"SPIELE"  - Stochastic Processes in EvoLution and Ecology

An international seminar organized by members of the probability groups in

Bath - Berlin - Frankfurt - Mainz - Warwick

Our aim is to provide a forum, in particular for early career researchers, but also senior scientists, to share and discuss their recent research in stochastic processes in evolution and ecology, and to build networks with researchers at other institutions (and potentially across disciplines).

Talks (online or in hybrid format - link available from the organizers)

03/07/23 4 pm CET (c.t.)

Vianney Brouard (Lyon)

"Genetic composition of supercritical branching populations under rare mutation rates"

Better understanding the genetic diversity within tumors is of key interest for clinicians to propose adaptive strategies. I will present a probabilistic model of tumorogenesis to provide quantitative results over time on the genetic diversity.
The trait space is modelled using a finite oriented graph. The population of cells follows a continuous time branching process. The  biological phenomenon taken into account are cell death and cell division. During each division event each daughter cell mutates, independently from each other, to another trait (using the edges of  the graph) with a certain probability.
The classical regime of « large population and rare mutation » is considered. It means that a parameter $n \in \mathbb{N}$ is used to  quantify both the decrease of the mutation probabilities, as negative powers of $n$, and also the typical size of the population, depending on $n$ as positive power of $n$, at which we are interested in  understanding the genetic composition.  The results are on the  asymptotic sizes of the subpopulations of cells. Notably, the behaviour of mutant cells will depend on whether the mutation is deleterious, neutral or selective.

Dr. Vianney Brouard: Genetic composition of supercritical branching populations under rare mutation rates

12/06/23 4 pm CET (c.t.)

Shubhamoy Nandan (Leiden)

"Spatial populations with seed banks in random environment"

This talk will focus on a spatially structured interacting Moran model with seed banks in random environment. The population sizes are sampled from a translation-invariant, ergodic, uniformly elliptic field that constitutes the static random environment of the model. Under mild assumptions on the model parameters, we identify the domain of attraction of each mono-type equilibrium and establish convergence to (mono-type) equilibrium for a large class of intitally consistent type-distribution. Our result shows that, for a.s. realisation of the population sizes, the fixation probability of the entire population to a single genotype homogenizes in the long run and crucially depends on the average relative seed-bank strength in the populations

Dr S. Nandan: Spatial populations with seed banks in random evironment

22/05/23 4 pm CET (c.t.)

Frederic Alberti (JGU Mainz)

"Loose linkage in the ancestral recombination graph"

Understanding the interplay between recombination and resampling is a significant challenge in mathematical population genetics and of great practical relevance. Asymptotic results about the distribution of samples when recombination is strong compared to resampling are often based on the approximate solution of certain recursions, which is technically hard and offers little conceptual insight. We generalise an elegant probabilistic argument, based on the coupling of ancestral processes but so far only available in the case of two sites, to the multilocus setting. This offers an alternative route to, and slightly generalises, a classical result of Bhaskar and Song.

24/04/23 4 pm CET (c.t.)

Jere Koskela (University of Warwick)

"Multiple merger coalescent model selection for whole genome cod data"

Multiple merger coalescents (MMCs) have long been suggested as appropriate models for the genetic diversity of organisms with skewed offspring distributions, such as many marine and microbial species. They predict an excess of low frequency mutations relative to the Kingman coalescent, similarly to other phenomena such as historical population growth. However, their predictions for the full site frequency spectrum differ from the Kingman coalescent even under fairly arbitrary demographic scenarios. I will describe joint work with Einar Arnason, Katrin Halldorsdottir, and Bjarki Eldon, in which we assessed the extent to which several prominent MMC families were able to explain the genetic diversity of cod populations sampled around Iceland. The Kingman coalescent provides a poor fit even under non-parametric, best-fit demographies or simple models of population structure. More surprisingly, so does the Beta-coalescent, which has often been seen as a natural candidate model for skewed offspring reproduction. Instead, an MMC model by Durrett & Schweinsberg for recurrent selective sweeps provides a remarkably good fit only a few free parameters. Our results are informative of possible mechanisms giving rise to the skewed and shallow genealogies observed among cod.

15/02/23 16.00 c.t. (jointly with Stochastik Kolloquium GU Frankfurt)

Charline Smadi (Université de Grenoble)

"Quasi-equilibria and click times for a variant of Muller's ratchet"

Abstract: We will introduce and study a variant of a well-known model in population genetics, namley Muller's ratchet, which is seen as one explanation of the ubiquity of sexual selection in Nature. Consider a population of N individuals, each of them carrying a type in N_0. The population evolves according to a Moran dynamics with selection and mutation, where an individual of type k has the same selective advantage over all individuals with type k′>k, and type k mutates to type k+1 at a constant rate (in the classical Muller's ratchet, the selective advantage is proportional to k′−k). For a regime of selection strength and mutation rates which is between the regimes of weak and strong selection/mutation, we obtain the asymptotic rate of the click times of the ratchet (i.e. the times at which the hitherto minimal (`best') type in the population is lost), and reveal the quasi-stationary type frequency profile between clicks. The large population limit of this profile is characterized as the normalized attractor of a ``dual'' hierarchical multitype logistic system. An important role in the proofs is played by a graphical representation of the model, both forward and backward in time, and a central tool is the ancestral selection graph decorated by mutations.
Charline Smadi "Quasi-equilibria and click times for a variant of Muller's ratchet"

23/01/23 16:00 c.t.

Paul Jenkins (University of Warwick)

“Estimating recombination by observing the diffusion of haplotype frequencies"

Abstract: Recombination is a fundamental evolutionary force, but it is difficult to quantify because the effect of a recombination event on patterns of variation in a sample of genetic data can be hard to discern. Estimators for the recombination rate, which are usually based on the idea of integrating over the unobserved possible evolutionary histories of a sample, can therefore be noisy. Here we consider a related question: how would an estimator behave if the evolutionary history actually was observed? This would offer an upper bound on the performance of estimators used in practice. I will derive an expression for the maximum likelihood estimator for the recombination rate based on a continuously observed, multi-locus, Wright-Fisher diffusion of haplotype frequencies, complementing existing work for an estimator of selection. The estimator has unusual properties because the observed information matrix can explode in finite time whereupon the recombination parameter is learned without error. We also show that the recombination estimator is robust to the presence of selection in the sense that incorporating selection into the model leaves the estimator unchanged. This is joint work with Bob Griffiths (Monash).

Paul Jenkins "Estimating recombination by observing the diffusion of haplotype frequencies"

19/12/22 16:00 c.t.

Marco Seiler (Goethe Universität Frankfurt)

“The contact process in an evolving random environment"

Recently, there has been an increasing interest in interacting particle systems on evolving random graphs, respectively in time evolving random environments. We are particularly interested in the contact process in an evolving (edge) random environment on (infinite) connected and transitive graphs. We assume that the evolving random environment is described by an autonomous ergodic spin systems with  finite range,  for example by  dynamical percolation.  This background process  determines which edges are open or closed for infections.

In particular, we discuss the phase transition of survival and the dependence of the associated critical infection rate on the random environment and on the initial configuration of the system. For the latter, we state sufficient conditions such that the initial configuration of the system has no influence on the phase transition between extinction and survival. We show that this phase transition coincides with the phase transition between ergodicity and non-ergodicity and discuss conditions for complete convergence. At the end of the talk we consider the special case of a contact process on dynamical percolation as an application.

This talk is based on joint work with Anja Sturm.

Marco Seiler "The contact Process in an evolving random enviroment"

28/11/22, 16:00. c.t.

Marta Dai Pra (Humboldt-Universität zu Berlin)

“The effects of migration in a population model with bottlenecks"

Organisms having a genealogy not well described by the Kingman coalescent are not rare. One example is the Atlantic cod which presents shallow genealogies and high-variance offspring number that might rather be described by a multiple merger coalescent. The aim of our work is then to find a realistic individual-based model fitting these data.

We focus on spatially structured populations undergoing localized, recurrent bottlenecks, and describe their ancestral lines. We start by presenting an individual based model introduced by González Casanova, Miró Pina, Siri-Jégousse (2022) whose genealogy is described by a Xi-coalescent known as the symmetric coalescent. We then introduce migration in this setting: we construct a multiple-island model and see how this structure affects the coalescent process. Depending on the severity and the length of the bottlenecks we derive as scaling limits different structured Xi-coalescents featuring simultaneous multiple mergers and migrations. This talk is based on ongoing work with Alison Etheridge, Jere Koskela and Maite Wilke Berenguer.

Marta Dai Pra "The effects of migration in a population model with bottlenecks"

07/11/22, 16:00 c.t.

Tobias Paul (Humboldt-Universität zu Berlin)

"The impact of dormancy on evolutionary branching"

Dormancy mechanisms allowing individuals to enter and exit a protected state of reduced metabolic activity are ubiquituous in nature. Hence, we aim to understand the consequences of dormancy on evolutionary and ecological properties of microbial populations. In this talk, we will consider a stochastic individual-based model as proposed by Champagnat and Méléard (2011) where we incorporate competition-induced dormancy. To study the behaviour of the population over time, we derive the Polymorphic Evolution Sequence and the Canonical Equation of Adaptive Dynamics (CEAD) as scaling limits of the model. At the equilibria of the CEAD we may observe evolutionary branching, which describes the splitting of a population into distinct traits and may hence be understood as speciation. We will show a general criterion for evolutionary branching and demonstrate the effect of dormancy in a specific model. Using our mathematical tools and simulations, we also see an impact of dormancy on subsequent branchings, the speed of adaptation, species diversity and niche width. This is joint work with Jochen Blath, András Tóbiás and Maite Wilke Berenguer.

Tobias Paul "The impact of dormancy on evolutionary branching"