Original- und Übersichtsarbeiten 2005-2000

Anatomie I

2005

Bahn A, Ljubojevic M, Lorenz H, Schultz C, Ghebremedhin E, Ugele B, Sabolic I, Burckhardt G, Hagos Y (2005) Murine renal organic anion transporters mOAT1 and mOAT3 facilitate the transport of neuroactive tryptophan metabolites. Am J Physiol Cell Physiol, 289: C1075-1084

Bas Orth C, Vlachos A, Del Turco D, Burbach GJ, Haas CA, Mundel P, Feng G, Frotscher M, Deller T (2005) Lamina-specific distribution of Synaptopodin, an actin-associated molecule essential for the spine apparatus, in identified principal cell dendrites of the mouse hippocampus. J Comp Neurol 487: 227-239

Braak H, Del Tredici K (2005) Preclinical and Clinical Stages in the Evolution of Parkinson’s Disease-Related Pathology. In: Willow MJ (ed.) Parkinson’s Disease: New Research. Hauppauge, Nova Science 1-49

Braak H, Rüb U, Del Tredici K (2005) Kognitive Veränderungen bei spontan auftretendem Morbus Parkinson – klinisch-neuropathologische Korrelation. Nervenheilkunde, 24: 1-8

Braak H, Rüb U, Jansen Steur EN, Del Tredici K*, de Vos RA* (2005) Cognitive status correlates with neuropathologic stage in Parkinson disease. Neurology 64: 1404-1410

Burbach GJ (2005) Amyloid plaque-associated axonal sprouting in aged APP23 transgenic mice. Ann Anat 187: 357-359

Czarnecki K, Haas CA, Bas Orth C, Deller T, Frotscher M (2005) Postnatal development of synaptopodin expression in the rodent hippocampus. J Comp Neurol 490: 133-144

Gierga K, Burk K, Bauer M, Orozco Diaz G, Auburger G, Schultz C, Vuksic M, Schols L, de Vos RA, Braak H, Deller T, Rüb U (2005) Involvement of the cranial nerves and their nuclei in spinocerebellar ataxia type 2 (SCA2). Acta Neuropathol 109: 617-631

Hellenbroich Y, Pawlack H, Rüb U, Schwinger E, Zuhlke C (2005) Spinocerebellar ataxia type 4 Investigation of 34 candidate genes. J Neurol 252: 1472-1475

Jedlicka P (2005) Neuroethics, reductionism and dualism. Trends Cogn Sci 9: 172

Kogel D, Schomburg R, Copanaki E, Prehn JH (2005) Regulation of gene expression by the amyloid precursor protein: inhibition of the JNK/c-Jun pathway. Cell Death Differ 12: 1-9

Müller CM, de Vos RA, Maurage CA, Thal DR, Tolnay M, Braak H (2005) Staging of sporadic Parkinson disease-related alpha-synuclein pathology: inter-and intra-rater reliability. J Neuropathol Exp Neurol 64: 623-628

Rüb U, Brunt ER, Gierga K, Seidel K, Schultz C, Schöls L, Auburger G, Heinsen H, Ippel PF, Glimmerveen WF, Wittebol-Post D, Arai K, Deller T*, de Vos RAI* (2005) Spinocerebellar ataxia type 7 (SCA7): First report of a systematic neuropathological study of the brain of a patient with a very short expanded CAG-repeat. Brain Pathol 15: 287-295

Rüb U, Del Turco D, Burk K, Diaz GO, Auburger G, Mittelbronn M, Gierga K, Ghebremedhin E, Schultz C, Schols L, Bohl J, Braak H, Deller T (2005) Extended pathoanatomical studies point to a consistent affection of the thalamus in spinocerebellar ataxia type 2. Neuropathol Appl Neurobiol 31: 127-140

Rüb U, Gierga K, Brunt ER, de Vos RA, Bauer M, Schols L, Burk K, Auburger G, Bohl J, Schultz C, Vuksic M, Burbach GJ, Braak H, Deller T (2005) Spinocerebellar ataxias types 2 and 3: degeneration of the precerebellar nuclei isolates the three phylogenetically defined regions of the cerebellum. J Neural Transm, 112: 1523-1545

Sandmann-Keil D, Braak H (2005) Zur postmortalen Diagnose des idiopathischen Morbus Parkinson. Pathologe, 26: 214-220

Schmidtko A, Del Turco D, Coste O, Ehnert C, Niederberger E, Ruth P, Deller T, Geisslinger G, Tegeder I (2005) Essential role of the synaptic vesicle protein synapsin II in formalin-induced hyperalgesia and glutamate release in the spinal cord. Pain, 115: 171-181

Ritter B, Ochojski M, Kuhn T, Schwarzacher SW, Zhang W (2005) Subcellular vesicular aggregations of GABAB R1a and R1b receptors increase with age in neurons of the developing mouse brain. Cell Tissue Res 319:181-189

Stalder AK, Ermini F, Bondolfi L, Krenger W, Burbach GJ, Deller T, Coomaraswamy J, Staufenbiel M, Landmann R, Jucker M (2005) Invasion of hematopoietic cells into the brain of amyloid precursor protein transgenic mice. J Neurosci 25: 11125-11132

Thal DR, Braak H (2005) Postmortale Diagnosestellung bei Morbus Alzheimer – Stadiengliederung der kennzeichnenden Hirnveränderungen. Pathologe, 26: 201-213

Thal DR, Capetillo-Zarate E, Schultz C, Rüb U, Saido TC, Yamaguchi H, Haass C, Griffin WS, Del Tredici K, Braak H, Ghebremedhin E (2005) Apolipoprotein E co-localizes with newly formed amyloid beta-protein (Abeta) deposits lacking immunoreactivity against N-terminal epitopes of Abeta in a genotype-dependent manner. Acta Neuropathol 110: 459-471

Thal DR, Schultz C, Botez G, Del Tredici K, Mrak RE, Griffin WS, Wiestler OD, Braak H, Ghebremedhin E (2005) The impact of argyrophilic grain disease on the development of dementia and its relationship to concurrent Alzheimer's disease-related pathology. Neuropathol Appl Neurobiol 31: 270-279

2004

Braak H, Del Tredici K (2004) Alzheimers disease: intraneuronal alterations precede insoluble amyloid-beta formation. Neurobiol Aging 25: 713-718

Braak H, Del Tredici K (2004) Poor and protacted myelination as a contributory factor to neurodegenerative disorders. Nerurobiol 25: 19-23

Braak H, Ghebremedhin E, Rüb U, Bratzke H, Del Tredici K (2004) Stages in the development of Parkinson´s disease-related pathology. Cell Tissue Res 318: 121-134

Burbach GJ, Dehn D, Del Turco D, Staufenbiel M, Deller T (2004) Laser microdissection reveals regional and cellular differences in GFAP mRNA upregulation following brain injury, axonal denervation, and amyloid plaque deposition. Glia 48: 76-84

Burbach GJ, Dehn D, Nagel B, Del Turco D, Deller T (2004) Laser microdissection of immunolabeled astrocytes allows quantification of astrocytic gene expression. J Neurosci Methods 138: 141-148

Burbach GJ, Hellweg R, Haas CA, Del Turco D, Deicke U, Abramowski D, Jucker M, Staufenbiel M, Deller T (2004) Induction of brain-derived neurotrophic factor in plaque-associated glial cells of aged APP23 transgenic mice. J Neurosci 24: 2421-2430

Conrad C, Vianna C, Schultz C, Thal DR, Ghebremedhin E, Lenz J, Braak H, Davies P (2004) Molecular evolution and genetics of the Saitohin gene and tau haplotype in Alzheimer´s disease and argyrophilic grain disease. J Neurochem 89: 179-188

Corder EH, Ghebremedhin E, Taylor MG, Thal DR, Ohm TG, Braak H (2004) The biphasic relationship between regional brain senile plaque and neurofibrillary tangle distributions: modification by age, sex, and APOE polymorphism. Ann N Y Acad Sci 1019: 24-28

Del Turco D, Gebhardt C, Burbach GJ, Pleasure SJ, Lowenstein DH, Deller T (2004) Laminar organization of the mouse dentate gyrus: insights from BETA2/Neuro D mutant mice. J Comp Neurol 477: 81-95

Jen JC, Chan WM, Bosley TM, Wan J, Carr JR, Rüb U, Shattuck D. Salamon G, Kudo LC, Ou J, Lin DD, Salih MA, Kansu T, Al Dhalaan H, Al Zayed Z, MacDonald DB, Stigsby B, Plaitakis A, Dretakis EK, Gottlob I, Pieh C, Traboulsi EI, Wang Q, Wang L, Andrews C, Yamada K, Demer JL, Karim S, Alger JR, Geschwind DH, Deller T, Sicotte NL, Nelson SF, Baloh RW, Engle EC (2004) Mutations in a human ROBO gene disrupt hindbrain axon pathway crossing and morphogenesis. Science 304: 1509-1513

Karolczak M, Burbach GJ, Sties G, Korf HW, Stehle JH (2004) Clock gene mRNA and protein rhythms in the pineal gland of mice. Eur J Neurosci 19: 3382-3388

Kovac AD, Kwidzinski E, Heimrich B, Bittigau P, Deller T, Nitsch R, Bechmann I (2004) Entorhinal cortex lesion in the mouse induces transsynaptic death of perforant path target neurons. Brain Pathol 14: 249-257

Phinney AL, Calhoun ME, Woods AG, Deller T, Jucker M (2004) Stereological analysis of the reorganization of the dentate gyrus following entorhinal cortex lesion in mice. Eur J Neurosci 19: 1731-1740

Rüb U, Brunt ER, de Vos RA, Del Turco D, Del Tredici K, Gierga K, Schultz C, Ghebremedhin E, Bürk K, Auburger G, Braak H (2004) Degeneration of the central vestibular system in spinocerebellar ataxia type 3 (SCA3) patients and its possible clinical significance. Neuropathol Appl Neurobiol 30: 402-414

Rüb U, Bürk K, Schöls L, Brunt ER, de Vos RA, Diaz GO, Gierga K, Ghebremedhin E, Schultz C, Del Turco D, Mittelbronn M, Auburger G, Deller T, Braak H (2004) Damage to the reticulotegmental nucleus of the pons in spinocerebellar ataxia type 1, 2, and 3. Neurology 63: 1258-1263

Schultz C, Ghebremedhin E, Del Tredici K, Rüb U, Braak H (2004) High prevalence of thorn-shaped astrocytes in the aged human medial temporal lobe. Neurobiol Aging 25: 397-405

Tegeder I, Del Turco D, Schmidtko A, Sausbier M, Feil R, Hofmann F, Deller T, Ruth P, Geisslinger G (2004) Reduced inflammatory hyperalgesia with preservation of acute thermal nociception in mice lacking cGMP-dependent protein kinase I. Proc Natl Acad Sci 101: 3253-3257

Thal DR, Del Tredici K, Braak H (2004) Neurodegeneration in normal brain aging and disease. Sci Aging Knowledge Environ 23: 26

Valente EM, Abou-Sleiman PM, Caputo V, Muquit MM, Harvey K, Gispert S, Ali Z, Del Turco D, Bentivoglio AR, Healy DG, Albanese A, Nussbaum R, Gonzalez-Maldonado R, Deller T, Salvi S, Cortelli P, Gilks WP, Latchman DS, Harvey RJ, Dallapiccola B, Auburger G, Wood NW (2004) Hereditary early-onset Parkinson´s disease caused by mutations in PINK1. Science 304: 1158-1160

2003

Burbach G, Dehn D, Del Turco D, Deller T (2003) Quantification of layer-specific gene expression in the hippocampus: Effective use of laser microdissection in combination with quantitative RT-PCR. J Neurosci Meth 131: 83-91

Knopman DS, Parisi JE, Salviati A, Floriach-Robert M, Boeve BF, Ivnik RJ, Smith GE, Dickson DW, Johnson KA, Petersen LE, McDonald WC, Braak H, Petersen RC (2003) Neuropathology of Cognitively Normal Elderly. J Neuropath Exp Neur 62: 1087-1095

Manzke T, Guenther U, Ponimaskin EG, Haller M, Dutschmann M, Schwarzacher S, Richter DW (2003) 5-HT4(a) receptors avert opioid-induced breathing depression without loss of analgesia. Science 301: 226-229

Schultz C, Ghebremedhin E, Del Tredici K, Rüb U, Braak H (2003) High prevalence of thorn-shaped astrocytes in the aged human medial temporal lobe. Neurobiol Aging 25: 397-405

Thal DR, Ghebremedhin E, Orantes M, Wiestler O (2003) Vascular Pathology in Alzheimer Disease: Correlation of Cerebral Amyloid Angiopathy and Arteriosclerosis/Lipohyalinosis with Cognitive Decline. J Neuropath Exp Neur 62: 1287-1301

An WL , Cowburn RF, Li L, Braak H, Alafuzoff I, Iqbal K, Grundke-Iqbal I, Winblad B, Pei JJ (2003) Up-Regulation of Phosphorylated/Activated p70 S6 Kinase and Its Relationship to Neurofibrillary Pathology in Alzheimer’s Disease. American J Pathol 163: 591-607

Braak H, Del Tredici K, Rüb U, de Vos RAI, Jansen Steur ENH, Braak E (2003) Staging of Brain, pathology related to sporadic Parkinson's disease. Neurobiol Aging 24: 197-211

Braak H, Rüb U, Del Tredici K (2003) Involvement of precerebellar nuclei in multiple system atrophy. Neuropathol Appl Neuro 29: 60-76

Braak H, Rüb U, Gai P, Del Tredici K (2003) Idiopathic Parkinson’s disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen. J Neural Transm 110: 517-536

Burbach G, Dehn D, Del Turco D, Deller T (2003) Quantification of layer-specific gene expression in the hippocampus: Effective use of laser microdissection in combination with quantitative RT-PCR. J Neurosci Meth 131: 83-91

Deller T, Korte M, Chabanis S, Drakew A, Schwegler H, Stefani GG, Zuniga A, Schwarz K , Bonhoeffer T, Zeller R, Frotscher M, Mundel P (2003) Synaptopodin-deficient mice lack a spine apparatus and show deficits in synaptic plasticity. Proc Natl Acad Sci 100: 10494-10499

Del Turco D, Woods AG, Gebhardt C, Phinney AL, Jucker M, Frotscher M, Deller T (2003) Commissural sprouting in mouse fascia dentata after unilateral entorhinal cortex lesion. Hippocampus 13: 685-699

Gispert S, Del Turco D, Garrett L, Chen A, Bernard DJ, Hamm-Clement J, Korf HW, Deller T, Braak H, Auburger G, Nussbaum RL (2003) Transgenic mice expressing mutant A53T human alpha-synuclein show neuronal dysfunction in the absence of aggregate formation. Mol Cell Neurosci 24: 419-429

Knopman DS, Parisi JE, Salviati A, Floriach-Robert M, Boeve BF, Ivnik RJ, Smith GE, Dickson DW, Johnson KA, Petersen LE, McDonald WC, Braak H, Petersen RC (2003) Neuropathology of Cognitively Normal Elderly. J Neuropath Exp Neur 62: 1087-1095

Manzke T, Guenther U, Ponimaskin EG, Haller M, Dutschmann M, Schwarzacher S, Richter DW (2003) 5-HT4(a) receptors avert opioid-induced breathing depression without loss of analgesia. Science 301: 226-229.

Papassotiropoulos A, Streffer JR, Tsolaki M, Schmid S, Thal DR, Nicosia F, Iakovidou V, Maddalena A, Lütjohann D, Ghebremedhin E, Hegi T, Pasch T, Träxler M, Brühl A, Benussi L, Binetti G, Braak H, Nitsch RM, Hock C (2003) Increased Brain, ß-Amyloid Load, Phosphorylated tau, and Ris of Alzheimer Disease associated with an intronic CY46 polymorphism. Arch Neurol, 60: 29-35

Pei JJ, Khatoon S, An WL, Nordlinder M, Tanaka T, Braak H, Tsujio I, Takeda M, Alafuzoff I, Winblad B, Cowburn RF, Grundke-Iqbal I, Iqbal K (2003) Role of protein kinase B in Alzheimer’s neurofibrillary pathology. Acta Neuropathol 105: 381-392

Prang P, Del Turco D, Deller T (2003) Associational sprouting in the mouse fascia dentata after entorhinal lesion in vitro. Brain Res 978: 205-212

Rüb U, Brunt ER, Del Turco D, de Vos RAI, Gierga K, Paulson H, Braak H (2003) Guidelines for the pathoanatomical examination of the lower Brain, stem in ingestive and swallowing disorders and ist application to a dysphagic spinocerebellar ataxia type 3 patient. Neuropathol Appl Neuro 29: 1-13

Rüb U, Brunt ER, Gierga K, Schultz C, Paulson H, de Vos RA, Braak H (2003) The nucleus raphe interpositus in spinocerebellar ataxia type 3 (Machado-Joseph disease). J Chem Neuroanat 25: 115-127

Rüb U, Del Turco D, Del Tredici K, de Vos RAI, Brunt ER, Reifenberger G, Seifried C, Schultz C, Auburger G, Braak H (2003) Thalamic involvement in a spinocerebellar ataxia type 2 (SCA2) and a spinocerebellar ataxia type 3 (SCA3) patient and ist clinical relevance. Brain 126: 2257-2272

Rüb U, Schultz C, Del Tredici K, Gierga K, Reifenberger G, de Vos RAI, Seifried C, Braak H, Auburger G (2003) Anatomically based guidelines for systematic investigations of the central somatosensory system and their application to a spinocerebellar ataxia type 2 (SCA2) patient. Neuropathol Appl Neuro 29: 418-433

Schultz C, Ghebremedhin E, Del Tredici K, Rüb U, Braak H (2003) High prevalence of thorn-shaped astrocytes in the aged human medial temporal lobe. Neurobiol Aging 25:397-405

Thal DR, Ghebremedhin E, Orantes M, Wiestler O (2003) Vascular Pathology in Alzheimer Disease: Correlation of Cerebral Amyloid Angiopathy and Arteriosclerosis/Lipohyalinosis with Cognitive Decline. J Neuropath Exp Neur 62: 1287-1301

Vogl TJ, Schwarz W, Blume S, Pietsch M, Shamsi K, Franz M, Lobeck H, Balzer T, del Tredici K, Neuhaus P, Felix R, Hammestingl RM (2003) Preoperative evaluation of malignant liver tumors: comparison of unenhanced and SPIO (Resovist)- enhanced MR imaging with biphasic CTAP and intraoperative US. Eur Radio 13: 262-272

Weiss KH, Johanssen C, Tielsch A, Herz J, Deller T, Frotscher M, Förster E (2003) Malformation of the radial glial scaffold in the dentate gyrus of reeler mice, scrambler mice and ApoER2/VLDLR deficient mice. J Comp Neurol 460: 56-64

2002

Dallner C, Woods AG, Deller T, Kirsch M, Hofmann HD (2002) CNTF and CNTF receptor alpha are constitutively expressed by astrocytes in the mouse brain. Glia 37: 374-378

Deller T, Haas CA, Frotscher M (2002) Sprouting in the hippocampus after entorhinal cortex lesion is layer-specific but not translaminar: Which molecules may be involved? Restor Neurol Neuros, 19: 159-167

Deller T, Haas CA, Deissenrieder K, Del Turco D, Coulin C, Gebhardt C, Drakew A, Mundel P, Frotscher M (2002) The laminar distribution of synaptopodin in normal and reeler mouse brain depends on the position of spine bearing neurons. J Comp Neurol 453: 3-44

Del Tredici K, Rüb U, De Vos RAI, Bohl J, Braak H (2002) Where does Parkinson disease pathology begin in the brain? J Neuropath Exp Neur, 61: 413-426

Drakew A, Deller T, Heimrich B, Gebhardt C, Del Turco D, Tielsch A, Förster E, Herz J, Frotscher M (2002) Dentate granule cells in reeler mutants and ApoER2/VLDLR double knockout mice. Exp Neurol 176: 12-24

Freiman TM, Gimbel K, Honegger J, Volk B, Zentner J, Frotscher M, Deller T (2002) Anterograde tracing of human hippocampus in vitro - a neuroanatomical tract tracing technique for the analysis of local fiber tracts in human brain. J Neurosci Meth, 120: 95-103

Gebhardt C, Del Turco D, Drakew A, Tielsch A, Herz J, Frotscher M, Deller T (2002) Abnormal positioning of granule cells alters afferent fiber distribution in the mouse fascia dentata: Morphological evidence from reeler, ApoE Receptor 2-, and VLDL receptor knock out mice . J Comp Neurol 445: 278-292

Ghebremedhin E, Thal DR, Schultz C, Braak H (2002) Age dependent association between butyrylcholinesterase K-variant and Alzheimer disease-related neuropathology in human brains. Neurosci Lett 320: 25-28

Ghebremedhin E, Schultz C, Thal DR, Del Tredici K, Rüb U, Braak H (2002) Genetic association of argyrophilic grain disease with polymorphisms in alpha-2 macroglobulin and low-density lipoprotein receptor-related protein genes. Neuropath Appl Neuro 28: 308-313

Kettner M, Willwohl D, Hubbard GB, Rüb U, Dick EJ jr , Cox  AB, Trottier Y, Auburger G, Braak H, Schultz C (2002) Intranuclear aggregation of nonexpanded ataxin-3 in marinesco bodies of the nonhuman primate substantia nigra. Exp Neurol 176: 117-121

Pei JJ, Braak H, Gong CX, Grundke-Iqbal I, Iqbal K, Winblad B, Cowburn RF (2002) Up-regulation of cell division cycle (cdc) 2 kinase in neurons with early stage Alzheimer's disease neurofibrillary degeneration. Acta Neuropathol 104: 369-376

Pei JJ, Braak H, An WL, Winblad B, Cowburn RF, Iqbal K, Grundke-Iqbal I (2002) Up-regulation of mitogen-activated with the progression of neurofibrillary degeneration in Alzheimer’s disease. Mol Brain Res 109: 45-55

Pfeifer M, Boncistiano S, Bondolfi L, Stalder A, Deller T, Staufenbiel M, Mathews P, Jucker M (2002) Cerebral hemorrhage following anti-Aß Immunotherapy. Science 298: 1379

Rüb U, De Vos RA, Schultz C, Brunt ER, Paulson H, Braak H (2002) Spinocerebellar ataxia type 3 (Machado-Joseph disease): severe destruction of the lateral reticular nucleus. Brain 125: 2115-2124

Rüb U, Del Tredici K, Del Turco D, Braak H (2002) The intralaminar nuclei assigned to the medial pain system and other components of this system are early and progressively affected by the Alzheimer's disease-related cytoskeletal pathology. J Chem Neuroanat 23: 279-290

Rüb U, Del Tredici K, Schultz C, Ghebremedhin E, de Vos R, Steur EJ, Gai WP, Braak H (2002) Parkinson's disease: The thalamic components of the limbic loop are severely impaired by a-Synuclein-immunopositive inclusion body pathology. Neurobiol Aging 23: 245-254

Rüb U, Del Tredici K, Schultz C, de Vos RAI, Jansen Steur EHN, Braak H (2002) Progressive supranuclear Palsy: neuronal and glial cytoskeletal pathology in the higher order processing autonomic nuclei of the lower brain stem. Neuropath Appl Neuro 28: 12-22

Rüb U, de Vos RAI, Brunt E, Schultz C, Paulson H, Del Tredici K, Braak H (2002) Degeneration of the external cuneate nucleus in spinocerebellar ataxia type 3. Brain Res 953: 26-134

Schwarzacher SW (2002) Brainstem organization of respiratory reflexes. In : Changing views of cajals neuron. C. Ribak and E. Azmitia, eds.. Elsevier, Prog Brain Res 136: 435-442

Schwarzacher SW, Pestean A, Günther S, Ballanyi (2002) Serotonergic modulation of respiratory motoneurons and interneurons in brainstem slices of neonatal rats. Neuroscience 115: 1247-1259

Thal DR, Ghebremedhin E, Haass C, Müller P, Schultz C (2002) UV-light-induced autofluoresence of Aß-protein deposits enables rapid detection of senile plaques and cerebral amyloid angiopathy. Clin Neuropathol 21: 35-40

Thal DR, Rüb U, Orantes M, Braak H (2002) Phases of Aß-deposition in the human brain and its relevance for the development of AD. Neurology 58: 1791-1800

Thal DR, Ghebremedhin E, Rüb U, Yamaguchi H, Del Tredici K, Braak H (2002) Two types of sporadic Cerebral Amyloid Angiopathy. J Neuropath Exp Neur 61: 282-293

Van de Nes, Sandmann-Keil D, Braak H (2002) Interstitial cells subjacent to the entorhinal region expressing somatostatin-28 immunoreactivity are susceptible to development of Alzheimer’s disease-related cytoskeletal changes. Acta Neuropathol 104: 351-356

Willwohl D, Kettner M, Braak H, Hubbard GB, Dick jr. EJ, Cox AB, Schultz C (2002) Pallido-nigral spheroids in nonhuman primates: accumulation of heat shock proteins in astroglial processes. Acta Neuropathol 103: 276-280

Xugang, X, Hofmann HD, Deller T, Kirsch M (2002) Induction of STAT3 signaling in activated astrocytes and sprouting septal neurons following entorhinal cortex lesion. Mol Cell Neuroscim, 21: 379-392

Zhukareva V, Shah K, Kunihiro U, Braak H, Del Tredici K, Sundarraj S, Clark C, Trojanowski JQ, Lee VMY (2002) Biochemical Analysis of B Proteins in Argyrophilic Grain Disease, Alzheimer’s Disease, and Pick’s Disease. Am J Pathol 161: 1135-1141

2001

Braak E, Sandmann-Keil D, Rüb U, Gai WP, de Vos RAI, Jansen Steur ENH, Arai K, Braak H (2001) Alpha-synuclein immunopositive Parkinson’s disease-related inclusion bodies in lower brainstem nuclei, Acta Neuropathol 101: 195-201

Thal DR, Barduzal S, Franz K, Herrmann G, Bode F, Lambrecht E, Schlote W (2001) Giant cell arteritis in a 19-year-old woman associated with vertebral artery aneurysm and subarachnoid hemorrhage. Clin Neuropathol 20: 80-86

Braak H, Del Tredici K, Gai WP, Braak E (2001) Alpha-synuclein is not a requisite component of synaptic boutons in the adult human central nervous system. J Chem Neuroanat 20: 245-252

Ghebremedhin E, Schultz C, Thal DR, Rüb U, Ohm TG, Braak E, Braak H (2001) Gender and age modify the association between APOE and AD-related neuropathology. Neurology 56: 1696-1701

Schultz C, Dick EJ, Cox AB, Hubbard GB, Braak E, Braak H (2001) Expression of stress proteins alpha B-crystalin, ubiquitin, and hsp27 in pallido-nigral spheroids of aged rhesus monkeys. Neurobiol Aging 22: 677-682

Pei JJ, Braak E, Braak H, Grundke-Iqbal I, Iqbal K, Winblad B, Cowburn RF (2001) Localization of active forms of C-jun kinase (JNK) and p38 kinase in Alzheimer's disease brains at different stages of neurofibrillary degeneration. J Alzheimer's disease 3: 41-48

Rüb U, Del Tredici K, Schultz C, Büttner-Ennever JA, Braak H (2001) The premotor region essential for rapid vertical eye movements shows early involvement in Alzheimer's disease-related cytoskeletal pathology. Vision Res 41: 2149-2156

Rüb U, Del Tredici K, Schultz C, Thal DR, Braak E, Braak H (2001) The autonomic higher order processing nuclei of the lower brain stem are among the early targets of the Alzheimer’s disease-related cytoskletal pathology. Acta Neuropathol 101: 555-564

Rüb U, Schultz C, Del Tredici K, Braak H (2001) Early involvement of the tegmentopontine reticular nucleus during the evolution of Alzheimer's disease-related cytoskeletal pathology. Brain Res 908: 107-112

Braak H, Del Tredici K, Sandmann-Keil D, Schultz C (2001) Nerve cells expressing heat-shock proteins in Parkinson's disease. Acta Neuropathol 102: 449-454

Deller T, Jucker M (2001) Axonsprossung im Zentralnervensystem nach einer Läsion. Neuroforum 7: 11-20

Stalder M, Deller T, Staufenbiel M, Jucker M (2001) 3D-Reconstruction of microglia and amyloid in APP23 transgenic mice: No evidence of intracellular amyloid. Neurobiol Aging 22: 427-434

Coulin C, Drakew A, Frotscher M, Deller T (2001) Stereological estimates of total neuron numbers in the hippocampus of adult reeler mutant mice: evidence for an increased survival of Cajal-Retzius cells. J Comp Neurol 439: 19-31

Burbach G J, Kim K, Zivony A, Aranda A, Wright S, Brown J, Caughman SW, Armstrong CA, Ansel JC (2001) The neurosensory tachykinins substance P and neurokinin A directly induce keratinocyte nerve growth factor. J Invest Dermatol, 117: 1075-1082

Burbach GJ, Naik S, Harten B, Liu L, Song IS, Armstrong C, Caughman SW, Ansel JC (2001) Interleukin-18 expression and modulation in corneal epithelial cells. Current Eye Res, 23: 64-68

Prang P, Del Turco D, Kapfhammer JP (2001) Regeneration of enthorinal fibers in mouse slice cultures is age dependent and can be stimulated by NT-4, GDNF and modulators of G-proteins and Proteinase C. Exp Neurol 169: 135-147

Schultz C, Braak E, Braak H (2001) Abnorme Phosphorylierung und Aggregation des Tau-Proteins im Zentralnervensystem. Neuroforum 2: 57-67

Schultz C, Hubbard GB, Del Tredici K, Braak E, Braak H (2001) Tau pathology in neurons and glial cells of aged baboons. Tolnay and Probst (eds.), Kluwer Academix/Plenum Publishers, New York, Neuropathology and Genetics of Dementia 59-69

2000

Braak H, Braak E: Neurofibrillary changes. the hallmark of Alzheimer' disease. In: Concepts of Alzheimer's disease: Biological, clinical and cultural perspectives. PJ Whitehouse, K Maurer, JF Ballenger (eds), The Johns Hopkins University Press 53-71

Botez G, Schultz C, Ghebremedhin E, Bohl H, Braak E, Braak H: Klinische Aspekte der „argyrophilic grain disease“. Nervenarzt 71: 38-43

Braak H, Del Tredici K, Arai K, Bohl J, Bratzke H, Braak E: Neuroanatomy of Alzheimer’s Disease: non-random decline of select neuronal types.Taniguchi Symposia on Brain Sciences N. 22;Challenges for Neuroscience in the 21st Century, Hayaishi O  (ed), Japan Scientific Societies Press, Tokyo and Karger, 17-34

Schultz C, Dehghani F, Hubbard GB, Thal DR, Struckhoff G, Braak E, Braak H: Filamentous tau pathology in nerve cells, astrocytes and oligodendrocytes of aged baboons. J Neuropathol Exp Neurol 59: 39-52

Braak H, Rüb U, Sandmann-Keil D, Gai WP, de Vos RAI, Jansen Steur ENH, Arai K, Braak E: Parkinson’s disease: affection of brain stem nuclei controlling premotor and motor neurons of the somatomotor system. Acta Neuropathol 99: 489-495

Braak H, Braak E: Pathoanatomy of Parkinson’s disease. J Neurology 247: (14) II3-II10

Sassin I, Schultz C, Thal DR, Rüb U, Arai K, Koppers D, Braak E, Braak H: Evolution of Alzheimer’s disease-related cytoskeletal changes in the basal nucleus of Meynert, Acta Neuropath 100: 259-269

Thal DR, Rüb U, Schultz C, Sassin I, Ghebremedhin E, DelTredici K, Braak E, Braak H: Sequence of Aß-protein deposition in the human medial temporal lobe, J Neuropathol Exp Neurol 59: 733-748

Braak H, Rüb U, Braak E: Neuroanatomie des Morbus Parkinson, Veränderungen des Zytoskeletts in nur wenige für den Krankheitsprozess empfängliche Nervenzelltypen führen zur progedredienten Zerstörung umschriebener Bereiche des limbischen und des motorischen Systems. Nervenarzt 71: 459-469

Braak H, Del Tredici K, Bohl J, Bratzke H, Braak E: Pathological changes in the parahippocampal region in select non-Alzheimer dementias: Annals of the New York Academy of Sciences 911: 221-239

Thal RD, Schultz C, Dehghani F, Yamaguchi H, Braak H, Braak E: Amyloid b-protein (Ab)-containing astrocytes are located preferentially near N-terminal-truncated Ab deposits in the human entorhinal cortex: Acta Neuropathol 100: 608-617

Rüb U, Del Tredici K, Schultz C, Thal DR, Braak E, Braak H: The evolution of Alzheimer’s disease- related cytoskeletal pathology in the human raphe nuclei. Neuropathology and Applied Neurobiology 26: 553-567

Schultz C, Hubbard GB, Rüb U, Braak E, Braak H: Age-related progression of tau pathology in brains of baboons, Neurobiology of aging, 21: 905-911

Braak H, Del Tredici K, Gai WP, Braak E: Alpha-synuclein is not a requisite component of synaptic boutons in the adult human central nervous system. R. Quirion & H. Steinbusch (eds.) Human Brain Neuroanatomy. Journal of Chemical Neuroanatomy (Special Issue) 20: 245-252

Braak H, Del Tredici K, Schultz C, Braak E: Vulnerability of selct neuronal types to Alzheimer’s disease. In Z.S. Khatchaturian & M. Mesulem (eds.), Alzheimer’s disease: A Compendium of Current Theories, Annals of the New York Academy of Sciences 924: 53-61

Deller T, Merten T, Roth SU, Mundel P, Frotscher M: The actin-associated protein synaptopodin in the rat hippocampal formation: localization in the spine neck and close association with the spine apparatus of principal neurons. J Comp Neurol 418: 164-181

Haas CA, Deller T, Krsnik Z, Tielsch A, Woods AG, Frotscher M: Entorhinal cortex lesion does not alter reelin mRNA expression in the dentate gyrus of young and adult rats. Neuroscience 97: 25-31

Deller T, Haas CA, Frotscher M: Reorganization of the rat fascia dentata after a unilateral entorhinal cortex lesion: Role of the extracellular matrix. Ann NY Acad Sci 911: 207-220

Kaltschmidt B, Deller T, Frotscher M, Kaltschmidt C: Ultrastructural localization of activated NF-kB in granule cells of the rat fascia dentata. Neuroreport 11: 839-844

Thon N, Haas CA, Rauch U, Merten T, Fässler R, Frotscher M, Deller T: The chondroitin sulfate proteoglycan brevican is upregulated by astrocytes after entorhinal cortex lesions in adult rats. Europ J Neurosci 12: 2547-2558

Deller T, Mundel P, Frotscher M: Potential role of synaptopodin in spine motility by coupling actin to the spine apparatus. Hippocampus 10: 569-581

Deller T, Naumann T, Frotscher M: Transmitter-specific retrograde and anterograde tracing in combination with electron microscopy. J Neurosci Meth 103: 117-126

Haas CA, Hollerbach E, Deller T, Naumann T, Frotscher M: Up-regulation of growth-associated protein 43 mRNA in rat medial septum neurons axotomized by fimbria-fornix transection. Europ J Neurosci 12: 4233-4242