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Publications

2011

  • Reggie, L., Lopez, J.J., Collinson, I., Glaubitz, C., Lorch, M. (2011) Dynamic Nuclear Polarization-Enhanced Solid-State NMR of a (13)C-Labeled Signal Peptide Bound to Lipid-Reconstituted Sec Translocon. J Am Chem Soc, in press
  • Hellmich, U.A., Duchardt-Ferner, E., Glaubitz, C., Wöhnert, J. (2011) Backbone NMR resonance assignments of the nucleotide binding domain of the ABC multidrug transporter LmrA from Lactococcus lactis in its ADP-bound state.Biomol NMR Assign, in press
  • Lakatos, A., Mörs, K., Glaubitz, C. (2011) How to investigate interactions between membrane proteins and ligands by solid-state NMR. Meth. Mol. Biol., Vol. "Membrane protein structure determination and prediction",  in press.
  • Reckel, S., Gottstein, D., Stehle, J., Löhr, F., Verhoefen, M.K., Takeda, M., Silvers, R., Kainosho, M., Glaubitz, C., Wachtveitl, J., Bernhard, F., Schwalbe, H., Güntert, P., Dötsch, V. (2011) Solution NMR structure of Proteorhodopsin. Angew Chem Int Ed  50, 1-6
  • Hüsch, J., Dutagaci, B., Glaubitz, C., Geppert, T., Schneider, G., Harms, M., Müller-Goymann, C.C., Fink, L., Schmidt, M.U., Setzer, C., Zirkel, J., Rebmann, H., Schubert-Zsilavecz, M., Abdel-Tawab, M. (2011) Structural properties of co-called NSAID-phospholipid-complexes. Eur. J. Pharm. Sci. 44, 103-116
  • Verhoefen, M.K, Schaefer, G., Shastri, S., Weber, I., Glaubitz, C., Maentele, W., Wachtveitl, J. (2011) Low temperature FTIR spectroscopy provides new insights in the pH-dependent proton pathway of proteorhodopsin. Biochim Biophys Acta 1807, 1583-90
  • Taylor, G.F., Wood, S.P., Moers, K., Glaubitz, C., Werner, J., Williamson, P.T.F (2011) Morphologiacal Differences between ß2-Microglobulin in Fibrils and Inclusion Bodies. ChemBioChem 12, 556-558
  • Hempelmann, F., Hölper, S., Verhoefen, M.K., Wörner, A., Köhler, T., Fiedler, S.A., Pfleger, N., Wachtveitl., S., Glaubitz. C. (2011) The His75-Asp97 Cluster in Green Proteorhodopsin. J. Am. Chem. Soc.133, 4645-54
  • Yang, J., Aslimovska, L., Glaubitz, C. (2011) Molecular Dynamics of Green Proteorhodopsin in Lipid Bilayers by Solid-state NMR., J. Am. Chem. Soc. 133, 4874-4881
  • Ullrich, S.J., Hellmich, U.A., Ullrich, S., Glaubitz, C. (2011) Interfacial enzyme kinetics of a membrane bound kinase analyzed by real-time MAS -NMR. Nature Chem. Biol. 7, 263-270
  • Zutz, A., Hoffmann, J., Hellmich, U.A., Glaubitz, C., Ludwig, B., Brutschy, B., Tampe, R. (2011) Asymmetric ATP Hydrolysis Cycle of the Heterodimeric Multidrug ABC Transport Complex TmrAB from Thermus thermophilus. J. Biol. Chem. 286, 7104-7115
  • Hefke F, Bagaria A, Reckel S, Ullrich SJ, Dötsch V, Glaubitz C, Güntert P. (2011) Optimization of amino acid type-specific (13)C and (15)N labeling for the backbone assignment of membrane proteins by solution- and solid-state NMR with the UPLABEL algorithm. J. Biomol. NMR 49, 75-84

2010

  • Maslennikov, I, Klammt, C., Hwang, E., Kefala, G., Okamura, M., Esquivies, L., Mörs, K., Glaubitz, C., Kwiatkowski, W., Jeon, Y.H., Choe, S. (2010) Membrane domain structures of three classes of histidine kinase receptros by cell-free expression and rapid NMR analysis. Proc.Natl.Acad.Sci.U.S.A. 107, 10902-10907
  • Hoffmann, J., Aslimovska, L., Bamann, C., Glaubitz, C., Bamberg, E., Brutschy, B.(2010) Studying the stoichiometries of membrane proteins by mass spectrometry: microbial rhodopsins and a potassium ion channel.Phys.Chem.Chem.Phys. 12, 3480-5
  • Cherepanov, A. V., Glaubitz, C., Schwalbe, H. (2010) High resolution studies of uniformly C-13, N15- labelled RNA by solid-state NMR spectroscopy. Angewandte Chemie Int. Ed. 49, 4747-4750
  • Kumar, J., Sreeramulu, S., Schmidt, T.L., Richter, C., Vonck, J., Heckel, A., Glaubitz, C., Schwalbe, H. (2010) Prion Protein Amyloid Formation Involves Structural Rearrangements in the C-Terminal Domain, ChemBioChem 11, 1208-1213
  • Hoffmann, M., Lopez, J.J., Pergola, C., Feisst, C., Pawelczik, S., Jakobsson, P.J., Sorg, B.L., Glaubitz, C., Steinhilber, D., Werz, O. (2010) Hyperforin induces Ca2+-independent arachidonic acid release in human 2 platelets by facilitating cytosolic phospholipase A2 activation through select 3 phosphilipid interactions, BBA Biomembranes 1801, 462-72.

2009

  • Lopez, J.J., Kaiser, C., Asami, S., Glaubitz, C. (2009) Higher sensitivity through selective 13C excitation in solid-state NMR spectroscopy. J.Am.Chem.Soc. 131, 15970-15971
  • Lörinczi, E., Verhoefen, M.K., Wachtveitl., J., Woerner, A.C., Glaubitz, C., Engelhard, M., Bamberg, E., Friedrich, T. (2009) Voltage- and pH-Dependet Changes in Vectoriality of Photocurrents Mediated by Wild-type and Mutant Proteorhodopsins upon Expression in Xenopus Oocytes, J.Mol. Biol. 393, 320-341
  • Maier, T.J. Schiffmann, S., Birod, K., Angioni.C., Hoffmann, M., Lopez, J.J., Glaubitz, C., Steinhilber, D., Geisslinger, G., Grösch, S. (2009) Cellular membranes function as a storage compartments for celecoxib, J. Mol. Med. 87, 981-993
  • Rinnenthal, J., Richter, C., Nozinovic., S., Fürtig, B., Lopez, J.J., Glaubitz, C., Schwalbe, H.. (2009) RNA phosphodiester backbone dynamics of a perdeuterated cUUCg tetraloop RNA from phosphorous-31 NMR relaxation analysis, J. Biomol. NMR 45, 143-155
  • Hellmich, U.A., Glaubitz, C. (2009) NMR and EPR Studies of Membrane Transporters, Biol. Chem.390, 815-834
  • Pfleger, N., Woerner, A.C., Yang, J., Shastri, S., Hellmich, .A., Aslimovska, L., Maier, M.S.M., Glaubitz, C. (2009) Solid-state NMR and functional studies on proteorhodopsin, BBA Bioenergetics, 1787, 697-705
  • Hellmich, U.A., Pfleger, N., Glaubitz, C. (2009) 19F-MAS NMR on Proteorhodopsin: Enhanced protocol for site-specific labeling for general application to membrane proteins, Photochem Photobiol. 85, 535-539
  • Schäfer, G., Shastri, S., Verhoefen, M.K., Vogel, V., Glaubitz, C., Wachtveitl, J., Mäntele, W. (2009) Characterizing the structure and photocycle of PR 2D crystals with CD-and FTIR spectroscopy, Photochem Photobiol. 85, 529-534
  • Verhoefen, M.K., Neumann, K., Weber, I., Glaubitz C., Wachtveitl, J. (2009) Primary reaction dynamics of proteorhodopsin mutant D97N observed by femtossecond infrared and visible spectroscopy, Photochem. Photobiol. 85, 540-549

2008

  • Göbel, M.W., Dürner, G., Lopez, J.L., Breitung, S.T., Suhartono, M., Glaubitz, C. (2008) A practical Synthesis of the 13C/15N-labelled Tripeptide N-Formyl-Met-Leu-Phe, useful as a Reference in Solid-State NMR  Spectroscopy, Beilstein J.Org Chem, 4,35
  • Hellmich, U.A., Haase, W., Velamakanni, S., van Veen, H., Glaubitz, C., (2008) Caught in the Act: ATP hydrolysis of an ABC-Multidrug transporter followed by real-time Magic Angle Spinning NMR, Febs Letters 582, 3557-62
  • Gieldon, A., Lopez. J.J., Glaubitz, C., Schwalbe, H. (2008) Theoretical Study of the Human Bradykinin - Bradykinin B2 Receptor Complex Supported by Solid-State NMR Spectrocopy Data, ChemBioChem 9, 2487-2497
  • Neumann, K., Verhoefen, M.K., Weber, I., Glaubitz, C., Wachtveitl, J. (2008) Initial reaction dynamics of proteorhodopsin observed by femtosecond infrared and visible spectroscopy, Biophys. J. 94, 4796-4897
  • Lopez, J.J., Kaiser*, C., Shastri, S., Glaubitz, C. (2008) Double quantum filtering homonuclear MAS NMR correlation spectra: A tool for membrane protein studies, J. Biomol. NMR 41, 97-104
  • Lehner, I., Basting, D., Meyer, B., Haase, W., Manolikas, T., Kaiser, C., Karas, M., Glaubitz C. (2008) The key residue for substrate transpor in the EmrE dimer is asymmetric, J. Biol. Chem, 283, 3281-3288
  • Lopez., J.J., Shukla, A.K., Reinhart, C., Schwalbe, H., Michel, H., Glaubitz, C. (2008) The structure of bradykinin bound to the human GPCR bradykini-2 as determined by solid-state NMR, Angew., Chem. Int. Ed. 47, 1668-1671
  • Klyszejnko*, A.L., Shastri*, S., Mari. S.A., Grubmüller, H., Müller, D.J., Glaubitz, C. (2008) Folding and Assembly of Proteorhodopsin, JMB 376, 35-41
  • Pfleger, N. Lorch, M., Wörner, A, Shastri, S., Glaubitz, C. (2008) Characterisation of Schiff base and Chromophore in Green Proteorhodopsin by Solid-State NMR, J. Biomol. NMR 40, 15-21
  • Basting, D., Lorch*, M., Lehner, I., GLaubitz, C. (2008) Transport Cycle Intermediate in Small Multidrug Resistance Protein is revealed by Substrate Fluorescence, FASEB J 22, 365-373

2007

  • Kaiser, C., Lopez, J.J., Bermel, W., Glaubitz, C. (2007) Dual Transormation of Homonuclear Solid-State NMR Spectra - an Option to Decrease Measuring Time, BBA Biomem. 1768, 3107-3115
  • Shastri, S., Vonck, J. Haase, W., Pfleger, N., Kuehlbrandt, W., Glaubitz, C. (2007) Proteorhodopsin: Characterisation of 2D Crystals by Electron Microscopy and Solid-State NMR, BBA Biomemm 1768, 3012-3019
  • Diller, A., Roy, E., Gast, P., van Gorkum, H.J., Glaubitz, C., Jeschke, G. Matysik, J., Alia, A. (2007) 15N photochemically induced dynamic nuclear polarization magic-angle spinning NMR analysis of the electron donor of photosystem II, PNAS 104, 12767-12771
  • Siarheyeva, A., Lopez, J.J., Lehner, I., Hellmich, U.A., van Veen, H., Glaubitz, C. (2007) Probing the Molecular Dynamics of the ABC Multidrug Transpporter LmrA by Deuterium Solid-State NMR, Biochemistry 46, 3075-83
  • Werner, K., Lehner, I., Dhiman, H.K., Richter, C., Glaubitz, C., Schwalbe, H., Klein-Seetharaman, J., Khorana, G. (2007) Combined solid state ans solution NMR sutdies of alpha, epsilon-N-15 labeled bovine rhodopsin, J. Biomol. NMR 37, 303-312
  • Lenz, M., Woerner, A., Glaubitz, C., Wachtveitl, J., (2007) Photoisomerization in Proteorhodopsin mutant D97N, Photochem Photobiol 83, 226-231
  • Lopez, J.J., Mason, A.J., Kaiser, C., Glaubitz, C. (2007) Separated Local Field NMR Experiments on riented Samples Rotating at the Magic Angle, J. Biomol. NMR 37, 97-111

2006

  • Siarheyeva, A., Lopez, J.J., Glaubitz, C. (2006) Localization of multidrug transporter substrates within model membranes, Biochemistry 45, 6203-11
  • Basting, D., Lehner, I., Lorch, M. and Glaubitz, C. (2006) Investigating transport proteins by solid state NMR, Naunyn-Schmiedberg´s Arch Pharmacol 372, 451-464

2005

  • Mason, A.J., Martinez, A., Glaubitz, C., Danos, O., Kichler, A. and Bechinger, B. (2005) The antibiotic and DNA-transfecting peptide LAH4 selectively associates with, and disorders, anionic lipids in mixed membranes, FASEB J 19, 320-322
  • Lorch, M., Fahem, S., Kaiser, C., Weber, I., Mason, A.J., Bowie, J., Glaubitz, C. (2005) How to prepare membrane proteins for solid-state NMR - A case study on the alpha-helical membrane protein DGK from E.coli, ChemBioChem 6, 1693-1700
  • Lorch, M., Lehner, I., Siarheyeva, A., Basting D., Pfleger, N., Manolikas, T., Glaubitz, C. (2005) NMR and fluorescence spectroscopy approaches to seconndary - and primary active multidrug efflux pumps, BioChemSocTrans 33, 873-877
  • Mason, A.J., Lopez, J.J., Beyermann, M., Glaubitz, C. (2005) A spectroscopic Study of the Membrane Interaction of Tuberoinfundibular Peptide of 39 Residues (TIP39), BBA Biomembranes 1714, 1-10
  • Diller, A., Alia, Roy, E., Gast, P., van Gorkum, H.J.M., Zaanem, J., de Groot, HJM, Glaubitz, C., Matysik, J. (2005) Photo-CIDNP solid-state NMR on photosystems I and II: What makes P680 special ?, Photosynthesis Research 84, 303-308
  • Mason, A.J., Turner, G., Glaubitz, C. (2005) Conformational Heterogeneity of transmembrane residues after the Schiff base reprotonation of bacteriorhodopsin - N-15 CPMAS NMR of D85N/T170C membranes, FEBS J 272, 2152-2164

before 2005

  • Mason, A.J., Siarheyeva, A., Haase, W., Lorch, M., van Veen, H. Glaubitz, C. (2004) Amino acid type selctive isotpe labelling of the multidrug ABC transporter LmrA for solid-state NMR studies, FEBS Lett 568, 117-121
  • Mason, A.J., Grage, S.L., Straus, S.K., Glaubitz, C., Watts, A. (2004) Identifying anisotropic constraints in multiply labeled bacteriorhodopsin by N-15 MAOSS NMR: A general apporach to structural studies of membrane proteins, Biophys. J. 86, 1610-1617
  • Klammt, C., Lohr, F., Schäfer, B., Haase, W., Dötsch, V., Rüterjans, H., Glaubitz, C. Bernhard, F. (2004) High level cell-free expression and specific labeling of integral membrane proteins, Eur. J. Biochem. 271, 568-580
  • Spooner, P.J.R., Sharples, J.M., Verhoeven, M.A., Lugtenburg, J., Glaubitz, C., Watts, A. (2002) Relative orientation between the beta-ionone ring and the polyene chain for the chromophore of rhodopsin in native membranes, Biochemistry 41, 7549-7555
  • Glaubitz, C., Carravetta, M., Eden, M., Levitt, M. (2001) Toward recoupling in marcoscopically ordered samples of membrane proteins, Persp. on Solid State NMR (ef. Kiihne, de Groot), 71-81
  • Middleton, D.A., Ahmed, Z., Glaubitz, C., Watts, A. (2000) REDOR NMR on a hysdrophobic peptide in oriented membranes, J Magn Reson 147, 366-370
  • Gaubitz, C., Groger, A., Gottschalk, K., Spooner, P., Watts, A., Schuldiner, S., Kessler, H. (2000) P-31-CP-MAS NMR studies on TPP+ bound to the ion-coupled multidrug transport protein EmrE, Febs Lett 480, 127-131
  • Grobner, G., Burnett, I.J., Glaubitz, C., Choi, G., Mason, A.J., Watts, A. (2000) Observations of light induced structural changes of retinal within rhodopsin, Nature 405, 810-813
  • Glaubitz, C. (2000) An introduction to MAS NMR spectroscopy on oirented membrane proteins, Conceps in Magnetic Resonance 12, 137-151
  • Glaubitz, C., Grobner, G., Watts, A. (2000) Structural and orientational information of teh membrane embedded M13 coat protein by C-13-MAS NMR spectroscopy, BBA Biomembranes 1463, 151-161
  • Grobner, G., Glaubitz, C., Watts, A. (1999) Probing membrane surfaces and the location of membrane-embedded peptides by C-13 MAS NMR using lanthanide ions, J. Magn Reson 141, 335-339
  • Watts, A., Burnett, I.J., Glaubitz, C., Grobner, G., Middleton, D.A., Spooner, P.J.R., Watts, J.A., Williamson, P.T.F. (1999) Membrane protein stucture determination by solid state NMR, Nat. Prod. Rep. 16, 419-423
  • Glaubitz, C., Burnett, I.J., Grobner, G., Mason, A.J., Watts, A. (1999) Deuterium-MAS NMR spectroscopy on oriented membrane proteins: Applications to photointermediates of bacteriorhodopsin, J Am Chem Soc 121, 5787-5794
  • Areas, J.A.G., Grobner, G., Glaubitz, C., Watts, A. (1998) Interaction of a type II myosin with biological membranes studied by H-2 solid state NMR, Biochemistry 37, 5582-5588
  • Glaubitz, C., Watts, A. (1998) Magic angle-oriented sample spinning (MAOSS): A new approach toward biomembrane studies, J Magn Reson 130, 305-316
  • Grobner, G., Choi, G., Burnett, I.J., Glaubitz, C., Verdegem, P.J.E., Lugtenburg, J., Watts, A. (1998) Photoreceptor rhodopsin: structural and conformational study of its chromophore 11-cis retinal in oriented membranes by deuterium solid state NMR, FEBS LETT 422, 201-204
  • Areas, J.A.G., Grobner, G.J., Pellacani, L.B., Glaubitz, C., Watts, A. (1997) Use of solid-state H-2 NMR for studying protein-lipid interactions at emulsion interfaces, Magn Reson Chem 35, 119-124
  • Grobner, G., Taylor, A., Williamson, P.T.F., Choi. G., Glaubitz, C., Watts, J.A., deGrip, W.J., Watts, A. (1997) Macroscopic orientation of natural and model membranes for structural studies, Anal Biochem 254, 132-138

 

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