Research Highlights
2021
2021
click on the picture for official notice
 |
 |
|
| Photo-induced receptor confinement drives ligand-independent GPCR signaling M. F. Sánchez, S. Els-Heindl, A. G. Beck-Sickinger, R. Wieneke, R. Tampé Science, 2021, https://science.sciencemag.org/lookup/doi/10.1126/science.abb7657 |
Cysteine oxidation and disulfide formation in the ribosomal exit tunnel. L. Schulte, J. Mao, J. Reitz, S. Sreeramulu, D. Kudlinzki, V-V. Hodirnau, J. Meier-Credo, K. Saxena, F. Buhr, J. D. Langer, M. Blackledge, A. S. Frangakis, C. Glaubitz, H. Schwalbe Nature Communications, 2021, https://doi.org/10.1038/s41467-020-19372-x |
|
 |
||
| Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2 B.-T. Berger, M. Amaral, D. B. Kokh, A. Nunes-Alves, D. Musil, T. Heinrich, M. Schröder, R. Neil, J. Wang, I. Navratilova, J. Bomke, J. M. Elkins, S. Müller, M. Frech, R. C. Wade, S. Knapp Cell Chemical Biology, 2021, https://doi.org/10.1016/j.chembiol.2021.01.003 |
||
2020
2020
click on the picture for official notice
 |
 |
|
| A platinum(II) metallonitrene with a triplet ground state. J. Sun, J. Abbenseth, H. Verplancke, M. Diefenbach, B. de Bruin, D. Hunger, C. Würtele, J. van Slageren, M. C. Holthausen, S. Schneider Nat. Chem. (2020) https://doi.org/10.1038/s41557-020-0522-4 |
Structure of LRRK2 in Parkinson’s disease and model for microtubule interaction. C K Deniston, J Salogiannis, S Mathea, D M Snead, I Lahiri, M Matyszewski, O Donosa, R Watanabe, J Böhning, A K Shiau, S Knapp, E Villa, S L Reck-Peterson, A E Leschziner. Nature. 2020 Aug 19 https://pubmed.ncbi.nlm.nih.gov/32814344/ |
|
 |
 |
|
|
PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase. |
Smart Molecular Nanosheets for Advanced Preparation of Biological Samples in Electron Cryo-Microscopy J. Scherr, Z. Tang, M. Küllmer, S. Balser, A. S. Scholz, A. Winter, K. Parey, A. Rittner, M. Grininger, V. Zickermann, D. Rhinow, A. Terfort, A. Turchanin, ACS Nano 2020, https://doi.org/10.1021/acsnano.0c03052 |
|
| |
 |
|
| A 300-fold enhancement of imino nucleic acid resonances by hyperpolarized water provides a new window for probing RNA refolding by 1D and 2D NMR. Mihajlo Novakovic, Gregory L. Olsen, György Pintér, Daniel Hymon, Boris Fürtig, Harald Schwalbe, Lucio Frydman. PNAS, 16. Januar 2020 https://doi.org/10.1073/pnas.1916956117 |
PROXIDRUGS unter Leitung der Goethe-Uni wurde in „Clusters4Future“ aufgenommen | |
|
Forscher veranschaulichen die molekularen Strukturen von TNF Rezeptoren in der Zellmembran |
||
| Single-molecule imaging reveals the oligomeric state of functional TNF--induced plasma membrane TNFR1 clusters in cells. C. Karathanasis, J. Medler, F. Fricke, S. Smith, S. Malkusch, D. Widera, S. Fulda, H. Wajant, S. J. L. van Wijk, I. Dikic, M. Heilemann. Sci. Signal. 13, eaax5647 (2020), DOI: 10.1126/scisignal.aax5647 |
||
2019
2019
click on the picture for official notice
 |
||
| Integrative Transcriptomics Reveals Sexually Dimorphic Control of the Cholinergic/Neurokine Interface in Schizophrenia and Bipolar Disorder S Lobentanzer, G Hanin, J Klein & H Soreq, CellReports, 2019, 29, 3, 764-777; DOI: 10.1016/j.celrep.2019.09.017 |
||
 |
 |
|
| A GABAergic and peptidergic sleep neuron as locomotion stop neuron with compartmentalized Ca2+ dynamics W Costa, P Van der Auwera, C Glock, J F Liewald, M Bach, C Schüler, S Wabnig, A Oranth, F Masurat, H Bringmann, L Schoofs, E H.K. Stelzer, S C. Fischer, A Gottschalk, Nature Communications 2019, 10, 4095; DOI: /10.1038/s41467-019-12098-5 |
Conformation space of a heterodimeric ABC exporter under turnover conditions S. Hofmann, D. Januliene, A. R. Mehdipour, C. Thomas, E. Stefan, S. Brüchert, B. T. Kuhn, E. R. Geertsma, G. Hummer, R. Tampé, A. Moeller, Nature 2019, 571, 580-583; DOI:10.1038/s41586-019-1391-0 |
|
 |
 |
|
| Photocycle-dependent conformational changes in the proteorhodopsin cross-protomer Asp–His–Trp triad revealed by DNP-enhanced MAS-NMR Maciejko, J.; Kaur, J.; Becker-Baldus, J.; Glaubitz, C., PNAS 2019, 201817665; DOI: 10.1073/pnas.1817665116 |
ACBE1 controls ribosome recycling by an asymmetric dynamic conformational equilibrium Giorgos Gouridis, Bianca Hetzert, Kristin Kiosze-Becker, Marijn de Boer, Holger Heinemann, Elina Nürenberg-Goloub, Thorben Cordes, Robert Tampé, Cell Reports 2019 DOI: 10.1016/j.celrep.2019.06.052 |
|
 |
 |
|
| The Reductive Coupling of Dinitrogen M-A Légaré, M Rang, G Bélanger-Chabot, J I Schweizer, I Krummenacher, R Bertermann, M Arrowsmith, M C Holthausen und H Braunschweig. Science, 2019, DOI: 10.1126/science.aav9593 |
Global response of diacylglycerol kinase towards substrate binding observed by 2D and 3D MAS NMR Möbius, K.; Kazemi, S.; Güntert, P.; Jakob, A.; Heckel, A.; Becker-Baldus, J.; Glaubitz, C., Scientific Reports, 2019, 9(1), 3995, DOI: doi.org/10.1038/s41598-019-40264-8 |
|
2018
2018
click on the picture for official notice
 |
 |
|
| Exhaustively Trichlorosilylated C1 and C2 Building Blocks: Beyond the Müller-Rochow Direct Process I. Georg, J. Teichmann, M. Bursch, J. Tillmann, B. Endeward, M. Bolte, H.-W. Lerner, S. Grimme and M. Wagner JACS, 2018, DOI: 10.1021/jacs.8b05950 |
Unexplored nucleotide binding modes for the ABC exporter MsbA
Kaur H, Abreu B, Akhmetzyanov D, Lakatos-Karoly A, Soares CM, Prisner T, Glaubitz C, JACS, 2018, doi: 10.1021/jacs.8b06739 |
|
 |
 |
|
|
Correlative single-molecule FRET and DNA-PAINT imaging |
Dynamics of nucleic acids at room temperature revealed by pulsed EPR M. Gränz, N. Erlenbach, P. Spindler, D. B. Gophane, L. S. Stelzl, S. Th. Sigurdsson & T. F. Prisner: Angewandte Chemie International Edition, 2018, http://dx.doi.org/10.1002/anie.201803682 |
|
 |
 |
|
|
Halogen‐aromatic pi-interactions modulate inhibitor residence time |
Oocyte DNA damage quality control requires consecutive interplay of CHK2 and CK1 to activate p63 M.Tuppi, S. Kehrloesser, D. W. Coutandin, V. Rossi, L. M. Luh, A. Strubel, K. Hötte, M. Hoffmeister, B. Schäfer, T. De Oliveira, F. Greten, E. H. K. Stelzer, S. Knapp, M. De Felici, C. B., F. Gioia Klinger & V. Dötsch: Nature Structural and Molecular Biology, 2018, DOI: 10.1038/s41594-018-0035-7 |
|
 |
 |
|
|
Protein aggregation of the p63 transcription factor underlies severe skin fragility in AEC syndrome |
The molecular basis of subtype selectivity of human kinin G-protein-coupled receptors L. Joedicke*, J. Mao*, G. Kuenze*, C. Reinhart, T. Kalavacherla, H. R A Jonker, C. Richter, H. Schwalbe, J. Meiler, J. Preu, H. Michel* & C. Glaubitz* Nature Chemical Biology, published online 15.1.2018 (first release) DOI: 10.1038/nchembio.25511 |
|
2017
2017
click on the picture for official notice
 |
 |
|
| Chromophore Distortions in Photointermediates of Proteorhodopsin Visualized by Dynamic Nuclear Polarization-Enhanced Solid-State NMR M. Mehler, C.E. Eckert, A.J. Leeder, J. Kaur, T. Fischer, N. Kubatova, L.J. Brown, R.C.D. Brown, J. Becker-Baldus, J. Wachtveitl, C. Glaubitz J. Am. Chem. Soc., 139 (2017) 16143-16153. DOI: 10.1021/jacs.7b05061 |
Structure of the human MHC-I peptide-loading complex A. Blees, D. Janulienė, T. Hofmann, N. Koller, C. Schmidt, S. Trowitzsch, A. Moeller & R. Tampé Nature 2017, DOI: 10.1038/nature24627 |
|
 |
 |
|
|
Quantitative single-molecule imaging of TLR4 reveals ligand-specific receptor dimerization |
Structure of the TAPBPR–MHC I complex defines the mechanism of peptide loading and editing |
|
 |
 |
|
|
Pausing guides RNA folding to populate transiently stable RNA structures for riboswitch-based transcription regulation |
Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-κB and restricts bacterial proliferation |
|
 |
 |
|
|
A Vicinal Electrophilic Diborylation Reaction Furnishes Doubly Boron-Doped Polycyclic Aromatic Hydrocarbons |
Structure of the 40S-ABCE1 post-splitting complex in ribosome recycling and translation initiation |
|
 |
 |
|
|
Engineering fungal de novo fatty acid synthesis for short chain fatty acid production J. Gajewski, R. Pavlovic, M. Fischer, E. Boles & M. Grininger Nature Communications, doi: 10.1038/NCOMMS14650 Engineering fatty acid synthases for directed polyketide production J. Gajewski, F. Buelens, S.Serdjukow, M. Janßen, N. Cortina, H. Grubmüller & M. Grininger Nature Chemical Biology, doi: 10.1038/nchembio.2314 |
Fast cAMP Modulation of Neurotransmission via Neuropeptide Signals and Vesicle Loading W. Steuer Costa, S.-C. Yu, J.F. Liewald, A. Gottschalk Current Biology, doi: 10.1016/j.cub.2016.12.055 |
2016
2016
 |
 |
|
|
Structure of the ribosome post-recycling complex probed by chemical cross-linking and mass spectrometry |
Reversible Dihydrogen Activation by Reduced Aryl Boranes as Main-Group Ambiphiles |
|
 |
 |
|
|
Atomic-resolution structure of a disease-relevant Aβ(1-42) amyloid fibril. |
Live-cell protein labelling with nanometre precision by cell squeezing |
|
 |
 |
|
|
Megasynthasen: Schlüssel zum Design neuer Antibiotika? |
||
2015-2012
2015-2012
| 2015 | ||
| Forschung Frankfurt: Photosynthese mit ultrakurzen Laserpulsen erforschen |
Identifying and quantifying two ligand-binding sites while imaging native human membrane receptors by AFM |
|
| Arrhythmogenic effects of mutated L-type Ca2+-channels on an optogenetically paced muscular pump in Caenorhabditis elegans Christina Schüler, Elisabeth Fischer, Lior Shaltiel, Wagner Steuer Costa, Alexander Gottschalk Nature Scientific Reports, 2015, doi:10.1038/srep14427 |
Optogenetic manipulation of cGMP in cells and animals by the tightly light-regulated guanylyl-cyclase opsin CyclOp Shiqiang Gao, Jatin Nagpal, Martin W. Schneider, Vera Kozjak-Pavlovic, Georg Nagel & Alexander Gottschalk Nature Communications, 2015, doi: 10.1038/ncomms9046 |
|
|
SLAP: Small Labeling Pair for Single-Molecule Super-Resolution Imaging |
Boron-Containing PAHs: Facile Synthesis of Stable, Redox-Active Luminophores M. Sc. Valentin M. Hertz, Dr. Michael Bolte, Dr. Hans-Wolfram Lerner and Prof. Dr. Matthias Wagner Angewandte Chemie International Edition, 2015, doi: 10.1002/anie.201502977 |
|
|
One-Step Synthesis of a [20]Silafullerane with an Endohedral Chloride Ion |
Mechanistic insight from the crystal structure of mitochondrial complex I Volker Zickermann, Christophe Wirth, Hamid Nasiri, Karin Siegmund, Harald Schwalbe, Carola Hunte, Ulrich Brandt (2015) Science, 2015, Vol. 347 no. 6217 pp. 44-49, DOI: 10.1126/science.1259859 |
|
| 2014 | ||
| Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB. Eicher, T., Seeger, M. A., Anselmi, C., Zhou, W., Brandstätter, L., Verrey, F., Diederichs, K., Faraldo-Gómez, J. D.*, Pos, K. M.* (2014) eLife 3:e03145. http://elifesciences.org/content/3/e03145 |
Subnanometre-resolution electron cryomicroscopy structure of a heterodimeric ABC exporter JungMin Kim, Shenping Wu, Thomas M. Tomasiak, Claudia Mergel, Michael B. Winter, Sebastian B. Stiller, Yaneth Robles-Colmanares, Robert M. Stroud, Robert Tampé, Charles S. Craik & Yifan Cheng (2014) Nature, ahead of print DOI:10.1038/nature13872 |
|
| Revealing the macromolecular targets of complex natural products Daniel Reker, Anna M. Perna, Tiago Rodrigues, Petra Schneider, Michael Reutlinger, Bettina Mönch, Andreas Koeberle, Christina Lamers, Matthias Gabler, Heinrich Steinmetz, Rolf Müller, Manfred Schubert-Zsilavecz, Oliver Werz & Gisbert Schneider (2014) Nature Chemistry, 2014, 6, 1072, DOI:10.1038/nchem.2095 |
Confirmed by X-ray Crystallography: The B·B One-Electron s Bond |
|
| 2013 | ||
| Molecular Mechanism of Prion Protein Oligomerization at Atomic Resolution, Kai Schlepckow, Harald Schwalbe (2013) Angew Chem Int Ed Engl. Epub ahead of print, DOI: 10.1002/ange.201305184 |
Three-state mechanism couples ligand and temperature sensing in riboswitches, Anke Reining, Senada Nozinovic, Kai Schlepckow, Florian Buhr, Boris Fürtig and Harald Schwalbe (2013) Nature, Vol 499, 355-359, DOI: 10.1038/nature12378 |
|
| 2012 | ||
| Optogenetic Analysis of a Nociceptor Neuron and Network Reveals Ion Channels Acting Downstream of Primary Sensors, Steven J. Husson, Wagner Steuer Costa, Sebastian Wabnig, Jeffrey N. Stirman, Joseph D. Watson, W. Clay Spencer, Jasper Akerboom, Loren L. Looger, Millet Treinin, David M. Miller, Hang Lu and Alexander Gottschalk (2012) Current Biology, Epub ahead of print, DOI:10.1016/j.cub.2012.02.066 |
Stochastic sensing of proteins with receptor-modified solid-state nanopores, Ruoshan Wei, Volker Gatterdam, Ralph Wieneke, Robert Tampé & Ulrich Rant (2012) Nature Nanotechnology, Epub ahead of print, DOI: 10.1038/NNANO.2012.24 |
|
| Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop, Thomas Eicher, Hi-jea Chaa, Markus A. Seeger, Lorenz Brandstätter, Jasmin El-Delik, Jürgen A. Bohnert, Winfried V. Kern, François Verrey, Markus G. Grütter, Kay Diederichs and Klaas M. Pos (2012) PNAS early edition, www.pnas.org/cgi/doi/10.1073/pnas.1114944109. |
2011-2009
2011-2009
2008-2004
2008-2004
| 2008 | ||
| The structure of bradykinin bound to the human GPCR bradykinin-2 as determined by solid-state NMR Lopez, J.J., Shukla, A.K., Reinhart, C., Schwalbe, H., Michel, H., Glaubitz, C Angew. Chem. Int. Ed.47, 1668-1671 |
Structural basis for the selectivity of the external thioesterase of the surfactin-synthetase Koglin, A., Löhr, F., Bernhard, F., Rogov, V. R., Frueh, D. P., Strieter, E. R., Mofid, M. R., Güntert, P., Wagner, G., Walsh, C. T., Marahiel, M. A. & Dötsch, V. Nature 454, 907–911 (2008), [Pressemitteilung] |
|
| 2007 | ||
| Identification of a lysosomal peptide transport system induced during dendritic cell development Ö. Demirel, Z. Waibler, U. Kalinke, F. Grünebach, S. Appel, P. Brossart, A. Hasilik, R. Tampé and R. Abele J. Biol. Chem. 2007; 282; 37836 - 43 |
Time-resolved NMR methods resolving ligand-induced RNA folding at atomic resolution J. Buck, B. Fürtig, J. Noeske, J. Wöhnert, H. Schwalbe Proc Natl Acad Sci U S A. 2007;104(40):15699-704 |
|
| Bidirectional optical control of neurons, neural circuits and behaviour in Caenorhabditis elegans M. Brauner, J. Liewald, A. Gottschalk NATURE 2007; 446; 633-639 |
Native protein nanolithography that can write, read and erase A. Tinazli, J. Piehler, M. Beuttler, R. Guckenberger, R. Tampe NATURE NANOTECHNOLOGY, 2007; 2 (4): 220-225 |
|
| 2006 | ||
| Highlights in asymmetric Synthesis and Catalysis M. Rueping, C. Azap, Angew. Chem. 2006, 118, 7996-7999 (Int. Ed. 45, 7832-7835) M. Rueping, A. P. Antonchick, T. Theissmann, Angew. Chem. 2006, 118, 6903-6907 (Int. Ed. 45, 6751-6755) M. Rueping, A. P. Antonchick, T. Theissmann, Angew. Chem. 2006, 118, 3765-3768 (Int. Ed. 45, 3683-3686) M. Rueping, E. Sugiono, C. Azap, Angew. Chem. 2006, 118, 2679-2681 (Int. Ed. 45, 2617-2619) Von der Natur lernen (aus Forschung Frankfurt, 2007) |
Molecular phylogeny and evolution of morphology in the social amoebas Schaap P, Winckler T, Nelson M, Alvarez-Curto E, Elgie B, Hagiwara H, Cavender J, Milano-Curto A, Rozen DE, Dingermann T, Mutzel R, Baldauf SL Science. 2006; 314(5799); 661-3 |
|
| Localization of multidrug transporter substrates within model membranes Siarheyeva A, Lopez JJ, Glaubitz C, Biochemistry 2006; 45(19); 6203-11 |
Conformational switches modulate protein interactions in peptide antibiotic synthetases Koglin A, Mofid MR, Lohr F, Schafer B, Rogov VV, Blum MM, Mittag T, Marahiel MA, Bernhard F, Dotsch V; Science 2006; 312(5771); 273-6. |
|
| 2005 | ||
| Hyperforin activates nonselective cation channels (NSCCs) Treiber K, Singer A, Henke B, Muller WE; Br J Pharmacol. 2005; 145(1); 75-83 |
Histamine H4 receptor stimulation suppresses IL-12p70 production and mediates chemotaxis in human monocytederived dendritic cells Ralf Gutzmer, Carola Diestel, Susanne Mommert, Brigitta Köther, Holger Stark, Miriam Wittmann, Alexander Kapp and Thomas Werfel; Journal of Immunology 2005; 174(9); 5224-5232 |
|
| The genome of the social amoeba Dictyostelium discoideum Nature 2005; 435, 43-57 |
Diagnostic tool for the identification of MLL rearrangements including unknown partner genes Meyer C, Schneider B, Reichel M, Angermueller S, Strehl S, Schnittger S, Schoch C, Jansen MW, van Dongen JJ, Pieters R, Haas OA, Dingermann T, Klingebiel T, Marschalek R; Proc. Natl. Acad. Sci. USA, 2005, 102(2), 449-454. |
|
| 2004 | ||
| The functional asymmetry of TAP is reflected in the different C-loop sequences Min Chen, Rupert Abele and Robert Tampé; Journal of Biological Chemistry, 2004, 279 (44), 46073-46081 |
Modulation of Compactness and Long-Range Interactions of Unfolded Lysozyme by Single Point Mutations Julia Wirmer, Christian Schlörb, Judith Klein-Seetharaman, Ryoma Hirano, Tadashi Ueda, Taiji Imoto, Harald Schwalbe; Angewandte Chemie (2004) 43, 5780-5785 |
Research Highlight
Publikationen (Stand 06/20)
| in 2020: | 147 |
| in 2019: | 321 |
| in 2018: | 324 |
| in 2017: | 329 |
| in 2016: | 296 |
| in 2015: | 318 |
| Total Articles (2000 - 05/2020): |
5472 |
| Publications in Web of Science | 5307 |
| Sum of times cited | 143.930 |
| Average citations per item | 27,1 |
| Average citations per year | 6257,8 |
| h-index: | 142 |
