Bolz, M., Thomas, L., Scheffer, U., Kalden, E., Hartmann, R.K., and Goebel, M.W. (2020). Redirection of miRNA-Argonaute Complexes to Specific Target Sites by Synthetic Adaptor Molecules. Chem. Biodiversity 17, e2000272. DOI:10.1002/cbdv.202000272

Zellmann, F., and Goebel, M.W. (2020). A trisbenzimidazole phosphoramidite building block enables high-yielding syntheses of RNA-cleaving oligonucleotide conjugates. Molecules 25, 1842. DOI:10.3390/molecules25081842

Hornung, J.-E., Hellwig, N., and Goebel, M.W. (2020). Peptide Nucleic Acid Conjugates of Quinone Methide Precursors Alkylate Ribonucleic Acid after Activation with Light. Bioconjugate Chem. 31, 639-645. DOI:10.1021/acs.bioconjchem.9b00796

Zellmann, F.; Thomas, L.; Scheffer, U.; Hartmann, R. K.; Göbel, M. W. (2019). Site-Specific Cleavage of RNAs Derived from the PIM1 3′-UTR by a Metal-Free Artificial Ribonuclease. Molecules 24, 807

Weinrich, T.; Jaumann, E.A.; Scheffer, U.; Prisner, T.F.; Göbel, M.W. (2018). A Cytidine Phosphoramidite with Protected Nitroxide Spin Label: Synthesis of a Full-Length TAR RNA and Investigation by In-Line Probing and EPR Spectroscopy. Chemistry 24, 6202–6207.

Weinrich, T.; Jaumann, E.A.; Scheffer, U.M.; Prisner, T.F.; Goebel, M.W. (2018). Phosphoramidite building blocks with protected nitroxides for the synthesis of spin-labeled DNA and RNA. Beilstein J. Org. Chem. 14, 1563–156.

Stark, T. Lieblein, T. Pohland, M. Kalden, E. Freund, P. Zangl, R. Grewal, R. Heilemann, M. Eckert, G.P. Morgner, N. Goebel, M.W. (2017). Peptidomimetics that inhibit and partially reverse the Aggregation of Aβ1-42. Biochemistry, 56, 4840.
DOI: 10.1021/acs.biochem.7b00223

Goldberg, M., Sartakov, D., Bats, J.W., Bolte, M., and Göbel, M.W. (2016). A chiral analog of the bicyclic guanidine TBD. Synthesis, structure and Brønsted base catalysis. Beilstein J. Org. Chem. 12, 1870-1876.

Wirth-Hamdoune, D., Ullrich, S., Scheffer, U., Radanović, T., Duerner, G., and Goebel, M.W. (2016). A Bis(guanidinium)alcohol Attached to a Hairpin Polyamide: Synthesis, DNA Binding, and Plasmid Cleavage. ChemBioChem 17, 506-514.

Dogandzhiyski, P., Ghidini, A., Danneberg, F., Stromberg, R., and Gobel, M.W. (2015). Studies on tris(2-aminobenzimidazole)-PNA based artificial nucleases: a comparison of two analytical techniques. Bioconjugate Chem. 26, 2514-2519.

Danneberg, F., Ghidini, A., Dogandzhiyski, P., Kalden, E., Strömberg, R., and Göbel, M.W. (2015). Sequence-specific RNA cleavage by PNA conjugates of the metal-free artificial ribonuclease tris(2-aminobenzimidazole). Beilstein J. Org. Chem. 11, 493-498.

Zeiger, M., Stark, S., Kalden, E., Ackermann, B., Ferner, J., Scheffer, U., Shoja-Bazargani, F., Erdel, V., Schwalbe, H., and Göbel, M.W. (2014). Fragment based search for small molecule inhibitors of HIV-1 Tat-TAR. Bioorg. Med. Chem. Lett.

Seven, I., Weinrich, T., Gränz, M., Grünewald, C., Brüß, S., Krstić, I., Prisner, T.F., Heckel, A., and Göbel, M.W. (2014). Photolabile Protecting Groups for Nitroxide Spin Labels. Eur. J. Org. Chem. 19 4037-4043

Cernescu, M.; Stark, T.; Kalden, E.; Kurz, C.; Leuner, K.; Deller, T.; Göbel, M.; Eckert, G. P.; Brutschy, B. (2012). Laser-Induced Liquid Bead Ion Desorption Mass Spectrometry: An Approach to Precisely Monitor the Oligomerization of the β-Amyloid Peptide. Anal. Chem. 84 5276–5284
DOI: 10.1021/ac300258m 

Pinto Gomes, C.; Metz, A.; Bats, J. W.; Gohlke, H.; Göbel, M. W. (2012). Modular Solid-Phase Synthesis of Teroxazoles as a Class of α-Helix Mimetics. Eur. J. Org. Chem. 3270–3277
DOI: 10.1002/ejoc.201200339 

Nosenko, Y.; Kunitski, M.; Stark, T.; Göbel, M.; Tarakeshwar, P.; Brutschy, B. (2011). 4-Aminobenzimidazole–1-Methylthymine: A Model for Investigating Hoogsteen Base-Pairing between Adenine and Thymine. J. Phys. Chem. A 115 11403–11411
DOI: 10.1021/jp205575w 

Ullrich, S., Nazir, Z., Büsing, A., Scheffer, U., Wirth, D., Bats, J.W., Dürner, G. and Göbel, M. W. (2011). Cleavage of Phosphodiesters and of DNA by a Bis(guanidinium)naphthol Acting as a Metal-Free Anion Receptors. ChemBioChem 12, 1223-1229
DOI: 10.1002/cbic.201100022 

Weimar, M., Dürner, G., Bats, J. W., and Göbel, M. W. (2010). Enantioselective Synthesis of (+)-Estrone Exploiting a Hydrogen Bond-Promoted Diels-Alder Reaction. J. Org. Chem. 75, 2718-2721.

Suhartono, M., Schneider, A. E., Duerner, G., and Goebel, M. W. (2010). Synthetic aromatic amino acids from a Negishi cross-coupling reaction. Synthesis, 293-303.

Sreeramulu, S., Gande, S. L., Goebel, M., and Schwalbe, H. (2009). Molecular Mechanism of Inhibition of the Human Protein Complex Hsp90-Cdc37, a Kinome Chaperone-Cochaperone, by Triterpene Celastrol. Angew. Chem., Int. Ed. 48, 5853-5855.

Ferner, J., Suhartono, M., Breitung, S., Jonker, H. R. A., Hennig, M., Woehnert, J., Goebel, M., and Schwalbe, H. (2009). Structures of HIV TAR RNA-Ligand Complexes Reveal Higher Binding Stoichiometries. ChemBioChem 10, 1490-1494.

Breitung, S. T., Lopez, J. J., Duerner, G., Glaubitz, C., Goebel, M. W., and Suhartono, M. (2008). A practical synthesis of the 13C/15N-labeled tripeptide N-Formyl-Met-Leu-Phe, useful as a reference in solid-state NMR spectroscopy. Beilstein J. Org. Chem. 4, No. 35.

Morgner, N., Barth, H.-D., Brutschy, B., Scheffer, U., Breitung, S., and Goebel, M. (2008). Binding sites of the viral RNA element TAR and of TAR mutants for various peptide ligands, probed with LILBID: A new laser mass spectrometry. J. Am. Soc. Mass. Spectrom. 19, 1600-1611.

Akalay, D., Duerner, G., and Goebel, M. W. (2008). A first case of asymmetric catalysis induced by metal-free bisoxazolines. Eur. J. Org. Chem., 2365-2368.

Schueller, A., Suhartono, M., Fechner, U., Tanrikulu, Y., Breitung, S., Scheffer, U., Goebel, M. W., and Schneider, G. (2008). The concept of template-based de novo design from drug-derived molecular fragments and its application to TAR RNA. J. Comput.-Aided Mol. Des. 22, 59-68.

Suhartono, M., Weidlich, M., Stein, T., Karas, M., Duerner, G., and Goebel, M. W. (2008). Synthesis of non-natural aromatic alpha -amino acids by a Heck reaction. Eur. J. Org. Chem., 1608-1614.

Akalay, D., Duerner, G., Bats, J. W., and Goebel, M. W. (2008). C2-symmetric bisamidines: chiral Bronsted bases catalysing the Diels-Alder reaction of anthrones. Beilstein J. Org. Chem. 4, No. 28.

Morgner, N., Barth, H. D., Schmidt, T. L., Heckel, A., Scheffer, U., Goebel, M., Fucini, P., and Brutschy, B. (2007). Detecting specific ligand binding to nucleic acids: a test for ultrasoft laser mass spectrometry. Z. Phys. Chem. 221, 689-704.

Akalay, D., Duerner, G., Bats, J. W., Bolte, M., and Goebel, M. W. (2007). Synthesis of C2-Symmetric Bisamidines: A New Type of Chiral Metal-Free Lewis Acid Analogue Interacting with Carbonyl Groups. J. Org. Chem. 72, 5618-5624.

Tanrikulu, Y., Nietert, M., Scheffer, U., Proschak, E., Grabowski, K., Schneider, P., Weidlich, M., Karas, M., Goebel, M., and Schneider, G. (2007). Scaffold hopping by fuzzy pharmacophores and its application to RNA targets. ChemBioChem 8, 1932-1936.

Ludwig, V., Krebs, A., Stoll, M., Dietrich, U., Ferner, J., Schwalbe, H., Scheffer, U., Durner, G., and Gobel, M. W. (2007). Tripeptides from synthetic amino acids block the Tat-TAR association and slow down HIV spread in cell cultures. Chembiochem 8, 1850-1856.

Givehchi, A., Ludwig, V., Boden, O., Krebs, A., Scheffer, U., Goebel, M., and Schneider, G. (2007). Classification and prediction of tripeptides inhibiting HIV-1 Tat/TAR-RNA interaction using a self-organizing map. Lett. Drug Des. Discovery 4, 410-416.

Nandi, C. K., Parui, P. P., Brutschy, B., Scheffer, U., and Goebel, M. (2007). Fluorescence correlation spectroscopy at single molecule level on the Tat-TAR complex and its inhibitors. Biopolymers 89, 17-25.

Gnaccarini, C., Peter, S., Scheffer, U., Vonhoff, S., Klussmann, S., and Goebel, M. W. (2006). Site-Specific Cleavage of RNA by a Metal-Free Artificial Nuclease Attached to Antisense Oligonucleotides. J. Am. Chem. Soc. 128, 8063-8067.

Scheffer, U., Strick, A., Ludwig, V., Peter, S., Kalden, E., and Gobel, M. W. (2005). Metal-free catalysts for the hydrolysis of RNA derived from guanidines, 2-aminopyridines, and 2-aminobenzimidazoles. J. Am. Chem. Soc. 127, 2211-2217.

Scheffer, U., and Göbel, M. (2005). Fluorescence-Based On-Line Detection as an Analytical Tool in RNA Electrophoresis. Methods Mol. Biol. (N. Y.) 288, 261-272.

Hey, M., and Goebel, M. (2005). Non-enzymatic template-directed RNA synthesis. Methods Mol. Biol. (N. Y.) 288, 305-318.

Renner, S., Ludwig, V., Boden, O., Scheffer, U., Göbel, M., and Schneider, G. (2005). New Inhibitors of the Tat–TAR RNA Interaction Found with a “Fuzzy” Pharmacophore Model. ChemBioChem 6, 1119-1125.

Riguet, E., Desire, J., Boden, O., Ludwig, V., Goebel, M., Bailly, C., and Decout, J.-L. (2005). Neamine dimers targeting the HIV-1 TAR RNA. Bioorg. Med. Chem. Lett. 15, 4651-4655.

Krebs, A., Ludwig, V., Pfizer, J., Durner, G., and Gobel, M. W. (2004). Enantioselective synthesis of non-natural aromatic alpha-amino acids. Chemistry 10, 544-553.

Hey, M., Hartel, C., and Göbel, M. W. (2003). Nonenzymatic oligomerization of ribonucleotides: Towards in vitro selection experiments. Helv. Chim. Acta 86, 844-854.

Krebs, A., Ludwig, V., Boden, O., and Göbel, M. W. (2003). Targeting the HIV Trans-Activation Responsive Region–Approaches Towards RNA-Binding Drugs. ChemBioChem 4, 972-978.

Pitsch, S., Scheffer, U., Hey, M., Strick, A., and Göbel, M. W. (2003). On Facts and Artefacts: The Difficulty to Evaluate an Artificial Nuclease. Helv. Chim. Acta 86, 7340-3752.

Schwalbe, H.; Göbel, M.; Wess, G. (2003). Editorial: RNA Targeting. ChemBioChem 4, 915-917

Tsogoeva, S. B., Dürner, G., Bolte, M., and Göbel, M. W. (2003). A C2-chiral bis(amidinium) catalyst for a Diels-Alder reaction constituting the key step of the Quinkert-Dane estrone synthesis. Eur. J. Org. Chem., 1661-1664.

Scarso, A., Scheffer, U., Gobel, M., Broxterman, Q. B., Kaptein, B., Formaggio, F., Toniolo, C., and Scrimin, P. (2002). A peptide template as an allosteric supramolecular catalyst for the cleavage of phosphate esters. Proc. Natl. Acad. Sci.U. S. A. 99, 5144-5149.

Hartel, C., and Göbel, M. W. (2000). Substitution of adenine by purine-2,6-diamine improves the non-enzymic oligomerization of ribonucleotides on templates containing thymidine. Helv. Chim. Acta 83, 2541-2549.

Schuster, T., Kurz, M., and Goebel, M. W. (2000). Catalysis of a Diels-Alder Reaction by Amidinium Ions. J. Org. Chem. 65, 1697-1701.

Schuster, T., Bauch, M., Duerner, G., and Goebel, M. W. (2000). Axially Chiral Amidinium Ions as Inducers of Enantioselectivity in Diels-Alder Reactions. Org. Lett. 2, 179-181.

Schuster, T., and Gobel, M. W. (1999). Synthesis of a chiral receptor molecule with converging amidinium and hydroxy groups. Synlett., 966-968.

Kurz, M., Göbel, K., Hartel, C., and Göbel, M. W. (1998). Acridine-labeled primers as tools for the study of nonenzymatic RNA oligomerization. Helv. Chim. Acta 81.

Kurz, M., Göbel, K., Hartel, C., and Göbel, M. W. (1997). Nonenzymic oligomerization of ribonucleotides on guanosine-rich templates: suppression of the self-pairing of guanosine. Angew. Chem., Int. Ed. Engl. 36, 842-845.

Muche, M.-S., Kamalaprija, P., and Gobel, M. W. (1997). Reaction cascade in the supramolecular phosphorylation of a bis(guanidinium) diol. Tetrahedron Lett. 38, 2923-2926.

Kurz, K., and Goebel, M. W. (1996). Hydrolytical cleavage of TAR-RNA, the trans-activation responsive region of HIV-1, by a bis(guanidinium) catalyst attached to arginine. Helv. Chim. Acta 79, 1967-1979.

Muche, M.-S., and Goebel, M. W. (1996). Bis(guanidinium) alcohols as models of staphylococcal nuclease: substrate binding through ion pair complexes and fast phosphoryl transfer reactions. Angew. Chemie, Int. Ed. Engl. 35, 2126-2129.

Schuetz, K., Kurz, M., and Goebel, M. W. (1995). Synthesis of oligodeoxyribonucleotides labeled with a novel type of chemically stable acridine dye. Tetrahedron Lett. 36, 8407-8410.

Reckenbeil, D., Bats, J. W., Duerner, G., and Goebel, M. W. (1994). Supramolecular phosphorylation of cationic alcohols with a 3-arylindole-4-carboxyamidine framework. Liebigs Ann. Chem., 1219-1229.

Mueller, G., Duerner, G., Bats, J. W., and Goebel, M. W. (1994). Supramolecular phosphoryl transfer reactions mediated by amidinium phosphate ion-pair complexes. Liebigs Ann. Chem., 1075-1092.

Goebel, M. W. (1994). Binuclear metal complexes as efficient mediators of biochemically relevant hydrolysis reactions. Angew. Chem. 106, 1201-1203

Lehr, S., Schuetz, K., Bauch, M., and Goebel, M. W. (1994). Axial-chiral amidinium ions with biaryl framework: a new structure type for host-guest chemistry. Angew. Chem. 106, 1041-1043

Gross, R., Bats, J. W., and Goebel, M. W. (1994). trans-Decalin as a spacer for axially configurated diamines: preparation of a phosphate binding bis(guanidinium) compound. Liebigs Ann. Chem., 205-210.

Gross, R., Duerner, G., and Goebel, M. W. (1994). Acceleration of substitution reactions of a phosphoric acid diester by bis(guanidinium) compounds. Liebigs Ann. Chem., 49-58.

Hunziker, J., Roth, H. J., Boehringer, M., Giger, A., Diederichsen, U., Goebel, M., Krishnan, R., Jaun, B., Leumann, C., and Eschenmoser, A. (1993). Why pentose- and not hexose-nucleic acids? Part III. Oligo(2',3'-dideoxy-b-D-glucopyranosyl)nucleotides. ('Homo-DNA'): base-pairing properties. Helv. Chim. Acta 76, 259-352.

Goebel, M. W., Bats, J. W., and Duerner, G. (1992). Approaches to synthetic phosphodiesterases: supramolecular phosphoryl transfer mediated by amidinium phosphate contact ion pairs. Angew. Chem. 104, 217-218.

Boehringer, M., Roth, H. J., Hunziker, J., Goebel, M., Krishnan, R., Giger, A., Schweizer, B., Schreiber, J., Leumann, C., and Eschenmoser, A. (1992). Why pentose and not hexose nucleic acids? Part II. Preparation of oligonucleotides containing 2',3'-dideoxy-b-D-glucopyranosyl building blocks. Helv. Chim. Acta 75, 1416-1477.

Leumann, C., Frueh, T., Goebel, M., and Eschenmoser, A. (1987). Chemistry of pyrrocorphines. Biomimetic regioselectivity of C-methylation on the ligand periphery of magnesium(II) uropyrrocorphinate octanitriles of type 1. Angew. Chem. 99, 273-275.