Group members
Group Head
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Univ.-Prof. Dr. Stefan Knapp |
Prof Stefan Knapp studied Chemistry at the University of Marburg (Germany) and at the University of Illinois (USA). He did his PhD in protein crystallography at the Karolinska Institute in Stockholm (Sweden) (1996) and continued his career at the Karolinska Institute as a postdoctoral scientist (1996-1999). In 1999, he joined the Pharmacia Corporation as a principal research scientist in structural biology and biophysics. He left the company in 2004 to set up a research group at the Structural Genomics Consortium at Oxford University (SGC). From 2008 to 2015 he was a Professor of Structural Biology at the Nuffield Department of Clinical Medicine (NDM) at Oxford University (UK) and between 2012 and 2015 he was the Director for Chemical Biology at the Target Discovery Institute (TDI). He joined Frankfurt University (Germany) in 2015 as a Professor of Pharmaceutical Chemistry and the Buchmann Institute of Molecular Life Sciences. Since 2017 he is the CSO of the newly founded SGC node at the Goethe-University Frankfurt.
Sekretariat
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Martina Scholz |
Bio 1
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Dr. Krishna SaxenaGroup leader Raum: BMLS 3.654 |
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Frederic FargesPhD student Raum: Tel.: 069/798- |
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Christopher LenzPhD student Raum: 2.638 Buchmann Inst. Tel.: 069/798-42510 |
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Martin SchwalmPhD student Tel.: 069/798-42701 |
Bio 2
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Dr. Andreas JoergerGroup leaderRaum: N240/303a |
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Dimitrios Ilias BalourdasPhD student Raum: N100/2.11 Tel.: 069/798-29307 |
Crystallography
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Dr. Andreas KrämerGroup leader Raum: N240/303a |
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Yeojin KimPhD student Raum N100-211 Tel.: 269/798-29307 |
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Raum N100/2.11 Tel.: 069/798-29307 |
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Rezart Zhubi Tel.: 069/798-29307 |
Medchem (Kinases)
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Dr. Thomas HankeGroup leaderRaum: N250/210 |
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Joshua GerninghausPhD student Raum N250/2.10 Tel.: 069/798-29313
E-mail: gerninghaus[at]pharmchem.uni-frankfurt.de |
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Francesco Aleksy GrecoPhD student Raum N250/2.10 Tel.: 069/798-29313 |
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Aleksandar LucicPhD student Raum N240-210 Tel.: 069/798-29496 |
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Theresa MensingPhD student Raum: N250/2.07 |
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Nicolai RaigPhD student Raum: N250/ 2.07 Tel.: 069/798-29874 |
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Athina ZervaPhD student Raum: N260-020 Tel.: 069/798-29385 |
E3s and PROTACs
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Dr. Vaclav NemecGroup leader Raum: N240/2.03 Tel.: 069/798-29914 |
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Adrian Haag Ph D student |
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Dr. Anton Ruben Hamann Postdoc |
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Lasse HoffmannPhD student Raum: N 260-207 Tel.: 069/798-29800 |
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Nebojsa MileticPhD student Raum N240/2.10 Tel.: 069/798-29496 |
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Nikos ToTechnician Raum: Tel.: 069/798- |
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Janik WeckesserPhD student Raum: N260/ 2.09 Tel.: 069/798-29317 |
Management
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Ralf BradenTechnician Raum: N260/2.05 Tel.: 069/798-29315 E-Mail: Braden[at]pharmchem.uni-frankfurt.de |
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BMLS 3.655 Tel.: |
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Hanna HolzmannLab manager Raum: BMLS 3.670 |
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Raum: BMLS 3.651 |
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Maria TralleroEuropean Affairs and Financial Coordinator Raum: BMLS 3.655 |
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Dr. Claudia TredupScientific Coordinator Raum N240/303b Tel.: 069/798-29401 |
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Lilia WeizelTechnician Raum: N260/2.07 Tel.: 069/798-29800 E-Mail: Weizel[at]pharmchem.uni-frankfurt.de |
Molecular Tools to Explore Cellular Networks
The group creates a diverse range of cellular model systems to establish the efficacy of novel inhibitors and PROTACs on their cognate target protein and characterize the effects of the compounds on cellular health. We further explore the biological function of the targeted proteins as well as validate their role in different disease models as target for pharmacological intervention.
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Dr. Susanne Müller-KnappGroup Leader Raum: BMLS 3.637 |
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Johannes DopferPhD student Raum: BMLS 3.674 Tel.: 069/798-42503 |
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Theresa EhretPhD student Raum: BMLS 3.672 Tel.: 069/798-42422 |
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Lewis ElsonTechnician Raum: BMLS 3.631 Tel.: 069/798-42706 |
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Raum BMLS 3.673 Tel.: 069/798- |
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Saran Aswathaman SivashanmugamPhD student Raum: BMLS 3.670 Tel.: 069/798-42xxx |
Autophagy
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Dr. Vladimir RogovGroup Leader Raum: BMLS 3.657 |
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Viktoria MoraschTechnician |
Pseudokinases and Baculo Expression
Neurodegeneration is a burning issue of our aging population, but there are no reliable cures. We work on better understanding the Parkinson's disease risk factors LRRK2 and RAB10 (also on related kinases and GTPases) to identify prospects for therapeutic intervention. With the focus on enzymatic assays and structural biology, we explore different modalities to targeting these proteins (reversible and covalent inhibitors, PROTACs).
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Dr. Sebastian MatheaGroup Leader Raum: BMLS 3.639 |
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Kamal Rayees Abdul AzeezPhD student Raum: 2.638 Buchmann Inst. Tel.: 069/798-42510 |
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Raum: BMLS 3.670 |
Covalent Inhibitors
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Dr. Sandra RöhmGroup Leader Raum: N260/2.09 Tel.: 069/798-29317 |
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Florian BornPhD student Raum: N260-209 Tel.: 069/798-29800 |
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Sebastian MandelPhD student Raum: N240/2.10 Tel.: 069/798-29496 |
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Guiqun WangPhD student Raum: N100/2.11 Tel.: 069/798-29307 |
Alumni
Marcel Rak (2019 - 2024)
Tim Krapoth (2023)
Jennifer Amrhein (2019 - 2023)
Amelie Tjaden (2020 - 2023)
Christian Muñoz Sosa (2022 - 2023)
Nicolas Bauer (2020 - 2023)
Lena Berger (2018 - 2023)
Benedict Tilman-Berger (2016 - 2023)
Haotian Wang (2018 - 2023)
Jelena Bozilovic (2016 - 2022)
Deep Chatterjee (2017 - 2022)
Xiaomin Ni (2017 - 2022)
Apirat Chaikuad (2014 - 2022)
Christian Kurz (2017 -2021)
Tim Weiser (2016 -2021)
Anja Dölle (2017 - 2021)
Nadine Ruß (2016 - 2021)
Rosa Aghighi (2019 - 2021)
Martin Schröder (2016 - 2021)
Marek Wanior (2015 - 2021)
Kathrin Cartsburg (2014 - 2021)
Roberta Tesch (2018 - 2021)
Leonore Novak (2020 - 2021)
Romain Lucas (2018 - 2020)
Anaïs Lucas (2018 - 2020)
Claire Mestdagh (2019 - 2020)
Mishal McAuley (2017 - 2020)
David Heidenreich (2016 - 2019)
