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Publikationen/Publications

2012

  • Brachmann AO, Reimer D, Lorenzen W, Augusto Alonso E, Kopp Y, Piel J, Bode HB, Reciprocal Cross Talk between Fatty Acid and Antibiotic Biosynthesis in a Nematode Symbiont, Angew Chem Int Ed Engl. 2012 Oct 24

  • Zhou Q, Dowling A, Heide H, Wöhnert J, Brandt U, Baum J, Ffrench-Constant R, Bode HB., Xentrivalpeptides a-q: depsipeptide diversification in Xenorhabdus, J Nat Prod. 2012 Oct 26;75(10):1717-22.

  • Thanwisai A, Tandhavanant S, Saiprom N, Waterfield NR, Ke Long P, Bode HB, Peacock SJ, Chantratita N., Diversity of Xenorhabdus and Photorhabdus spp. and their symbiotic entomopathogenic nematodes from Thailand, PLoS One. 2012;7(9):e43835

  • Brat D, Weber C, Lorenzen W, Bode HB, Boles E., Cytosolic re-localization and optimization of valine synthesis and catabolism enables inseased isobutanol production with the yeast Saccharomyces cerevisiae, Biotechnol Biofuels. 2012 Sep 6;5(1):65

  • Sebastian W. Fuchs, Christian C. Sachs, Carsten Kegler, Friederike I. Nollmann, Michael Karas, and Helge B. Bode, Neutral Loss Fragmentation Pattern Based Screening for Arginine-Rich Natural Products in Xenorhabdus and Photorhabdus, Analytical Chemistry, 2012;84(16):6948-55, Software NLFPS developed for screening is available for download (123kb Version 0.1)

  • F. Grundmann, V. Dill, A. Dowling, A. Thanwisai, E. Bode, N. Chantratita, R. ffrench-Constant, H.B. Bode*, Identification and isolation of insecticidal oxazoles from Pseudomonas sp., Beilstein J. Org. Chem., 2012, 8, 749-752
  • F.I. Nollmann, A. Dowling, M. Kaiser, K. Deckmann, S. Grösch, R. ffrench-Constant, H.B. Bode*, Synthesis of szentiamide, a depsipeptide from entomopathogenic Xenorhabdus szentirmaii with activity against Plasmodium falciparum, Beilstein J. Org. Chem., 2012, 8, 528-533
  • H.B. Bode*, D. Reimer, S.W. Fuchs, F. Kirchner, C. Dauth, C. Kegler, W. Lorenzen, A.O. Brachmann, P. Grün, Determination of the absolute configuration of peptide natural products using stable isotope labeling and mass spectrometry, Chem. Eur. J., published online DOI: 10.1002/chem.201103479

  • J.M. Chaston, G. Suen, S.L. Tucker, A.W. Andersen, A. Bhasin, E. Bode, H.B. Bode, A.O. Brachmann, C.E. Cowles, K.N. Cowles, C. Darby, L. de Léon, K. Drace, Z. Du, A. Givaudan, E.E. Herbert Tran, K.A. Jewell, J.J. Knack, K.C. Krasomil-Osterfeld, R. Kukor, A. Lanois, P. Latreille, N.K. Leimgruber, C.M. Lipke, R. Liu, X. Lu, E.C. Martens, P. R. Marri, C. Médigue, M.L. Menard, N.M. Miller, N. Morales-Soto, S Norton, J.-C. Ogier, S.S. Orchard, D. Park,Y. Park, B.A. Qurollo, D. Renneckar Sugar, G.R. Richards, Z. Rouy, B. Slominski, K. Slominski, H. Snyder, B.C. Tjaden, R. van der Hoeven, R.D. Welch, C. Wheeler, B. Xiang, B. Barbazuk, S. Gaudriault, B. Goodner, S.C. Slater, S. Forst, B.S. Goldman*, H. Goodrich-Blair*, The Entomopathogenic Bacterial Endosymbionts Xenorhabdus and Photorhabdus: Convergent Lifestyles from Divergent Genomes, PLoS ONE, 2011, 6, e27909

  • A.O. Brachmann, F. Kirchner, C. Kegler, S.W. Kinski, I. Schmitt, H.B. Bode*, Triggering the production of the cryptic blue pigment indigoidine from Photorhabdus luminescens. J. Biotechnol. 2012, 157, 96-99

2011

  • D. Reimer, K.M. Pos, M. Thines, P. Grün, H.B. Bode*, A natural prodrug activation mechanism in nonribosomal peptide synthesis.Nat. Chem. Biol. 2011, 7, 888-890. 

  • A. Proschak, K. Schultz, J. Herrmann, A.J. Dowling, A.O. Brachmann, R. ffrench-Constant, R. Müller, H.B. Bode*, Cytotoxic fatty acid amides from Xenorhabdus.ChemBioChem 2011, 12, 2011-2015

  • M. Kopp, H. Irschik, K. Gemperlein, K. Buntin, P. Meiser, K.J. Weissman, H.B. Bode, R. Müller*, Insights into the complex biosynthesis of the leupyrrins in Sorangium cellulosum So ce690. Mol. Biosyst. 2011, 7, 1549-1563

  • S.W. Fuchs, A. Proschak, T.W. Jaskolla, M. Karas, H.B. Bode*, Structure elucidation and biosynthesis of lysine-rich cyclic peptides in Xenorhabdus nematophila. Org. Biomol. Chem. 2011, 9, 3130-3132

2010

  • H.B. Bode*, Insect-Associated Microorganisms as a Source for Novel Secondary Metabolites with Therapeutic Potential (Chapter 5) in: Vilcinskas, A. (Ed.) Insect Biotechnology, Springer, 2010.

  • H.B. Bode*, Insektenpathogene Bakterien als Quelle neuer Naturstoffe, Biospektrum, 2010, 266-270

2009

  • E. Hoiczyk, M.W. Ring, C.A. McHugh, G. Schwär, E. Bode, D. Krug, M.O. Altmeyer, J.Z. Lu, H.B. Bode, Lipid body formation plays a central role in cell fate determination during developmental differentiation of Myxococcus xanthus, Mol. Microbiol. 2009, 74, 497-517.

  • D. Park, K. Ciezki, R. van der Hoeven, S. Singh, D. Reimer, H.B. Bode, S. Forst, Genetic analysis of xenocoumacin antibiotic production in the mutualistic bacterium Xenorhabdus nematophila, Mol. Microbiol. 2009, 73, 938-949.

  • W. Lorenzen, M.W. Ring, G. Schwär, H.B. Bode, Isoprenoids are essential for fruiting body formation in Myxococcus xanthus, J. Bacteriol. 2009, 191, 5849-5853.

  • D. Reimer, E. Luxenburger, A.O. Brachmann, H.B. Bode*, A new type of pyrrolidine biosynthesis is involved in the late steps of xenocoumacin production in Xenorhabdus nematophila, ChemBioChem 2009, 10, 1997-2001.

  • M.W. Ring, G. Schwär, H.B. Bode*, Biosynthesis of 2‑hydroxy and iso‑even fatty acids is connected to sphingolipid formation in myxobacteria, ChemBioChem 2009, 10, 2003-2010.

  • H.B. Bode, Insects: True pioneers in anti-infective therapy and what we can learn from them, Angew. Chem. Int. Ed Engl 2009, 48, 6394-6396.

  • M.W. Ring, E. Bode, G. Schwär, H.B. Bode*, Functional analysis of desaturases from the myxobacterium Myxococcus xanthus, FEMS Microbiol. Lett. 2009, 296, 124-130.

  • A. Zöllner, C.A. Dragan, D. Pistorius, R. Müller, H.B. Bode, F.T. Peters, H.H. Maurer, M. Bureik, Human CYP4Z1 catalyzes the in-chain hydroxylation of lauric acid and myristic acid, Biol. Chem. 2009, 390, 313-317.

  • B. Ohlendorf, W. Lorenzen, S. Kehraus, A. Krick, H.B. Bode, G.M. König*, Myxotyrosides A and B, unusual Rhamnosides from Myxococcus sp., J. Nat. Prod. 2009, 72, 82-86.

  • H.B. Bode, M.W. Ring, G. Schwär, M.O. Altmeyer, C. Kegler, I.R. Jose, M. Singer, R. Müller*, Identification of additional players in the alternative biosynthesis pathway to isovaleryl-CoA in the myxobacterium Myxococcus xanthus, ChemBioChem 2009, 10, 128-140.

  • H.B. Bode*, Entomopathogenic bacteria as source of new secondary metabolites, Curr. Opin. Chem. Biol. 2009, 13, 224-230.

2008

  • N.R. Waterfield*, M. Sanchez-Contreras, I. Eleftherianos, A. Dowling, P. Wilkinson, J. Parkhill, N. Thomson, S.E. Reynolds, H.B. Bode, S. Dorus, R.H. ffrench-Constant, Rapid Virulence Annotation (RVA): Identification of virulence factors using a bacterial genome library and multiple invertebrate hosts, Proc. Natl. Acad. Sci. USA 2008, 105, 15967-15972.

  • S.C. Wenzel, H.B. Bode, I. Kochems, R. Müller*, A type I/type III polyketide synthase hybrid biosynthetic pathway for the structurally unique ansa compound kendomycin, ChemBioChem 2008, 9, 2711-2721.

  • P. Meiser, K.J. Weissman, H.B. Bode, J.S. Dickschat, A. Sandmann, R. Müller*, DKxanthene biosynthesis – Understanding the basis for diversity-oriented synthesis in myxobacterial secondary metabolism, Chem. Biol. 2008, 15, 771-781.

  • S.A. Joyce, A.O. Brachmann, I. Glazer, L. Lango, G. Schwär, D.J. Clarke*, H.B. Bode*, Bacterial biosynthesis of a multipotent stilbene, Angew. Chem. Int. Ed.2008, 47, 1942-1945. (ausgewählt als VIP-Paper).

2007

  • S. Schneiker, O. Perlova, A. Alici, M.O. Altmeyer, D. Bartels, T. Bekel, S. Beyer, H. Blöcker, E. Bode, H.B. Bode, C. Bolten, J.V. Choudhuri, S. Doss, Y.A. Elnakady, B. Frank, L. Gaigalat, K. Gerth, A. Goesmann, C. Groeger, F. Gross, L. Jelsbak, L. Jelsbak, O. Kaiser, J. Kalinowski, C. Kegler, T. Knauber, S. Konietzny, M. Kopp, L. Krause, D. Krug, B. Linke, T. Mahmud, R. Martinez-Arias, A.C. McHardy, M. Merai, F. Meyer, S. Mormann, J. Munoz-Dorado, J. Perez, S. Rachid, G. Raddatz, F. Rosenau, C. Rückert, F. Sasse, M. Scharfe, S.C. Schuster, G. Suen, A. Treuner-Lange, G.J. Velicer, F.-J. Vorhölter, K.J. Weissman, R.D. Welch, S.C. Wenzel, D. Whitworth, S. Wilhelm, C. Wittmann, A. Pühler, R. Müller*, Complete sequence of the largest known bacterial genome from the myxobacterium Sorangium cellulosum, Nature Biotechnol. 2007, 25, 1281-1289.

  • B. Frank, S.C Wenzel, H.B. Bode, M. Scharfe; H. Blöcker, R. Müller*, From genetic diversity to metabolic unity: studies on the biosynthesis of aurafurones and aurafuron-like structures in myxobacteria and streptomycetes, J. Mol. Biol. 2007, 374, 24-38.

  • H.B. Bode*, P. Meiser, T. Klefisch, N. Socorro d. J. Cortina, D. Krug, A. Göhring, G. Schwär, T. Mahmud, Y.A. Elnakady, R. Müller*, Mutasynthesis-derived myxalamids and origin of the isobutyryl-CoA starter unit of myxalamid B, ChemBioChem 2007, 8, 2139-2144.

  • P. Latreille, S. Norton, B.S. Goldman, J. Henkhaus, N. Miller, B. Barbazuk, H.B. Bode, C. Darby, Z. Du, S. Forst, S. Gaudriault, B. Goodner, H. Goodrich-Blair, S. Slater*, Optical Mapping as a Routine Tool for Bacterial Genome Sequence Finishing, BMC Genomics 2007, 8, 321.

  • A.O. Brachmann, S.A. Joyce, H. Jenke-Kodama, G. Schwär, D.J. Clarke, H.B. Bode*, A type II polyketide synthase is responsible for anthraquinone biosynthesis in Photorhabdus luminescens, ChemBioChem 2007, 8, 1721-1728.

  • H.B. Bode and Rolf Müller*, Secondary metabolism in Myxobacteria (Chapter 15) in: Whitworth, D. (Ed) Myxobacteria: multicellularity and differentiation. ASM press, Chicago, 2007.

  • H.B. Bode* and R. Müller*, Reversible sugar transfer by glycosyltransferases as a tool for natural product (bio)synthesis, Angew. Chem. Int. Ed. 2007, 46, 2147-2150.

2006

  • A.O. Brachmann, S. Forst, G.M. Furgani, A. Fodor, H.B. Bode*, Xenofuranones A and B: Phenylpyruvate dimers from Xenorhabdus szentirmaii, J. Nat. Prod. 2006, 69, 1830-1832.

  • P. Meiser, H.B. Bode, R. Müller*, The unique DKxanthene secondary metabolite family from the myxobacterium Myxococcus xanthus is required for developmental sporulation, Proc. Natl. Acad. Sci. USA 2006, 103, 19128-33.

  • M.W. Ring, G. Schwär, V. Thiel, J.S. Dickschat, R.M. Kroppenstedt, S. Schulz, H.B. Bode*, Novel iso-branched etherlipids as specific markers of developmental sporulation in the myxobacterium Myxococcus xanthus, J. Biol. Chem. 2006, 281,36691-36700.

  • H.B. Bode*, M.W. Ring, G. Schwär, R.M. Kroppenstedt, D. Kaiser, R. Müller*, 3-Hydroxy-3-methylglutaryl-coenzyme A (CoA) synthase is involved in the biosynthesis of isovaleryl-CoA in the myxobacterium Myxococcus xanthus during fruiting body formation, J. Bacteriol. 2006, 188, 6524-6528.

  • H.B. Bode*, M.W. Ring, D. Kaiser, A.C. David, R.M. Kroppenstedt, G. Schwär, Straight-chain fatty acids are dispensable in the myxobacterium Myxococcus xanthus, J. Bacteriol. 2006, 188, 5632-5634.

  • H.B. Bode*, No need to be pure: mix the cultures!, Chem. Biol. 2006, 13, 1245-1246.

  • H.B. Bode*, Mehr als nur Naturstoffe, transkript 2006, 12, 55

  • H.B. Bode and R. Müller*, Analysis of myxobacterial secondary metabolism goes molecular, J. Ind. Biotechnol. Microbiol. 2006, 33, 577-588.

2005

  • J. S. Dickschat, H.B. Bode, T. Mahmud, R. Müller, S. Schulz*, A novel type of Geosmin biosynthesis in myxobacteria, J. Org. Chem. 2005, 70, 5174-82.

  • J. S. Dickschat, H.B. Bode, R. M. Kroppenstedt, R. Müller, S. Schulz*, Biosynthesis of iso-fatty acids in myxobacteria, Org. Biomol. Chem. 2005, 3, 2824-31.

  • J.S. Dickschat, H.B. Bode, S.C. Wenzel, R. Müller, S. Schulz*, Biosynthesis and Identification of Volatiles Released by the Myxobacterium Stigmatella aurantiaca, ChemBioChem2005, 6, 2023-2033.

  • H.B. Bode, J.S. Dickschat, R.M. Kroppenstedt, S. Schulz, R. Müller*, Biosynthesis of iso-fatty acids in myxobacteria: iso-even fatty acids are derived from a-oxidation of iso-odd fatty acids, J. Am. Chem. Soc., 2005, 127, 532-533.

  • T. Mahmud, S.C. Wenzel, E. Wan, K.W. Wen, H.B. Bode, N. Gaitatzis, R. Müller*, A Novel Biosynthetic Pathway to Isovaleryl-CoA in Myxobacteria: The Involvement of the Mevalonate Pathway, ChemBioChem, 2005, 6, 322-330.

  • H.B. Bode and R. Müller*, The impact of bacterial genomics on natural product research, Angew. Chem.Int. Ed. 2005, 44, 6828-6846.

2004

2003

  • H.B. Bode, H. Irschik, S.C. Wenzel, H. Reichenbach, R. Müller, G. Höfle*, The Leupyrrins: a structurally unique family of secondary metabolites from the myxobacterium Sorangium cellulosum, J. Nat. Prod., 2003, 66, 1203-1206.

  • H.B. Bode, B. Zeggel, B. Silakowski, S.C. Wenzel, H. Reichenbach, R. Müller*, Steroid biosynthesis in prokaryotes: Identification of myxobacterial steroids and cloning of the first bacterial 2,3(S)-oxidosqualene cyclase from the myxobacterium Stigmatella aurantiaca, Mol. Microbiol, 2003, 47, 471-481.

  • S. Busch, H.B. Bode, A.A. Brakhage, G.H. Braus*, Impact of the cross-pathway control on the metabolic flux towards lysine and penicillin in Aspergillus nidulans, Curr. Genetics, 2003, 42, 209-219.

  • H.B. Bode and R. Müller*, Possibility of bacterial recruitment of plant genes associated with the biosynthesis of secondary metabolites, Plant Physiol., 2003, 132, 1153-1161.

2002

  • T. Mahmud, H.B. Bode, B. Silakowski, R.M. Kroppenstedt, M. Xu, S. Nordhoff, G. Höfle, R. Müller*, A novel biosynthetic pathway providing precursors for fatty acid biosynthesis and secondary metabolite formation in myxobacteria, J. Biol. Chem., 2002, 277, 32768-32774.

  • H.B. Bode, R. Höfs, B. Bethe, A. Zeeck*, Big effects from small changes: possible ways to explore nature´s chemical diversity, ChemBioChem, 2002, 3, 619-627.

2001

  • H.B. Bode, K. Kerkhoff, D. Jendrossek*, Bacterial degradation of natural and synthetic rubber, Biomacromolecules, 2001, 2, 295-303.

  • H.B. Bode*, „Junge“ Naturstoffchemie, Nachrichten aus der Chemie, 2001, 49, 951

2000

  • H.B. Bode, A. Zeeck, K. Plückhahn, D. Jendrossek*, Physiological and chemical investigations into microbial degradation of synthetic poly(cis-1,4-isoprene), Appl. Environ. Microbiol., 2000, 66, 3680-3685.

  • H.B. Bode, A. Zeeck*, Structure and biosynthesis of kendomycin, a carbocyclic ansa-compound from Streptomyces, J. Chem. Soc., Perkin Trans. 1, 2000, 323-328.

  • H.B. Bode, A. Zeeck*, Biosynthesis of kendomycin: Origin of the oxygen atoms and further investigations, J. Chem. Soc., Perkin Trans. 1, 2000, 2665-2670.

  • H.B. Bode, B. Wegner, A. Zeeck*, Biosynthesis of cladospirone bisepoxide, a member of the spirobisnaphthalene family, J. Antibiotics, 2000, 53, 153-157.

  • H.B. Bode, A. Zeeck*, Sphaerolone and dihydrosphaerolone, two bisnaphthyl-pigments from the fungus Sphaeropsidales sp. F-24´707, Phytochemistry, 2000, 54, 597-601.

  • H.B. Bode, A. Zeeck*, UV mutagenesis and enzyme inhibitors as tools to elucidate the late biosynthesis of the spirobisnaphthalenes, Phytochemistry, 2000, 55, 311-316.

  • H.B. Bode, M. Walker, A. Zeeck*, Structure and biosynthesis of mutolide, a novel macrolide from a UV mutant of the fungus F-24´707, Eur. J. Org. Chem., 2000, 1451-1456.

  • H.B. Bode, M. Walker, A. Zeeck*, Cladospirones B to I from Sphaeropsidales sp. F-24´707 by variation of culture conditions, Eur. J. Org. Chem., 2000, 3185-3193.

 

 

geändert am 16. Januar 2014  E-Mail: Tilman Ahrendtahrendt@bio.uni-frankfurt.de

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