Research Highlights
2022
2022
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Project funding of "Targeted Nitroxoline Delivery for Treatment of Multidrug-resistant Pathogens (TANDEM)" by jpiamr.
Thomas Wichelhaus, Goethe-University, Germany (Coordinator); Kerstin Sander, University College London, United Kingdom; Heiko Herwald, Lund University, Sweden; Eugen Proschak, Goethe University, Germany |
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Sprunginnovation: 1,4 Millionen Euro für Entwicklung von neuartigem COVID-19-Wirkstoff |
Structure of a fully assembled tumor-specific T-cell receptor ligated by pMHC L. Sušac, M. T. Vuong, C. Thomas, S. von Bülow, C. O’Brien-Ball, A. Mafalda Santos, R. A. Fernandes, G. Hummer, R. Tampé, S. J. Davis: Cell (2022) 185, Aug 18 https://doi.org/10.1016/j.cell.2022.07.010 |
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Molecular basis of MHC I quality control in the peptide loading complex |
Chemoenzymatic synthesis of fluorinated polyketides A. Rittner, M. Joppe, J.J. Schmidt, L.M. Mayer, S. Reiners, E. Heid, D. Herzberg, D.H. Sherman, M. Grininger: Nature Chemistry (2022) https://doi.org/10.1038/s41557-022-00996-z |
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Harald Schwalbe erhält Richard-R.-Ernst-Preis für Magnetische Resonanz Mit dem Richard-R.-Ernst-Preis für Magnetische Resonanz der internationalen EUROMAR-Konferenz in Utrecht wurde jetzt Prof. Harald Schwalbe von der Goethe-Universität, Chemiker und Spezialist für Kernspinresonanz-(NMR)-Spektroskopie, ausgezeichnet. Er erhielt den Preis für seine wegweisenden Beiträge zur Entwicklung und Anwendung neuartiger Methoden in der biomolekularen NMR-Spektroskopie. Der Preis ist mit 15.000 Euro dotiert und wird vom Laborgerätehersteller Bruker gesponsert. Ein internationales Komitee aus renommierten Wissenschaftlerinnen und Wissenschaftlern kürte den Preisträger. |
Der SFB 1507 „Proteinverbünde und Maschinerien in Zellmembranen“ nimmt ein Grundprinzip des Lebens in den Blick: biochemische Reaktionen und subzelluläre Architekturen an Membranen. Die Wissenschaftler:innen untersuchen dazu Proteinkomplexe in der Zellmembran – von Protein-Verbünden über zelluläre Maschinen bis zu Superkomplexen. |
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Formation, Signaling and Occurrence of Specialized Pro-Resolving Lipid Mediators—What is the Evidence so far? |
Unidirectional mannitol synthesis of Acinetobacter baumannii MtlD is facilitated by the helix-loop-helix-mediated dimer formation. |
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| Tele-Forschung“: Fernsteuerungsprojekt soll Kernspin-Strukturanalysen erleichtern und Vernetzung der europäischen Forschung weiter vorantreiben
1,5 Million Euro für europäisches Forschungsgroßprojekt Remote-NMR – Koordination durch Goethe-Universität Frankfurt |
pVHL-mediated SMAD3 degradation suppresses TGFß signalling J Zhou, Y Dabiri, RA Gama-Brambila, G Shahrouz, M Altinbay, A Mehrabi, M Golriz, B Blagojevic, S Reuter, K Han, A Seidel, S Wölfl, X Cheng: Journal of Cell Biology, 2022, doi.org/10.1083/jcb.202012097 |
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Von den 6600 am meisten zitiertesten Wissenschaftlern der Welt sind sechs an der Goethe-Universität beheimatet. Dies zeigt das diesjährige Zitationsranking des „Web of Science“ Prof. Dr. Stefan Knapp Institut für Pharmazeutische Chemie der Goethe-Universität in der Kategorie „Cross Field“ |
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2021
2021
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Closantel is an allosteric inhibitor of human Taspase1. |
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Förderlinie LOEWE-Exploration |
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Room-temperature dynamic nuclear polarization enhanced NMR spectroscopy of small biological molecules in water. |
„Gezielte Hemmung der mRNA-Translation zur Therapie chronischer Schmerzen“ Prof. Robert Fürst vom Institut für Pharmazeutische Biologie und Prof. Achim Schmidtko vom Institut für Pharmakologie und Klinische Pharmazie (beide Goethe-Universität Frankfurt) untersuchen, inwieweit Sensibilisierungsprozesse im schmerzverarbeitenden System durch eine gezielte Hemmung der Protein-Biosynthese (mRNA-Translation) beeinflusst werden können. |
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| [Cl@Si20H20]−: Parent Siladodecahedrane with Endohedral Chloride Ion. M. Bamberg, M. Bursch, A. Hansen, M. Brandl, G. Sentis, L. Kunze, M. Bolte, H.-W. Lerner, S. Grimme, M. Wagner: J. Am. Chem. Soc. 2021, 143, 10865–10871 https://doi.org/10.1021/jacs.1c05598 Selective One-Pot Syntheses of Mixed Silicon-Germanium Heteroadamantane Clusters. B. Köstler, M. Bolte, H.-W. Lerner, M. Wagner: Chem. Eur. J. 2021 https://doi.org/10.1002/chem.202102732 |
Switching at the ribosome: riboswitches need rProteins as modulators to regulate translation. V. de Jesus, N. S. Qureshi, S. Warhaut, J. K. Bains, M. S. Dietz, M. Heilemann, H. Schwalbe, B. Fürtig, Nature Communications, 2021, DOI: 10.1038/s41467-021-25024-5 |
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SARS-CoV-2: Achillesfersen im Viren-Erbgut |
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Bestimmte Regionen im SARS-CoV-2-Erbgut könnten sich als Ziel für künftige Medikamente eignen. Dies fanden jetzt Wissenschaftlerinnen und Wissenschaftler der Goethe-Universität Frankfurt und ihre Kooperationspartner im internationalen COVID-19-NMR-Konsortium heraus. Mithilfe einer speziellen Substanzdatenbank identifizierten sie mehrere kleine Moleküle, die an bestimmte Stellen des SARS-CoV-2-Genoms binden, die fast nie durch Mutationen verändert werden. |
Exploring the druggability of conserved RNA regulatory elements in the SARS-CoV-2 genome. S Sreeramulu, C Richter, H Berg, MA Wirtz Martin, B Ceylan, T Matzel, J Adam, N Altincekic, K Azzaoui, J Kaur Bains, MJJ Blommers, J Ferner, B Fürtig, M Göbel, JT Grün, M Hengesbach, KF Hohmann, D Hymon, B Knezic, JN Martins, KR Mertinkus, A Niesteruk, SA Peter, DJ Pyper, NS Qureshi, U Scheffer, A Schlundt, R Schnieders, E Stirnal, A Sudakov, A Tröster, J Vögele, A Wacker, JE Weigand, J Wirmer-Bartoschek, J Wöhnert, H Schwalbe Angew. Chem. Int. Ed. Engl., 2021, in press doi.org/10.1002/anie.202103693 |
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| A PROTAC targets splicing factor 3B1 R-A Gama-Brambila, J Chen, J Zhou, G Tascher, C Munch, X Cheng: Cell Chem Biol 2021. doi.org/10.1016/j.chembiol.2021.04.018 |
A Chemical Toolbox for Labeling and Degrading Engineered Cas Proteins R-A Gama-Brambila, J Chen, Y Dabiri, G Tascher, V Němec, C Münch, G Song, S Knapp, X Cheng: Journal of the American Chemical Society Au, 2021. doi.org/10.1021/jacsau.1c00007 |
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COVID-19-Behandlung: Erforschung zweier Angriffspunkte des viralen Stoffwechsels Zwei Forschungskooperationen der Goethe-Universität zu neuen COVID-19-Therapieansätzen fördert jetzt die Volkswagenstiftung mit insgesamt rund 1,4 Millionen Euro: |
BIPOLES: a tool for bidirectional dual-color optogenetic control of neurons J Vierock, S Rodriguez-Rozada, F Pieper, A Dieter, A Bergs, N Zeitzschel, J Ahlbeck, K Sauter, A Gottschalk, AK Engel, P Hegemann, S Wiegert bioRxiv, 16th July 2020. doi: doi.org/10.1101/2020.07.15.204347 |
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| Allosteric drug transport mechanism of multidrug transporter AcrB HK Tam, WE Foong, C Oswald, A Herrmann, H Zeng, KM Pos Nature Communications, 2021, 12, Article number: 3889 doi.org/10.1038/s41467-021-24151-3 |
Nox4-Dependent Upregulation of S100A4 after Peripheral Nerve Injury Modulates Neuropathic Pain Processing G Wack, K Metzner, MS Kuth, E Wang, A Bresnick, RP Brandes, K Schröder, I Wittig, A Schmidtko, W Kallenborn-Gerhardt Free Radic Biol Med. 2021 S0891-5849(21)00180-5. DOI: 10.1016/j.freeradbiomed.2021.03.021 |
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| Large-Scale Recombinant Production of the SARS-CoV-2 Proteome for High-Throughput and Structural Biology Application N Altincekic, SM Korn, NS Qureshi, M Dujardin, M Ninot-Pedrosa, R Abele, MJ Abi Saad, C Alfano, FCL Almeida, I Alshamleh, GC de Amorim, TK Anderson, CD Anobom, C Anorma, JK Bains, A Bax, M Blackledge, J Blechar, A Böckmann, L Brigandat, A Bula, M Bütikofer, AR Camacho-Zarco, T Carlomagno, IP Caruso, B Ceylan, A Chaikuad, F Chu, L Cole, MG Crosby, V de Jesus, K Dhamotharan, IC Felli, J Ferner, Y Fleischmann, ML Fogeron, NK Fourkiotis, C Fuks, B Fürtig, A Gallo, SL Gande, JA Gerez, D Ghosh, .... Front Mol Biosci 2021. 8, 653148. DOI: 10.3389/fmolb.2021.653148 |
Structure-Based Design of Selective Salt-Inducible Kinase Inhibitor R Tesch, M Rak, M Raab, LM Berger, T Kronenberger, AC Joerger, BT Berger, I Abdi, T Hanke, A Poso, K Strebhardt, M Sanhaji, S Knapp J Med Chem 2021. 64 (12): 8142-8160 DOI: 10.1021/acs.jmedchem.0c02144 |
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| How Photoswitchable Lipids Affect the Order and Dynamics of Lipid Bilayers and Embedded Proteins M Doroudgar, J Morstein, J Becker-Baldus, D Trauner, C Glaubitz J Am Chem Soc. 2021 Jun 16. doi: doi.org/10.1021/jacs.1c03524 |
De novo macrocyclic peptides dissect energy coupling of a heterodimeric ABC transporter by multimode allosteric inhibition“ E Stefan, R Obexer, S Hofmann, K Vu Huu, Y Huang und N Morgner, zudem federführend H Suga und R Tampé eLife 2021;10:e67732 doi: 10.7554/eLife.67732 |
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| In vivo inducible reverse genetics in patients’ tumors to identify individual therapeutic targets. M Carlet, K Völse, J Vergalli, M Becker, T Herold, A Arner, D Senft, V Jurinovic, WH Liu, Y Gao, V Dill, B Fehse, C Baldus, L Bastian, L Lenk, D Schewe, J Bagnoli, B Vick, J Schmid, A Wilhelm, R Marschalek, P Jost, C Miehting, K Riecken, M Schmidt-Supprian, V Binder Nat. Communications 2021 under review |
Quantum dynamics of exciton transport and dissociation in multichromophoric systems W Popp, D Brey, R Binder, I Burghardt Rev. Phys. Chem., 2021, 72, 591 doi.org/10.1146/annurev-physchem-090419-040306 |
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| What defines a synthetic riboswitch? - Conformational dynamics of ciprofloxacin aptamers with similar binding affinities but varying regulatory potentials C Kaiser, J Schneider, E Groher, B Suess and J Wachtveitl Nucleic Acids Res. 2021 49, 3661-3671 doi.org/10.1021/acs.jpcc.0c09891 |
C81-evoked inhibition of the TNFR1-NFκB pathway during inflammatory processes for stabilization of the impaired vascular endothelial barrier for leukocytes GM Krishnathas, B Strödke, L Mittmann, T Zech, CA Reichel, T Schmid, S Knapp, S Müller-Knapp, F Bracher, R Fürst; I Bischoff-Kont FASEB J. 2021; 35: e21656. doi.org/10.1096/fj.202100037R |
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Synapsin Is Required for Dense Core Vesicle Capture and cAMP-Dependent Neuropeptide Release |
Endogenous vitamin E metabolites mediate allosteric PPARγ activation with unprecedented co-regulatory interactions S Willems, L Gellrich, A Chaikuad, S Kluge, O Werz, J Heering, S Knapp, S Lorkowski, M Schubert-Zsilavecz, D Merk Cell Chem Biol 2021 DOI: 10.1016/j.chembiol.2021.04.019 |
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The Desensitized Channelrhodopsin-2 Photointermediate Contains 13-cis,15-syn RetinalSchiff Base. |
Structural Insights into Plasticity and Discovery of Remdesivir Metabolite GS-441524 Binding in SARS-CoV‑2 Macrodomain X Ni, M Schröder, V Olieric, M E Sharpe, V Hernandez-Olmos, E Proschak, D Merk, S Knapp, A Chaikuad ACS Med. Chem. Lett. 2021, 12, 603−609 pubs.acs.org/doi/10.1021/acsmedchemlett.0c00684 |
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| Multi-Color, Bleaching-Resistant Super-Resolution Optical Fluctuation Imaging with Oligonucleotide-Based Exchangeable Fluorophores M Glogger, C Spahn, J Enderlein, M Heilemann Angew. Chem. Int. Ed. 2021, 60, 12, 6310-6313 doi.org/10.1002/anie.202013166
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Electron-Irradiation Promoted Exchange Reaction as a Tool for Surface Engineering and Chemical Lithography A Terfort, M Zharnikov Adv. Mater. Interf., 2021, 8, 2100148 doi.org/10.1002/admi.202100148 |
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Probing the photointermediates of light-driven sodium ion pump KR2 by DNP- enhanced solid-state NMR |
Unravelling the kinetics of spare-tire DNA G-quadruplex folding JT Grün, A Blümler, I Burkhart, J Wirmer-Bartoschek, A Heckel, H Schwalbe J. Am. Chem. Soc., 2020, 143, 6185-6193. pubs.acs.org/doi/10.1021/jacs.1c01089 |
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| Natural products as drugs and tools for influencing core process of eukaryotic mRNA translation LD Burgers, R Fürst Pharmacol Res. 2021; 170: 105535. doi.org/10.1016/j.phrs.2021.105535 |
Photo-induced receptor confinement drives ligand-independent GPCR signaling |
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| A Stable N-Heterocyclic Silylene with a 1,1'-Ferrocenediyl Backbone N Weyer, M Heinz, JI Schweizer, C Bruhn, MC Holthausen, U Siemeling Angew. Chem. Int. Ed., 2021, 60, 2624 doi.org/10.1002/anie.202011691 |
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| Large-scale recombinant production of the SARS-CoV-2 proteome for high-throughput and structural biology applications N Altincekic, S M Korn, N S Qureshi, M Dujardin, M Ninot-Pedrosa, M Hengesbach, A Schlundt et al. Frontiers in Molecular Biosciences, 2021 doi.org/10.3389/fmolb.2021.653148 |
Photo-induced receptor confinement drives ligand-independent GPCR signaling MF Sánchez, S Els-Heindl, A G Beck-Sickinger, R Wieneke, R Tampé Science, 2021, science.sciencemag.org/lookup/doi/10.1126/science.abb7657 |
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| Cysteine oxidation and disulfide formation in the ribosomal exit tunnel L Schulte, J Mao, J Reitz, S Sreeramulu, D Kudlinzki, V-V Hodirnau, J Meier-Credo, K Saxena, F Buhr, J D Langer, M Blackledge, A S Frangakis, C Glaubitz, H Schwalbe Nature Communications, 2021, doi.org/10.1038/s41467-020-19372-x |
Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2 B-T Berger, M Amaral, D B Kokh, A Nunes-Alves, D Musil, T Heinrich, M Schröder, R Neil, J Wang, I Navratilova, J Bomke, J M Elkins, S Müller, M Frech, R C Wade, S Knapp Cell Chemical Biology, 2021, doi.org/10.1016/j.chembiol.2021.01.003 |
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| Combined Cardioprotective and Adipocyte Browning Effects Promoted by the Eutomer of Dual sEH/PPARγ Modulator M Hartmann, SI Bibli, D Tews, X Ni, T Kircher, JS Kramer, W Kilu, J Heering, V Hernandez-Olmos, L Weizel, GKE Scriba, SKrait, S Knapp, A Chaikuad, D Merk, I Fleming, P Fischer-Posovszky, E Proschak J. Med. Chem. 2020, 64, 2815-2828 doi.org/10.1021/acs.jmedchem.0c02063 |
Structure determination of organic compounds by a fit to the pair distribution function from scratch without prior indexing C. Schlesinger, S. Habermehl, D. Prill J. Appl. Cryst. 2021, 54, http://doi.org/10.1107/S1600576721002569 |
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| Design, Synthesis, and Evaluation of WD-Repeat-Containing Protein 5 (WDR5) Degraders A Dölle, B Adhikari, A Krämer, J Weckesser, N Berner, LM Berger, M Diebold, MM Szewczyk, D Barsyte-Lovejoy, CH Arrowsmith, J Gebel, F Löhr, V Dötsch, M Eilers, S Heinzlmeir, B Kuster, C Sotriffer, E Wolf, S Knapp J Med Chem 2021, DOI: 10.1021/acs.jmedchem.1c00146 |
Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2 BT Berger, M Amaral, DB Kokh, A Nunes-Alves, D Musil, T Heinrich, M Schröder, R Neil, J Wang, I Navratilova, J Bomke, JM Elkins, S Müller, M Frech, RC Wade, S Knapp Cell Chem Biol 2021. 28 (5): 686-698.e7. DOI: 10.1016/j.chembiol.2021.01.003 |
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| Exploiting vulnerabilities of SWI/SNF chromatin remodelling complexes for cancer therapy M Wanior, A Krämer, S Knapp, AC Joerger Oncogene 2021. 40 (21): 3637-3654 DOI: 10.1038/s41388-021-01781-x |
Structure and Inhibitor Binding Characterization of Oncogenic MLLT1 Mutants X Ni, AT Londregan, DR Owen, S Knapp, A Chaikuad ACS Chem Biol 2021. 16 (4): 571-578 DOI: 10.1021/acschembio.0c00960 |
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| Structural Insights into Plasticity and Discovery of Remdesivir Metabolite GS-441524 Binding in SARS-CoV-2 Macrodomain X Ni, M Schröder, V Olieric, ME Sharpe, V Hernandez-Olmos, E Proschak, D Merk, S Knapp, A Chaikuad ACS Med Chem Lett 2021. 12 (4): 603-609 DOI: 10.1021/acsmedchemlett.0c00684 |
Functional Coupling of Slack Channels and P2X3 Receptors Contributes to Neuropathic Pain Processing R Lu, K Metzner, F Zhou, C Flauaus, A Balzulat, P Engel, J Petersen, R Ehinger, A Bausch, P Ruth, R Lukowski, A Schmidtko J. Mol. Sci. 2021, 22, 405. doi: 10.3390/ijms22010405 |
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| Clinical Implications of Minimal Residual Disease Detection in Infants With KMT2A-Rearranged Acute Lymphoblastic Leukemia Treated on the Interfant-06 Protocol J Stutterheim, IM van der Sluis, P de Lorenzo, J Alten, P Ancliffe, A Attarbaschi, B Brethon, A Biondi, M Campbell, G Cazzaniga, G Escherich, A Ferster, RS Kotecha, B Lausen, CK Li,L Lo Nigro, F Locatelli, R Marschalek, C Meyer, M Schrappe, J Stary, A Vora, J Zuna, VHJ van der Velden, T Szczepanski, MG Valsecchi, R PieterS J Clin Oncol. 2021 Feb 20;39(6):652-662 DOI: 10.1200/JCO.20.02333 |
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Cell culture NAIL-MS allows insight into human tRNA and rRNA modification dynamics in vivo |
Propranolol Activates the Orphan Nuclear Receptor TLX to Counteract Proliferation and Migration of Glioblastoma Cells G Faudone, I Bischoff-Kont, L Rachor, S Willems, R Zhubi, A Kaiser, A Chaikuad, S Knapp, R Fürst, J Heering, D Merk J Med Chem 2021. 64 (12): 8727-8738 DOI: 10.1021/acs.jmedchem.1c00733 |
2020
2020
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| Transfer RNA fragments replace microRNAs regulators of the cholinergic post-stroke immune blockade K Winek, S Lobentanzer, B Nadorp, S Dubnov, C Dames, G Moshitzky, B Hotter, C Meisel, DS Greenberg, S Shifman, J Klein, S Shenhar-Tsarfaty, A Meisel und H Soreq Proc. Natl. Acad. Sci. USA, 2020, doi.org/10.1073/pnas.2013542117 |
Structural rearrangement of amyloid-β upon inhibitor binding suppresses formation of Alzheimer disease related oligomers T Lieblein, R Zangl, J Martin, J Hoffmann, MJ Hutchison, T Stark, E Stirnal, T Schrader, H Schwalbe, N Morgner eLife 2020 doi: 10.7554/eLife.59306 |
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| Structural basis of proton-coupled potassium transport in the KUP family I Tascon, J Sousa, RA Corey, DJ Mills, D Griwatz, N Aumüller, V Mikusevic, PJ Stansfeld, J Vonck, I Hänelt Nat Comm, 2020, 11:626, doi.org/10.1038/s41467-020-14441-7 |
A Platinum(ii) Metallonitrene with a Triplet Ground State J Sun, J Abbenseth, H Verplancke, M Diefenbach, B de Bruin, D Hunger, C Würtele, J van Slageren, MC Holthausen, S Schneider Nature Chem., 2020, 12, 1054 doi.org/10.1038/s41557-020-0522-4 |
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| Secondary structure determination of conserved SARS-CoV-2 RNA elements by NMR spectroscopy A Wacker, JE Weigand, S-R Akabayov, N Altincekic, J Bains, E Banijamali, O Binas, J Castillo-Martínez, E Cetiner, B Ceylan, L-Y Chiu, J Davila-Calderon, V de Jesus, K Dhamotharan, E Duchardt-Ferner, J Ferner, L Frydman, B Fürtig, J Gallego, JT Grün, C Hacker, C Haddad, M Hähnke, M Hengesbach, F Hiller, KH Hohmann, D Hymon, H Jonker, H Keller, B Knezic, T Landgraf, F Löhr, L Luo, K Mertinkus, C Muhs, M Novakovic, A Oxenfarth, M Palomino-Schätzlein, K Petzold, S Peters, D Pyper, N Qureshi, M Riad, C Richter, K Saxena, T Schamber, T Scherf, J Schlagnitweit, A Schlundt, R Schnieders, H Schwalbe*, A Simba-Lahuasi, S Sreeramulu, E Stirnal, A Sudakov, J-N Tants, B Tolbert, J Vögele, L Weiss, J Wirmer-Bartoschek, M A Wirtz Martin, J Wöhnert, H Zetzsche Nucl. Acids Res. 2020, 48, 12415-12435 (breakthrough paper). doi.org/10.1093/nar/gkaa1013 |
The interplay between chromophore and protein determines the extended excited state dynamics in a single-domain phytochrome |
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| A platinum(II) metallonitrene with a triplet ground state J Sun, J Abbenseth, H Verplancke, M Diefenbach, B de Bruin, D Hunger, C Würtele, J van Slageren, M C Holthausen, S Schneider Nat. Chem. (2020) doi.org/10.1038/s41557-020-0522-4 |
Compaction of RNA duplexes in the cell A Collauto, S von Bülow, D Gophane, S Saha, LS Stelzl, G Hummer, STh Sigurdsson T Prisner Angew. Chem. Int. Ed., 2020, 59, 1-6 doi.org/10.1002/anie.202009800 |
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| Light-induced uncaging for time-resolved observations of biochemical reactions by MAS NMR spectroscopy J de Mos, A Jakob, J Becker-Baldus, A Heckel, C Glaubitz Chemistry, 2020, 26(30):6789-6792 DOI: 10.1002/chem.202000770 |
Electron Transfer Dynamics and Structural Effects in Benzonitrile Monolayers with Tuned Dipole Moments by Differently Positioned Fluorine Atoms P Werner, T Wächter, A Asyuda, A Wiesner, M Kind, M Bolte, L Weinhardt, A Terfort, M Zharnikov ACS Appl. Mater. Interf., 2020), 12, 39859 doi.org/10.1021/acsami.0c10513 |
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| Molecular analysis of the ribosome recycling factor ABCE1 bound to the 30S post-splitting complex E Nürenberg-Goloub, H Kratzat, H Heinemann, A Heuer, P Kötter, O Berninghausen, T Becker, R Tampé, R Beckmann EMBO J.2020;e:103788 doi.org/10.15252/embj.2019103788 |
Cysteine oxidation and disulfide formation in the ribosomal exit tunnel |
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| Coligand Role in the NHC Nickel Catalyzed C–F Bond Activation: Investigations on the Insertion of bis(NHC) Nickel into the C–F Bond of Hexafluorobenzene MW Kuntze-Fechner, H Verplancke, L Tendera, M Diefenbach, I Krummenacher, H Braunschweig, TB Marder, MC Holthausen, U Radius Chem. Sci., 2020, 11, 11009 doi.org/10.1039/D0SC04237D |
The Ketosynthase Domain Constrains the Design of Polyketide Synthases |
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PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase. |
Smart Molecular Nanosheets for Advanced Preparation of Biological Samples in Electron Cryo-Microscopy J Scherr, Z Tang, M Küllmer, S Balser, A S Scholz, A Winter, K Parey, A Rittner, M Grininger, V Zickermann, D Rhinow, A Terfort, A Turchanin ACS Nano 2020, doi.org/10.1021/acsnano.0c03052 |
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| Rab27a Contributes to the Processing of Inflammatory Pain in Mice T Gross, G Wack, KMJ Syhr, T Tolmachova, MC Seabra, G Geisslinger, E Niederberger, A Schmidtko, W Kallenborn-Gerhardt Cells, 2020, 9(6):1488 doi: 10.3390/cells9061488 |
Neuropathic and cAMP-induced pain behavior is ameliorated in mice lacking CNGB1 W Kallenborn-Gerhardt, K Metzner, R Lu, J Petersen, MS Kuth, S Heine, O Drees, M Paul, E Becirovic, L Kennel, C Flauaus, T Groß, G Wack, SW Hohmann, D Nemirovski,D Del Turco, M Biel, G Geisslinger, S Michalakis, A Schmidtko Neuropharmacology, 2020, (171):108087 doi.org/10.1016/j.neuropharm.2020.108087 |
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| Multiquantum Counting of Trityl Radicals M Bretschneider, PE Spindler, OY Rogozhnikova, DV Trukhin, B Endeward, AA Kuzhelev, E Bagryanskaya, VM Tormyshev and TF Prisner J. Phys. Chem. Lett., 2020, 11, 6286-6290 doi.org/10.1021/acs.jpclett.0c01615 |
Crystal structure of sodium ethoxide (C2H5ONa), unravelled after a 180 years |
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The resolution revolution in cryoEM requires new sample preparation procedures: A rapid pipeline to high resolution maps of yeast FAS |
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| Mechanoradicals in tensed tendon collagen as asource of oxidative stress C Zapp, A Obarska-Kosinska, B Rennekamp, M Kurth, MD Hudson, D Mercadante, U Barayeu, TP Dick, V Denysenkov, TF Prisner, M Bennati, C Daday, R Kappl and F Gräter Nat Commun, 2020, 11, 2315 doi.org/10.1038/s41467-020-15567-4 |
Structure of the intermediates in the industrial separation of perinone isomers L Tapmeyer, M Bolte, MR Chierotti, MU Schmidt Dyes and Pigments, 2020, 181, 108442, doi.org/10.1016/j.dyepig.2020.108442 |
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| New pathways for the skin´s stress response: the cholinergic neuropeptide SLURP-1 can activate mast cells and alter cytokine production in mice CM Ertle, FR Rommel, S Tumala, Y Moriwaki, J Klein, J Kruse, U Gieler and EM Peters Front. Immunol. 2020, 12, 631881 doi.org/10.3389/fimmu.2021.631881 |
Structure of LRRK2 in Parkinson’s disease and model for microtubule interaction. C K Deniston, J Salogiannis, S Mathea, D M Snead, I Lahiri, M Matyszewski, O Donosa, R Watanabe, J Böhning, A K Shiau, S Knapp, E Villa, S L Reck-Peterson, A E Leschziner Nature. 2020 Aug 19 pubmed.ncbi.nlm.nih.gov/32814344/ |
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| Local-in-time error in variational quantum dynamics R Martinazzo, I Burghardt Rev. Lett., 2020, 124, 150601 DOI 10.1103/PhysRevLett.124.150601 |
First-principles quantum simulations of exciton diffusion on a minimal oligothiophene chain at finite temperature R Binder, I Burghardt Faraday Discuss., 2020, 221, 406. doi.org/10.1039/C9FD00066F |
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| A 300-fold enhancement of imino nucleic acid resonances by hyperpolarized water provides a new window for probing RNA refolding by 1D and 2D NMR. M Novakovic, GL Olsen, G Pintér, D Hymon, B Fürtig, H Schwalbe, L Frydman PNAS, 16. Januar 2020 doi.org/10.1073/pnas.1916956117 |
PROXIDRUGS unter Leitung der Goethe-Uni wurde in „Clusters4Future“ aufgenommen | |
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Forscher veranschaulichen die molekularen Strukturen von TNF Rezeptoren in der Zellmembran |
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| Dual Soluble Epoxide Hydrolase Inhibitor/PPAR-γ Agonist Attenuates Renal Fibrosis A Stavniichuk, MA Hye Khan, MM Yeboah, MA Chesnik, WK Jankiewicz, M Hartmann, R Blöcher, T Kircher, O Savchuk, E Proschak, JD Imig Prostaglandins Other Lipid Mediat. 2020 EPub doi.org/10.1016/j.prostaglandins.2020.106472 |
Single-molecule imaging reveals the oligomeric state of functional TNF--induced plasma membrane TNFR1 clusters in cells. C Karathanasis, J Medler, F Fricke, S Smith, S Malkusch, D Widera, S Fulda, H Wajant, SJL van Wijk, I Dikic, M Heilemann Sci. Signal. 13, eaax5647 (2020), DOI: 10.1126/scisignal.aax5647 |
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A single power stroke by ATP binding drives substrate translocation in a heterodimeric ABC transporter |
A loop structure allows TAPBPR to exert its dual function as MHC I chaperone and peptide editor |
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| Chemosensory cell-derived acetylcholine drives tracheal mucociliary clearance in response to virulence-associated formyl peptides S Perniss, S Liu, B Boonen, M Keshavarz, AL Ruppert, T Timm, U Pfeil, A Soultanova, S Kusumakshi, L Delventhal, Ö Aydin, M Pyrski, K Deckmann, T Hain, N Schmidt, C Ewers, A Günther, G Lochnit, V Chubanov, T Gudermann, J Oberwinkler, J Klein, K Mikoshiba, T Leinders-Zufall, S Offermans, B Schütz, U Boehm, F Zufall, B Bufe und W Kummer Immunity 2020, 52, 683-699 doi.org/10.1016/j.immuni.2020.03.005 |
High-resolution EPR distance measurements on RNA and DNA with the non-covalent G´ spin label M Heinz, N Erlenbach, LS Stelzl, G Thierolf, NR Kamble, STh Sigurdsson, TF Prisner; G Hummer Nucleic Acids Res., 48, 924-933 doi.org/10.1093/nar/gkz1096 |
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| Single-molecule imaging reveals the oligomeric state of functional TNFα-induced plasma membrane TNFR1 clusters in cells C Karathanasis, J Medler, F Fricke, S Smith, S Malkusch, D Widera, S Fulda, H Wajant, SJL van Wijk, I Dikic, M Heilemann Sci Signal, 2020, 13(614):eaax5647. DOI: 10.1126/scisignal.aax5647 |
Light Dynamics of the Retinal-Disease-Relevant G90D Bovine Rhodopsin Mutant N Kubatova, J Mao, CE Eckert, K Saxena, SL Gande, J Wachtveitl, C Glaubitz, H Schwalbe Angew Chem Int Ed Engl. 2020 Jun 30;59(36):15656–64. doi:10.1002/anie.202003671. |
2019
2019
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| Integrative Transcriptomics Reveals Sexually Dimorphic Control of the Cholinergic/Neurokine Interface in Schizophrenia and Bipolar Disorder S Lobentanzer, G Hanin, J Klein & H Soreq, CellReports, 2019, 29, 3, 764-777; DOI: 10.1016/j.celrep.2019.09.017 |
Molecular tuning of farnesoid X receptor partial agonism. D Merk*, S Sreeramulu, D Kudlinzki, K Saxena, V Linhardt, SL Gande, F Hiller, C Lamers, E Nilsson, A Aagard, L Wissler, N Dekker, K Bamberg, M Schubert-Zsilavecz, H Schwalbe*: Nat. Commun., 2019, 10, 2915. doi.org/10.1038/s41467-019-10853-2 |
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| Narciclasine exerts anti-inflammatory actions by blocking leukocyte-endothelial cell interactions and downregulation of the endothelial TNF receptor 1 A. Stark, R Schwenk, G Wack, G Zuchtriegel, MG Hatemler, J Bräutigam, A Schmidtko, CA Reichel, I Bischoff, R Fürst FASEB J. 2019; 33: 8771-8781. doi.org/10.1096/fj.201802440R |
In-situ observation of conformational dynamics and protein-ligand/substrate interaction in outer membrane proteins with DEER/PELDOR spectroscopy B Joseph, EA Jaumann, A Sikora, K Barth, TF Prisner, DS Cafiso Nat. Protoc., 2019, 14, 2344-2369 doi.org/10.1038/s41596-019-0182-2 |
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| A GABAergic and peptidergic sleep neuron as locomotion stop neuron with compartmentalized Ca2+ dynamics W Costa, P Van der Auwera, C Glock, J F Liewald, M Bach, C Schüler, S Wabnig, A Oranth, F Masurat, H Bringmann, L Schoofs, E H.K. Stelzer, S C. Fischer, A Gottschalk, Nature Communications 2019, 10, 4095; DOI: /10.1038/s41467-019-12098-5 |
Conformation space of a heterodimeric ABC exporter under turnover conditions S Hofmann, D Januliene, AR Mehdipour, C Thomas, E Stefan, S Brüchert, BT Kuhn, ER Geertsma, G Hummer, R Tampé, A Moeller, Nature 2019, 571, 580-583; DOI:10.1038/s41586-019-1391-0 |
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| Distinct functions of soluble guanylyl cyclase isoforms NO-GC1 and NO-GC2 in inflammatory and neuropathic pain processing J Petersen, E Mergia, L Kennel, O Drees, RD Steubing, CI Real, W Kallenborn-Gerhardt, R Lu, A Friebe, D Koesling, A Schmidtko Pain, 2019, 160(3):607–618 DOI: 10.1097/j.pain.0000000000001440 |
Human MLL/KMT2A gene exhibits a second breakpoint cluster region for recurrent MLL-USP2 fusions C Meyer, BA Lopes, A Caye-Eude, H Cavé, C Arfeuille, W Cuccuini, R Sutton, NC Venn, SH Oh, G Tsaur, G Escherich, T Feuchtinger, HJ Kosasih, SL Khaw, PG Ekert, MS Pombo-de-Oliveira, A Bidet, B Djahanschiri, I Ebersberger, M Zaliova, J Zuna, Z Zermanova, V Juvonen, RP Grümayer, G Fazio, G Cazzaniga, P Larghero, M Emerenciano, R Marschalek Leukemia. 2019 Sep;33(9):2306-2340 https://doi.org/10.1038/s41375-019-0451-7 |
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| Photocycle-dependent conformational changes in the proteorhodopsin cross-protomer Asp–His–Trp triad revealed by DNP-enhanced MAS-NMR J Maciejko, J Kaur, J Becker-Baldus, C Glaubitz PNAS 2019, 201817665; DOI: 10.1073/pnas.1817665116 |
ACBE1 controls ribosome recycling by an asymmetric dynamic conformational equilibrium G Gouridis, B Hetzert, K Kiosze-Becker, M de Boer, H Heinemann, E Nürenberg-Goloub, T Cordes, R Tampé Cell Reports 2019 DOI: 10.1016/j.celrep.2019.06.052 |
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Enhanced hemato-endothelial specification during human embryonic differentiation through developmental cooperation between AF4-MLL and MLL-AF4 fusions |
Coherent Charge Transfer Exciton Formation in Regioregular P3HT: A Quantum Dynamical Study W Popp, M Polkehn, R Binder, I Burghardt Phys. Chem. Lett., 2019, 10, 3326. https://doi.org/10.1021/acs.jpclett.9b01105 |
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| Vibrational spectroscopic imaging and live cell video microscopy for studying differentiation of primary human alveolar epithelial cells B Vukosavljevic, M Hittinger, H Hachmeister, C Pilger, X Murgia, MM Gepp, L Gentile, H Huwer, N Schneider-Daum, T Huser, CM Lehr, M Windbergs J Biophotonics. 2019 Jun;12(6):e201800052 doi.org/10.1002/jbio.201800052 |
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| Protein denaturation at the water-air interface and how to prevent it E D'Imprima, D Floris, M Joppe, R Sánchez, M Grininger, W Kühlbrandt eLife 2019;8:e42747 DOI 10.7554/eLife.42747 |
Engineering of Chimeric Polyketide Synthases Using SYNZIP Docking Domains M Klaus, AD D'Souza, A Nivina, C Khosla, M Grininger ACS Chem Biol., 2019, 14, 426-433. doi.org/10.1021/acschembio.8b01060 |
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| The Reductive Coupling of Dinitrogen M-A Légaré, M Rang, G Bélanger-Chabot, J I Schweizer, I Krummenacher, R Bertermann, M Arrowsmith, M C Holthausen und H Braunschweig. Science, 2019, DOI: 10.1126/science.aav9593 |
Global response of diacylglycerol kinase towards substrate binding observed by 2D and 3D MAS NMR K Möbius, S Kazemi, P Güntert, A Jakob, A Heckel, J Becker-Baldus, C Glaubitz Scientific Reports, 2019, 9(1), 3995, DOI: doi.org/10.1038/s41598-019-40264-8 |
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| Protein-Specific, Multicolor and 3D STED Imaging in Cells with DNA-Labeled Antibodies C Spahn, F Hurter, M Glaesmann, C Karathanasis, M Lampe, M Heilemann Angew Chem Int Ed Engl. 2019 Dec 19;58(52):18835-18838 DOI: 10.1002/anie.201910115 |
Liquid-Phase Epitaxial Growth of Highly Oriented and Multivariate Surface-Attached Metal-Organic Frameworks XJ Yu, YM Xian, C Wang, HL Mao, M Kind, T Abu-Husein, Z Chen, SB Zhu, B Ren, A Terfort, JL Zhuang J. Am. Chem. Soc., 2019, 141, 18984 doi.org/10.1021/jacs.9b08169 |
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| Bottom-Up Synthesis of Graphene Monolayers with Tunable Crystallinity and Porosity C Neumann, D Kaiser, MJ Mohn, M Füser, NE Weber, O Reimer, A Gölzhauser, T Weimann, A Terfort, U Kaiser, A Turchanin ACS Nano, 2019,13, 7310 doi.org/10.1021/acsnano.9b03475 |
A channel profile report of the unusual K+ channel KtrB V Mikusevic, M Schrecker, M Patiño-Ruiz, K Fendler, I Hänelt J Gen Physiol, 2019, 151:1357-1368 10.1085/jgp.201912384 |
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| Oxidative Coupling of Terminal Rhenium Pnictide Complexes J Abbenseth, M Diefenbach, A Hinz, L Alig, C Würtele, JM Goicoechea, MC Holthausen, S Schneider Angew. Chem. Int. Ed., 2019, 58, 10966 doi.org/10.1002/anie.201905130 |
A Terminal Iridium Oxo Complex with a Triplet Ground State D Delony, M Kinauer, M Diefenbach, S Demeshko, C Würtele, MC Holthausen, S Schneider Angew. Chem. Int. Ed., 2019, 58, 10971 doi.org/10.1002/anie.201905325 |
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| Synthesis and reduction chemistry of mixed-Lewis-Base-Stabilized Chloroborylenes M Arrowsmith, JI Schweizer, M Heinz, M Härterich, I Krummenacher, MC Holthausen, H Braunschweig Chem. Sci., 2019, 10, 5095 doi.org/10.1039/C9SC01039D |
The reductive coupling of dinitrogen M-A Légaré, M Rang, G Bélanger-Chabot, JI Schweizer, I Krummenacher, R Bertermann, M Arrowsmith, MC Holthausen, H Braunschweig Science 363, 1329 (2019) |
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| Reductive nitric oxide coupling at a dinickel core: Isolation of a key cis-hyponitrite intermediate en route to N2O formation E Ferretti, S Dechert, S Demeshko, MC Holthausen, F Meyer Angew. Chem. Int. Ed., 2019, 58, 1705 doi.org/10.1002/anie.201811925 |
Intercepting the Disilene-Silylsilylene Equilibrium MW Stanford, JI Schweizer, M Menche, GS Nichol, MC Holthausen, MJ Cowley Angew. Chem. Int. Ed., 2019, 58, 1329 /doi.org/10.1002/anie.201810056 |
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| Reactive Dimerization of an N-heterocyclic Plumbylene: CH Activation with PbII R Guthardt, J Oetzel, JI Schweizer, C Blum, R Langer, M Maurer, J Vícha, P Shestakova, MC Holthausen, U Siemeling Angew. Chem. Int. Ed., 2019, 58, 1387 doi.org/10.1002/anie.201811559 |
2018
2018
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| Exhaustively Trichlorosilylated C1 and C2 Building Blocks: Beyond the Müller-Rochow Direct Process I. Georg, J. Teichmann, M. Bursch, J. Tillmann, B. Endeward, M. Bolte, H.-W. Lerner, S. Grimme and M. Wagner JACS, 2018, DOI: 10.1021/jacs.8b05950 |
Unexplored nucleotide binding modes for the ABC exporter MsbA
Kaur H, Abreu B, Akhmetzyanov D, Lakatos-Karoly A, Soares CM, Prisner T, Glaubitz C, JACS, 2018, doi: 10.1021/jacs.8b06739 |
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Correlative single-molecule FRET and DNA-PAINT imaging |
Dynamics of nucleic acids at room temperature revealed by pulsed EPR M. Gränz, N. Erlenbach, P. Spindler, D. B. Gophane, L. S. Stelzl, S. Th. Sigurdsson & T. F. Prisner: Angewandte Chemie International Edition, 2018, http://dx.doi.org/10.1002/anie.201803682 |
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Halogen‐aromatic pi-interactions modulate inhibitor residence time |
Oocyte DNA damage quality control requires consecutive interplay of CHK2 and CK1 to activate p63 M.Tuppi, S. Kehrloesser, D. W. Coutandin, V. Rossi, L. M. Luh, A. Strubel, K. Hötte, M. Hoffmeister, B. Schäfer, T. De Oliveira, F. Greten, E. H. K. Stelzer, S. Knapp, M. De Felici, C. B., F. Gioia Klinger & V. Dötsch: Nature Structural and Molecular Biology, 2018, DOI: 10.1038/s41594-018-0035-7 |
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Protein aggregation of the p63 transcription factor underlies severe skin fragility in AEC syndrome |
The molecular basis of subtype selectivity of human kinin G-protein-coupled receptors L. Joedicke*, J. Mao*, G. Kuenze*, C. Reinhart, T. Kalavacherla, H. R A Jonker, C. Richter, H. Schwalbe, J. Meiler, J. Preu, H. Michel* & C. Glaubitz* Nature Chemical Biology, published online 15.1.2018 (first release) DOI: 10.1038/nchembio.25511 |
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| Life times of metastable states guide regulatory signaling in transcription riboswitches. C. Helmling, D. Klötzner, F. Sochor, R.A. Mooney, A. Wacker, R. Landing, B. Fürtig, A. Heckel*, H. Schwalbe*: Nat. Commun., 2018, 9, 944 doi.org/10.1038/s41467-018-03375-w |
A novel dual PPAR-γ agonist/sEH inhibitor treats diabetic complications in a rat model of type 2 diabetes MA Hye Khan, L Kolb, M Skibba, M Hartmann, R Blöcher, E Proschak, JD Imig Diabetologia 2018, 61; 2235-2246 DOI: 10.1007/s00125-018-4685-0 |
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| Dynamic Nuclear Polarization of 13C Nuclei in the Liquid State over a 10 Tesla Field Range T Orlando, R Dervisoglu, L Levien, I Tkach, TF Prisner, LB Andreas, VP Denysenkov and M Bennati Angew. Chem. Int. Ed., 2018, 58, 1402–1406 doi.org/10.1002/anie.201811892 |
Cryo-EM structures of KdpFABC suggest a K+ transport mechanism via two inter-subunit half-channels |
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| Characterization of the polyspecific transferase of murine type I fatty acid synthase (FAS) and implications for polyketide synthase (PKS) engineering A Rittner, KS Paithankar, K Vu Huu, M Grininger ACS Chem Biol. 3, 723-732 DOI: 10.1021/acschembio.7b00718 |
2017
2017
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| Chromophore Distortions in Photointermediates of Proteorhodopsin Visualized by Dynamic Nuclear Polarization-Enhanced Solid-State NMR M. Mehler, C.E. Eckert, A.J. Leeder, J. Kaur, T. Fischer, N. Kubatova, L.J. Brown, R.C.D. Brown, J. Becker-Baldus, J. Wachtveitl, C. Glaubitz J. Am. Chem. Soc., 139 (2017) 16143-16153. DOI: 10.1021/jacs.7b05061 |
Structure of the human MHC-I peptide-loading complex A. Blees, D. Janulienė, T. Hofmann, N. Koller, C. Schmidt, S. Trowitzsch, A. Moeller & R. Tampé Nature 2017, DOI: 10.1038/nature24627 |
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Quantitative single-molecule imaging of TLR4 reveals ligand-specific receptor dimerization |
Structure of the TAPBPR–MHC I complex defines the mechanism of peptide loading and editing |
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Pausing guides RNA folding to populate transiently stable RNA structures for riboswitch-based transcription regulation |
Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-κB and restricts bacterial proliferation |
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A Vicinal Electrophilic Diborylation Reaction Furnishes Doubly Boron-Doped Polycyclic Aromatic Hydrocarbons |
Structure of the 40S-ABCE1 post-splitting complex in ribosome recycling and translation initiation |
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Engineering fungal de novo fatty acid synthesis for short chain fatty acid production J. Gajewski, R. Pavlovic, M. Fischer, E. Boles & M. Grininger Nature Communications, doi: 10.1038/NCOMMS14650 Engineering fatty acid synthases for directed polyketide production J. Gajewski, F. Buelens, S.Serdjukow, M. Janßen, N. Cortina, H. Grubmüller & M. Grininger Nature Chemical Biology, doi: 10.1038/nchembio.2314 |
Fast cAMP Modulation of Neurotransmission via Neuropeptide Signals and Vesicle Loading W. Steuer Costa, S.-C. Yu, J.F. Liewald, A. Gottschalk Current Biology, doi: 10.1016/j.cub.2016.12.055 |
2016
2016
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Structure of the ribosome post-recycling complex probed by chemical cross-linking and mass spectrometry |
Reversible Dihydrogen Activation by Reduced Aryl Boranes as Main-Group Ambiphiles |
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Atomic-resolution structure of a disease-relevant Aβ(1-42) amyloid fibril. |
Live-cell protein labelling with nanometre precision by cell squeezing |
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Megasynthasen: Schlüssel zum Design neuer Antibiotika? |
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2015-2012
2015-2012
| 2015 | ||
| Forschung Frankfurt: Photosynthese mit ultrakurzen Laserpulsen erforschen |
Identifying and quantifying two ligand-binding sites while imaging native human membrane receptors by AFM |
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| Arrhythmogenic effects of mutated L-type Ca2+-channels on an optogenetically paced muscular pump in Caenorhabditis elegans Christina Schüler, Elisabeth Fischer, Lior Shaltiel, Wagner Steuer Costa, Alexander Gottschalk Nature Scientific Reports, 2015, doi:10.1038/srep14427 |
Optogenetic manipulation of cGMP in cells and animals by the tightly light-regulated guanylyl-cyclase opsin CyclOp Shiqiang Gao, Jatin Nagpal, Martin W. Schneider, Vera Kozjak-Pavlovic, Georg Nagel & Alexander Gottschalk Nature Communications, 2015, doi: 10.1038/ncomms9046 |
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SLAP: Small Labeling Pair for Single-Molecule Super-Resolution Imaging |
Boron-Containing PAHs: Facile Synthesis of Stable, Redox-Active Luminophores M. Sc. Valentin M. Hertz, Dr. Michael Bolte, Dr. Hans-Wolfram Lerner and Prof. Dr. Matthias Wagner Angewandte Chemie International Edition, 2015, doi: 10.1002/anie.201502977 |
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One-Step Synthesis of a [20]Silafullerane with an Endohedral Chloride Ion |
Mechanistic insight from the crystal structure of mitochondrial complex I Volker Zickermann, Christophe Wirth, Hamid Nasiri, Karin Siegmund, Harald Schwalbe, Carola Hunte, Ulrich Brandt (2015) Science, 2015, Vol. 347 no. 6217 pp. 44-49, DOI: 10.1126/science.1259859 |
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| N-Benzylbenzamides: a novel merged scaffold for orally available dual soluble epoxide hydrolase / peroxisome proliferator-activated receptor γ modulators R Blöcher, C Lamers, SK Wittmann, D Merk, M Hartmann, L Weizel, O Diehl, A Brüggerhof, M Boß, A Kaiser, T Schader, T Göbel, M Grundmann, C Angioni, J Heering, G Geisslinger, M Wurglics, E Kostenis, B Brüne, D Steinhilber, M Schubert-Zsilavecz, AS Kahnt, E Proschak J. Med. Chem. 59, 61-81. https://doi.org/10.1021/acs.jmedchem.5b01239 |
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| 2014 | ||
| Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB. Eicher, T., Seeger, M. A., Anselmi, C., Zhou, W., Brandstätter, L., Verrey, F., Diederichs, K., Faraldo-Gómez, J. D.*, Pos, K. M.* (2014) eLife 3:e03145. http://elifesciences.org/content/3/e03145 |
Subnanometre-resolution electron cryomicroscopy structure of a heterodimeric ABC exporter JungMin Kim, Shenping Wu, Thomas M. Tomasiak, Claudia Mergel, Michael B. Winter, Sebastian B. Stiller, Yaneth Robles-Colmanares, Robert M. Stroud, Robert Tampé, Charles S. Craik & Yifan Cheng (2014) Nature, ahead of print DOI:10.1038/nature13872 |
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| Revealing the macromolecular targets of complex natural products Daniel Reker, Anna M. Perna, Tiago Rodrigues, Petra Schneider, Michael Reutlinger, Bettina Mönch, Andreas Koeberle, Christina Lamers, Matthias Gabler, Heinrich Steinmetz, Rolf Müller, Manfred Schubert-Zsilavecz, Oliver Werz & Gisbert Schneider (2014) Nature Chemistry, 2014, 6, 1072, DOI:10.1038/nchem.2095 |
Confirmed by X-ray Crystallography: The B·B One-Electron s Bond |
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| 2013 | ||
| Molecular Mechanism of Prion Protein Oligomerization at Atomic Resolution, Kai Schlepckow, Harald Schwalbe (2013) Angew Chem Int Ed Engl. Epub ahead of print, DOI: 10.1002/ange.201305184 |
Three-state mechanism couples ligand and temperature sensing in riboswitches, Anke Reining, Senada Nozinovic, Kai Schlepckow, Florian Buhr, Boris Fürtig and Harald Schwalbe (2013) Nature, Vol 499, 355-359, DOI: 10.1038/nature12378 |
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| 2012 | ||
| Optogenetic Analysis of a Nociceptor Neuron and Network Reveals Ion Channels Acting Downstream of Primary Sensors, Steven J. Husson, Wagner Steuer Costa, Sebastian Wabnig, Jeffrey N. Stirman, Joseph D. Watson, W. Clay Spencer, Jasper Akerboom, Loren L. Looger, Millet Treinin, David M. Miller, Hang Lu and Alexander Gottschalk (2012) Current Biology, Epub ahead of print, DOI:10.1016/j.cub.2012.02.066 |
Stochastic sensing of proteins with receptor-modified solid-state nanopores, Ruoshan Wei, Volker Gatterdam, Ralph Wieneke, Robert Tampé & Ulrich Rant (2012) Nature Nanotechnology, Epub ahead of print, DOI: 10.1038/NNANO.2012.24 |
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| Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop, Thomas Eicher, Hi-jea Chaa, Markus A. Seeger, Lorenz Brandstätter, Jasmin El-Delik, Jürgen A. Bohnert, Winfried V. Kern, François Verrey, Markus G. Grütter, Kay Diederichs and Klaas M. Pos (2012) PNAS early edition, www.pnas.org/cgi/doi/10.1073/pnas.1114944109. |
2011-2009
2011-2009
2008-2004
2008-2004
| 2008 | ||
| The structure of bradykinin bound to the human GPCR bradykinin-2 as determined by solid-state NMR Lopez, J.J., Shukla, A.K., Reinhart, C., Schwalbe, H., Michel, H., Glaubitz, C Angew. Chem. Int. Ed.47, 1668-1671 |
Structural basis for the selectivity of the external thioesterase of the surfactin-synthetase Koglin, A., Löhr, F., Bernhard, F., Rogov, V. R., Frueh, D. P., Strieter, E. R., Mofid, M. R., Güntert, P., Wagner, G., Walsh, C. T., Marahiel, M. A. & Dötsch, V. Nature 454, 907–911 (2008), [Pressemitteilung] |
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| 2007 | ||
| Identification of a lysosomal peptide transport system induced during dendritic cell development Ö. Demirel, Z. Waibler, U. Kalinke, F. Grünebach, S. Appel, P. Brossart, A. Hasilik, R. Tampé and R. Abele J. Biol. Chem. 2007; 282; 37836 - 43 |
Time-resolved NMR methods resolving ligand-induced RNA folding at atomic resolution J. Buck, B. Fürtig, J. Noeske, J. Wöhnert, H. Schwalbe Proc Natl Acad Sci U S A. 2007;104(40):15699-704 |
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| Bidirectional optical control of neurons, neural circuits and behaviour in Caenorhabditis elegans M. Brauner, J. Liewald, A. Gottschalk NATURE 2007; 446; 633-639 |
Native protein nanolithography that can write, read and erase A. Tinazli, J. Piehler, M. Beuttler, R. Guckenberger, R. Tampe NATURE NANOTECHNOLOGY, 2007; 2 (4): 220-225 |
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| 2006 | ||
| Highlights in asymmetric Synthesis and Catalysis M. Rueping, C. Azap, Angew. Chem. 2006, 118, 7996-7999 (Int. Ed. 45, 7832-7835) M. Rueping, A. P. Antonchick, T. Theissmann, Angew. Chem. 2006, 118, 6903-6907 (Int. Ed. 45, 6751-6755) M. Rueping, A. P. Antonchick, T. Theissmann, Angew. Chem. 2006, 118, 3765-3768 (Int. Ed. 45, 3683-3686) M. Rueping, E. Sugiono, C. Azap, Angew. Chem. 2006, 118, 2679-2681 (Int. Ed. 45, 2617-2619) Von der Natur lernen (aus Forschung Frankfurt, 2007) |
Molecular phylogeny and evolution of morphology in the social amoebas Schaap P, Winckler T, Nelson M, Alvarez-Curto E, Elgie B, Hagiwara H, Cavender J, Milano-Curto A, Rozen DE, Dingermann T, Mutzel R, Baldauf SL Science. 2006; 314(5799); 661-3 |
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| Localization of multidrug transporter substrates within model membranes Siarheyeva A, Lopez JJ, Glaubitz C, Biochemistry 2006; 45(19); 6203-11 |
Conformational switches modulate protein interactions in peptide antibiotic synthetases Koglin A, Mofid MR, Lohr F, Schafer B, Rogov VV, Blum MM, Mittag T, Marahiel MA, Bernhard F, Dotsch V; Science 2006; 312(5771); 273-6. |
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| 2005 | ||
| Hyperforin activates nonselective cation channels (NSCCs) Treiber K, Singer A, Henke B, Muller WE; Br J Pharmacol. 2005; 145(1); 75-83 |
Histamine H4 receptor stimulation suppresses IL-12p70 production and mediates chemotaxis in human monocytederived dendritic cells Ralf Gutzmer, Carola Diestel, Susanne Mommert, Brigitta Köther, Holger Stark, Miriam Wittmann, Alexander Kapp and Thomas Werfel; Journal of Immunology 2005; 174(9); 5224-5232 |
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| The genome of the social amoeba Dictyostelium discoideum Nature 2005; 435, 43-57 |
Diagnostic tool for the identification of MLL rearrangements including unknown partner genes Meyer C, Schneider B, Reichel M, Angermueller S, Strehl S, Schnittger S, Schoch C, Jansen MW, van Dongen JJ, Pieters R, Haas OA, Dingermann T, Klingebiel T, Marschalek R; Proc. Natl. Acad. Sci. USA, 2005, 102(2), 449-454. |
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| 2004 | ||
| The functional asymmetry of TAP is reflected in the different C-loop sequences Min Chen, Rupert Abele and Robert Tampé; Journal of Biological Chemistry, 2004, 279 (44), 46073-46081 |
Modulation of Compactness and Long-Range Interactions of Unfolded Lysozyme by Single Point Mutations Julia Wirmer, Christian Schlörb, Judith Klein-Seetharaman, Ryoma Hirano, Tadashi Ueda, Taiji Imoto, Harald Schwalbe; Angewandte Chemie (2004) 43, 5780-5785 |
Research Highlight
Publikationen (Stand 06/21)
| in 2021: | 195 |
| in 2020: | 293 |
| in 2019: | 321 |
| in 2018: | 324 |
| in 2017: | 329 |
| in 2016: | 296 |
| in 2015: | 318 |
| Total Articles (2000 - 06/2021): |
5943 |
| Publications in Web of Science | 5675 |
| Sum of times cited | 165.277 |
| Average citations per item | 29,1 |
| Average citations per year | 6886,5 |
| h-index: | 150 |
