Franca Klingler

Dipl.-Chem.

ResearchGate: https://www.researchgate.net/profile/Franca-Maria_Klingler/



Areas of interest

  • Development of functional assays
  • Protein overexpression and purification
  • Fragment-based drug design
  • Molecular docking
  • Homology modelling
  • STD-NMR
  • 19F-NMR, 31P-NMR
  • Synthesis
  • HPLC


Conference contributions

Posters:

  • "Virtual Screening and in vitro Evaluation of Inhibitors for different Metallo-β-Lactamases", Drug Discovery Chemistry 2013, Munich, Germany
  • "Inhibitors of sEH phosphatase activity found by virtual, biophysical and biochemical screening", EFMC-ISMC 2012, Berlin, Germany
  • "Complementary Fragment Screening Techniques for the Development of Inhibitors of the Phosphatase Activity of Soluble Epoxide Hydrolase", CCG European User Group Meeting 2011, Barcelona, Spain


Publications

  • Janosch Achenbach, Franca-Maria Klingler, René Blöcher, Daniel Moser, Ann-Kathrin Häfner, Carmen B. Rödl, Simon Kretschmer, Björn Krüger, Frank Löhr, Holger Stark, Bettina Hofmann, Dieter Steinhilber, and Ewgenij Proschak. Exploring the Chemical Space of Multitarget Ligands Using Aligned Self-Organizing Maps, ACS Med. Chem. Lett. 2013, just accepted
  • Estel la Buscató, Dominik Büttner, Astrid Brüggerhoff, Franca-Maria Klingler, Julia Weber, Bastian Scholz, Aleksandra Zivkovic, Rolf Marschalek, Holger Stark, Dieter Steinhilber, Helge B. Bode, Ewgenij Proschak. From a Multipotent Stilbene to Soluble Epoxide Hydrolase Inhibitors with Antiproliferative Properties, ChemMedChem 2013, 8, 919-923
  • Karin Meirer, Carmen B Rödl, Joanna M Wisniewska, Sven George, Ann-Kathrin Häfner, Estel la Buscató, Franca-Maria Klingler, Steffen Hahn, Dirk Berressem, Sandra K Wittmann, Dieter Steinhilber, Bettina Hofmann, Ewgenij Proschak. Synthesis and Structure Activity Relationship Studies of Novel Dual Inhibitors of Soluble Epoxide Hydrolase and 5-Lipoxygenase, J. Med. Chem. 2013, 56, 1777-1781
  • Estel.la Buscato, René Blöcher, Christina Lamers, Franca-Maria Klingler, Steffen Hahn, Dieter Steinhilber, Manfred Schubert-Zsilavecz, Ewgenij Proschak. Design and Synthesis of Dual Modulators of Soluble Epoxide Hydrolase and Peroxisome Proliferator-Activated Receptors, J.Med.Chem., 2012, 55, 10771-10775
  • Daniel Moser, Janosch Achenbach, Franca-Maria Klingler, Estel·la Buscató, Steffen Hahn, and Ewgenij Proschak, Evaluation of structure-derived pharmacophore of soluble epoxide hydrolase inhibitors by virtual screening, Bioorg. Med. Chem. Lett., 2012, 22, 6762-6765.
  • Daniel Moser, Joanna M. Wisniewska, Steffen Hahn, Janosch Achenbach, Estel·la Buscató, Franca-Maria Klingler, Bettina Hofmann, Dieter Steinhilber and Ewgenij Proschak, Dual-target virtual screening by pharmacophore elucidation and molecular shape filtering, ACS Med. Chem. Lett, 2012, 3, 155–158.
  • Steffen Hahn and Janosch Achenbach, Estel·la Buscató, Franca-Maria Klingler, Mirjam Schroeder, Karin Meirer, Martina Hieke, Jan Heering, Eduardo Barbosa-Sicard, Frank Loehr, Ingrid Fleming, Volker Doetsch, Manfred Schubert-Zsilavecz, Dieter Steinhilber, Ewgenij Proschak, Complementary Screening Techniques Yielded Fragments that Inhibit the Phosphatase Activity of Soluble Epoxide Hydrolase, ChemMedChem, 2011, 6, 2146–2149.