We offer complex 3D human in vitro models of different organ systems, including the intestine, the lung, the skin as well as the blood-brain barrier. The models can be employed for a wide range of scientific research questions, such as permeation, biocompatibility or immunogenicity testing. Based on the adaptable composition, we can simulate physiological and pathophysiological conditions, emulating inflamed or infected tissues, or incorporating immune cells to study, e.g., wound healing. Besides using bio-relevant culture media and culture substrates simulating the in vivo extracellular matrix, we deploy microfluidic organ-on-a-chip tissue models for specific research questions. Down-stream analyses of single cells or the whole multicellular 3D tissue models, including different microscopy techniques (label-free Raman, confocal laser scanning, as well as electron microscopy) and molecular biological assays (e.g. ELISA, RTq-PCR) allow for further in-depth characterization of the in vitro models.
Technical Specifications
Cell Culture
- Primary human cells and human cell lines
- Co-culture systems
- Immunocompetent and wound healing models
- Infection and Inflammation models
- Microfluidic-based models
Instrumentation
- Imaging and molecular analyses
- Nanoindentation
- Aerosol deposition
- Impedance spectroscopy
Responsible: Dr. Maike Windbergs