Original- und Übersichtsarbeiten 2005-1999

Anatomie II


Chaurasia SS, Rollag MD, Jiang G, Hayes WP, Haque R, Natesan A, Zatz M, Tosini G, Liu C, Korf HW, Iuvone PM, Provencio I (2005) Molecular cloning, localization and circadian expression of chicken melanopsin (Opn4): differential regulation of expression in pineal and retinal cell types. J Neurochem 92: 158-170

von Gall C, Weaver DR, Moek J, Jilg A, Stehle JH, Korf HW (2005) Melatonin plays a crucial role in the regulation of rhythmic clock gene expression in the mouse pars tuberalis. Ann N Y Acad Sci 1040: 508-511

Gispert S, Trenkwalder C, Mota-Vieira L, Kostic V, Auburger G (2005) Failure to find alpha-synuclein gene dosage changes in 190 patients with familial Parkinson disease. Arch Neurol 62: 96-98

Hailer NP, Vogt C, Korf HW, Dehghani F (2005) Interleukin-1beta exacerbates and interleukin-1 receptor antagonist attenuates neuronal injury and microglial activation after excitotoxic damage in organotypic hippocampal slice cultures. Eur J Neurosci 21: 2347-2360

Jilg A, Moek J, Weaver DR, Korf HW, Stehle JH, von Gall C (2005) Rhythms in clock proteins in the mouse pars tuberalis depend on MT1 melatonin receptor signalling. Eur J Neurosci 22: 2845-2854

Karolczak M, Korf HW, Stehle JH (2005) The rhythm and blues of gene expression in the rodent pineal gland. Endocrine 27: 89-100

Kessler KR, Hamscho N, Morales B, Menzel C, Barrero F, Vives F, Gispert S, Auburger G (2005) Dopaminergic function in a family with the PARK6 form of autosomal recessive Parkinson's syndrome. J Neural Transm 112: 1345-1353

Schomerus C, Korf HW (2005) Mechanisms regulating melatonin synthesis in the Mammalian pineal organ. Ann N Y Acad Sci 1057: 372-383

Sheynzon P, Karolczak M, Dehghani F, Korf HW (2005) Diurnal variation in CREB phosphorylation and PER1 protein levels in lactotroph cells of melatonin-proficient C3H and melatonin-deficient C57BL mice: similarities and differences. Cell Tissue Res 321: 211-217

Stavridis SI, Dehghani F, Korf HW, Hailer NP (2005) Characterisation of transverse slice culture preparations of postnatal rat spinal cord: preservation of defined neuronal populations. Histochem.Cell Biol 123: 377-392


Dehghani F, Conrad A, Kohl A, Korf HW, Hailer NP (2004) Clodronate inhibits the secretion of proinflammatory cytokines and NO by isolated microglial cells and reduces the number of proliferating glial cells in excitotoxically injured organotypic hippocampal slice cultures. Exp Neurol 189: 241-251

Karolczak M, Burbach GJ, Sties G, Korf HW, Stehle JH (2004) Clock gene mRNA and protein rhythms in the pineal gland of mice. Eur J Neurosci 19: 3382-3388

Kell CA, Dehghani F, Wicht H, Molina CA, Korf HW, Stehle JH (2004) Distribution of transcription factor inducible cyclicAMP early repressor (ICER) in rodent brain and pituitary. J Comp Neurol. 478: 379

Kell CA, Dehghani F, Wicht H, Molina CA, Korf HW, Stehle JH (2004) Distribution of transcription factor inducible cyclicAMP early repressor (ICER) in rodent brain and pituitary. J Comp Neurol. 478: 379

Korf HW, Wicht H (2004) The public cadaver. Nature 428: 805

Schomerus C, Laedtke E, Korf HW (2004) Activation of arylalkylamine N-acetyltransferase by phorbol esters in bovine pinealocytes suggests a novel regulatory pathway in melatonin synthesis. J Neuroendocrinol 16: 741-749

Valente EM, Abou-Sleiman PM, Caputo V, Muqit MM, Harvey K, Gispert S, Ali Z, Del Turco D, Bentivoglio AR, Healy DG, Albanese A, Nussbaum R, Gonzalez-Maldonado R, Deller T, Salvi S, Cortelli P, Gilks WP, Latchman DS, Harvey RJ, Dallapiccola B, Auburger G, Wood NW (2004) Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science 304: 1158-1160


Arens J, Moar KM, Eiden S, Weide K, Schmidt I, Mercer JG, Simon E, Korf HW (2003) Age-dependent hypothalamic expression of neuropeptides in wild-type and melanocortin-4 receptor-deficient mice. Physiol Genomics 16: 38-46

Beyer C, Pawlak J, Brito V, Karolczak M, Ivanova T, Kuppers E (2003) Regulation of gene expression in the developing midbrain by estrogen: implication of classical and nonclassical steroid signaling. Ann N Y Acad Sci 1007: 17-28

Beyer C, Pawlak J, Karolczak M (2003) Membrane receptors for oestrogen in the brain. J Neurochem 87: 545-550

Beyer C, Kuppers E, Karolczak M, Trotter A (2003) Ontogenetic expression of estrogen and progesterone receptors in the mouse lung. Biol Neonate 84: 59-63

Dehghani F, Hischebeth GT, Wirjatijasa F, Kohl A, Korf HW, Hailer NP (2003) The immunosuppressant mycophenolate mofetil attenuates neuronal damage after excitotoxic injury in hippocampal slice cultures. Eur J Neurosci 18: 1061-1072

Ekhart D, Korf HW, Wicht H (2003) Cytoarchitecture, topography, and descending supraspinal projections in the anterior central nervous system of Branchiostoma lanceolatum. J Comp Neurol 466: 319-330

Forger DB, Dean DA, Gurdziel K, Leloup JC, Lee C, von Gall C, Etchegaray JP, Kronauer RE, Goldbeter A, Peskin CS, Jewett ME, Weaver DR (2003) Development and validation of computational models for mammalian circadian oscillators. Omics 7: 387-400

Gispert S, Del Turco D, Garrett L, Chen A, Bernard DJ, Hamm-Clement J, Korf HW, Deller T, Braak H, Auburger G, Nussbaum RL (2003) Transgenic mice expressing mutant A53T human alpha-synuclein show neuronal dysfunction in the absence of aggregate formation. Mol Cell Neurosci 24: 419-429

Jin X, von Gall C, Pieschl RL, Gribkoff VK, Stehle JH, Reppert SM, Weaver DR (2003) Targeted disruption of the mouse Mel(1b) melatonin receptor. Mol Cell Biol 23: 1054-1060

Koch M, Mauhin V, Stehle JH, Schomerus C, Korf HW (2003) Dephosphorylation of pCREB by protein serine/threonine phosphatases is involved in inactivation of Aanat gene transcription in rat pineal gland. J Neurochem 85: 170-179

Kohl A, Dehghani F, Korf HW, Hailer NP (2003) The bisphosphonate clodronate depletes microglial cells in excitotoxically injured organotypic hippocampal slice cultures. Exp Neurol 181: 1-11

Korf HW, von Gall C, Stehle J (2003) The circadian system and melatonin: lessons from rats and mice. Chronobiol Int 20: 697-710

Mutoh T, Shibata S, Korf HW, Okamura H (2003) Melatonin modulates the light-induced sympathoexcitation and vagal suppression with participation of the suprachiasmatic nucleus in mice. J Physiol 547: 317-332

Rami A, Volkmann T, Agarwal R, Schoninger S, Nurnberger F, Saido TC, Winckler J (2003) beta2-Adrenergic receptor responsiveness of the calpain-calpastatin system and attenuation of neuronal death in rat hippocampus after transient global ischemia. Neurosci Res 47: 373-382

Romanos GE, Toh CG, Siar CH, Wicht H, Yacoob H, Nentwig GH (2003) Bone-implant interface around titanium implants under different loading conditions: a histomorphometrical analysis in the Macaca fascicularis monkey. J Periodontol 74: 1483-1490

Schomerus C, Laedtke E, Korf HW (2003) Norepinephrine-dependent phosphorylation of the transcription factor cyclic adenosine monophosphate responsive element-binding protein in bovine pinealocytes. J Pineal Res 34: 103-109

Stehle JH, von Gall C, Korf HW (2003) Melatonin: a clock-output, a clock-input. J Neuroendocrinol 15: 383-389

von Gall C (2003) Rhythmic clock gene expression in the hypophyseal pars tuberalis is regulated by melatonin. Ann Anat 185: 301-302

von Gall C, Noton E, Lee C, Weaver DR (2003) Light does not degrade the constitutively expressed BMAL1 protein in the mouse suprachiasmatic nucleus. Eur J Neurosci 18: 125-133


Bisler S, Schleicher A, Gass P, Stehle JH, Zilles K, Staiger JF (2002) Expression of c-Fos, ICER, Krox-24 and JunB in the whisker-to-barrel pathway of rats: time course of induction upon whisker stimulation by tactile exploration of an enriched environment. J Chem Neuroanat 23: 187-198

Gau D, Lemberger T, von Gall C, Kretz O, Le Minh N, Gass P, Schmid W, Schibler U, Korf HW, Schutz G (2002) Phosphorylation of CREB Ser142 regulates light-induced phase shifts of the circadian clock. Neuron 34: 245-253

Hattenbach LO, Falk B, Nurnberger F, Koch FH, Ohrloff C (2002) Detection of inducible nitric oxide synthase and vascular endothelial growth factor in choroidal neovascular membranes. Ophthalmologica 216: 209-214

Koch M, Korf HW (2002) Distribution of regulatory subunits of protein kinase A and A kinase anchor proteins (AKAP 95, 150) in rat pinealocytes. Cell Tissue Res 310: 331-338

Korf HW, Stehle JH (2002) The circadian system: circuits-cells-clock genes. Cell Tissue Res 309: 1-2

Revermann M, Maronde E, Ruth P, Korf HW (2002) Protein kinase G I immunoreaction is colocalized with arginine-vasopressin immunoreaction in the rat suprachiasmatic nucleus. Neurosci Lett 334: 119-122

Schomerus C, Laedtke E, Olcese J, Weller JL, Klein DC, Korf HW (2002) Signal transduction and regulation of melatonin synthesis in bovine pinealocytes: impact of adrenergic, peptidergic and cholinergic stimuli. Cell Tissue Res 309: 417-428

Schoniger S, Maronde E, Kopp MD, Korf HW, Nurnberger F (2002) Transcription factor CREB and its stimulus-dependent phosphorylation in cell and explant cultures of the bovine subcommissural organ. Cell Tissue Res 308: 131-142

Schoniger S, Kopp MD, Schomerus C, Maronde E, Dehghani F, Meiniel A, Rodriguez M, Korf HW, Nurnberger F (2002) Effects of neuroactive substances on the activity of subcommissural organ cells in dispersed cell and explant cultures. Cell Tissue Res 307: 101-114

Sotiriou S, Gispert S, Cheng J, Wang Y, Chen A, Hoogstraten-Miller S, Miller GF, Kwon O, Levine M, Guttentag SH, Nussbaum RL (2002) Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival. Nat Med 8: 514-517

Stehle JH, von Gall C, Korf HW (2002) Organisation of the circadian system in melatonin-proficient C3H and melatonin-deficient C57BL mice: a comparative investigation. Cell Tissue Res 309: 173-182

von Gall C, Stehle JH, Weaver DR (2002) Mammalian melatonin receptors: molecular biology and signal transduction. Cell Tissue Res 309: 151-162

von Gall C, Garabette ML, Kell CA, Frenzel S, Dehghani F, Schumm-Draeger PM, Weaver DR, Korf HW, Hastings MH, Stehle JH (2002) Rhythmic gene expression in pituitary depends on heterologous sensitization by the neurohormone melatonin. Nat Neurosci 5: 234-238

Willbold E, Huhn J, Korf HW, Voisin P, Layer PG (2002) Light-dark and circadian melatonin rhythms are established de novo in re-aggregates of the embryonic chicken retina. Dev Neurosci 24: 504-511

Wirjatijasa F, Dehghani F, Blaheta RA, Korf HW, Hailer NP (2002) Interleukin-4, interleukin-10, and interleukin-1-receptor antagonist but not transforming growth factor-beta induce ramification and reduce adhesion molecule expression of rat microglial cells. J Neurosci Res 68: 579-587


Coon, S.L., Weller, J.L., Korf, H.W., Namboodiri, M.A., Rollag, M. & Klein, D.C. (2001) cAmp regulation of arylalkylamine N-acetyltransferase (AANAT, EC a new cell line (1E7) provides evidence of intracellular AANAT activation. J Biol Chem 276: 24097-24107

Fleming, I., Michaelis, U.R., Bredenkotter, D., Fisslthaler, B., Dehghani, F., Brandes, R.P. & Busse, R. (2001) Endothelium-derived hyperpolarizing factor synthase (Cytochrome P450 2C9) is a functionally significant source of reactive oxygen species in coronary arteries. Circ Res 88: 44-51

Hailer, N.P., Wirjatijasa, F., Roser, N., Hischebeth, G. T., Korf, H.W. & Dehghani, F. (2001) Astrocytic factors protect neuronal integrity and reduce microglial activation in an in vitro model of N-methyl-D-aspartate-induced excitotoxic injury in organotypic hippocampal slice cultures. Eur J Neurosci 14: 315-326

Kopp, M. D., Meissl, H., Dehghani, F. & Korf, H.W. (2001) The pituitary adenylate cyclase-activating polypeptide modulates glutamatergic calcium signalling: investigations on rat suprachiasmatic nucleus neurons. J Neurochem 79: 161-171

Maronde, E., Korf, H.W., Niemann, P. & Genieser, H.G. (2001) Direct comparison of the potency of three novel cAMP analogs to induce CREB-phophorylation in rat pinealocytes. J Pineal Res 31: 183-185

Nurnberger, F. & Schoniger, S. (2001) Presence and functional significance of neuropeptide and neurotransmitter receptors in subcommissural organ cells. Microsc Res Tech 52: 534-540

Schoniger, S., Wehming, S., Gonzalez, C., Schobitz, K., Rodriguez, E., Oksche, A., Yulis, C.R. & Nurnberger, F. (2001) The dispersed cell culture as model for functional studies of the subcommissural organ: preparation and characterization of the culture system. J Neurosci Methods 107: 47-61

Stehle, J.H., von Gall, C. & Korf, H.W. (2001) Analysis of cell signalling in the rodent pineal gland deciphers regulators of dynamic transcription in neural/endocrine cells. Eur J Neurosci 14: 1-9

Stehle, J.H., von Gall, C., Schomerus, C. & Korf, H.W. (2001) Of rodents and ungulates and melatonin: creating a uniform code for darkness by different signaling mechanisms. J Biol Rhythms 16: 312-325

von Gall, C., Schneider-Huther, I., Pfeffer, M., Dehghani, F., Korf, H.W. & Stehle, J.H. (2001) Clock gene protein mPER1 is rhythmically synthesized and under cAMP control in the mouse pineal organ. J Neuroendocrinol 13: 313-316


Dehghani F, Maronde E, Schachenmayr W, Korf HW (2000) Neurofilament H immunoreaction in oligodendrogliomas as demonstrated by a new polyclonal antibody. Acta Neuropathol (Berl) 100: 122-130

Gispert S, Dutra A, Lieberman A, Friedlich D, Nussbaum RL (2000) Cloning and genomic organization of the mouse gene slc23a1 encoding a vitamin C transporter. DNA Res 7: 339-345

Gorlach A, Brandes RP, Nguyen K, Amidi M, Dehghani F, Busse R (2000) A gp91phox containing NADPH oxidase selectively expressed in endothelial cells is a major source of oxygen radical generation in the arterial wall. Circ Res 87: 26-32

Kroeber S, Meissl H, Maronde E, Korf HW (2000) Analyses of signal transduction cascades reveal an essential role of calcium ions for regulation of melatonin biosynthesis in the light-sensitive pineal organ of the rainbow trout (Oncorhynchus mykiss). J Neurochem 74: 2478-2489

Pfeffer M, Maronde E, Korf HW, Stehle JH (2000) Antisense experiments reveal molecular details on mechanisms of ICER suppressing cAMP-inducible genes in rat pinealocytes. J Pineal Res 29: 24-33

Schomerus C, Korf HW, Laedtke E, Weller JL, Klein DC (2000) Selective adrenergic/cyclic AMP-dependent switch-off of proteasomal proteolysis alone switches on neural signal transduction: an example from the pineal gland. J Neurochem 75: 2123-2132

Schultz C, Dehghani F, Hubbard GB, Thal DR, Struckhoff G, Braak E, Braak H (2000) Filamentous tau pathology in nerve cells, astrocytes, and oligodendrocytes of aged baboons. J Neuropathol Exp Neurol 59: 39-52

Staiger JF, Bisler S, Schleicher A, Gass P, Stehle JH, Zilles K (2000) Exploration of a novel environment leads to the expression of inducible transcription factors in barrel-related columns. Neuroscience 99: 7-16

Thal DR, Schultz C, Dehghani F, Yamaguchi H, Braak H, Braak E (2000) Amyloid beta-protein (Abeta)-containing astrocytes are located preferentially near N-terminal-truncated Abeta deposits in the human entorhinal cortex. Acta Neuropathol (Berl) 100: 608-617

von Gall C, Weaver DR, Kock M, Korf HW, Stehle JH (2000) Melatonin limits transcriptional impact of phosphoCREB in the mouse SCN via the Mel1a receptor. Neuroreport 11: 1803-1807

von Gall C, Lewy A, Schomerus C, Vivien-Roels B, Pevet P, Korf HW, Stehle JH (2000) Transcription factor dynamics and neuroendocrine signalling in the mouse pineal gland: a comparative analysis of melatonin-deficient C57BL mice and melatonin-proficient C3H mice. Eur J Neurosci 12: 964-972


Jacobs RA, Schaad NC, Vanecek J, Leaver S, Aubry JM, Korf HW, Dahia PL, Chew SL, Grossman AB (1999) Pineal nitric oxide synthase, but not heme oxygenase, mRNA is suppressed by continuous exposure to light. Brain Res Mol Brain Res 70: 264-272

Kopp MD, Schomerus C, Dehghani F, Korf HW, Meissl H (1999) Pituitary adenylate cyclase-activating polypeptide and melatonin in the suprachiasmatic nucleus: effects on the calcium signal transduction cascade. J.Neurosci 19: 206-219

Korf HW (1999) Evolution of melatonin-producing pinealocytes. Adv Exp Med Biol 460: 17-29

Maronde E, Pfeffer M, von Gall C, Dehghani F, Schomerus C, Wicht H, Kroeber S, Olcese J, Stehle JH, Korf HW (1999) Signal transduction in the rodent pineal organ. From the membrane to the nucleus. Adv Exp Med Biol 460: 109-131

Maronde E, Wicht H, Tasken K, Genieser HG, Dehghani F, Olcese J, Korf HW (1999) CREB phosphorylation and melatonin biosynthesis in the rat pineal gland: involvement of cyclic AMP dependent protein kinase type II. J Pineal Res 27: 170-182

Maronde E, Pfeffer M, Olcese J, Molina CA, Schlotter F, Dehghani F, Korf HW, Stehle JH (1999) Transcription factors in neuroendocrine regulation: rhythmic changes in pCREB and ICER levels frame melatonin synthesis. J Neurosci 19: 3326-3336

Pfeffer M, Maronde E, Molina CA, Korf HW, Stehle JH (1999) Inducible cyclic AMP early repressor protein in rat pinealocytes: a highly sensitive natural reporter for regulated gene transcription. Mol Pharmacol, 56: 279-289

Schneider C, Wicht H, Enderich J, Wegner M, Rohrer H (1999) Bone morphogenetic proteins are required in vivo for the generation of sympathetic neurons. Neuron, 24: 861-870

Schomerus C, Korf HW (1999) Cholinergic signal transduction cascades in rat pinealocytes: functional and ontogenetic aspects. Reprod Nutr Dev 39: 305-314

Schomerus C, Laedtke E, Korf HW (1999) Analyses of signal transduction cascades in rat pinealocytes reveal a switch in cholinergic signaling during postnatal development. Brain Res. 833: 39-50

Wicht H, Maronde E, Olcese J, Korf HW (1999) A semiquantitative image-analytical method for the recording of dose-response curves in immunocytochemical preparations. J.Histochem.Cytochem 47: 411-420

Wullimann MF, Puelles L, Wicht H (1999) Early postembryonic neural development in the zebrafish: a 3-D reconstruction of forebrain proliferation zones shows their relation to prosomeres. Eur J Morphol 37: 117-121