Arbeitskreis Prof. Dr. Knapp

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Welcome

My laboratory is interested in understanding the structural mechanisms regulating cellular signalling as well as the development and rational design of selective inhibitors, so called chemical probes. Our research focusses on the following areas:

  • Targeting protein interactions modules that mediate the recognitions of key posttranslational modifications such as ε-N-lysine acetylation specific epigenetic reader domains and other modulators of chromatin structure.
  • The development of chemical tools for the ubiquitin system including the discovery of new inhibitors for E3 ligases and the use of these ligands for PROTAC development.
  • Structural studies and the development of chemical tools for the human protein kinase family including covalent and allosteric inhibitors.

As part of the Structural Genomics Consortium (SGC) our laboratory is committed to “Open science and innovation” und unencumbered release of research reagents including chemical probes and chemogenomic compound collections.



Publikationen

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