Open Position

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The Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Germany, currently offers a position for a postdoctoral scientists (E13 TV-G-U) in medicinal chemistry in the research group of Prof Knapp ( The position is available immediately and the appointment is funded for 3 years. Female candidates are especially encouraged to apply. Precedence will be given to handicapped candidates at equal qualification.

The project is funded by the Deutsche Krebshilfe and comprises an interdisciplinary work on the structure based development of selective inhibitors targeting epigenetic reader domains and HDACs for treatment of pancreatic ductal adenocarcinoma. Both target classes are key signalling molecule that play an important role regulating cell proliferation and survival. Goal of the project is the development of inhibitors with dual BET/HDAC activity. We are collaborating with an interdisciplinary team of clinicians and cell biologists at University hospitals in Göttingen, Essen and Würzburg with the goal to find new treatments for this aggressive cancer type.


The ideal candidate will have a Master degree and a PhD in Chemistry or Pharmacy. A proven track record in medicinal chemistry and chemical biology is essential. In addition, the candidate should have a good publication record in medicinal or synthetic chemistry. The candidate should have experience working in interdisciplinary research teams and should have excellent communication skills in English. Experience in assay development, epigenetics and structural biology would be of advantage but are not required for this position.  

The planned research will be carried out in a highly stimulating and international research environment at the life science campus Riedberg, in close collaboration with an international network of scientists working on a better understanding of cancer and on new opportunities for a cure.  Interested candidates are encourage to submit their CVs to the following e-mail address: