The human body is made up of trillions of functionally specialized cells. Each cell is densely packed with molecules that carry out biochemical reactions, convert energy, transmit signals or enable cells to move on demand. We want to understand the choreography in which molecules self-organize to conduct complex cellular functions.

The SCALE consortium bridges diverse technological expertise from cell biology, biophysics, molecular biology, neurobiology, chemistry, bioinformatics and mathematics. They will develop radically novel experimental techniques to map and to simulate the interior of cells, and to predict their behavior. This research will provide important new insights into bacterial resistance, inflammation, neurodegenerative diseases and immune defense.


Field of Research: Subcellular architecture and cell bihaviour

Department: Biosciences, Cell Biology and Neuroscience

Principal Investigator, Speaker : Prof. Dr. Jasmin Hefendehl


Website Hefendehl Lab

SCALE Website

Spring: April/May-September (latest)
Summer: June-September (latest)
Winter: October-March (latest

Project Description

How cell-cell interfaces remodel their barrier function at different environmental conditions?

We will solve the ultrastructure of intact and malfunctioning cell-cell junctions to understand their assembly and impact on neurodegenerative disease.


Not specified.