Hier finden Sie die frühere Beiträge der Rubrik
"Aktuelle Forschungs-Highlights"

2012

• Optogenetic Analysis of a Nociceptor Neuron and Network Reveals Ion Channels Acting Downstream of Primary Sensors,
  Steven J. Husson, Wagner Steuer Costa, Sebastian Wabnig, Jeffrey N. Stirman, Joseph D. Watson, W. Clay Spencer, Jasper Akerboom, Loren L. Looger, Millet Treinin, David M. Miller, Hang Lu and Alexander Gottschalk (2012)
  Current Biology, Epub ahead of print, DOI:10.1016/j.cub.2012.02.066
• Stochastic sensing of proteins with receptor-modified solid-state nanopores,
  Ruoshan Wei, Volker Gatterdam, Ralph Wieneke, Robert Tampé & Ulrich Rant (2012)
  Nature Nanotechnology, Epub ahead of print, DOI: 10.1038/NNANO.2012.24
• Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop,
  Thomas Eicher, Hi-jea Chaa, Markus A. Seeger, Lorenz Brandstätter, Jasmin El-Delik, Jürgen A. Bohnert, Winfried V. Kern, François Verrey, Markus G. Grütter, Kay Diederichs and Klaas M. Pos (2012)
  PNAS early edition, www.pnas.org/cgi/doi/10.1073/pnas.1114944109.

2011

• Construction of a Structurally Defined Double-Stranded DNA Catenane
  Schmidt TL and Heckel A (2011)
  Nano Letters, Epub ahead of print, DOI: 10.1021/nl200303m
• Interfacial enzyme kinetics of a membrane bound kinase analyzed by real-time MAS -NMR.
  Ullrich, S.J., Hellmich, U.A., Ullrich, S., Glaubitz, C. (2011)
  Nature Chem. Biol. Epub ahead of print, doi:10.1038/nchembio.543   [Pressemitteilung]

• DNA Damage in Oocytes Induces a Switch of the Quality Control Factor TAp63α from Dimer to Tetramer.
  G. B. Deutsch, E. M. Zielonka, D. Coutandin, T. A. Weber, B. Schäfer, J. Hannewald, L. M. Luh, F. G. Durst, M. Ibrahim, J. Hoffmann, F. H. Niesen, A. Sentürk, H. Kunkel, B. Brutschy, E. Schleiff, S. Knapp, A. Acker-Palmer, M. Grez, F. McKeon, V. Dötsch
  Cell, Vol. 144, 566-576 (2011)     

• Ribosome recycling depends on a mechanistic link between the FeS cluster domain and a conformational switch of the twin-ATPase ABCE1.
  Barthelme, D., Dinkelaker, S., Albers, S.‐V., Ermler, U. & Tampé, R. (2011)
  Proc Natl Acad Sci U S A. (published ahead of print January, 31st)
  Supporting Information
• Real-time multimodal optical control of neurons and muscles in freely behaving Caenorhabditis elegans
  Jeffrey N Stirman, Matthew M Crane, Steven J Husson, Sebastian Wabnig, Christian Schultheis, Alexander Gottschalk & Hang Lu
  Nature Methods, Vol. 8, 153–158 (2011) DOI: doi:10.1038/nmeth.1555
• Conformation of peptides bound to the transporter associated with antigen processing (TAP).
  Herget M, Baldauf C, Schölz C, Parcej D, Wiesmüller KH, Tampé R, Abele R, Bordignon E. (2011)
  Proc Natl Acad Sci U S A. (published ahead of print January, 4th; PMID: 21205905)
  Supporting Information

2010

• Multiplexed Parallel Single Transport Recordings on Nanopore Arrays
  Alexander Kleefen, Daniel Pedone, Christian Grunwald, Ruoshan Wei, Matthias Firnkes, Gerhard Abstreiter, Ulrich Rant, and Robert Tampé (2010)
  Nano Lett., Articles ASAP (published ahead of print October 27, 2010, DOI: 10.1021/nl1033528)
• Prediction of blood–brain barrier penetration of poorly soluble drug candidates using surface activity profiling
  Anna Christine Petereita, Kelly Swinneyb, Jurgen Menschb, Claire Mackiec, Sigrid Stokbroekxb, Marcus Brewsterb and Jennifer B. Dressman (2010)
  European Journal of Pharmaceutics and Biopharmaceutics, Vol. 75, 405-410
• Structural Studies of 13C,15N-labeled RNA by Solid-State NMR spectroscopy
  Alexey V. Cherepanov, Clemens Glaubitz and Harald Schwalbe (2010)
  Angew. Chem., published ahead of print June 8, 2010, DOI: 10.1002/anie.200906885.
• Single residue within the antigen translocation complex TAP controls the epitope repertoire by stabilizing a receptive conformation
  Baldauf C, Schrodt S, Herget M, Koch J, and Tampé R (2010)
  Proceedings of the National Academy of Sciences USA (published online May 3rd. doi/10.1073/pnas.1001308107).
• In situ assembly of macromolecular complexes triggered by light
  Grunwald C, Schulze K, Reichel A, Weiss VU, Piehler J, Wiesmüller KH and Tampé R (2010)
  Proceedings of the National Academy of Sciences USA (published online March 1st. doi/10.1073/pnas.0912617107 ).

2009

• Unfolded-State Structure and Dynamics Influence the Fibril Formation of Human Prion Protein
  Christian Gerum, Robert Silvers, Julia Wirmer-Bartoschek, and Harald Schwalbe
  Angew. Chem. 2009, 121, 9616 –9620
• Bioactivity-guided mapping and navigation of chemical space
  Steffen Renner , Willem A L van Otterlo , Marta Dominguez Seoane , Sabine M|[ouml]|cklinghoff , Bettina Hofmann , Stefan Wetzel , Ansgar Schuffenhauer , Peter Ertl , Tudor I Oprea , Dieter Steinhilber , Luc Brunsveld , Daniel Rauh & Herbert Waldmann
  Nature Chemical Biology 2009, 5, 585–592
• Protein structure determination in living cells by in-cell NMR spectroscopy
  Sakakibara, D., Sasaki, A., Ikeya, T., Hamatsu, J., Hanashima, T., Mishima, M., Yoshimasu, M., Hayashi, N., Mikawa, T., Wälchli, M., Smith, B. O., Shirakawa, M., Güntert, P. & Ito, Y
  Nature 458, 102-105 (2009),
  [Pressemitteilung]

2008

• The structure of bradykinin bound to the human GPCR bradykinin-2 as determined by solid-state NMR
  Lopez, J.J., Shukla, A.K., Reinhart, C., Schwalbe, H., Michel, H., Glaubitz, C
  Angew. Chem. Int. Ed.47, 1668-1671
  
• Structural basis for the selectivity of the external thioesterase of the surfactin-synthetase
  Koglin, A., Löhr, F., Bernhard, F., Rogov, V. R., Frueh, D. P., Strieter, E. R., Mofid, M. R., Güntert, P., Wagner, G., Walsh, C. T., Marahiel, M. A. & Dötsch, V.
  Nature 454, 907–911 (2008),
  [Pressemitteilung]

2007

• Identification of a lysosomal peptide transport system induced during dendritic cell development
  Ö. Demirel, Z. Waibler, U. Kalinke, F. Grünebach, S. Appel, P. Brossart, A. Hasilik, R. Tampé and R. Abele
  J. Biol. Chem. 2007; 282; 37836 - 43
• Time-resolved NMR methods resolving ligand-induced RNA folding at atomic resolution
  J. Buck, B. Fürtig, J. Noeske, J. Wöhnert, H. Schwalbe 
  Proc Natl Acad Sci U S A. 2007;104(40):15699-704
• Bidirectional optical control of neurons, neural circuits and behaviour in Caenorhabditis elegans
  M. Brauner, J. Liewald, A. Gottschalk 
  NATURE 2007; 446; 633-639
• Native protein nanolithography that can write, read and erase
  A. Tinazli, J. Piehler, M. Beuttler, R. Guckenberger, R. Tampe 
  NATURE NANOTECHNOLOGY, 2007;  2 (4): 220-225

2006

• Highlights in asymmetric Synthesis and Catalysis
  M. Rueping, C. Azap, Angew. Chem. 2006, 118, 7996-7999 (Int. Ed. 45, 7832-7835)
  M. Rueping, A. P. Antonchick, T. Theissmann, Angew. Chem. 2006, 118, 6903-6907 (Int. Ed. 45, 6751-6755)
  M. Rueping, A. P. Antonchick, T. Theissmann, Angew. Chem. 2006, 118, 3765-3768 (Int. Ed. 45, 3683-3686)
  M. Rueping, E. Sugiono, C. Azap, Angew. Chem. 2006, 118, 2679-2681 (Int. Ed. 45, 2617-2619)
  Von der Natur lernen (aus Forschung Frankfurt, 2007)
• Molecular phylogeny and evolution of morphology in the social amoebas
  Schaap P, Winckler T, Nelson M, Alvarez-Curto E, Elgie B, Hagiwara H, Cavender J, Milano-Curto A, Rozen DE, Dingermann T, Mutzel R, Baldauf SL
  Science. 2006; 314(5799); 661-3
• Localization of multidrug transporter substrates within model membranes
  Siarheyeva A, Lopez JJ, Glaubitz C,
  Biochemistry 2006; 45(19); 6203-11
• Conformational switches modulate protein interactions in peptide antibiotic synthetases
  Koglin A, Mofid MR, Lohr F, Schafer B, Rogov VV, Blum MM, Mittag T, Marahiel MA, Bernhard F, Dotsch V;
  Science 2006; 312(5771); 273-6.

2005

• Hyperforin activates nonselective cation channels (NSCCs)
  Treiber K, Singer A, Henke B, Muller WE;
  Br J Pharmacol. 2005; 145(1); 75-83
• Histamine H4 receptor stimulation suppresses IL-12p70 production and mediates chemotaxis in human monocytederived dendritic cells
  Ralf Gutzmer, Carola Diestel, Susanne Mommert, Brigitta Köther, Holger Stark, Miriam Wittmann, Alexander Kapp and Thomas Werfel;
  Journal of Immunology  2005; 174(9); 5224-5232
• The genome of the social amoeba Dictyostelium discoideum
  Nature 2005;  435, 43-57
• Diagnostic tool for the identification of MLL rearrangements including unknown partner genes
  Meyer C, Schneider B, Reichel M, Angermueller S, Strehl S, Schnittger S, Schoch C, Jansen MW, van Dongen JJ, Pieters R, Haas OA, Dingermann T, Klingebiel T, Marschalek R;
  Proc. Natl. Acad. Sci. USA, 2005, 102(2), 449-454.

2004

• The functional asymmetry of TAP is reflected in the different C-loop sequences
  Min Chen, Rupert Abele and Robert Tampé;
  Journal of Biological Chemistry, 2004, 279 (44), 46073-46081
• Modulation of Compactness and Long-Range Interactions of Unfolded Lysozyme by Single Point Mutations
  Julia Wirmer, Christian Schlörb, Judith Klein-Seetharaman, Ryoma Hirano, Tadashi Ueda, Taiji Imoto, Harald Schwalbe;
  Angewandte Chemie (2004) 43, 5780-5785

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