Medizin
Fachbereich 16

Persönliche Daten Harald von Melchner, MD, PhD Kronstadt/Romania 27.03.1951, married, 2 children     eMail: melchner@em.uni-frankfurt.de

Letzte berufliche Funktion

• 03.1992 - 04.2017 Department Head and Professor for Cell Biology and Molecular Genetics, Department of Molecular Hematology, University of Frankfurt Medical School

Curriculum vitae

• Medical education: 1969-1975 , University of Cluj Medical School/Cluj, Romania
• MD: 09.1975, University of Cluj Medical School, Cluj/Romania
• Intern: 1974-1976, Internal Medicine, University Hospital/Cluj, Romania
• Resident: 1976-1979, West German Cancer Center, University of Essen Medical School/Essen, Germany
• Science education: 1979-1982, Cancer Research Unit, The Walter and Eliza Hall Institute of Medical
• Research, Melbourne, Australia (thesis advisor: Prof. Donald.Metcalf)
• PhD: 10.1983, University of Melbourne/Australia.
• Group leader: 1982-1985, Laboratory for Experimental Hematology, West German Cancer Center, University of Essen Medical School, Essen/Germany.
• Visiting scientist: 1985-1992, Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, U.S.A in the Laboratories of Profs. David Housman and H. Earl Ruley
• "Habilitation" for Experimental Oncology: 1987, West German Cancer Center, University of Essen (Prof. C.G. Schmidt)

Forschungsschwerpunkte

• Expertise: molecular and cellular biology, genetics, gene therapy, experimental hematology, mouse mutagenesis, embryonic stem cells, virology, developmental biology.

Literaturauswahl

• Mutant non-coding RNA resource in mouse embryonic stem cells 

  Jens Hansen, Harald von Melchner, Wolfgang Wurst. Dis Models Mech 14:dmm047803
• High Efficiency Gene Correction in Hematopoietic Cells by Donor-Template-Free CRISPR/Cas9 Genome Editing Duran Sürün, Joachim Schwäble, Ana Tomasovic, Roy Ehling, Stefan Stein, Nina Kurrle, Harald von Melchner, Frank Schnütgen. Mol Therap Nucleic Acids 10:1-8, 2018.
• Resources for proteomics in mouse embryonic stem cells Frank Schnütgen, Franziska Ehrmann, Ina Poser, Nina C Hubner, Jens Hansen, Thomas Floss, Ingrid deVries, Wolfgang Wurst, Anthony Hyman, Matthias Mann, Harald von Melchner. Nat Methods 8:103-104, 2011
• Enhanced gene trapping in mouse embryonic stem cells Frank Schnütgen, Jens Hansen, Silke De-Zolt, Carsten Horn, Marcus Lutz, Thomas Floss, Wolfgang Wurst, Patricia Ruiz Noppinger, Harald von Melchner. Nucleic Acids Res 36:e133, 2008
• Splinkerette PCR for more efficient characterization of gene trap eventsCarsten Horn, Jens Hansen, Frank Schnütgen, Claudia Seisenberger, Thomas Floss, Markus Irgang, Silke De-Zolt, Wolfgang Wurst, Harald von Melchner, Patricia Ruiz Noppinger. Nat Genet 39:933-934, 2007
• Genomewide production of multipurpose alleles for the functional analysis of the mouse genome Frank Schnütgen, Silke De-Zolt, Petra Van Sloun, Melanie Hollatz, Thomas Floss, Jens Hansen, Joachim Altschmied, Claudia Seisenberger, Norbert B Ghyselinck, Patricia Ruiz, Pierre Chambon, Wolfgang Wurst, Harald von Melchner. Proc Natl Acad Sci USA 102:7221-7226
• Disruption of the gene encoding the latent transforming growth factor-β binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer Anja Sterner-Kock, Irmgard S Thorey, Katri Koli, Frank Wempe, Jürgen Otte, Thorsten Bangsow, Katharina Kuhlmeier, Thomas Kirchner, Shenchu Jin, Jorma Keski-Oja, Harald von Melchner. Genes Dev 16:2264-2273 
• (86 Publications, see https://www.ncbi.nlm.nih.gov/pubmed (von Melchner)

Weitere Interessen

• Memberships: German National Network for Genome Research (NGFN and NGFNplus), European Conditional Mouse Mutagenesis (EUCOMM) consortium, International Mouse Knock-out Consortium (IKMC), International Gene Trap Consortium (IGTC).

• Pharma industry co-operations: ASTA-Medica/Degussa, Schering AG, TachonicArtemis GmbH, Bionaut Pharmaceuticals, Co-founder of FrankGen Biotechnologie AG and Maingen Biotechnologie GmbH
• Patents: 17 (see https://worldwide.espacenet.com/searchResults?ST=singleline&locale=en_EP&submitted=true&DB=&query=von+Melchner)