemistry and Biochemistry.