Arbeitskreis Prof. Dr. Knapp

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My laboratory is interested in the development and rational design of selective inhibitors targeting key signalling molecules (chemical probes) and their use for the validation of new targets.  The research team focusses two main key areas:

1)     Targeting protein interactions module that mediate the recognitions of key posttranslational modifications such as ε-N-lysine acetylation specific bromodomains.

2)     Targeting protein kinases. As part of the structural genomics consortium (SGC) our laboratory has solved a comprehensive set of crystal structure of this large protein family offering new opportunities for the design of selective inhibitors. We are particularly interested developing inhibitors targeting unusual binding modes and novel allosteric binding sites. 


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Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance.

Fedorov O, Castex J, Tallant C, Owen DR, Martin S, Aldeghi M, Monteiro O, Filippakopoulos P, Picaud S, Trzupek JD, Gerstenberger BS, Bountra C, Willmann D, Wells C, Philpott M, Rogers C, Biggin PC, Brennan PE, Bunnage ME, Schüle R, Günther T, Knapp S, Müller S. Sci Adv. 2015 Nov 13;1(10):e1500723. doi: 10.1126/sciadv.1500723. eCollection 2015 Nov.

complete list of publications

open position

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open position

The Institut of Pharmazeutical Chemstry, department of Biochemistry, Chemistry und Pharmacy at the Goethe-University Frankfurt am Main at the Goethe-University Frankfurt am Main offers a


Postdoctoral Scientist position in Medicinal Chemistry
(E13 TV-G-U)

The position is based in the research group of Prof Knapp ( in close collaboration with the project manager of the SGC chemical probe program (Dr Müller-Knapp). The position is available immediately and the appointment is initially funded for 2 years. In order to increase the number of female researchers, female candidates are especially encouraged to apply. Precedence will be also given to handicapped candidates at equal qualification.