Open Position

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The Institut of Pharmazeutical Chemstry, department of Biochemistry, Chemistry und Pharmacy at the Goethe-University Frankfurt am Main at the Goethe-University Frankfurt am Main offers a


Postdoctoral Scientist position in Medicinal Chemistry
(E13 TV-G-U)

The position is based in the research group of Prof Knapp ( in close collaboration with the project manager of the SGC chemical probe program (Dr Müller-Knapp). The position is available immediately and the appointment is initially funded for 2 years. In order to increase the number of female researchers, female candidates are especially encouraged to apply. Precedence will be also given to handicapped candidates at equal qualification. The successful candidate will be part of the chemical probe program and the pharma probe initiative. The project will involve synthetic work both in our lab as well as with CROs, but will also comprise project management aspects such as liaising with different pharmaceutical and chemical companies and discussing and reporting progress. The overall goal of the project is to generate selective inhibitors and inactive control compounds targeting a diversity of different proteins in collaboration of industrial laboratories. We are looking for people that are highly qualified and motivated to join our interdisciplinary team consisting of chemists, biochemists, crystallographers and cell biologists.

The Structural Genomics Consortium (SGC) is a not-for-profit, public-private partnership encompassing 9 pharmaceutical companies that conducts pre-competitive research to facilitate the discovery of new medicines. Based at several international universities (Oxford, Toronto, Chapel Hill, Campinas and Frankfurt), the SGC's work contributes to the validation of new disease modifying targets and a better understanding of human disease.  A key objective is the rational development of highly selective inhibitors, chemical probes in particular for epigenetic regulators and protein kinases and their evaluation in disease relevant model systems. A new project within the SGC probe initiative is the ‘Open Science Probe Program’, a program that makes high quality inhibitors no longer pursued within pharma companies available to the public domain and to collate probe associated data in an open database. Thus, the successful candidate will need to be well trained in synthetic medicinal chemistry and would need to have a good level of biological understanding and the drug discovery process in order to efficiently interact with scientist trained in different disciplines.


The ideal candidate will have a Master degree and a PhD in Chemistry or Pharmacy. A proven track record in medicinal chemistry and chemical biology is essential. In addition, the candidate should have a good publication record in particular in medicinal or synthetic chemistry. The candidate should have experience working in interdisciplinary research teams and should have excellent communication skills in English. Experience in assay development and structural biology would be of advantage but are not required for this position. 

The planned research will be carried out in a highly stimulating and international research environment at the life science campus Riedberg, in close collaboration with an international network of scientists. Interested candidates are encouraged to submit a cover letter stating career interests, CV and contact detailed of at least two referees to the following e-mail address:

The closing date for applications is Tuesday 3 June 2018