Our group applies quantitative MRI (qMRI) techniques in patients with Multiple Sclerosis (MS) to take insight into microstructural changes in tissues outside of MS lesions which appear normal on conventional MRI. We could demonstrate that cortical T1 prolongation and PD increase are present in early MS stages, reflecting changes in cortical architecture (Gracien et al., Eur Rad, 2016). Another study characterized cortical pathology by applying a multi-parametric qMRI protocol including T1, proton density (PD) and magnetization transfer ratio (MTR) mapping in an RRMS patient group, which covered a broad range of disability severity and disease duration, and revealed a relationship between cortical T1 relaxation time and the clinical status (Gracien et al., JMRI, 2016). We quantified cortical demyelination at early MS stages with T2 relaxometry, providing a method for cortical assessment as an alternative to the technically more difficult T1 and PD mapping (Gracien et al., NMR Biomed, 2016). A study assessing WM pathology has shown tissue remodeling in accordance with inflammatory activity (Reitz et al., Brain Imaging Behav., 2016). In secondary progressive MS (SPMS) global neurodegeneration gains significance which can be hardly quantified with conventional MRI. We demonstrated that qMRI methods are promising candidates for the assessment of neurodegeneration in relationship to the degree of disability in SPMS (Gracien et al., Plos One, 2016). Furthermore it could be shown that a new method for PD mapping in MS which utilizes T1 mapping and the so called Fatouros equation for the estimation of the receive coil sensitivity profile provides more reliable results than the standard method especially in peripheral brain regions (Gracien et al., Magma, 2016).