René Blöcher

M. Sc. Chemistry


Areas of interest

Design, synthesis and pharmacological profiling of novel potential drugs. Current project deals with dual modulators of the soluble epoxide hydrolase and peroxisome proliferator-activated receptors for treatment of the metabolic syndrome.


Conference contributions

Posters:

  • "Design, synthesis and pharmacological profiling of dual modulators of soluble Epoxide Hydrolase and Peroxisome Proliferator activated Receptors ", 3rd international Conference on Medicinal Chemistry & Computer Aided Drug Design, December 2014, San Francisco, USA o/s
  • "Dual Modulation of soluble Epoxide Hydrolase and Peroxisome Proliferator activated Receptors for treatment of the Metabolic Syndrome", Frontiers in Medicinal Chemistry, March 2014, Tübingen, Germany
  • "Design, synthesis and evaluation in vitro of dual modulators of soluble Epoxide Hydrolase and Peroxisome Proliferator activated Receptors", XVII Lipid Meeting, December 2013, Leipzig, Germany
  • "Design, synthesis and evaluation in vitro of dual modulators of soluble Epoxide Hydrolase and Peroxisome Proliferator activated Receptors", 5th International Symposium on Advances in Synthetic and Medicinal Chemistry, May 2013, Moscow, Russia
  • "Design, synthesis and evaluation in vitro of dual modulators of soluble Epoxide Hydrolase and Peroxisome Proliferator activated Receptors", 6th Summer School of Medicinal Chemistry, September 2012, Regensburg, Germany


Publications

  • Janosch Achenbach, Franca-Maria Klingler, René Blöcher, Daniel Moser, Ann-Kathrin Häfner, Carmen Rödl, Björn Krüger, Frank Löhr, Holger Stark, Bettina Hofmann, Dieter Steinhilber, Ewgenij Proschak, Exploring the chemical space of multi-target ligands using aligned self-organizing maps, ACS Med. Chem. Lett, 2013, 4 (12), 1169-1172.
  • René Blöcher, Estel•la Buscató, Christina Lamers, Franca-Maria Klingler, Steffen Hahn, Dieter Steinhilber, Manfred Schubert-Zsilavecz and Ewgenij Proschak, Design and synthesis of dual modulators of soluble epoxide hydrolase and peroxisome proliferator-activated receptors, J. Med. Chem., 2012, 55 (23), pp 10771-10775.
  • Mirka Verhoefen, Christian Bamann, René Blöcher, Ute Förster, Prof Ernst Bamberg, Prof Josef Wachtveitl, The photocycle of channelrhodopsin-2: ultrafast reaction dynamics and subsequent reaction steps, ChemPhysChem, 2010, 4 (14), pp 3113-3122