Publikationen Prof. Abdelhaq Rami
Original- und Übersichtsarbeiten | Buchartikel
2020 - 2022
Hanke N and Rami A (2022) Cerebral Ischemia Induces Iron Deposit, Ferritin Accumulation, Nuclear Receptor Coactivator 4-depletion, and Ferroptosis. Curr Neurovasc Res, 19:47-60s
Klionsky DJ, Rami A et al (2021) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Autophagy, 17: 1-382. doi: 10.1080/15548627.2020.1797280. Epub 2021Feb 8. PMID: 33634751; PMCID: PMC7996087
Börner JH, Rawashdeh O, Rami A (2021) Exacerbated Age-Related Hippocampal Alterations of Microglia Morphology, β-Amyloid and Lipofuscin Deposition and Presenilin Overexpression in Per1-Mice. Antioxidants, 10: 1330. doi: 10.3390/antiox10091330. PMID: 34572962;PMCID: PMC8469021
2011 - 2019
Rami A, Niquet J, Konoplew, A (2019) Early Aberrant Growth of Mossy Fibers after Status Epilepticus in the Immature Rat Brain. Mol Neurobiol, 56: 5025-5031. doi: 10.1007/s12035-018-1432-y. Epub 2018 Nov 17. PMID: 30448889
Halbe L, Rami A (2019) Trehalase localization in the cerebral cortex, hippocampus and cerebellum of mouse brains. J Adv Res, 18: 71-79
Halbe L, Rami A (2019) Inhibition of Autophagy Potentiated Hippocampal Cell Death Induced by Endoplasmic Reticulum Stress and its Activation by Trehalose Failed to be Neuroprotective. Curr Neurovasc Res. doi: 10.2174/1567202616666190131155834
Jilg A, Bechstein P, Saade A, Dick M, Li TX, Tosini G, Rami A, Zemmar A, Stehle JH (2019) Melatonin modulates daytime-dependent synaptic plasticity and learning efficiency. J Pineal Res, 66: e12553
Rami A, Benz A (2018) Exclusive Activation of Caspase-3 in Mossy Fibers and Altered Dynamics of Autophagy Markers in the Mice Hippocampus upon Status Epilepticus Induced by Kainic Acid. Mol Neurobiol, 55: 4492-4503
Rami A, Fekadu J, Rawashdeh O (2017) The Hippocampal Autophagic Machinery is Depressed in the Absence of the Circadian Clock Protein PER1 that may Lead to Vulnerability During Cerebral Ischemia. Curr Neurovasc Res, 14: 207-214
Fekadu J, Rami A (2015) Beclin-1 Deficiency Alters Autophagosome Formation, Lysosome Biogenesis and Enhances Neuronal Vulnerability of HT22 Hippocampal Cells. Mol Neurobiol [Epub ahead of print]
Rami A, Benz AP, Niquet J, Langhagen A (2015) Axonal Accumulation of Lysosomal-Associated Membrane Protein 1 (LAMP1) Accompanying Alterations of Autophagy Dynamics in the Rat Hippocampus Upon Seizure-Induced Injury. Neurochem Res [Epub ahead of print]
Milosch N, Tanriöver G, Kundu A, Rami A, François JC, Baumkötter F, Weyer SW, Samanta A, Jäschke A, Brod F, Buchholz CJ, Kins S, Behl C, Müller UC, Kögel D (2014) Holo-APP and G-protein-mediated signaling are required for sAPPα-induced activation of the Akt survival pathway. Cell Death Dis
Benz AP, Niquet J, Wasterlain CG, Rami A (2014) Status epilepticus in the immature rodent brain alters the dynamics of autophagy. Curr Neurovasc Res, 11: 125-135
Kim M, Fekadu J, Maronde E, Rami A (2013) Alleviation of autophagy by knockdown of Beclin-1 enhances susceptibility of hippocampal neurons to proapoptotic signals induced by amino acid starvation. Histochem Cell Biol, 139: 99-108
Wiebking N, Maronde E, Rami A (2013) Increased neuronal injury in clock gene Per-1 deficient-mice after cerebral ischemia. Curr Neurovasc Res, 10: 112-125
2006 - 2010
Rami A, Kim M, Niquet J (2010) Translocation of the serine protease Omi/HtrA2 from mitochondria into the cytosol upon seizure-induced hippocampal injury in the neonatal rat brain. Neurochem Res, 35: 2199-2207
Seidel K, Schöls L, Nuber S, Petrasch-Parwez E, Gierga K, Wszolek Z, Dickson D, Gai WP, Bornemann A, Riess O, Rami A, Den Dunnen WF, Deller T, Rüb U, Krüger R (2010) First appraisal of brain pathology owing to A30P mutant alpha-synuclein. Ann Neurol, 67: 684-689
Steiger-Barraissoul S, Rami A (2009) Serum deprivation induced autophagy and predominantly an AIF-dependent apoptosis in hippocampal HT22 neurons. Apoptosis 14: 1274–1288
Rami A (2009) Review: autophagy in neurodegeneration: firefighter and/or incendiarist? Neuropathol Appl Neurobiol, 35: 449-461
Siegelin MD, Siegelin Y, Habel A, Rami A, Gaiser T (2009) KAAD-cyclopamine augmented TRAIL-mediated apoptosis in malignant glioma cells by modulating the intrinsic and extrinsic apoptotic pathway. Neurobiol Dis, 34: 259-266
Siegelin MD, Reuss DE, Habel A, Rami A, von Deimling A (2009) Quercetin promotes degradation of survivin and thereby enhances death-receptor-mediated apoptosis in glioma cells. Neuro Oncol, 11: 122-131
Czech B, Pfeilschifter W, Mazaheri-Omrani N, Strobel MA, Kahles T, Neumann-Haefelin T, Rami A, Huwiler A, Pfeilschifter J (2009) The immunomodulatory sphingosine 1-phosphate analog FTY720 reduces lesion size and improves neurological outcome in a mouse model of cerebral ischemia. Biochem Biophys Res Commun, 389: 251-256
Rotarska-Jagiela A, Oertel-Knoechel V, Demartino F, van de Ven V, Formisano E, Roebroeck A, Rami A, Schoenmeyer R, Haenschel C, Hendler T, Maurer K, Vogeley K, Linden DE (2009) Anatomical brain connectivity and positive symptoms of schizophrenia: A diffusion tensor imaging study. Psychiatry Res,174: 9-16
Gaiser T, Becker MR, Habel A, Reuss DE, Ehemann V, Rami A, Siegelin MD. (2008) TRAIL-mediated apoptosis in malignant glioma cells is augmented by celecoxib through proteasomal degradation of survivin. Neurosci Lett 442: 109-113
Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS, Baba M, Baehrecke EH, Bahr BA, Ballabio A, Bamber BA, Bassham DC, Bergamini E, Bi X, Biard-Piechaczyk M, Blum JS, Bredesen DE, Brodsky JL, Brumell JH, Brunk UT, Bursch W, Camougrand N, Cebollero E, Cecconi F, Chen Y, Chin LS, Choi A, Chu CT, Chung J, Clarke PG, Clark RS, Clarke SG, Clave C, Cleveland JL, Codogno P, Colombo MI, Coto-Montes A, Cregg JM, Cuervo AM, Debnath J, Demarchi F, Dennis PB, Dennis PA, Deretic V, Devenish RJ, Di Sano F, Dice JF, Difiglia M, Dinesh-Kumar S, Distelhorst CW, Djavaheri-Mergny M, Dorsey FC, Droge W, Dron M, Dunn WA, Jr., Duszenko M, Eissa NT, Elazar Z, Esclatine A, Eskelinen EL, Fesus L, Finley KD, Fuentes JM, Fueyo J, Fujisaki K, Galliot B, Gao FB, Gewirtz DA, Gibson SB, Gohla A, Goldberg AL, Gonzalez R, Gonzalez-Estevez C, Gorski S, Gottlieb RA, Haussinger D, He YW, Heidenreich K, Hill JA, Hoyer-Hansen M, Hu X, Huang WP, Iwasaki A, Jaattela M, Jackson WT, Jiang X, Jin S, Johansen T, Jung JU, Kadowaki M, Kang C, Kelekar A, Kessel DH, Kiel JA, Kim HP, Kimchi A, Kinsella TJ, Kiselyov K, Kitamoto K, Knecht E, Komatsu M, Kominami E, Kondo S, Kovacs AL, Kroemer G, Kuan CY, Kumar R, Kundu M, Landry J, Laporte M, Le W, Lei HY, Lenardo MJ, Levine B, Lieberman A, Lim KL, Lin FC, Liou W, Liu LF, Lopez-Berestein G, Lopez-Otin C, Lu B, Macleod KF, Malorni W, Martinet W, Matsuoka K, Mautner J, Meijer AJ, Melendez A, Michels P, Miotto G, Mistiaen WP, Mizushima N, Mograbi B, Monastyrska I, Moore MN, Moreira PI, Moriyasu Y, Motyl T, Munz C, Murphy LO, Naqvi NI, Neufeld TP, Nishino I, Nixon RA, Noda T, Nurnberg B, Ogawa M, Oleinick NL, Olsen LJ, Ozpolat B, Paglin S, Palmer GE, Papassideri I, Parkes M, Perlmutter DH, Perry G, Piacentini M, Pinkas-Kramarski R, Prescott M, Proikas-Cezanne T, Raben N, Rami A, Reggiori F, Rohrer B, Rubinsztein DC, Ryan KM, Sadoshima J, Sakagami H, Sakai Y, Sandri M, Sasakawa C, Sass M, Schneider C, Seglen PO, Seleverstov O, Settleman J, Shacka JJ, Shapiro IM, Sibirny A, Silva-Zacarin EC, Simon HU, Simone C, Simonsen A, Smith MA, Spanel-Borowski K, Srinivas V, Steeves M, Stenmark H, Stromhaug PE, Subauste CS, Sugimoto S, Sulzer D, Suzuki T, Swanson MS, Tabas I, Takeshita F, Talbot NJ, Talloczy Z, Tanaka K, Tanaka K, Tanida I, Taylor GS, Taylor JP, Terman A, Tettamanti G, Thompson CB, Thumm M, Tolkovsky AM, Tooze SA, Truant R, Tumanovska LV, Uchiyama Y, Ueno T, Uzcategui NL, van dK, I, Vaquero EC, Vellai T, Vogel MW, Wang HG, Webster P, Wiley JW, Xi Z, Xiao G, Yahalom J, Yang JM, Yap G, Yin XM, Yoshimori T, Yu L, Yue Z, Yuzaki M, Zabirnyk O, Zheng X, Zhu X, Deter RL (2008) Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy, 4: 151-175
Rami A, Bechmann I, Stehle JH (2008) Exploiting endogenous anti-apoptotic proteins for novel therapeutic strategies in cerebral ischemia. Prog Neurobiol, 85: 273-296
Rami A, Kögel D (2008) Apoptosis meets autophagy-like cell death in the ischemic penumbra:Two sides of the same coin? Autophagy 4: 1-5
Rami A, Langhagen A, Steiger S (2008) Focal cerebral ischemia induces up-regulation of Beclin 1 and autophagy-like cell death. Neurobiology of Disease 29: 132-41
Rami A (2008) Upregulation of Beclin 1 in the ischemic penumbra. Autophagy 4: 227-229
Spahn A, Blondeau N, Heurteaux C, Dehghani F, Rami A (2008) Concomitant transitory up-regulation of X-linked inhibitor of apoptosis protein (XIAP) and the heterogeneous nuclear ribonucleoprotein C1-C2 in surviving cells during neuronal apoptosis. Neurochemical Research 33: 1859-1868
Althaus J, Siegelin MD, Dehghani F, Cilenti L, Zervos AS, Rami A (2007) The serine protease Omi/HtrA2 is involved in XIAP cleavage and in neuronal cell death following focal cerebral ischemia/reperfusion. Neurochem Int 50: 172-180
Rami A, Agarwal R, Spahn A (2007) Synergetic Effects of Caspase 3 and mu-Calpain in XIAP-Breakdown upon Focal Cerebral Ischemia. Neurochem Res 32: 2072-2079
Althaus J, Bernaudin M, Petit E, Toutain J, Touzani O, Rami A (2006) Expression of the gene encoding the pro-apoptotic BNIP3 protein and stimulation of hypoxia-inducible factor-1alpha (HIF-1alpha) protein following focal cerebral ischemia in rats. Neurochemistry International 48: 687-695
2000 - 2005
Siegelin M, Touzani O, Toutain J, Liston P, Rami A (2005) Induction and redistribution of the XAF1, antagonist of XIAP in the rat brain after transient Focal ischemia. Neurobiology of Disease 20: 509-518
Zekri L, Chebli K, Tourrière H, Nielsen FC, Hansen TV, Itier JM, Tremp G, Rami A, Tazi J (2005) Control of foetal growth and neonatal survival by the RasGAP Associated Endoribonuclease G3BP. Molecular Cell Biology 25: 8703-8716
Kahles T, Foerch C, Sitzer M, Schroeter M, Steinmetz H, Rami A, Neumann-Haefelin T (2005) Tissue plasminogen activator – mediated blood-brain-barrier damage in transient focal cerebral ischemia in rats: Relevance of interactions between thrombotic material and thrombolytic agent. Vascular Pharmacology 43: 254-259 IF: 2.6
König HG, Kögel D, Rami A, Prehn JHM (2005) TGF-ß1 activates two distinct type I receptors in neurons: implications for neuronal NF-kB signaling. Journal of Cell Biology 168: 1077-1086
Siegelin MD, Kossatz LS, Winckler J, Rami A (2005) Regulation of XIAP and Smac/DIABLO in the rat hippocampus following transient forebrain ischemia. Neurochemistry International 46: 41-51
Thees S, Hubbard GB, Winckler J, Schultz C, Rami A (2005) Specific alteration of the Bax/Bcl2 ratio and cytochrome c without execution of apoptosis in the hippocampus of aged baboons. Restorative Neurology and Neuroscience 23: 1-9
Rami A. Calpain and caspase in cerebral ischemia and neuronal apoptosis (2003) the “calpain-calpastatin-caspase-hypothesis” Neurobiology of Disease 13: 75-88
Rami A, T. Volkmann, R. Agarwal, S. Schoninger, F. Nürnberger, TC Saido , J. Winckler (2003) ß2-adrenergic receptor responsiveness of the calpain-calpastatin system and attenuation of neuronal death in rat hippocampus after transient global ischemia. Neuroscience Research 47: 373-82
Agarwal R and Rami A (2003) Redistribution of glucose-6-phosphate dehydrogenase in response to cerebral ischemia in rat brain.Indian Journal of ClinicalBiochemistry 18: 64-70
Reinmetz C, Kögel D, Rami A, Chittenden T, and Prehn JHM (2003) “Gene Expression during ER Stress-Induced Apoptosis in Neurons: Induction of the BH3-Only Protein Bbc3/PUMA and Activation of the Mitochondrial Apoptosis Pathway“ Journal of Cell Biology“ 162: 587-597
Rami A, Jansen J, Giesser I, Winckler J (2003) Post-ischemic activation of caspase-3 in the rat hippocampus: Evidence of an axonal and dendritic localisation. Neurochemistry International 43: 211-223
Rami A, Sims J, Botez G, Winckler J (2003) Spatial resolution of phospholipid scramblase 1 (PLSCR1), caspase-3 activation and DNA-fragmentation in the human hippocampus after cerebral ischemia. Neurochemistry International 43: 79-87
Rami A. Calpain and caspase in cerebral ischemia and neuronal apoptosis (2003) the “calpain-calpastatin-caspase-hypothesis” Neurobiology of Disease 13: 75-88
Agarwal R and Rami A (2002) istochemical localisation of glucose-6- Phosphate dehydrogenase activity in rat brain. Indian Journal of Medical Biochemistry 6: 19-23
Botez G and Rami A (2001) Immunoreactivity for bcl-2 and c-jun/AP1 in hippocampal corpora amylacea after ischaemia in human. Neuropathology and Applied Neurobiology 27: 474-480
Rami A, Volkmann T, Winckler J (2001) Effective reduction of neuronal death by inhibiting gap junctional intercellular communication in a rodent model of global transient cerebral ischemia. Experimental Neurology 170: 297-304
Rami A, R. Agarwal, G. Botez and J. Winckler (2000) µ-Calpain Activation, DNA-Fragmentation, and synergistic effects of caspase- and calpain-inhibitors in protecting hippocampal neurons from ischemic damage. Brain Reserach 866: 299-312
Zhu Y, Roth-Eichhorn S, Braun N, Culmsee C, Rami A, Krieglstein J. (2000) The expression of transforming growth factor-beta1 (TGF-beta1) in hippocampal neurons: a temporary upregulated protein level after transient forebrain ischemia in the rat. Brain Reserach 866: 286-98
1986 - 1999
Rami A and Krieglstein J (1998) Scopolamine rescues hippocampal neurons from glutamate neurotoxicity. Brain Research 788: 323-326
Rami A, Rabié and Winckler J (1998) Synergy between chronic corticosterone treatment and cerebral ischemia in producing damage in non-calbindinergic neurons. Experimental Neurology 149: 439-446
Rami A, Ausmeier F, Krieglstein J, and Winckler J (1997) Differential effects of scopolamine on neuronal survival in cerebral ischemia and glutamate-induced neurotoxicity: Relationships to the excessive vulnerability of the dorsoseptal hippocampus. Journal of Chemical Neuroanatomy 13: 201-208
Rami A, Ferger D, and Kreiglstein J (1997) Blocakde of proteolytic activity rescues neurons from glutamate excitotoxicity. Neuroscience Research 27: 93-97
Semkova I, Schilling M, Henrich-Noack P, Rami A, and Krieglstein J (1996) Clenbuterol protects mouse cerebral cortex and rat hippocampus from ischemic damage and attenuates glutamate neurotoxicity in cultured hippocampal neurons by induction of NGF. Brain Research 717: 44-54
Rami A and Krieglstein J (1994) Neuronal protective effects of calcium antagonists in cerebral ischemia. Life Science 55: 2205-2113
Rami A and Krieglstein J (1993) Protective effects of calpain inhibitors against neuronal damage caused by cytotoxic hypoxia in vitro and ischemia in vivo. Brain Research 609: 67-70
Nikolov R, Rami A, and Krieglstein J (1993) Endothelin-1 exacerbates focal cerebral ischemia without exerting neurotoxic action in vitro. European Journal of Pharmacology 248: 205-208
Rami A and Krieglstein J (1993) Brain damage caused by ischemia: pathophysiological and pahrmacological aspects. Dementia 4: 21-31
Rischke R, Rami A, Bachmann U, Rabié A, and Krieglstein J (1992) Activated astrocytes, but not pyramidal cells, increase glucose utilization in rat hippocampal CA1 subfield after ischemia. Pharmacology 45: 142-153
Rami A and Krieglstein J (1992) Thyroxine attenuates hippocampal neuronal damage caused by ischemia in the rat. Life Science 50: 645-650
Rami A, Rabié A, Thomasset M, and Krieglstein J (1992) Calbindin-D28k and ischemic damage of pyramidal cells in rat hippocampus. Journal of Neuroscience Research 31: 89-95
Faivre-Sarrailh C, Rami A, Fages C, and Tardy M (1991) Effect of thyroid deficiency on glial fibrillary acidic protein (GFAP) and GFAP-mRNA in the cerebellum and hippocampal formation of the developing rat. Glia 4: 276-284
Rami A and Rabié A (1990) Delayed synaptogenesis in the dentate gyrus of the thyroid-deficient developing rat. Developmental Neuroscience 12: 398-405
Rami A, Barberis C, and Clos J (1989) Effects of hypothyroidism on high affinity vasopressin binding sites in developing hippocamapal synaptosomes. Synapse 3: 200-204
Rami A, Clos J, and Rabié A (1989) Time course of hippocampal cholinergic innervation in the developing hypothyroid rat. A combined histochemical and biochemical study of acetylcholinesterase activity. International Journal of Developmental Neuroscience 7: 301-308
Rami A, Lomri N, Bréhier T, Thomasset M, and Rabié A (1989) Effects of altered thyroid states and undernutrition on the calbindin-D 28k content of the hippocampal formation in the developing rat. Brain Research 485: 20-28
Rami A and Rabié A (1987) Effects of thyroid deficiency on the development of glia in the hippocampal formation of the rat: an imminocytochemical study. Glia 1: 337-345
Rami A, Bréhier, Thomasset M, and Rabié A (1987) Cholecalcin (28 kDa calcium-binding protein) in the rat hippocampus: development in normal animals and in altered thyroid states. An immunocytochemical study. Developmental Biology 124: 228-238
Rami A, Brehier A, Thomasset M, Rabie A (1987) The comparative immunocytochemical distribution of 28 kDa cholecalcin (CaBP) in the hippocampus of rat, guinea pig and hedgehog. Brain Research 422:149-153
Rami A, Rabié A, and Patel AJ (1986) Thyroid hormone and development of the rat hippocampus: cell acquisition in the dentate gyrus. Neuroscience 19: 1207-1216
Rami A, Patel AJ, and Rabié A (1986) Thyroid hormone and development of the hippocampus: Morphological alterations in granule and pyramidal cells. Neuroscience 19: 1217-1226
Artikel und Bücher
Buchartikel
Rami A, Winckler J, and Rabié A (1997) Corticosterone Upregulates hippocampal Calbindin-D28K in region specific manner and Exacerbates Ischemic Damage exclusively in non-calbindinergic neurons. Neuroendocrinology-Retrospect and Perspectives. Korf-Usadel, Eds. pp 193-205
Semkova I, Rami A, and Krieglstein J (1994) Neuroprotective activity of clenbuterol against excitotoxic neuronal damage. In: Pharmacology of Cerebral Ischemia (Hrsg. J. Krieglstein and H. Oberpichler-Schwenk), Wiss Verlagges, Stuttgart, pp 397-406
Rami A and Krieglstein J (1993) Inhibition of proteolysis prevents neuronal damage caused by cytotoxic hypoxia or ischemia. In: Pharmacology of Cerebral Ischemia (Hrsg. J. Krieglstein and H. Oberpichler), Wiss Verlagsges, Stuttgart, pp 301-307
Rami A, Rabié A, Thomasset M, and Krieglstein J (1990) Calbindin-D28k and delayed neuronal death in the rat hippocampus after cerebral ischemia. In: Pharmacology of Cerebral Ischemia (Hrsg. J. Krieglstein, H. Oberpichler), Wiss Verlagsges-Stuttgart, pp 123-128
Rischke R, Rami A, Bachmann U, Rabié A, and Krieglstein J (1990) Different vulnerability to ischemia of pre- and postsynaptic terminals in rat hippocampus. In: Pharmacology of Cerebral Ischemia (Hrsg. J. Krieglstein, H. Oberpichler), Wiss. Verlagsges. Stuttgart, pp 129-13
Rami A, Rabié A, Thomasset M, and Krieglstein J (1990) Calbindin-D28k and delayed neuronal death in the rat hippocampus after cerebral ischemia. In: Pharmacology of Cerebral Ischemia (Hrsg. J. Krieglstein, H. Oberpichler), Wiss. Verlagsges. Stuttgart, pp 123-128