Research Highlights

2021

2021

click on the picture for official notice

   
[Cl@Si20H20]: Parent Siladodecahedrane with Endohedral Chloride Ion. 
M. Bamberg, M. Bursch, A. Hansen, M. Brandl, G. Sentis, L. Kunze, M. Bolte, H.-W. Lerner, S. Grimme, M. Wagner: . J. Am. Chem. Soc. 2021, 143, 10865–10871  https://doi.org/10.1021/jacs.1c05598 

Selective One-Pot Syntheses of Mixed Silicon-Germanium Heteroadamantane Clusters.
B. Köstler, M. Bolte, H.-W. Lerner, M. Wagner: Chem. Eur. J. 2021 https://doi.org/10.1002/chem.202102732
  Switching at the ribosome: riboswitches need rProteins as modulators to regulate translation.
V. de Jesus, N. S. Qureshi, S. Warhaut, J. K. Bains, M. S. Dietz, M. Heilemann, H. Schwalbe, B. Fürtig, Nature Communications, 2021, DOI: 10.1038/s41467-021-25024-5
     




SARS-CoV-2: Achillesfersen im Viren-Erbgut
 

Bestimmte Regionen im SARS-CoV-2-Erbgut könnten sich als Ziel für künftige Medikamente eignen. Dies fanden jetzt Wissenschaftlerinnen und Wissenschaftler der Goethe-Universität Frankfurt und ihre Kooperationspartner im internationalen COVID-19-NMR-Konsortium heraus. Mithilfe einer speziellen Substanzdatenbank identifizierten sie mehrere kleine Moleküle, die an bestimmte Stellen des SARS-CoV-2-Genoms binden, die fast nie durch Mutationen verändert werden.

  Exploring the druggability of conserved RNA regulatory elements in the SARS-CoV-2 genome.
S Sreeramulu, C Richter, H Berg, MA Wirtz Martin, B Ceylan, T Matzel, J Adam, N Altincekic, K Azzaoui, J Kaur Bains, MJJ Blommers, J Ferner, B Fürtig, M Göbel, JT Grün, M Hengesbach, KF Hohmann, D Hymon, B Knezic, JN Martins, KR Mertinkus, A Niesteruk, SA Peter, DJ Pyper, NS Qureshi, U Scheffer, A Schlundt, R Schnieders, E Stirnal, A Sudakov, A Tröster, J Vögele, A Wacker, JE Weigand, J Wirmer-Bartoschek, J Wöhnert, H Schwalbe
Angew. Chem. Int. Ed. Engl., 2021, in press doi.org/10.1002/anie.202103693
     
   

COVID-19-Behandlung: Erforschung zweier Angriffspunkte des viralen Stoffwechsels

Zwei Forschungskooperationen der Goethe-Universität zu neuen COVID-19-Therapieansätzen fördert jetzt die Volkswagenstiftung mit insgesamt rund 1,4 Millionen Euro:
„Target-RNA-antiV“ Prof. Dr. Maike Windbergs
, Institut für Pharmazeutische Technologie & Prof. Dr. Harald Schwalbe, Institut für Chemie und chemische Biologie
„CoVmacro“, Prof. Dr. Stefan Knapp, Institut für Pharmazeutische Chemie

  BIPOLES: a tool for bidirectional dual-color optogenetic control of neurons
J Vierock, S Rodriguez-Rozada, F Pieper, A Dieter, A Bergs, N Zeitzschel, J Ahlbeck, K Sauter, A Gottschalk, AK Engel, P Hegemann, S Wiegert
bioRxiv, 16th July 2020. doi: doi.org/10.1101/2020.07.15.204347
     
     
Allosteric drug transport mechanism of multidrug transporter AcrB
HK Tam, WE Foong, C Oswald, A Herrmann, H Zeng, KM Pos
Nature Communications, 2021, 12, Article number: 3889 doi.org/10.1038/s41467-021-24151-3
  Nox4-Dependent Upregulation of S100A4 after Peripheral Nerve Injury Modulates Neuropathic Pain Processing
G Wack, K Metzner, MS Kuth, E Wang, A Bresnick, RP Brandes, K Schröder, I Wittig, A Schmidtko, W Kallenborn-Gerhardt
Free Radic Biol Med. 2021 S0891-5849(21)00180-5. DOI: 10.1016/j.freeradbiomed.2021.03.021
     
Large-Scale Recombinant Production of the SARS-CoV-2 Proteome for High-Throughput and Structural Biology Application
N Altincekic, SM Korn, NS Qureshi, M Dujardin, M Ninot-Pedrosa, R Abele, MJ Abi Saad, C Alfano, FCL Almeida, I Alshamleh, GC de Amorim,  TK Anderson, CD Anobom, C Anorma, JK Bains, A Bax, M Blackledge, J Blechar, A Böckmann, L Brigandat, A Bula, M Bütikofer, AR Camacho-Zarco, T Carlomagno, IP Caruso, B Ceylan, A Chaikuad, F Chu, L Cole, MG Crosby, V de Jesus, K Dhamotharan, IC Felli, J Ferner, Y Fleischmann, ML Fogeron, NK Fourkiotis, C Fuks, B Fürtig, A Gallo, SL Gande, JA Gerez, D Ghosh, ....
Front Mol Biosci 2021. 8, 653148. DOI: 10.3389/fmolb.2021.653148
  Structure-Based Design of Selective Salt-Inducible Kinase Inhibitor
R Tesch, M Rak, M Raab, LM Berger, T Kronenberger, AC Joerger, BT Berger, I Abdi, T Hanke, A Poso, K Strebhardt, M Sanhaji, S Knapp
J Med Chem 2021. 64 (12): 8142-8160 DOI: 10.1021/acs.jmedchem.0c02144
     
   
How Photoswitchable Lipids Affect the Order and Dynamics of Lipid Bilayers and Embedded Proteins
M Doroudgar, J Morstein, J Becker-Baldus, D Trauner, C Glaubitz
J Am Chem Soc. 2021 Jun 16. doi: doi.org/10.1021/jacs.1c03524
  De novo macrocyclic peptides dissect energy coupling of a heterodimeric ABC transporter by multimode allosteric inhibition“
E Stefan, R Obexer, S Hofmann, K Vu Huu, Y Huang und N Morgner, zudem federführend H Suga und R Tampé
eLife 2021;10:e67732 doi: 10.7554/eLife.67732
     
In vivo inducible reverse genetics in patients’ tumors to identify individual therapeutic targets.
M Carlet, K Völse, J Vergalli, M Becker, T Herold, A Arner, D Senft, V Jurinovic, WH Liu, Y Gao, V Dill, B Fehse, C Baldus, L Bastian, L Lenk, D Schewe, J Bagnoli, B Vick, J Schmid, A Wilhelm, R Marschalek, P Jost, C Miehting, K Riecken, M Schmidt-Supprian, V Binder
Nat. Communications 2021 under review
  Quantum dynamics of exciton transport and dissociation in multichromophoric systems
W Popp, D Brey, R Binder, I Burghardt
Rev. Phys. Chem., 2021, 72, 591 doi.org/10.1146/annurev-physchem-090419-040306
     
   
What defines a synthetic riboswitch? - Conformational dynamics of ciprofloxacin aptamers with similar binding affinities but varying regulatory potentials
C Kaiser, J Schneider, E Groher, B Suess and J Wachtveitl
Nucleic Acids Res. 2021 49, 3661-3671 doi.org/10.1021/acs.jpcc.0c09891
  C81-evoked inhibition of the TNFR1-NFκB pathway during inflammatory processes for stabilization of the impaired vascular endothelial barrier for leukocytes
GM Krishnathas, B Strödke, L Mittmann, T Zech, CA Reichel, T Schmid, S Knapp, S Müller-Knapp, F Bracher, R Fürst; I Bischoff-Kont
FASEB J. 2021; 35: e21656. doi.org/10.1096/fj.202100037R
     

Synapsin Is Required for Dense Core Vesicle Capture and cAMP-Dependent Neuropeptide Release
S-c Yu, JF Liewald, J Shao, W Steuer Costa and A Gottschalk
Journal of Neuroscience 12 May 2021, 41 (19) 4187-4201; DOI: doi.org/10.1523/JNEUROSCI.2631-20.2021 

  Endogenous vitamin E metabolites mediate allosteric PPARγ activation with unprecedented co-regulatory interactions
S Willems, L Gellrich, A Chaikuad, S Kluge, O Werz, J Heering, S Knapp, S Lorkowski, M Schubert-Zsilavecz, D Merk
Cell Chem Biol 2021 DOI: 10.1016/j.chembiol.2021.04.019
     
   

The Desensitized Channelrhodopsin-2 Photointermediate Contains 13-cis,15-syn RetinalSchiff Base.
J Becker-Baldus, A Leeder, LJ Brown, RCD Brown, C Bamann, C Glaubitz
Angew Chem Int Ed Engl. 2021 May 11. doi: doi.org/10.1002/anie.202015797

  Structural Insights into Plasticity and Discovery of Remdesivir Metabolite GS-441524 Binding in SARS-CoV‑2 Macrodomain
X Ni, M Schröder, V Olieric, M E Sharpe, V Hernandez-Olmos, E Proschak, D Merk, S Knapp, A Chaikuad
ACS Med. Chem. Lett. 2021, 12, 603−609 pubs.acs.org/doi/10.1021/acsmedchemlett.0c00684
     
Multi-Color, Bleaching-Resistant Super-Resolution Optical Fluctuation Imaging with Oligonucleotide-Based Exchangeable Fluorophores
M Glogger, C Spahn, J Enderlein, M Heilemann
Angew. Chem. Int. Ed. 2021, 60, 12, 6310-6313 doi.org/10.1002/anie.202013166
  Electron-Irradiation Promoted Exchange Reaction as a Tool for Surface Engineering and Chemical Lithography
A Terfort, M Zharnikov
Adv. Mater. Interf., 2021, 8, 2100148 doi.org/10.1002/admi.202100148
     
     

Probing the photointermediates of light-driven sodium ion pump KR2 by DNP- enhanced solid-state NMR
O Jakdetchai, P Eberhardt, M Asido, J Kaur, CN Kriebel, J Mao, AJ Leeder, LJ Brown, RCD Brown, J Becker-Baldus, C Bamann, J Wachtveitl, C Glaubitz: Sci Adv. 2021 Mar 12;7(11):eabf4213. doi:10.1126/sciadv.abf4213

  Unravelling the kinetics of spare-tire DNA G-quadruplex folding
JT Grün, A Blümler, I Burkhart, J Wirmer-Bartoschek, A Heckel, H Schwalbe
J. Am. Chem. Soc., 2020, 143, 6185-6193. pubs.acs.org/doi/10.1021/jacs.1c01089
     
     
Natural products as drugs and tools for influencing core process of eukaryotic mRNA translation
LD Burgers, R Fürst
Pharmacol Res. 2021; 170: 105535. doi.org/10.1016/j.phrs.2021.105535
 

Photo-induced receptor confinement drives ligand-independent GPCR signaling
MF Sánchez, S Els-Heindl, AG Beck-Sickinger, R Wieneke, R Tampé
Science. 2021 Feb 25: eabb7657. doi: 10.1126/science.abb7657

     
A Stable N-Heterocyclic Silylene with a 1,1'-Ferrocenediyl Backbone
N Weyer, M Heinz, JI Schweizer, C Bruhn, MC Holthausen, U Siemeling
Angew. Chem. Int. Ed., 2021, 60, 2624 doi.org/10.1002/anie.202011691
   
     
 
Large-scale recombinant production of the SARS-CoV-2 proteome for high-throughput and structural biology applications
N Altincekic, S M Korn, N S Qureshi, M Dujardin, M Ninot-Pedrosa, M Hengesbach, A Schlundt et al.
Frontiers in Molecular Biosciences, 2021 doi.org/10.3389/fmolb.2021.653148
  Photo-induced receptor confinement drives ligand-independent GPCR signaling
MF Sánchez, S Els-Heindl, A G Beck-Sickinger, R Wieneke, R Tampé
Science, 2021, science.sciencemag.org/lookup/doi/10.1126/science.abb7657
     
   
Cysteine oxidation and disulfide formation in the ribosomal exit tunnel
L Schulte, J Mao, J Reitz, S Sreeramulu, D Kudlinzki, V-V Hodirnau, J Meier-Credo, K Saxena, F Buhr, J D Langer, M Blackledge, A S Frangakis, C Glaubitz, H Schwalbe
Nature Communications, 2021, doi.org/10.1038/s41467-020-19372-x
  Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2
B-T Berger, M Amaral, D B Kokh, A Nunes-Alves, D Musil, T Heinrich, M Schröder, R Neil, J Wang, I Navratilova, J Bomke, J M Elkins, S Müller, M Frech, R C Wade, S Knapp
Cell Chemical Biology, 2021, doi.org/10.1016/j.chembiol.2021.01.003
     
   
Combined Cardioprotective and Adipocyte Browning Effects Promoted by the Eutomer of Dual sEH/PPARγ Modulator
M Hartmann, SI Bibli, D Tews, X Ni, T Kircher, JS Kramer, W Kilu, J Heering, V Hernandez-Olmos, L Weizel, GKE Scriba, SKrait, S Knapp, A Chaikuad, D Merk, I Fleming, P Fischer-Posovszky, E Proschak
J. Med. Chem. 2020, 64, 2815-2828 doi.org/10.1021/acs.jmedchem.0c02063
  Structure determination of organic compounds by a fit to the pair distribution function from scratch without prior indexing
C. Schlesinger, S. Habermehl, D. Prill
J. Appl. Cryst. 2021, 54, http://doi.org/10.1107/S1600576721002569
     
Design, Synthesis, and Evaluation of WD-Repeat-Containing Protein 5 (WDR5) Degraders
A Dölle, B Adhikari, A Krämer, J Weckesser, N Berner, LM Berger, M Diebold, MM Szewczyk, D Barsyte-Lovejoy, CH Arrowsmith, J Gebel, F Löhr, V Dötsch, M Eilers, S Heinzlmeir, B Kuster, C Sotriffer, E Wolf, S Knapp
J Med Chem 2021, DOI: 10.1021/acs.jmedchem.1c00146
  Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2
BT Berger, M Amaral, DB Kokh, A Nunes-Alves, D Musil, T Heinrich, M Schröder, R Neil, J Wang, I Navratilova, J Bomke, JM Elkins, S Müller, M Frech, RC Wade, S Knapp
Cell Chem Biol 2021. 28 (5): 686-698.e7. DOI: 10.1016/j.chembiol.2021.01.003
     
Exploiting vulnerabilities of SWI/SNF chromatin remodelling complexes for cancer therapy
M Wanior, A Krämer, S Knapp, AC Joerger
Oncogene 2021. 40 (21): 3637-3654 DOI: 10.1038/s41388-021-01781-x
  Structure and Inhibitor Binding Characterization of Oncogenic MLLT1 Mutants
X Ni, AT Londregan, DR Owen, S Knapp, A Chaikuad
ACS Chem Biol 2021. 16 (4): 571-578 DOI: 10.1021/acschembio.0c00960
     
     
Structural Insights into Plasticity and Discovery of Remdesivir Metabolite GS-441524 Binding in SARS-CoV-2 Macrodomain
X Ni, M Schröder, V Olieric, ME Sharpe, V Hernandez-Olmos, E Proschak, D Merk, S Knapp, A Chaikuad
ACS Med Chem Lett 2021. 12 (4): 603-609 DOI: 10.1021/acsmedchemlett.0c00684
  Functional Coupling of Slack Channels and P2X3 Receptors Contributes to Neuropathic Pain Processing
R Lu, K Metzner, F Zhou, C Flauaus, A Balzulat, P Engel, J Petersen, R Ehinger, A Bausch, P Ruth, R Lukowski, A Schmidtko
J. Mol. Sci. 2021, 22, 405. doi: 10.3390/ijms22010405
     
Clinical Implications of Minimal Residual Disease Detection in Infants With KMT2A-Rearranged Acute Lymphoblastic Leukemia Treated on the Interfant-06 Protocol
J Stutterheim, IM van der Sluis, P de Lorenzo, J Alten, P Ancliffe, A Attarbaschi, B Brethon, A Biondi, M Campbell, G Cazzaniga, G Escherich, A Ferster, RS Kotecha, B Lausen, CK Li,L Lo Nigro, F Locatelli, R Marschalek, C Meyer, M Schrappe, J Stary, A Vora, J Zuna, VHJ van der Velden, T Szczepanski, MG Valsecchi, R PieterS
J Clin Oncol. 2021 Feb 20;39(6):652-662 DOI: 10.1200/JCO.20.02333
   
     

Cell culture NAIL-MS allows insight into human tRNA and rRNA modification dynamics in vivo
M Heiss, F Hagelskamp, V Marchand, Y Motorin Y, S Kellner
Nat Commun. 2021 Jan 15;12(1):389. DOI: 10.1038/s41467-020-20576-4

  Propranolol Activates the Orphan Nuclear Receptor TLX to Counteract Proliferation and Migration of Glioblastoma Cells
G Faudone, I Bischoff-Kont, L Rachor, S Willems, R Zhubi, A Kaiser, A Chaikuad, S Knapp, R Fürst, J Heering, D Merk
J Med Chem 2021. 64 (12): 8727-8738 DOI: 10.1021/acs.jmedchem.1c00733

2020

2020

click on the picture for official notice

 

Transfer RNA fragments replace microRNAs regulators of the cholinergic post-stroke immune blockade
K Winek, S Lobentanzer, B Nadorp, S Dubnov, C Dames, G Moshitzky, B Hotter, C Meisel, DS Greenberg, S Shifman, J Klein, S Shenhar-Tsarfaty, A Meisel und H Soreq
Proc. Natl. Acad. Sci. USA, 2020, doi.org/10.1073/pnas.2013542117
  Structural rearrangement of amyloid-β upon inhibitor binding suppresses formation of Alzheimer disease related oligomers
T Lieblein, R Zangl, J Martin, J Hoffmann, MJ Hutchison, T Stark, E Stirnal, T Schrader, H Schwalbe, N Morgner
eLife 2020 doi: 10.7554/eLife.59306
     
Structural basis of proton-coupled potassium transport in the KUP family
I Tascon, J Sousa, RA Corey, DJ Mills, D Griwatz, N Aumüller, V Mikusevic, PJ Stansfeld, J Vonck, I Hänelt
Nat Comm, 2020, 11:626, doi.org/10.1038/s41467-020-14441-7
  A Platinum(ii) Metallonitrene with a Triplet Ground State
J Sun, J Abbenseth, H Verplancke, M Diefenbach, B de Bruin, D Hunger, C Würtele, J van Slageren, MC Holthausen, S Schneider
Nature Chem., 2020, 12, 1054 doi.org/10.1038/s41557-020-0522-4
     
   

Secondary structure determination of conserved SARS-CoV-2 RNA elements by NMR spectroscopy
A Wacker, JE Weigand, S-R Akabayov, N Altincekic, J Bains, E Banijamali, O Binas, J Castillo-Martínez, E Cetiner, B Ceylan, L-Y Chiu, J Davila-Calderon, V de Jesus, K Dhamotharan, E Duchardt-Ferner, J Ferner, L Frydman, B Fürtig, J Gallego, JT Grün, C Hacker, C Haddad, M Hähnke, M Hengesbach, F Hiller, KH Hohmann, D Hymon, H Jonker, H Keller, B Knezic, T Landgraf, F Löhr, L Luo, K Mertinkus, C Muhs, M Novakovic, A Oxenfarth, M Palomino-Schätzlein, K Petzold, S Peters, D Pyper, N Qureshi, M Riad, C Richter, K Saxena, T Schamber, T Scherf, J Schlagnitweit, A Schlundt, R Schnieders, H Schwalbe*, A Simba-Lahuasi, S Sreeramulu, E Stirnal, A Sudakov, J-N Tants, B Tolbert, J Vögele, L Weiss, J Wirmer-Bartoschek, M A Wirtz Martin, J Wöhnert, H Zetzsche
Nucl. Acids Res. 2020, 48, 12415-12435 (breakthrough paper). doi.org/10.1093/nar/gkaa1013
 

The interplay between chromophore and protein determines the extended excited state dynamics in a single-domain phytochrome
C. Slavov, T Fischer, A Barnoy, H Shin, AG Rao, C Wiebeler, X Zeng, Y Sun, Q Xu, A Gutt, K-H Zhao, W Gärtner, X Yang, I Schapiro and J Wachtveitl
Natl. Acad. Sci. USA, 2020, 117 (28), 16356-16362 doi.org/10.1073/pnas.1921706117

     
 
A platinum(II) metallonitrene with a triplet ground state
J Sun, J Abbenseth, H Verplancke, M Diefenbach, B de Bruin, D Hunger, C Würtele, J van Slageren, M C Holthausen, S Schneider
Nat. Chem. (2020) doi.org/10.1038/s41557-020-0522-4
  Compaction of RNA duplexes in the cell
A Collauto, S von Bülow, D Gophane, S Saha, LS Stelzl, G Hummer, STh Sigurdsson T Prisner
Angew. Chem. Int. Ed., 2020, 59, 1-6 doi.org/10.1002/anie.202009800
     
Light-induced uncaging for time-resolved observations of biochemical reactions by MAS NMR spectroscopy
J de Mos, A Jakob, J Becker-Baldus, A Heckel, C Glaubitz
Chemistry, 2020, 26(30):6789-6792 DOI: 10.1002/chem.202000770
  Electron Transfer Dynamics and Structural Effects in Benzonitrile Monolayers with Tuned Dipole Moments by Differently Positioned Fluorine Atoms
P Werner, T Wächter, A Asyuda, A Wiesner, M Kind, M Bolte, L Weinhardt, A Terfort, M Zharnikov
ACS Appl. Mater. Interf., 2020), 12, 39859 doi.org/10.1021/acsami.0c10513
     
   
Molecular analysis of the ribosome recycling factor ABCE1 bound to the 30S post-splitting complex
E Nürenberg-Goloub, H Kratzat, H Heinemann, A Heuer, P Kötter, O Berninghausen, T Becker, R Tampé, R Beckmann
EMBO J.2020;e:103788 doi.org/10.15252/embj.2019103788
 

Cysteine oxidation and disulfide formation in the ribosomal exit tunnel
L Schulte, J Mao, J Reitz, S Sreeramulu, D Kudlinzki, VV Hodirnau, J Meier-Credo, K Saxena, F Buhr, JD Langer, M Blackledge, AS Frangakis, C GlaubitZ, H Schwalbe
Nat Commun. 2020 Nov 4;11(1):5569. doi: 10.1038/s41467-020-19372-x

     
Coligand Role in the NHC Nickel Catalyzed C–F Bond Activation: Investigations on the Insertion of bis(NHC) Nickel into the C–F Bond of Hexafluorobenzene
MW Kuntze-Fechner, H Verplancke, L Tendera, M Diefenbach, I Krummenacher, H Braunschweig, TB Marder, MC Holthausen, U Radius
Chem. Sci., 2020, 11, 11009 doi.org/10.1039/D0SC04237D
 

The Ketosynthase Domain Constrains the Design of Polyketide Synthases
M Klaus, L Buyachuihan, M Grininger
ACS Chem Biol., 2020, 15, 2422-2432 doi.org/10.1021/acschembio.0c00405

     
 

PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase.
B Adhikari, J Bozilovic, M Diebold, J D Schwarz, J Hofstetter, M Schröder, M Wanior, A Narain, M Vogt, N D Stankovic, A Baluapuri, L Schönemann, L Eing, P Bhandare, B Kuster, A Schlosser, S Heinzlmeir, C Sotriffer, S Knapp and E Wolf
Nature Chemical Biology, 28.09.2020. www.nature.com/articles/s41589-020-00652-y

  Smart Molecular Nanosheets for Advanced Preparation of Biological Samples in Electron Cryo-Microscopy
J Scherr, Z Tang, M Küllmer, S Balser, A S Scholz, A Winter, K Parey, A Rittner, M Grininger, V Zickermann, D Rhinow, A Terfort, A Turchanin
ACS Nano 2020, doi.org/10.1021/acsnano.0c03052
     
Rab27a Contributes to the Processing of Inflammatory Pain in Mice
T Gross, G Wack, KMJ Syhr, T Tolmachova, MC Seabra, G Geisslinger, E Niederberger, A Schmidtko, W Kallenborn-Gerhardt
Cells, 2020, 9(6):1488 doi: 10.3390/cells9061488
  Neuropathic and cAMP-induced pain behavior is ameliorated in mice lacking CNGB1
W Kallenborn-Gerhardt, K Metzner, R Lu, J Petersen, MS Kuth, S Heine, O Drees, M Paul, E Becirovic, L Kennel, C Flauaus, T Groß, G Wack, SW Hohmann, D Nemirovski,D Del Turco, M Biel, G Geisslinger, S Michalakis, A Schmidtko
Neuropharmacology, 2020, (171):108087 doi.org/10.1016/j.neuropharm.2020.108087
     
     
Multiquantum Counting of Trityl Radicals
M Bretschneider, PE Spindler, OY Rogozhnikova, DV Trukhin, B Endeward, AA Kuzhelev, E Bagryanskaya, VM Tormyshev and TF Prisner
J. Phys. Chem. Lett., 2020, 11, 6286-6290 doi.org/10.1021/acs.jpclett.0c01615
 

Crystal structure of sodium ethoxide (C2H5ONa), unravelled after a 180 years
M Beske, L Tapmeyer and MU Schmidt
Chem. Commun., 2020, 56, 3520-3523, doi.org/10.1039/C9CC08907A

     

The resolution revolution in cryoEM requires new sample preparation procedures: A rapid pipeline to high resolution maps of yeast FAS
Joppe M, D’Imprima E, Salustros N, Paithankar K S, Vonck J, Grininger M, Kühlbrandt, W
IUCrJ 7, 2020, 220-227 doi.org/10.1107/S2052252519017366

   
     
   


Mechanoradicals in tensed tendon collagen as asource of oxidative stress
C Zapp, A Obarska-Kosinska, B Rennekamp, M Kurth, MD Hudson, D Mercadante, U Barayeu, TP Dick, V Denysenkov, TF Prisner, M Bennati, C Daday, R Kappl and F Gräter
Nat Commun, 2020, 11, 2315 doi.org/10.1038/s41467-020-15567-4
  Structure of the intermediates in the industrial separation of perinone isomers
L Tapmeyer, M Bolte, MR Chierotti, MU Schmidt
Dyes and Pigments
, 2020, 181, 108442, doi.org/10.1016/j.dyepig.2020.108442
     

   
New pathways for the skin´s stress response: the cholinergic neuropeptide SLURP-1 can activate mast cells and alter cytokine production in mice
CM Ertle, FR Rommel, S Tumala, Y Moriwaki, J Klein, J Kruse, U Gieler and EM Peters
Front. Immunol. 2020, 12, 631881 doi.org/10.3389/fimmu.2021.631881
  Structure of LRRK2 in Parkinson’s disease and model for microtubule interaction.
C K Deniston, J Salogiannis, S Mathea, D M Snead, I Lahiri, M Matyszewski, O Donosa, R Watanabe, J Böhning, A K Shiau, S Knapp, E Villa, S L Reck-Peterson, A E Leschziner
Nature. 2020 Aug 19 pubmed.ncbi.nlm.nih.gov/32814344/
     
Local-in-time error in variational quantum dynamics
R Martinazzo, I Burghardt
Rev. Lett.,
2020, 124, 150601 DOI 10.1103/PhysRevLett.124.150601
  First-principles quantum simulations of exciton diffusion on a minimal oligothiophene chain at finite temperature
R Binder, I Burghardt
Faraday Discuss., 2020, 221, 406. doi.org/10.1039/C9FD00066F
     
     
A 300-fold enhancement of imino nucleic acid resonances by hyperpolarized water provides a new window for probing RNA refolding by 1D and 2D NMR.
M Novakovic, GL Olsen, G Pintér, D Hymon, B Fürtig, H Schwalbe, L Frydman
PNAS, 16. Januar 2020 doi.org/10.1073/pnas.1916956117
   PROXIDRUGS unter Leitung der Goethe-Uni wurde in „Clusters4Future“ aufgenommen
     
     

Forscher veranschaulichen die molekularen Strukturen von TNF Rezeptoren in der Zellmembran

Dual Soluble Epoxide Hydrolase Inhibitor/PPAR-γ Agonist Attenuates Renal Fibrosis
A Stavniichuk, MA Hye Khan, MM Yeboah, MA Chesnik, WK Jankiewicz, M Hartmann, R Blöcher, T Kircher, O Savchuk, E Proschak, JD Imig
Prostaglandins Other Lipid Mediat. 2020 EPub doi.org/10.1016/j.prostaglandins.2020.106472
  Single-molecule imaging reveals the oligomeric state of functional TNF--induced plasma membrane TNFR1 clusters in cells.
C Karathanasis, J Medler, F Fricke, S Smith, S Malkusch, D Widera, S Fulda, H Wajant, SJL van Wijk, I Dikic, M Heilemann
Sci. Signal. 13, eaax5647 (2020), DOI: 10.1126/scisignal.aax5647
     

A single power stroke by ATP binding drives substrate translocation in a heterodimeric ABC transporter
E Stefan, S Hofmann, R Tampé
eLife 2020;9:e55943 doi: 10.7554/eLife.55943

 

A loop structure allows TAPBPR to exert its dual function as MHC I chaperone and peptide editor
L Sagert, F Hennig, C Thomas, R Tampé R
eLife 2020;9:e55326 doi: 10.7554/eLife.55326

     
Chemosensory cell-derived acetylcholine drives tracheal mucociliary clearance in response to virulence-associated formyl peptides
S Perniss, S Liu, B Boonen, M Keshavarz, AL Ruppert, T Timm, U Pfeil, A Soultanova, S Kusumakshi, L Delventhal, Ö Aydin, M Pyrski, K Deckmann, T Hain, N Schmidt, C Ewers, A Günther, G Lochnit, V Chubanov, T Gudermann, J Oberwinkler, J Klein, K Mikoshiba, T Leinders-Zufall, S Offermans, B Schütz, U Boehm, F Zufall, B Bufe und W Kummer
Immunity 2020, 52, 683-699 doi.org/10.1016/j.immuni.2020.03.005
  High-resolution EPR distance measurements on RNA and DNA with the non-covalent G´ spin label
M Heinz, N Erlenbach, LS Stelzl, G Thierolf, NR Kamble, STh Sigurdsson, TF Prisner; G Hummer
Nucleic Acids Res., 48, 924-933 doi.org/10.1093/nar/gkz1096
     
Single-molecule imaging reveals the oligomeric state of functional TNFα-induced plasma membrane TNFR1 clusters in cells
C Karathanasis, J Medler, F Fricke, S Smith, S Malkusch, D Widera, S Fulda, H Wajant, SJL van Wijk, I Dikic, M Heilemann
Sci Signal, 2020, 13(614):eaax5647. DOI: 10.1126/scisignal.aax5647
  Light Dynamics of the Retinal-Disease-Relevant G90D Bovine Rhodopsin Mutant
N Kubatova, J Mao, CE Eckert, K Saxena, SL Gande, J Wachtveitl, C Glaubitz, H Schwalbe
Angew Chem Int Ed Engl. 2020 Jun 30;59(36):15656–64. doi:10.1002/anie.202003671

2019

2019

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Integrative Transcriptomics Reveals Sexually Dimorphic Control of the Cholinergic/Neurokine Interface in Schizophrenia and Bipolar Disorder
S Lobentanzer, G Hanin, J Klein & H Soreq, CellReports, 2019, 29, 3, 764-777; DOI: 10.1016/j.celrep.2019.09.017
  Molecular tuning of farnesoid X receptor partial agonism.
D Merk*, S Sreeramulu, D Kudlinzki, K Saxena, V Linhardt, SL Gande, F Hiller, C Lamers, E Nilsson, A Aagard, L Wissler, N Dekker, K Bamberg, M Schubert-Zsilavecz, H Schwalbe*: Nat. Commun., 2019, 10, 2915. doi.org/10.1038/s41467-019-10853-2
     
Narciclasine exerts anti-inflammatory actions by blocking leukocyte-endothelial cell interactions and downregulation of the endothelial TNF receptor 1
A. Stark, R Schwenk, G Wack, G Zuchtriegel, MG Hatemler, J Bräutigam, A Schmidtko, CA Reichel, I Bischoff, R Fürst
FASEB J. 2019; 33: 8771-8781. doi.org/10.1096/fj.201802440R
  In-situ observation of conformational dynamics and protein-ligand/substrate interaction in outer membrane proteins with DEER/PELDOR spectroscopy
B Joseph, EA Jaumann, A Sikora, K Barth, TF Prisner, DS Cafiso
Nat. Protoc., 2019, 14, 2344-2369 doi.org/10.1038/s41596-019-0182-2
     
   
A GABAergic and peptidergic sleep neuron as locomotion stop neuron with compartmentalized Ca2+ dynamics
W Costa, P Van der Auwera, C Glock, J F Liewald, M Bach, C Schüler, S Wabnig, A Oranth, F Masurat, H Bringmann, L Schoofs, E H.K. Stelzer, S C. Fischer, A Gottschalk, Nature Communications 2019, 10, 4095; DOI: /10.1038/s41467-019-12098-5
  Conformation space of a heterodimeric ABC exporter under turnover conditions
S Hofmann, D Januliene, AR Mehdipour, C Thomas, E Stefan, S Brüchert, BT Kuhn, ER Geertsma, G Hummer, R Tampé, A Moeller, Nature 2019, 571, 580-583; DOI:10.1038/s41586-019-1391-0
     
Distinct functions of soluble guanylyl cyclase isoforms NO-GC1 and NO-GC2 in inflammatory and neuropathic pain processing
J Petersen, E Mergia, L Kennel, O Drees, RD Steubing, CI Real, W Kallenborn-Gerhardt, R Lu, A Friebe, D Koesling, A Schmidtko
Pain, 2019, 160(3):607–618 DOI: 10.1097/j.pain.0000000000001440
  Human MLL/KMT2A gene exhibits a second breakpoint cluster region for recurrent MLL-USP2 fusions
C Meyer, BA Lopes, A Caye-Eude, H Cavé, C Arfeuille, W Cuccuini, R Sutton, NC Venn, SH Oh, G Tsaur, G Escherich, T Feuchtinger, HJ Kosasih, SL Khaw, PG Ekert, MS Pombo-de-Oliveira, A Bidet, B Djahanschiri, I Ebersberger, M Zaliova, J Zuna, Z Zermanova, V Juvonen, RP Grümayer, G Fazio, G Cazzaniga, P Larghero, M Emerenciano, R Marschalek
Leukemia. 2019 Sep;33(9):2306-2340 https://doi.org/10.1038/s41375-019-0451-7
     
 
Photocycle-dependent conformational changes in the proteorhodopsin cross-protomer Asp–His–Trp triad revealed by DNP-enhanced MAS-NMR
J Maciejko, J Kaur, J Becker-Baldus, C Glaubitz
PNAS 2019, 201817665; DOI: 10.1073/pnas.1817665116
  ACBE1 controls ribosome recycling by an asymmetric dynamic conformational equilibrium
G Gouridis, B Hetzert, K Kiosze-Becker, M de Boer, H Heinemann, E Nürenberg-Goloub, T Cordes, R Tampé
Cell Reports 2019 DOI: 10.1016/j.celrep.2019.06.052
     

Enhanced hemato-endothelial specification during human embryonic differentiation through developmental cooperation between AF4-MLL and MLL-AF4 fusions
C Bueno, FJ Calero-Nieto, X Wang, R Valdés-Mas, F Gutiérrez-Agüera, H Roca-Ho, V Ayllon, PJ Real, D Arambilet, L Espinosa, R Torres-Ruiz, A Agraz-Doblas, I Varela, J de Boer, A Bigas, B Gottgens, R Marschalek, P Menendez 
Haematologica 2019 Jun;104(6):1189-1201.DOI: 10.3324/haematol.2018.202044

  Coherent Charge Transfer Exciton Formation in Regioregular P3HT: A Quantum Dynamical Study 
W Popp, M Polkehn, R Binder, I Burghardt
Phys. Chem. Lett., 2019, 10, 3326. https://doi.org/10.1021/acs.jpclett.9b01105
     
Vibrational spectroscopic imaging and live cell video microscopy for studying differentiation of primary human alveolar epithelial cells
B Vukosavljevic, M Hittinger, H Hachmeister, C Pilger, X Murgia, MM Gepp, L Gentile, H Huwer, N Schneider-Daum, T Huser, CM Lehr, M Windbergs
J Biophotonics. 2019 Jun;12(6):e201800052 doi.org/10.1002/jbio.201800052
   
     
Protein denaturation at the water-air interface and how to prevent it
E D'Imprima, D Floris, M Joppe, R Sánchez, M Grininger, W Kühlbrandt
eLife 2019;8:e42747 DOI 10.7554/eLife.42747
  Engineering of Chimeric Polyketide Synthases Using SYNZIP Docking Domains
M Klaus, AD D'Souza, A Nivina, C Khosla, M Grininger
ACS Chem Biol., 2019, 14, 426-433. doi.org/10.1021/acschembio.8b01060
     
     
The Reductive Coupling of Dinitrogen
M-A Légaré, M Rang, G Bélanger-Chabot, J I Schweizer, I Krummenacher, R Bertermann, M Arrowsmith, M C Holthausen und H Braunschweig. Science, 2019, DOI: 10.1126/science.aav9593
  Global response of diacylglycerol kinase towards substrate binding observed by 2D and 3D MAS NMR
K Möbius, S Kazemi, P Güntert, A Jakob, A Heckel, J Becker-Baldus, C Glaubitz
Scientific Reports, 2019, 9(1), 3995, DOI: doi.org/10.1038/s41598-019-40264-8
     
Protein-Specific, Multicolor and 3D STED Imaging in Cells with DNA-Labeled Antibodies
C Spahn, F Hurter, M Glaesmann, C Karathanasis, M Lampe, M Heilemann
Angew Chem Int Ed Engl. 2019 Dec 19;58(52):18835-18838 DOI: 10.1002/anie.201910115
  Liquid-Phase Epitaxial Growth of Highly Oriented and Multivariate Surface-Attached Metal-Organic Frameworks
XJ Yu, YM Xian, C Wang, HL Mao, M Kind, T Abu-Husein, Z Chen, SB Zhu, B Ren, A Terfort, JL Zhuang
J. Am. Chem. Soc., 2019, 141, 18984 doi.org/10.1021/jacs.9b08169
     
Bottom-Up Synthesis of Graphene Monolayers with Tunable Crystallinity and Porosity
C Neumann, D Kaiser, MJ Mohn, M Füser, NE Weber, O Reimer, A Gölzhauser, T Weimann, A Terfort, U Kaiser, A Turchanin
ACS Nano, 2019,13, 7310 doi.org/10.1021/acsnano.9b03475
  A channel profile report of the unusual K+ channel KtrB
V Mikusevic, M Schrecker, M Patiño-Ruiz, K Fendler, I Hänelt
J Gen Physiol, 2019, 151:1357-1368 10.1085/jgp.201912384
     
Oxidative Coupling of Terminal Rhenium Pnictide Complexes
J Abbenseth, M Diefenbach, A Hinz, L Alig, C Würtele, JM Goicoechea, MC Holthausen, S Schneider
Angew. Chem. Int. Ed., 2019, 58, 10966 doi.org/10.1002/anie.201905130
  A Terminal Iridium Oxo Complex with a Triplet Ground State
D Delony, M Kinauer, M Diefenbach, S Demeshko, C Würtele, MC Holthausen, S Schneider
Angew. Chem. Int. Ed., 2019, 58, 10971 doi.org/10.1002/anie.201905325
     
Synthesis and reduction chemistry of mixed-Lewis-Base-Stabilized Chloroborylenes
M Arrowsmith, JI Schweizer, M Heinz, M Härterich, I Krummenacher, MC Holthausen, H Braunschweig
Chem. Sci., 2019, 10, 5095 doi.org/10.1039/C9SC01039D
  The reductive coupling of dinitrogen
M-A Légaré, M Rang, G Bélanger-Chabot, JI Schweizer, I Krummenacher, R Bertermann, M Arrowsmith, MC Holthausen, H Braunschweig
Science 363, 1329 (2019)
     
Reductive nitric oxide coupling at a dinickel core: Isolation of a key cis-hyponitrite intermediate en route to N2O formation
E Ferretti, S Dechert, S Demeshko, MC Holthausen, F Meyer
Angew. Chem. Int. Ed.,
2019, 58, 1705 doi.org/10.1002/anie.201811925 
  Intercepting the Disilene-Silylsilylene Equilibrium
MW Stanford, JI Schweizer, M Menche, GS Nichol, MC Holthausen, MJ Cowley
Angew. Chem. Int. Ed.,
2019, 58, 1329  /doi.org/10.1002/anie.201810056
     
Reactive Dimerization of an N-heterocyclic Plumbylene: CH Activation with PbII
R
Guthardt, J Oetzel, JI Schweizer, C Blum, R Langer, M Maurer, J Vícha, P Shestakova, MC Holthausen, U Siemeling
Angew. Chem. Int. Ed., 2019, 58, 1387 doi.org/10.1002/anie.201811559
   

2018

2018

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Exhaustively Trichlorosilylated C1 and C2 Building Blocks: Beyond the Müller-Rochow Direct Process
I. Georg, J. Teichmann, M. Bursch, J. Tillmann, B. Endeward, M. Bolte, H.-W. Lerner, S. Grimme and M. Wagner JACS, 2018, DOI: 10.1021/jacs.8b05950
 
Unexplored nucleotide binding modes for the ABC exporter MsbA
Kaur H, Abreu B, Akhmetzyanov D, Lakatos-Karoly A, Soares CM, Prisner T, Glaubitz C, JACS, 2018, doi: 10.1021/jacs.8b06739
     
 

Correlative single-molecule FRET and DNA-PAINT imaging
N. Deußner-Helfmann, A. Auer, M. Strauss, S. Malkusch, M. Dietz, H.-D. Barth, R. Jungmann* and M. Heilemann* Nano Letters, 2018, published online 26 June 2018. dx.doi.org/10.1021/acs.nanolett.8b02185

  Dynamics of nucleic acids at room temperature revealed by pulsed EPR
M. Gränz, N. Erlenbach, P. Spindler, D. B. Gophane, L. S. Stelzl, S. Th. Sigurdsson & T. F. Prisner: Angewandte Chemie International Edition, 2018,  http://dx.doi.org/10.1002/anie.201803682
     
 

Halogen‐aromatic pi-interactions modulate inhibitor residence time
Heroven C, Georgi V, Ganotra GK, Brennan PE, Wolfreys F, Wade RC, Fernandez-Montalvan AE, Chaikuad A*, Knapp S*: Angewandte Chemie International Edition, 2018, DOI:10.1002/anie.201801666

  Oocyte DNA damage quality control requires consecutive interplay of CHK2 and CK1 to activate p63
M.Tuppi, S. Kehrloesser, D. W. Coutandin, V. Rossi, L. M. Luh, A. Strubel, K. Hötte, M. Hoffmeister, B. Schäfer, T. De Oliveira, F. Greten, E. H. K. Stelzer, S. Knapp, M. De Felici, C. B., F. Gioia Klinger & V. Dötsch: Nature Structural and Molecular Biology, 2018, DOI: 10.1038/s41594-018-0035-7
     
 

Protein aggregation of the p63 transcription factor underlies severe skin fragility in AEC syndrome
C. Russo, C. Osterburg, A. Sirico, D. Antonini, R. Ambrosio, J. M. Würz, J. Rinnenthal, M. Ferniani, S. Kehrloesser, B. Schäfer, P. Güntert, S. Sinha, V. Dötsch und C. Missero: PNAS early edition, 2018, www.pnas.org/cgi/doi/10.1073/pnas.1713773115

   The molecular basis of subtype selectivity of human kinin G-protein-coupled receptors
L. Joedicke*, J. Mao*, G. Kuenze*, C. Reinhart, T. Kalavacherla, H. R A Jonker, C. Richter, H. Schwalbe, J. Meiler, J. Preu, H. Michel* & C. Glaubitz*
Nature Chemical Biology, published online 15.1.2018 (first release) DOI: 10.1038/nchembio.25511
     
   
Life times of metastable states guide regulatory signaling in transcription riboswitches.
C. Helmling, D. Klötzner, F. Sochor, R.A. Mooney, A. Wacker, R. Landing, B. Fürtig, A. Heckel*, H. Schwalbe*: Nat. Commun., 2018, 9, 944 doi.org/10.1038/s41467-018-03375-w
  A novel dual PPAR-γ agonist/sEH inhibitor treats diabetic complications in a rat model of type 2 diabetes
MA Hye Khan, L Kolb, M Skibba, M Hartmann, R Blöcher, E Proschak, JD Imig
Diabetologia 2018, 61; 2235-2246 DOI: 10.1007/s00125-018-4685-0
     
Dynamic Nuclear Polarization of 13C Nuclei in the Liquid State over a 10 Tesla Field Range
T Orlando, R Dervisoglu, L Levien, I Tkach, TF Prisner, LB Andreas, VP Denysenkov and M Bennati
Angew. Chem. Int. Ed., 2018, 58, 1402–1406 doi.org/10.1002/anie.201811892
 

Cryo-EM structures of KdpFABC suggest a K+ transport mechanism via two inter-subunit half-channels
C Stock, L Hielkema, I Tascon, D Wunnicke; G Oostergetel, M Azkargorta, C Paulino, I Hänelt
Nat Comm, 2018, 9:4971 doi.org/10.1038/s41467-018-07319-2

     
Characterization of the polyspecific transferase of murine type I fatty acid synthase (FAS) and implications for polyketide synthase (PKS) engineering
A Rittner, KS Paithankar, K Vu Huu, M Grininger
ACS Chem Biol. 3, 723-732 DOI: 10.1021/acschembio.7b00718
   

2017

2017

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Chromophore Distortions in Photointermediates of Proteorhodopsin Visualized by Dynamic Nuclear Polarization-Enhanced Solid-State NMR
M. Mehler, C.E. Eckert, A.J. Leeder, J. Kaur, T. Fischer, N. Kubatova, L.J. Brown, R.C.D. Brown, J. Becker-Baldus, J. Wachtveitl, C. Glaubitz
J. Am. Chem. Soc., 139 (2017) 16143-16153. DOI: 10.1021/jacs.7b05061
  Structure of the human MHC-I peptide-loading complex
A. Blees, D. Janulienė, T. Hofmann, N. Koller, C. Schmidt, S. Trowitzsch, A. Moeller & R. Tampé
Nature 2017, DOI: 10.1038/nature24627

     
 

Quantitative single-molecule imaging of TLR4 reveals ligand-specific receptor dimerization
C. L. Krüger, M.-T. Zeuner, G. S. Cottrell, D. Widera, M. Heilemann
Science Signaling 2017, DOI: 10.1126/scisignal.aan1308

 

Structure of the TAPBPR–MHC I complex defines the mechanism of peptide loading and editing
C. Thomas, R. Tampé
Science 2017, DOI: 10.1126/science.aao6001

     
 

Pausing guides RNA folding to populate transiently stable RNA structures for riboswitch-based transcription regulation
H. Steinert, F. Sochor, A. Wacker; J. Buck, C. Helmling, F. Hiller, S. Keyhani, J. Noeske, S. Grimm, M. M Rudolph, H. Keller,  R. A. Mooney, R. Landick, B. Suess, B. Fürtig, J. Wöhnert, H. Schwalbe
eLife 2017, 6:e21297, DOI: 10.7554/eLife.21297

 

Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-κB and restricts bacterial proliferation
S. J. L. van Wijk, F. Fricke, L. Herhaus, J. Gupta, K. Hötte, F. Pampaloni, P. Grumati, M. Kaulich, Y. Sou, M. Komatsu, F. R. Greten, S. Fulda, M. Heilemann & I. Dikic
Nature Microbiology 2017, doi 10.1038/nmicrobiol.2017.66

     
 

A Vicinal Electrophilic Diborylation Reaction Furnishes Doubly Boron-Doped Polycyclic Aromatic Hydrocarbons
A. John, M. Bolte, H.-W. Lerner, M. Wagner:
Angew. Chem. Int. Ed. 2017, DOI:10.1002/anie.201701591

 

Structure of the 40S-ABCE1 post-splitting complex in ribosome recycling and translation initiation
A. Heuer, M. Gerovac, C. Schmidt, S. Trowitzsch, A. Preis, P. Kötter, O. Berninghausen, T. Becker, R. Beckmann & R. Tampé
Nature Structure and Molecular Biology, doi:10.1038/nsmb.3396

     
 

Engineering fungal de novo fatty acid synthesis for short chain fatty acid production J. Gajewski, R. Pavlovic, M. Fischer, E. Boles & M. Grininger Nature Communications, doi: 10.1038/NCOMMS14650

Engineering fatty acid synthases for directed polyketide production J. Gajewski, F. Buelens, S.Serdjukow, M. Janßen, N. Cortina, H. Grubmüller & M. Grininger Nature Chemical Biology, doi: 10.1038/nchembio.2314

  Fast cAMP Modulation of Neurotransmission via Neuropeptide Signals and Vesicle Loading
W. Steuer Costa, S.-C. Yu, J.F. Liewald, A. Gottschalk
Current Biology, doi: 10.1016/j.cub.2016.12.055

2016

2016

 

Structure of the ribosome post-recycling complex probed by chemical cross-linking and mass spectrometry
K. Kiosze-Becker, A. Ori, M. Gerovac, A. Heuer, E. Nürenberg-Goloub, U. J. Rashid, T. Becker, R. Beckmann, M. & R.Tampé
Nature Communications, doi: 10.1038/NCOMMS13248

 

Reversible Dihydrogen Activation by Reduced Aryl Boranes as Main-Group Ambiphiles
E. v Grotthuss, M. Diefenbach, M. Bolte, HW Lerner, M. Holthausen, M. Wagner
Angew. Chem. Int. Ed. 2016, DOI: 10.1002/anie.201608324

     
 

Atomic-resolution structure of a disease-relevant Aβ(1-42) amyloid fibril.
Wälti, M. A., Ravotti, F., Arai, H., Glabe, C., Wall, J., Böckmann, A., Güntert, P., Meier, B. H. & Riek, R.
Proceedings of the National Academy of Sciences of the United States of America, 2015, doi: 10.1073/pnas.1600749113

 

Live-cell protein labelling with nanometre precision by cell squeezing
Alina Kollmannsperger, Armon Sharei, Anika Raulf, Mike Heilemann, Robert Langer, Klavs F. Jensen, Ralph Wieneke & Robert Tampé
Nature Cummunications, 2015, 7:10372: doi: 10.1038/ncomms10372

     
   

Megasynthasen: Schlüssel zum Design neuer Antibiotika?
LOEWE Schwerpunkt MegaSyn erforscht Syntheseprinzip riesiger Enzyme/ 4,6 Millionen Euro für vier Jahre

  
     
     
     

2015-2012

2015-2012

2015    
Forschung Frankfurt: Photosynthese mit ultrakurzen Laserpulsen erforschen         

Identifying and quantifying two ligand-binding sites while imaging native human membrane receptors by AFM
Moritz Pfreundschuh, David Alsteens, Ralph Wieneke, Cheng Zhang, Shaun R. Coughlin, Robert Tampé, Brian K. Kobilka, Daniel J. Müller
Nature Cummunications, 2015: doi:10.1038/ncomms9857

Arrhythmogenic effects of mutated L-type Ca2+-channels on an optogenetically paced muscular pump in Caenorhabditis elegans
Christina Schüler, Elisabeth Fischer, Lior Shaltiel, Wagner Steuer Costa, Alexander Gottschalk
Nature Scientific Reports, 2015, doi:10.1038/srep14427
  Optogenetic manipulation of cGMP in cells and animals by the tightly light-regulated guanylyl-cyclase opsin CyclOp
Shiqiang Gao, Jatin Nagpal, Martin W. Schneider, Vera Kozjak-Pavlovic, Georg Nagel & Alexander Gottschalk
Nature Communications, 2015, doi: 10.1038/ncomms9046
     
 

SLAP: Small Labeling Pair for Single-Molecule Super-Resolution Imaging
Dr. Ralph Wieneke, Anika Raulf, Alina Kollmannsperger, Prof. Mike Heilemann and Prof. Robert Tampé
Angewandte Chemie International Edition, 2015, doi: 10.1002/anie.201506234

  Boron-Containing PAHs: Facile Synthesis of Stable, Redox-Active Luminophores
M. Sc. Valentin M. Hertz, Dr. Michael Bolte, Dr. Hans-Wolfram Lerner and Prof. Dr. Matthias Wagner
Angewandte Chemie International Edition, 2015, doi: 10.1002/anie.201502977
     

One-Step Synthesis of a [20]Silafullerane with an Endohedral Chloride Ion
Jan Tillmann,Josef Heinrich Wender, Ute Bahr, Michael Bolte, Hans-Wolfram Lerner, Max C. Holthausen and Matthias Wagner
Angewandte Chemie International Edition, 2015, 54, 1-6, DOI: 10.1002/anie.201412050

  Mechanistic insight from the crystal structure of mitochondrial complex I
Volker Zickermann, Christophe Wirth, Hamid Nasiri, Karin Siegmund, Harald Schwalbe, Carola Hunte, Ulrich Brandt (2015)
Science, 2015, Vol. 347 no. 6217 pp. 44-49, DOI: 10.1126/science.1259859
     
N-Benzylbenzamides: a novel merged scaffold for orally available dual soluble epoxide hydrolase / peroxisome proliferator-activated receptor γ modulators
R Blöcher, C Lamers, SK Wittmann, D Merk, M Hartmann, L Weizel, O Diehl, A Brüggerhof, M Boß, A Kaiser, T Schader, T Göbel, M Grundmann, C Angioni, J Heering, G Geisslinger, M Wurglics, E Kostenis, B Brüne, D Steinhilber, M Schubert-Zsilavecz, AS Kahnt, E Proschak
J. Med. Chem. 59, 61-81. https://doi.org/10.1021/acs.jmedchem.5b01239
   
     
2014    
Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB.
Eicher, T., Seeger, M. A., Anselmi, C., Zhou, W., Brandstätter, L., Verrey, F., Diederichs, K., Faraldo-Gómez, J. D.*, Pos, K. M.* (2014)
eLife 3:e03145. http://elifesciences.org/content/3/e03145
  Subnanometre-resolution electron cryomicroscopy structure of a heterodimeric ABC exporter
JungMin Kim, Shenping Wu, Thomas M. Tomasiak, Claudia Mergel, Michael B. Winter, Sebastian B. Stiller, Yaneth Robles-Colmanares, Robert M. Stroud, Robert Tampé, Charles S. Craik & Yifan Cheng (2014)
Nature, ahead of print DOI:10.1038/nature13872
     
Revealing the macromolecular targets of complex natural products
Daniel Reker, Anna M. Perna, Tiago Rodrigues, Petra Schneider, Michael Reutlinger, Bettina Mönch, Andreas Koeberle, Christina Lamers, Matthias Gabler, Heinrich Steinmetz, Rolf Müller, Manfred Schubert-Zsilavecz, Oliver Werz & Gisbert Schneider (2014)
Nature Chemistry, 2014, 6, 1072, DOI:10.1038/nchem.2095
 

Confirmed by X-ray Crystallography: The B·B One-Electron s Bond
Alexander Hübner, Andreas M. Diehl, Martin Diefenbach, Burkhard Endeward, Michael Bolte, Hans-Wolfram Lerner, Max C. Holthausen,* and Matthias Wagner* (2014)
Angew Chem Int Ed Engl. Epub ahead of print,  DOI: 10.1002/ange.201402158

     
2013    
Molecular Mechanism of Prion Protein Oligomerization at Atomic Resolution,
Kai Schlepckow, Harald Schwalbe (2013)
Angew Chem Int Ed Engl. Epub ahead of print, DOI: 10.1002/ange.201305184  
  Three-state mechanism couples ligand and temperature sensing in riboswitches,
Anke Reining, Senada Nozinovic, Kai Schlepckow, Florian Buhr, Boris Fürtig and Harald Schwalbe (2013)
Nature, Vol 499, 355-359, DOI: 10.1038/nature12378
     
2012    
Optogenetic Analysis of a Nociceptor Neuron and Network Reveals Ion Channels Acting Downstream of Primary Sensors,
Steven J. Husson, Wagner Steuer Costa, Sebastian Wabnig, Jeffrey N. Stirman, Joseph D. Watson, W. Clay Spencer, Jasper Akerboom, Loren L. Looger, Millet Treinin, David M. Miller, Hang Lu and Alexander Gottschalk (2012)
Current Biology, Epub ahead of print, DOI:10.1016/j.cub.2012.02.066
  Stochastic sensing of proteins with receptor-modified solid-state nanopores,
Ruoshan Wei, Volker Gatterdam, Ralph Wieneke, Robert Tampé & Ulrich Rant (2012)
Nature Nanotechnology, Epub ahead of print, DOI: 10.1038/NNANO.2012.24
     
Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop,
Thomas Eicher, Hi-jea Chaa, Markus A. Seeger, Lorenz Brandstätter, Jasmin El-Delik, Jürgen A. Bohnert, Winfried V. Kern, François Verrey, Markus G. Grütter, Kay Diederichs and Klaas M. Pos (2012)
PNAS early edition, www.pnas.org/cgi/doi/10.1073/pnas.1114944109.
   

2011-2009

2011-2009

2011    
Construction of a Structurally Defined Double-Stranded DNA Catenane
Schmidt TL and Heckel A (2011)
Nano Letters, Epub ahead of print, DOI: 10.1021/nl200303m
          Interfacial enzyme kinetics of a membrane bound kinase analyzed by real-time MAS -NMR  [Pressemitteilung]
Ullrich, S.J., Hellmich, U.A., Ullrich, S., Glaubitz, C. (2011)
Nature Chem. Biol. Epub ahead of print, doi:10.1038/nchembio.543  
     
DNA Damage in Oocytes Induces a Switch of the Quality Control Factor TAp63α from Dimer to Tetramer.
G. B. Deutsch, E. M. Zielonka, D. Coutandin, T. A. Weber, B. Schäfer, J. Hannewald, L. M. Luh, F. G. Durst, M. Ibrahim, J. Hoffmann, F. H. Niesen, A. Sentürk, H. Kunkel, B. Brutschy, E. Schleiff, S. Knapp, A. Acker-Palmer, M. Grez, F. McKeon, V. Dötsch
Cell, Vol. 144, 566-576 (2011)
  Ribosome recycling depends on a mechanistic link between the FeS cluster domain and a conformational switch of the twin-ATPase ABCE1.
Barthelme, D., Dinkelaker, S., Albers, S.‐V., Ermler, U. & Tampé, R. (2011)
Proc Natl Acad Sci U S A. (published ahead of print January, 31st)
     
Real-time multimodal optical control of neurons and muscles in freely behaving Caenorhabditis elegans
Jeffrey N Stirman, Matthew M Crane, Steven J Husson, Sebastian Wabnig, Christian Schultheis, Alexander Gottschalk & Hang Lu
Nature Methods, Vol. 8, 153–158 (2011) DOI: doi:10.1038/nmeth.1555
 

Conformation of peptides bound to the transporter associated with antigen processing (TAP)
Herget M, Baldauf C, Schölz C, Parcej D, Wiesmüller KH, Tampé R, Abele R, Bordignon E. (2011)
Proc Natl Acad Sci U S A. (published ahead of print January, 4th; PMID: 21205905)

     
2010    
 Multiplexed Parallel Single Transport Recordings on Nanopore Arrays
Alexander Kleefen, Daniel Pedone, Christian Grunwald, Ruoshan Wei, Matthias Firnkes, Gerhard Abstreiter, Ulrich Rant, and Robert Tampé (2010)
Nano Lett., Articles ASAP (published ahead of print October 27, 2010, DOI: 10.1021/nl1033528)
 

Prediction of blood–brain barrier penetration of poorly soluble drug candidates using surface activity profiling
Anna Christine Petereita, Kelly Swinneyb, Jurgen Menschb, Claire Mackiec, Sigrid Stokbroekxb, Marcus Brewsterb and Jennifer B. Dressman (2010)
European Journal of Pharmaceutics and Biopharmaceutics, Vol. 75, 405-410

     

Structural Studies of 13C,15N-labeled RNA by Solid-State NMR spectroscopy
Alexey V. Cherepanov, Clemens Glaubitz and Harald Schwalbe (2010)
Angew. Chem., published ahead of print June 8, 2010, DOI: 10.1002/anie.200906885

  Single residue within the antigen translocation complex TAP controls the epitope repertoire by stabilizing a receptive conformation
Baldauf C, Schrodt S, Herget M, Koch J, and Tampé R (2010)
Proceedings of the National Academy of Sciences USA (published online May 3rd. doi/10.1073/pnas.1001308107).
In situ assembly of macromolecular complexes triggered by light
Grunwald C, Schulze K, Reichel A, Weiss VU, Piehler J, Wiesmüller KH and Tampé R (2010)
Proceedings of the National Academy of Sciences USA (published online March 1st. doi/10.1073/pnas.0912617107 ).
   
     
2009    
Unfolded-State Structure and Dynamics Influence the Fibril Formation of Human Prion Protein
Christian Gerum, Robert Silvers, Julia Wirmer-Bartoschek, and Harald Schwalbe
Angew. Chem. 2009, 121, 9616 –9620
  Transferrin- and transferrin-receptor-antibody-modified nanoparticles enable drug delivery across the blood-brain barrier (BBB)
Ulbrich, K; Hekmatara, T; Herbert, E; Kreuter, J
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 71, 251-256 (2009)
     
2012    
Bioactivity-guided mapping and navigation of chemical space
S. Renner, W. A L van Otterlo, M. Dominguez Seoane, S. Mücklinghoff, B. Hofmann, S. Wetzel, A. Schuffenhauer, P. Ertl, T. Oprea, D. Steinhilber, L. Brunsveld, D. Rauh & H. Waldmann
Nature Chemical Biology 2009, 5, 585–592
  Protein structure determination in living cells by in-cell NMR spectroscopy
Sakakibara, D., Sasaki, A., Ikeya, T., Hamatsu, J., Hanashima, T., Mishima, M., Yoshimasu, M., Hayashi, N., Mikawa, T., Wälchli, M., Smith, B. O., Shirakawa, M., Güntert, P. & Ito, Y
Nature 458, 102-105 (2009),
[Pressemitteilung]
     
     

2008-2004

2008-2004

2008    
The structure of bradykinin bound to the human GPCR bradykinin-2 as determined by solid-state NMR
Lopez, J.J., Shukla, A.K., Reinhart, C., Schwalbe, H., Michel, H., Glaubitz, C
Angew. Chem. Int. Ed.47, 1668-1671
          Structural basis for the selectivity of the external thioesterase of the surfactin-synthetase
Koglin, A., Löhr, F., Bernhard, F., Rogov, V. R., Frueh, D. P., Strieter, E. R., Mofid, M. R., Güntert, P., Wagner, G., Walsh, C. T., Marahiel, M. A. & Dötsch, V.
Nature 454, 907–911 (2008),
[Pressemitteilung]
     
 2007    
Identification of a lysosomal peptide transport system induced during dendritic cell development
Ö. Demirel, Z. Waibler, U. Kalinke, F. Grünebach, S. Appel, P. Brossart, A. Hasilik, R. Tampé and R. Abele
J. Biol. Chem. 2007; 282; 37836 - 43
  Time-resolved NMR methods resolving ligand-induced RNA folding at atomic resolution
J. Buck, B. Fürtig, J. Noeske, J. Wöhnert, H. Schwalbe 
Proc Natl Acad Sci U S A. 2007;104(40):15699-704
     
Bidirectional optical control of neurons, neural circuits and behaviour in Caenorhabditis elegans
M. Brauner, J. Liewald, A. Gottschalk 
NATURE 2007; 446; 633-639
  Native protein nanolithography that can write, read and erase
A. Tinazli, J. Piehler, M. Beuttler, R. Guckenberger, R. Tampe 
NATURE NANOTECHNOLOGY, 2007;  2 (4): 220-225
     
2006    
Highlights in asymmetric Synthesis and Catalysis
M. Rueping, C. Azap, Angew. Chem. 2006, 118, 7996-7999 (Int. Ed. 45, 7832-7835)
M. Rueping, A. P. Antonchick, T. Theissmann, Angew. Chem. 2006, 118, 6903-6907 (Int. Ed. 45, 6751-6755)
M. Rueping, A. P. Antonchick, T. Theissmann, Angew. Chem. 2006, 118, 3765-3768 (Int. Ed. 45, 3683-3686)
M. Rueping, E. Sugiono, C. Azap, Angew. Chem. 2006, 118, 2679-2681 (Int. Ed. 45, 2617-2619)
Von der Natur lernen (aus Forschung Frankfurt, 2007)
  Molecular phylogeny and evolution of morphology in the social amoebas
Schaap P, Winckler T, Nelson M, Alvarez-Curto E, Elgie B, Hagiwara H, Cavender J, Milano-Curto A, Rozen DE, Dingermann T, Mutzel R, Baldauf SL
Science. 2006; 314(5799); 661-3
     
Localization of multidrug transporter substrates within model membranes
Siarheyeva A, Lopez JJ, Glaubitz C,
Biochemistry 2006; 45(19); 6203-11
  Conformational switches modulate protein interactions in peptide antibiotic synthetases
Koglin A, Mofid MR, Lohr F, Schafer B, Rogov VV, Blum MM, Mittag T, Marahiel MA, Bernhard F, Dotsch V;
Science 2006; 312(5771); 273-6.
     
2005    
Hyperforin activates nonselective cation channels (NSCCs)
Treiber K, Singer A, Henke B, Muller WE;
Br J Pharmacol. 2005; 145(1); 75-83
  Histamine H4 receptor stimulation suppresses IL-12p70 production and mediates chemotaxis in human monocytederived dendritic cells
Ralf Gutzmer, Carola Diestel, Susanne Mommert, Brigitta Köther, Holger Stark, Miriam Wittmann, Alexander Kapp and Thomas Werfel;
Journal of Immunology  2005; 174(9); 5224-5232
     
The genome of the social amoeba Dictyostelium discoideum
Nature 2005;  435, 43-57
  Diagnostic tool for the identification of MLL rearrangements including unknown partner genes
Meyer C, Schneider B, Reichel M, Angermueller S, Strehl S, Schnittger S, Schoch C, Jansen MW, van Dongen JJ, Pieters R, Haas OA, Dingermann T, Klingebiel T, Marschalek R;
Proc. Natl. Acad. Sci. USA, 2005, 102(2), 449-454.
     
 2004    
The functional asymmetry of TAP is reflected in the different C-loop sequences
Min Chen, Rupert Abele and Robert Tampé;
Journal of Biological Chemistry, 2004, 279 (44), 46073-46081
  Modulation of Compactness and Long-Range Interactions of Unfolded Lysozyme by Single Point Mutations
Julia Wirmer, Christian Schlörb, Judith Klein-Seetharaman, Ryoma Hirano, Tadashi Ueda, Taiji Imoto, Harald Schwalbe;
Angewandte Chemie (2004) 43, 5780-5785