Eukaryotic cells rely on specialized organelles to perform essential tasks, with each organelle exhibiting a unique architecture precisely adapted to its function. Among these, mitochondria and the endoplasmic reticulum (ER) play central roles in lipid synthesis, energy production, and the regulation of cellular metabolism. Our research aims to uncover how the architecture of these organelles is maintained and dynamically remodeled. A particular focus lies on contact sites—specialized membrane regions where two organelles closely interact to coordinate lipid metabolism and energy homeostasis.

We use live-cell super-resolution microscopy to visualize subcellular structures and organelle dynamics beyond the diffraction limit. By integrating advanced imaging techniques with biochemical and molecular approaches, we investigate the mechanisms that govern organelle communication and metabolic coordination.

Through this interdisciplinary approach, we aim to address fundamental questions in cell biology: How does organelle architecture emerge? What regulates ER–mitochondria interactions? And how do these processes shape lipid metabolism and support cellular adaptation?