Selected Publications

2020 2019 | 2018  |  2017  |  2016  |  2015  |  2014  |  2013  |  2012  |  2011  |  2010 and earlier


Oxygen-dependent asparagine hydroxylation of the ubiquitin-associated (UBA) domain in Cezanne regulates ubiquitin binding.
Mader J, Huber J, Bonn F, Doetsch V, Rogov VV, Bremm A.
J Biol Chem. 2020 Jan 14. pii: jbc.RA119.010315. doi: 10.1074/jbc.RA119.010315. [Epub ahead of print]
PMID: 31937588 [PubMed - as supplied by publisher]



Regulation of Phosphoribosyl-Linked Serine Ubiquitination by Deubiquitinases DupA and DupB.
Shin D, Mukherjee R, Liu Y, Gonzalez A, Bonn F, Liu Y, Rogov VV, Heinz M, Stolz A, Hummer G, Dötsch V, Luo ZQ, Bhogaraju S, Dikic I.
Mol Cell. 2019 Nov 5. pii: S1097-2765(19)30797-X. doi: 10.1016/j.molcel.2019.10.019. [Epub ahead of print]
PMID: 31732457 [PubMed - as supplied by publisher] Free Article


A TP63 mutation causes prominent alopecia with mild ectodermal dysplasia.A.
Duchatelet S, Russo C, Osterburg C, Mallet S, Bole-Feysot C, Nitschké P, Richard MA, Dötsch V, Missero C, Nassif A, Hovnanian A.
J Invest Dermatol. 2019 Nov 1. pii: S0022-202X(19)33376-7. doi: 10.1016/j.jid.2019.06.154. [Epub ahead of print] No abstract available.
PMID: 31682841 [PubMed - as supplied by publisher]


A Diversity of Selective Autophagy Receptors Determines the Specificity of the Autophagy Pathway.
Kirkin V, Rogov VV.
Mol Cell. 2019 Sep 21. pii: S1097-2765(19)30690-2. doi: 10.1016/j.molcel.2019.09.005. [Epub ahead of print] Review.
PMID: 31585693 [PubMed - as supplied by publisher]


TA*p63 and GTAp63 achieve tighter transcriptional regulation in quality control by converting an inhibitory element into an additional transactivation domain.
Pitzius S, Osterburg C, Gebel J, Tascher G, Schäfer B, Zhou H, Münch C, Dötsch V.
Cell Death Dis. 2019 Sep 17;10(10):686. doi: 10.1038/s41419-019-1936-z.
PMID: 31527723 [PubMed - in process]


Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites.
Holdgaard SG, Cianfanelli V, Pupo E, Lambrughi M, Lubas M, Nielsen JC, Eibes S, Maiani E, Harder LM, Wesch N, Foged MM, Maeda K, Nazio F, de la Ballina LR, Dötsch V, Brech A, Frankel LB, Jäättelä M, Locatelli F, Barisic M, Andersen JS, Bekker-Jensen S, Lund AH, Rogov VV, Papaleo E, Lanzetti L, De Zio D, Cecconi F.
Nat Commun. 2019 Sep 13;10(1):4176. doi: 10.1038/s41467-019-12094-9.
PMID: 31519908 [PubMed - in process] Free PMC Article

An atypical LIR motif within UBA5 (ubiquitin like modifier activating enzyme 5) interacts with GABARAP proteins and mediates membrane localization of UBA5
Huber J, Obata M, Gruber J, Akutsu M, Löhr F, Rogova N, Güntert P, Dikic I, Kirkin V, Komatsu M, Dötsch V, Rogov VV
Autophagy. 2019 Apr 16. doi: 10.1080/15548627.2019.1606637. [Epub ahead of print]
PMID: 30990354 [PubMed - as supplied by publisher]
Towards complete polypeptide backbone NH assignment via combinatorial labeling.
Löhr F, Gebel J, Henrich E, Hein C, Dötsch V.
J Magn Reson. 2019 Mar 29;302:50-63. doi: 10.1016/j.jmr.2019.03.010. [Epub ahead of print]
PMID: 30959416 [PubMed - as supplied by publisher]
Deletions and loss-of-function variants in TP63 associated with orofacial clefting.
Khandelwal KD, van den Boogaard MH, Mehrem SL, Gebel J, Fagerberg C, van Beusekom E, van Binsbergen E, Topaloglu O, Steehouwer M, Gilissen C, Ishorst N, van Rooij IALM, Roeleveld N, Christensen K, Schoenaers J, Bergé S, Murray JC, Hens G, Devriendt K, Ludwig KU, Mangold E, Hoischen A, Zhou H, Dötsch V, Carels CEL, van Bokhoven H.
Eur J Hum Genet. 2019 Mar 8. doi: 10.1038/s41431-019-0370-0. [Epub ahead of print] PMID: 30850703 [PubMed - as supplied by publisher]
Cell cycle arrest in mitosis promotes interferon-induced necroptosis.
Frank T, Tuppi M, Hugle M, Dötsch V, van Wijk SJL, Fulda S.
Cell Death Differ. 2019 Feb 11. doi: 10.1038/s41418-019-0298-5. [Epub ahead of print] PMID: 30742091 [PubMed - as supplied by publisher]
Synthetic Biology-Based Solution NMR Studies on Membrane Proteins in Lipid Environments.
Henrich E, Löhr F, Mezhyrova J, Laguerre A, Bernhard F, Dötsch V.
Methods Enzymol. 2019;614:143-185. doi: 10.1016/bs.mie.2018.08.019. Epub 2018 Dec 21.
PMID: 30611423


Structural and functional analysis of the GABARAP interaction motif (GIM).
Rogov VV, Stolz A, Ravichandran AC, Rios-Szwed DO, Suzuki H, Kniss A, Löhr F, Wakatsuki S, Dötsch V, Dikic I, Dobson RC, McEwan DG.
EMBO Rep. 2018 Dec;19(12). pii: e47268. doi: 10.15252/embr.201847268. No abstract available.
The soluble loop BC region guides, but not dictates, the assembly of the transmembrane cytochrome b6.
Tome-Stangl L, Schaetzel C, Tenzer S, Bernhard F, Schneider D.
PLoS One. 2017 Dec 14;12(12):e0189532. doi: 10.1371/journal.pone.0189532. eCollection 2017.
PMID: 29240839
Rat Organic Cation Transporter 1 Contains Three Binding Sites for Substrate 1-Methyl-4-phenylpyridinium per Monomer.
Keller T, Gorboulev V, Mueller T, Dotsch V, Bernhard F, Koepsell H.
Mol Pharmacol. 2018 Nov 8. pii: mol.118.113498. doi: 10.1124/mol.118.113498. [Epub ahead of print]
PMID: 30409791
Structural and functional insights into the interaction and targeting hub TMD0 of the polypeptide transporter TAPL.
Bock C, Löhr F, Tumulka F, Reichel K, Würz J, Hummer G, Schäfer L, Tampé R, Joseph B, Bernhard F, Dötsch V, Abele R.
Sci Rep. 2018 Oct 23;8(1):15662. doi: 10.1038/s41598-018-33841-w.
PMID: 30353140
  Molecular Determinants for Ligand Selectivity of the Cell-Free Synthesized Human Endothelin B Receptor.
Dong F, Rues RB, Kazemi S, Dötsch V, Bernhard F.
J Mol Biol. 2018 Oct 18. pii: S0022-2836(18)30556-4. doi: 10.1016/j.jmb.2018.10.006. [Epub ahead of print]
PMID: 30342934
  Lipid conversion by cell-free synthesized phospholipid methyltransferase Opi3 in defined nanodisc membranes supports in trans mechanism
. Henrich E, Lőhr F, Pawlik G, Peetz O, Dötsch V, Morgner N, Kroon AI, Bernhard F.
Biochemistry. 2018 Sep 18. doi: 10.1021/acs.biochem.8b00807. [Epub ahead of print]
PMID: 30226041
LILBID and nESI: Different Native Mass Spectrometry Techniques as Tools in Structural Biology.
Peetz O, Hellwig N, Henrich E, Mezhyrova J, Dötsch V, Bernhard F, Morgner N.
J Am Soc Mass Spectrom. 2018 Sep 17. doi: 10.1007/s13361-018-2061-4. [Epub ahead of print] PMID: 30225732
HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα
Di Rita A, Peschiaroli A, D Acunzo P, Strobbe D, Hu Z, Gruber J, Nygaard M, Lambrughi M, Melino G, Papaleo E, Dengjel J, El Alaoui S, Campanella M, Dötsch V, Rogov VV, Strappazzon F, Cecconi F.
Nat Commun. 2018 Sep 14;9(1):3755. doi: 10.1038/s41467-018-05722-3.
PMID: 30217973
Regulation of the Activity in the p53 Family Depends on the Organization of the Transactivation Domain.
Krauskopf K, Gebel J, Kazemi S, Tuppi M, Löhr F, Schäfer B, Koch J, Güntert P, Dötsch V, Kehrloesser S.
Structure. 2018 Aug 7;26(8):1091-1100.e4. doi: 10.1016/j.str.2018.05.013. Epub 2018 Jun 28.
PMID: 30099987
Structural investigation of glycan recognition by the ERAD quality control lectin Yos9
Kniss A, Kazemi S, Löhr F, Berger M, Rogov VV, Güntert P, Sommer T, Jarosch E, Dötsch V.
J Biomol NMR. 2018 Jul 31. doi: 10.1007/s10858-018-0201-6. [Epub ahead of print]
PMID: 30066206
Precursor-based selective methyl labelling of cell-free synthesized proteins
Lazarova M, Lőhr F, Rues RB, Kleebach R, Dötsch V, Bernhard F.
ACS Chem Biol. 2018 Jun 12. doi: 10.1021/acschembio.8b00338. [Epub ahead of print]
PMID: 29894149
Donated chemical probes for open science
Müller S, Ackloo S, Arrowsmith CH, Bauser M, Baryza JL, Blagg J, Böttcher J, Bountra C, Brown PJ, Bunnage ME, Carter AJ, Damerell D, Dötsch V, Drewry DH, Edwards AM, Edwards J, Elkins JM, Fischer C, Frye SV, Gollner A, Grimshaw CE, IJzerman A, Hanke T, Hartung IV, Hitchcock S, Howe T, Hughes TV, Laufer S, Li VM, Liras S, Marsden BD, Matsui H, Mathias J, O'Hagan RC, Owen DR, Pande V, Rauh D, Rosenberg SH, Roth BL, Schneider NS, Scholten C, Singh Saikatendu K, Simeonov A, Takizawa M, Tse C, Thompson PR, Treiber DK, Viana AY, Wells CI, Willson TM, Zuercher WJ, Knapp S, Mueller-Fahrnow A.
Elife. 2018 Apr 20;7. pii: e34311. doi: 10.7554/eLife.34311.
PMID: 29676732
CHK2 sets the stage for CK1 in oocyte quality control
Kehrloesser S, Tuppi M, Dötsch V.
Cell Death Differ. 2018 Apr 17. doi: 10.1038/s41418-018-0107-6. [Epub ahead of print] No abstract available.
PMID: 29666471
Structural Characterization of the Interaction of the Fibroblast Growth Factor Receptor with a Small Molecule Allosteric Inhibitor
Kappert F, Sreeramulu S, Jonker HRA, Richter C, Rogov VV, Proschak E, Hargittay B, Saxena K, Schwalbe H.
Chemistry. 2018 Apr 14. doi: 10.1002/chem.201801770. [Epub ahead of print]
PMID: 29656465
Protein labeling strategies for liquid-state NMR spectroscopy using cell-free synthesis
Hoffmann B, Löhr F, Laguerre A, Bernhard F, Dötsch V.
Prog Nucl Magn Reson Spectrosc. 2018 Apr;105:1-22. doi: 10.1016/j.pnmrs.2017.11.004. Epub 2017 Dec 7. Review.
PMID: 29548364
Oocyte DNA damage quality control requires consecutive interplay of CHK2 and CK1 to activate p63
Tuppi M, Kehrloesser S, Coutandin DW, Rossi V, Luh LM, Strubel A, Hötte K, Hoffmeister M, Schäfer B, De Oliveira T, Greten F, Stelzer EHK, Knapp S, De Felici M, Behrends C, Klinger FG, Dötsch V.
Nat Struct Mol Biol. 2018 Feb 26. doi: 10.1038/s41594-018-0035-7. [Epub ahead of print]
PMID: 29483652

Systematic optimization of cell-free synthesized human endothelin B receptor folding.
Rues RB, Dong F, Dötsch V, Bernhard F
Methods. 2018 Jan 26. pii: S1046-2023(17)30386-9. doi: 10.1016/j.ymeth.2018.01.012. [Epub ahead of print]

Chain Assembly and Disassembly Processes Differently Affect the Conformational
Space of Ubiquitin Chains.

Kniss A, Schuetz D, Kazemi S, Pluska L, Spindler PE, Rogov VV, Husnjak K, Dikic I, Güntert P, Sommer T, Prisner TF, Dötsch V.
Structure. 2018 Jan 17. pii: S0969-2126(17)30410-0. doi: 10.1016/j.str.2017.12.011.
[Epub ahead of print] PMID:29358025

Protein aggregation of the p63 transcription factor underlies severe skin fragility
in AEC syndrome.

Russo C, Osterburg C, Sirico A, Antonini D, Ambrosio R, Würz JM, Rinnenthal J, Ferniani M, Kehrloesser S, Schäfer B, Güntert P, Sinha S, Dötsch V, Missero C.
Proc Natl Acad Sci U S A. 2018 Jan 16. pii: 201713773. doi: 10.1073/pnas.1713773115.
[Epub ahead of print] PMID: 29339502



Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase.
Reckel S, Gehin C, Tardivon D, Georgeon S, Kükenshöner T, Löhr F, Koide A, Buchner L, Panjkovich A, Reynaud A, Pinho S, Gerig B, Svergun D, Pojer F, Güntert P, Dötsch V, Koide S, Gavin AC, Hantschel O.
Nat Commun. 2017 Dec 13;8(1):2101. doi: 10.1038/s41467-017-02313-6.

Non-oncogenic roles of TAp73: from multiciliogenesis to metabolism.
Nemajerova A, Amelio I, Gebel J, Dötsch V, Melino G, Moll UM.
Cell Death Differ. 2017 Oct 27. doi: 10.1038/cdd.2017.178. [Epub ahead of print] Review.
PMID: 29077094

Insights into co-translational membrane protein insertion by combined LILBID-mass spectrometry and NMR spectroscopy
Peetz O, Henrich E, Laguerre A, Lőhr F, Hein C, Dötsch V, Bernhard F, Morgner N.
Anal Chem. 2017 Oct 17. doi: 10.1021/acs.analchem.7b03309. [Epub ahead of print]
PMID: 29039652

The E. coli S30 lysate proteome: A prototype for cell-free protein production.
Foshag D, Henrich E, Hiller E, Schäfer M, Kerger C, Burger-Kentischer A, Diaz-Moreno I, García-Mauriño SM, Dötsch V, Rupp S, Bernhard F.
N Biotechnol. 2017 Sep 21. pii: S1871-6784(17)30250-9. doi: 10.1016/j.nbt.2017.09.005. [Epub ahead of print]
PMID: 28943390

Control mechanisms in germ cells mediated by p53 family proteins.
Gebel J, Tuppi M, Krauskopf K, Coutandin D, Pitzius S, Kehrloesser S, Osterburg C, Dötsch V.
J Cell Sci. 2017 Aug 9. pii: jcs.204859. doi: 10.1242/jcs.204859. [Epub ahead of print] Review.
PMID: 28794013

Site-specific inhibition of the SUMO-conjugating enzyme Ubc9 selectively impairs SUMO chain formation.
Wiechmann S, Gärtner A, Kniss A, Stengl A, Behrends C, Rogov VV, Rodriguez MS, Dötsch V, Müller S, Ernst A.
J Biol Chem. 2017 Aug 7. pii: jbc.M117.794255. doi: 10.1074/jbc.M117.794255. [Epub ahead of print]
PMID: 28784659

The soluble loop BC guides, but not dictates, the assembly of the transmembrane cytochrome b6.
Tome, L., Schätzel, C., Tenzer, S., Bernhard, F., and Schneider, D. (2017)  PlosOne.

Insights into co-translational membrane protein insertion by combined LILBID-mass spectrometry and NMR spectroscopy.
Peetz, O., Henrich, E., Laguerre, A., Löhr, F., Hein, C., Dötsch, V., Bernhard, F., and Morgner, N. (2017)  Anal. Chem. 89: 12314-12318.
doi: 10.1021/acs.analchem.7b03309.

Cell-free protein synthesis in micro compartments: building a minimal cell from biobricks.
Jia H, Heymann M, Bernhard F, Schwille P, Kai L.
N Biotechnol. 2017 Jul 6. pii: S1871-6784(16)32503-1. doi: 10.1016/j.nbt.2017.06.014. [Epub ahead of print] Review.
PMID: 28690157

Structural and functional analysis of the GABARAP interaction motif (GIM).
Rogov VV, Stolz A, Ravicahandran AC, Rios-Szwed DO, Suzuki H, Kniss A, Löhr F, Wakatsuki S, Dötsch V, Dikic I, Dobson RC, McEwan DG.
EMBO Rep. 2017 Jun 27. pii: e201643587. doi: 10.15252/embr.201643587. [Epub ahead of print]
PMID: 28655748

Membrane Protein Production in E. coli Lysates in Presence of Preassembled Nanodiscs.
Rues RB, Gräwe A, Henrich E, Bernhard F.
Methods Mol Biol. 2017;1586:291-312. doi: 10.1007/978-1-4939-6887-9_19.
PMID: 28470613

From Gene to Function: Cell-free Electrophysiological and Optical Analysis of Ion Pumps in Nanodiscs.
Henrich E, Sörmann J, Eberhardt P, Peetz O, Mezhyrova J, Morgner N, Fendler K, Dötsch V, Wachtveitl J, Bernhard F, Bamann C.
Biophys J. 2017 Apr 24. pii: S0006-3495(17)30345-4. doi: 10.1016/j.bpj.2017.03.026.
PMID: 28450130

Phosphorylation of the mitochondrial autophagy receptor Nix enhances its interaction with LC3 proteins.
Rogov VV, Suzuki H, Marinković M, Lang V, Kato R, Kawasaki M,
Buljubašić M, Šprung M, Rogova N, Wakatsuki S, Hamacher-Brady A, Dötsch V, Dikic I, Brady NR, Novak I.
Sci Rep. 2017 Apr 25;7(1):1131. doi: 10.1038/s41598-017-01258-6.
PMID: 28442745

Apoptosis inhibitor 5 is an endogenous inhibitor of caspase-2.
Imre G, Berthelet J, Heering J, Kehrloesser S, Melzer IM, Lee BI, Thiede B, Dötsch V, Rajalingam K.
EMBO Rep. 2017 Mar 23. pii: e201643744. doi: 10.15252/embr.201643744. [Epub ahead of print]
PMID: 28336776

Methods for Studying Interactions Between Atg8/LC3/GABARAP and LIR-Containing Proteins.
Johansen T, Birgisdottir ÅB, Huber J, Kniss A, Dötsch V, Kirkin V, Rogov VV.
Methods Enzymol. 2017;587:143-169. doi: 10.1016/bs.mie.2016.10.023.
PMID: 28253953

Integral Membrane Proteins Can Be Crystallized Directly from Nanodiscs.
M. Nikolaev, E. Round, I. Gushchin, V. Polovinkin, T. Balandin, P. Kuzmichev, V. Shevchenko, V. Borshchevskiy, A. Kuklin, A. Round, F. Bernhard, D. Willbold, G.Bueldt and V. Gordeliy(2017)  Cryst. Growth Des. 17, 945-948.

Analyzing native membrane protein assembly in nanodiscs by combined non-covalent mass spectrometry and synthetic biology.
Henrich E, Peetz O, Hein C, Laguerre A, Hoffmann B, Hoffmann J, Dötsch V, Bernhard F, Morgner N.
Elife. 2017 Jan 9;6. pii: e20954. doi: 10.7554/eLife.20954. [Epub ahead of print]
PMID: 28067619



Acceleration of protein backbone NMR assignment by combinatorial labeling: Application to a small molecule binding study.
Hein C, Löhr F, Schwarz D, Dötsch V.
Biopolymers. 2016 Dec 30. doi: 10.1002/bip.23013. [Epub ahead of print]
PMID: 28035667

Fluorescence-based ATG8 sensors monitor localization and function of LC3/GABARAP proteins.
Stolz A, Putyrski M, Kutle I, Huber J, Wang C, Major V, Sidhu SS, Youle RJ, Rogov VV, Dötsch V, Ernst A, Dikic I.
EMBO J. 2016 Dec 27. pii: e201695063. doi: 10.15252/embj.201695063. [Epub ahead of print]
PMID: 28028054

The synaptic vesicle protein SV31 assembles into a dimer and transports Zn2.
Waberer L, Henrich E, Peetz O, Morgner N, Dötsch V, Bernhard F, Volknandt W.
J Neurochem. 2016 Nov 5. doi: 10.1111/jnc.13886. [Epub ahead of print]
PMID: 27917477

Mechanism of TAp73 inhibition by ΔNp63 and structural basis of p63/p73 hetero-tetramerization.
Gebel J, Luh LM, Coutandin D, Osterburg C, Löhr F, Schäfer B, Frombach AS, Sumyk M, Buchner L, Krojer T, Salah E, Mathea S, Güntert P, Knapp S, Dötsch V.
Cell Death Differ. 2016 Oct 7. doi: 10.1038/cdd.2016.83.

From Nanodiscs to Isotropic Bicelles: A Procedure for Solution Nuclear Magnetic Resonance Studies of Detergent-Sensitive Integral Membrane Proteins.
Laguerre A, Löhr F, Henrich E, Hoffmann B, Abdul-Manan N, Connolly PJ, Perozo E, Moore JM,Bernhard F, Dötsch V.
Structure. 2016 Sep 15. pii: S0969-2126(16)30228-3. doi: 10.1016/j.str.2016.07.017. [Epub ahead of print]

Cell-Free Production of Membrane Proteins in Escherichia coli Lysates for Functional and Structural Studies.
Rues RB, Henrich E, Boland C, Caffrey M, Bernhard F.
Methods Mol Biol. 2016;1432:1-21. doi: 10.1007/978-1-4939-3637-3_1.

Intrinsic aggregation propensity of the p63 and p73 TI domains correlates with p53R175H interaction and suggests further significance of aggregation events in the p53 family.
Kehrloesser S, Osterburg C, Tuppi M, Schäfer B, Vousden KH, Dötsch V.
Cell Death Differ. 2016 Jul 22. doi: 10.1038/cdd.2016.75. [Epub ahead of print]

Combining In vitro Folding with Cell-Free Protein Synthesis for Membrane Protein Expression.
Focke PJ, Hein C, Hoffmann B, Matulef K, Bernhard F, Dötsch V, Valiyaveetil FI.
Biochemistry. 2016 Jul 6. [Epub ahead of print] PMID: 27384110

The CUE Domain of Cue1 Aligns Growing Ubiquitin Chains with Ubc7 for Rapid Elongation.
von Delbrück M, Kniss A, Rogov VV, Pluska L, Bagola K, Löhr F, Güntert P, Sommer T, Dötsch V.
Mol Cell. 2016 May 31. pii: S1097-2765(16)30107-1. doi: 10.1016/j.molcel.2016.04.031. [Epub ahead of print]

Co-translational formation and pharmacological characterization of beta1-adrenergic receptor/nanodisc complexes with different lipid environments.
Rues RB, Dötsch V, Bernhard F.
Biochim Biophys Acta. 2016 Jun;1858(6):1306-16. doi: 10.1016/j.bbamem.2016.02.031. Epub 2016 Feb 26.

Quality control in oocytes by p63 is based on a spring-loaded activation mechanism on the molecular and cellular level.
Coutandin D, Osterburg C, Srivastav RK, Sumyk M, Kehrloesser S, Gebel J, Tuppi M, Hannewald J, Schäfer B, Salah E, Mathea S, Müller-Kuller U, Doutch J, Grez M, Knapp S, Dötsch V.
Elife. 2016 Mar 29;5. pii: e13909. doi: 10.7554/eLife.13909. [Epub ahead of print]

Structural Evolution and Dynamics of the p53 Proteins.
Chillemi G, Kehrloesser S, Bernassola F, Desideri A, Dötsch V, Levine AJ, Melino G.
Cold Spring Harb Perspect Med. 2016 Apr 18. pii: a028308. doi: 10.1101/cshperspect.a028308. [Epub ahead of print]

Structural and functional analysis of a novel interaction motif within UFM1-activating enzyme 5 (UBA5) required for binding to ubiquitin-like proteins and ufmylation.
Habisov S, Huber J, Ichimura Y, Akutsu M, Rogova N, Loehr F, McEwan DG, Johansen T, Dikic I, Doetsch V, Komatsu M, Rogov VV, Kirkin V.
J Biol Chem. 2016 Feb 29. pii: jbc.M116.715474. [Epub ahead of print]

Lipid Requirements for the Enzymatic Activity of MraY Translocases and in Vitro Reconstitution of the Lipid II Synthesis Pathway.
Henrich E, Ma Y, Engels I, Münch D, Otten C, Schneider T, Henrichfreise B, Sahl HG, Dötsch V, Bernhard F.
J Biol Chem. 2016 Jan 29;291(5):2535-46. doi: 10.1074/jbc.M115.664292. Epub 2015 Nov 30.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Klionsky DJ, [...] Doetsch V, [...] Rogov VV et al.
Autophagy. 2016 Jan 2;12(1):1-222. No abstract available.



Labeling of Membrane Proteins by Cell-Free Expression.
Laguerre A, Löhr F, Bernhard F, Dötsch V.
Methods Enzymol. 2015;565:367-88. doi: 10.1016/bs.mie.2015.06.001. Epub 2015 Jul 2.

Structural investigations of the p53/p73 homologs from the tunicate species Ciona intestinalis reveal the sequence requirements for the formation of a tetramerization domain.
Heering J, Jonker HR, Löhr F, Schwalbe H, Dötsch V.
Protein Sci. 2015 Oct 16. doi: 10.1002/pro.2830. [Epub ahead of print]

Probing metallo-β-lactamases with molecular fragments identified by consensus docking.
Klingler FM, Moser D, Büttner D, Wichelhaus TA, Löhr F, Dötsch V, Proschak E.
Bioorg Med Chem Lett. 2015 Nov 15;25(22):5243-6. doi: 10.1016/j.bmcl.2015.09.056. Epub 2015 Sep 28.

TECPR2 Cooperates with LC3C to Regulate COPII-Dependent ER Export.
Stadel D, Millarte V, Tillmann KD, Huber J, Tamin-Yecheskel BC, Akutsu M, Demishtein A, Ben-Zeev B, Anikster Y, Perez F, Dötsch V, Elazar Z, Rogov V, Farhan H, Behrends C.
Mol Cell. 2015 Oct 1;60(1):89-104. doi: 10.1016/j.molcel.2015.09.010.

Assembling a Correctly Folded and Functional Heptahelical Membrane Protein by Protein Trans-splicing.
Mehler M, Eckert CE, Busche A, Kulhei J, Michaelis J, Becker-Baldus J, Wachtveitl J, Dötsch V, Glaubitz C.
J Biol Chem. 2015 Nov 13;290(46):27712-22. doi: 10.1074/jbc.M115.681205. Epub 2015 Sep 24.

Biosynthesis of membrane dependent proteins in insect cell lysates: identification of limiting parameters for folding and processing.
Merk H, Rues RB, Gless C, Beyer K, Dong F, Dötsch V, Gerrits M, Bernhard F.
Biol Chem. 2015 Sep;396(9-10):1097-107. doi: 10.1515/hsz-2015-0105.

Structure and Biophysical Characterization of the S-Adenosylmethionine-dependent O-Methyltransferase PaMTH1, a Putative Enzyme Accumulating during Senescence of Podospora anserina.
Chatterjee D, Kudlinzki D, Linhard V, Saxena K, Schieborr U, Gande SL, Wurm JP, Wöhnert J, Abele R, Rogov VV, Dötsch V, Osiewacz HD, Sreeramulu S, Schwalbe H.
J Biol Chem. 2015 Jun 26;290(26):16415-30. doi: 10.1074/jbc.M115.660829. Epub 2015 May 15.

An extended combinatorial 15N, 13Cα, and 13C' labeling approach to protein backbone resonance assignment.
Löhr F, Tumulka F, Bock C, Abele R, Dötsch V.
J Biomol NMR. 2015 Jul;62(3):263-79. doi: 10.1007/s10858-015-9941-8. Epub 2015 May 8.

Membrane protein production in Escherichia coli cell-free lysates.
Henrich E, Hein C, Dötsch V, Bernhard F.
FEBS Lett. 2015 Jul 8;589(15):1713-22. doi: 10.1016/j.febslet.2015.04.045. Epub 2015 May 1. Review.

Screening for lipid requirements of membrane proteins by combining cell-free expression with nanodiscs.
Henrich E, Dötsch V, Bernhard F.
Methods Enzymol. 2015;556:351-69. doi: 10.1016/bs.mie.2014.12.016. Epub 2015 Mar 20.

FAM96A is a novel pro-apoptotic tumor suppressor in gastrointestinal stromal tumors.
Schwamb B, Pick R, Fernández SB, Völp K, Heering J, Dötsch V, Bösser S, Jung J, Beinoraviciute-Kellner R, Wesely J, Zörnig I, Hammerschmidt M, Nowak M, Penzel R, Zatloukal K, Joos S, Rieker RJ, Agaimy A, Söder S, Reid-Lombardo KM, Kendrick ML, Bardsley MR, Hayashi Y, Asuzu DT, Syed SA, Ordog T, Zörnig M.
Int J Cancer. 2015 Sep 15;137(6):1318-29. doi: 10.1002/ijc.29498. Epub 2015 Mar 12.

CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling.
Genau HM, Huber J, Baschieri F, Akutsu M, Dötsch V, Farhan H, Rogov V, Behrends C.
Mol Cell. 2015 Mar 19;57(6):995-1010. doi: 10.1016/j.molcel.2014.12.040. Epub 2015 Feb 12.

Cell-free expression of G-protein-coupled receptors.
Orbán E, Proverbio D, Haberstock S, Dötsch V, Bernhard F.
Methods Mol Biol. 2015;1261:171-95. doi: 10.1007/978-1-4939-2230-7_10.

Co-translational stabilization of insoluble proteins in cell-free expression systems.
Kai L, Orbán E, Henrich E, Proverbio D, Dötsch V, Bernhard F.
Methods Mol Biol. 2015;1258:125-43. doi: 10.1007/978-1-4939-2205-5_7. Review.



Time-shared experiments for efficient assignment of triple-selectively labeled proteins.
Löhr F, Laguerre A, Bock C, Reckel S, Connolly PJ, Abdul-Manan N, Tumulka F, Abele R, Moore JM, Dötsch V.
J Magn Reson. 2014 Nov;248:81-95. doi: 10.1016/j.jmr.2014.09.014. Epub 2014 Sep 30.

Functional interplay between MDM2, p63/p73 and mutant p53.
Stindt MH, Muller PA, Ludwig RL, Kehrloesser S, Dötsch V, Vousden KH.
Oncogene. 2015 Aug 13;34(33):4300-10. doi: 10.1038/onc.2014.359. Epub 2014 Nov 24.

Cell-free expression of G-protein coupled receptors: new pipelines for challenging targets.
Rues RB, Orbán E, Dötsch V, Bernhard F.
Biol Chem. 2014 Dec;395(12):1425-34. doi: 10.1515/hsz-2014-0217. Review.

Stabilisation and characterisation of the isolated regulatory domain of human 5-lipoxygenase.
Schröder M, Häfner AK, Hofmann B, Rådmark O, Tumulka F, Abele R, Dötsch V, Steinhilber D.
Biochim Biophys Acta. 2014 Oct;1842(10):1538-47. doi: 10.1016/j.bbalip.2014.07.022. Epub 2014 Aug 8.

In-cell NMR and EPR spectroscopy of biomacromolecules.
Hänsel R, Luh LM, Corbeski I, Trantirek L, Dötsch V.
Angew Chem Int Ed Engl. 2014 Sep 22;53(39):10300-14. doi: 10.1002/anie.201311320. Epub 2014 Jul 28. Review.

Cell-free expression and in meso crystallisation of an integral membrane kinase for structure determination.
Boland C, Li D, Shah ST, Haberstock S, Dötsch V, Bernhard F, Caffrey M.
Cell Mol Life Sci. 2014 Dec;71(24):4895-910. doi: 10.1007/s00018-014-1655-7. Epub 2014 Jul 11.

Crystal structure of a PCP/Sfp complex reveals the structural basis for carrier protein posttranslational modification.
Tufar P, Rahighi S, Kraas FI, Kirchner DK, Löhr F, Henrich E, Köpke J, Dikic I, Güntert P, Marahiel MA, Dötsch V.
Chem Biol. 2014 Apr 24;21(4):552-62. doi: 10.1016/j.chembiol.2014.02.014. Epub 2014 Apr 3.

Peak picking NMR spectral data using non-negative matrix factorization.
Tikole S, Jaravine V, Rogov V, Dötsch V, Güntert P.
BMC Bioinformatics. 2014 Feb 11;15:46. doi: 10.1186/1471-2105-15-46.

Interactions between autophagy receptors and ubiquitin-like proteins form the molecular basis for selective autophagy.
Rogov V, Dötsch V, Johansen T, Kirkin V.
Mol Cell. 2014 Jan 23;53(2):167-78. doi: 10.1016/j.molcel.2013.12.014. Review.

High-level cell-free production of membrane proteins with nanodiscs.
Roos C, Kai L, Haberstock S, Proverbio D, Ghoshdastider U, Ma Y, Filipek S, Wang X, Dötsch V, Bernhard F.
Methods Mol Biol. 2014;1118:109-30. doi: 10.1007/978-1-62703-782-2_7.



SPLICEFINDER - a fast and easy screening method for active protein trans-splicing positions.
Zettler J, Eppmann S, Busche A, Dikovskaya D, Dötsch V, Mootz HD, Sonntag T.
PLoS One. 2013 Sep 2;8(9):e72925. doi: 10.1371/journal.pone.0072925. eCollection 2013.

Conformational stabilization of the membrane embedded targeting domain of the lysosomal peptide transporter TAPL for solution NMR.
Tumulka F, Roos C, Löhr F, Bock C, Bernhard F, Dötsch V, Abele R.
J Biomol NMR. 2013 Oct;57(2):141-54. doi: 10.1007/s10858-013-9774-2. Epub 2013 Sep 7.

Molecular crowding drives active Pin1 into nonspecific complexes with endogenous proteins prior to substrate recognition.
Luh LM, Hänsel R, Löhr F, Kirchner DK, Krauskopf K, Pitzius S, Schäfer B, Tufar P, Corbeski I, Güntert P, Dötsch V.
J Am Chem Soc. 2013 Sep 18;135(37):13796-803. doi: 10.1021/ja405244v. Epub 2013 Sep 6.

How to switch a master switch.
Hein C, Wittinghofer A, Dötsch V.
Elife. 2013 Jul 30;2:e01159. doi: 10.7554/eLife.01159.

Endoplasmic reticulum targeting and insertion of tail-anchored membrane proteins by the GET pathway.
Denic V, Dötsch V, Sinning I.
Cold Spring Harb Perspect Biol. 2013 Aug 1;5(8):a013334. doi: 10.1101/cshperspect.a013334. Review.

Structural basis for phosphorylation-triggered autophagic clearance of Salmonella.
Rogov VV, Suzuki H, Fiskin E, Wild P, Kniss A, Rozenknop A, Kato R, Kawasaki M,
McEwan DG, Löhr F, Güntert P, Dikic I, Wakatsuki S, Dötsch V.
Biochem J. 2013 Sep 15;454(3):459-66.

Functional properties of cell-free expressed human endothelin A and endothelin B receptors in artificial membrane environments.
Proverbio D, Roos C, Beyermann M, Orbán E, Dötsch V, Bernhard F.
Biochim Biophys Acta. 2013 Sep;1828(9):2182-92. doi: 10.1016/j.bbamem.2013.05.031. Epub 2013 Jun 6.

Analysis of the oligomeric state and transactivation potential of TAp73α.
Luh LM, Kehrloesser S, Deutsch GB, Gebel J, Coutandin D, Schäfer B, Agostini M, Melino G, Dötsch V.
Cell Death Differ. 2013 Aug;20(8):1008-16. doi: 10.1038/cdd.2013.23. Epub 2013 Mar 29.

Artificial environments for the co-translational stabilization of cell-free expressed proteins.
Kai L, Dötsch V, Kaldenhoff R, Bernhard F.
PLoS One. 2013;8(2):e56637. doi: 10.1371/journal.pone.0056637. Epub 2013 Feb 22.

High-resolution insight into G-overhang architecture.
Hänsel R, Löhr F, Trantirek L, Dötsch V.
J Am Chem Soc. 2013 Feb 20;135(7):2816-24. doi: 10.1021/ja312403b. Epub 2013 Feb 5.

Modified lipid and protein dynamics in nanodiscs.
Mörs K, Roos C, Scholz F, Wachtveitl J, Dötsch V, Bernhard F, Glaubitz C.
Biochim Biophys Acta. 2013 Apr;1828(4):1222-9. doi: 10.1016/j.bbamem.2012.12.011. Epub 2012 Dec 28.



Characterization of the ground state dynamics of proteorhodopsin by NMR and optical spectroscopies.
Stehle J, Scholz F, Löhr F, Reckel S, Roos C, Blum M, Braun M, Glaubitz C, Dötsch V, Wachtveitl J, Schwalbe H.
J Biomol NMR. 2012 Dec;54(4):401-13. doi: 10.1007/s10858-012-9684-8. Epub 2012 Nov 17.

A method for integrative structure determination of protein-protein complexes.
Schneidman-Duhovny D, Rossi A, Avila-Sakar A, Kim SJ, Velázquez-Muriel J, Strop P, Liang H, Krukenberg KA, Liao M, Kim HM, Sobhanifar S, Dötsch V, Rajpal A, Pons J, Agard DA, Cheng Y, Sali A.
Bioinformatics. 2012 Dec 15;28(24):3282-9. doi: 10.1093/bioinformatics/bts628. Epub 2012 Oct 23.

Cell-free expression of human glucosamine 6-phosphate N-acetyltransferase (HsGNA1) for inhibitor screening.
Ma Y, Ghoshdastider U, Wang J, Ye W, Dötsch V, Filipek S, Bernhard F, Wang X.
Protein Expr Purif. 2012 Dec;86(2):120-6. doi: 10.1016/j.pep.2012.09.011. Epub 2012 Oct 2.

Characterization of co-translationally formed nanodisc complexes with small multidrug transporters, proteorhodopsin and with the E. coli MraY translocase.
Roos C, Zocher M, Müller D, Münch D, Schneider T, Sahl HG, Scholz F, Wachtveitl J, Ma Y, Proverbio D, Henrich E, Dötsch V, Bernhard F.
Biochim Biophys Acta. 2012 Dec;1818(12):3098-106. doi: 10.1016/j.bbamem.2012.08.007. Epub 2012 Aug 18.

Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer.
Tucci P, Agostini M, Grespi F, Markert EK, Terrinoni A, Vousden KH, Muller PA, Dötsch V, Kehrloesser S, Sayan BS, Giaccone G, Lowe SW, Takahashi N, Vandenabeele P, Knight RA, Levine AJ, Melino G.
Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15312-7. Epub 2012 Sep 4. Erratum in: Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2855.

Investigation of quadruplex structure under physiological conditions using in-cell NMR.
Hänsel R, Foldynová-Trantírková S, Dötsch V, Trantírek L.
Top Curr Chem. 2013;330:47-65. doi: 10.1007/128_2012_332. Review.

Co-translational association of cell-free expressed membrane proteins with supplied lipid bilayers.
Roos C, Kai L, Proverbio D, Ghoshdastider U, Filipek S, Dötsch V, Bernhard F.
Mol Membr Biol. 2013 Feb;30(1):75-89. doi: 10.3109/09687688.2012.693212. Epub 2012 Jun 20.

Requirements on paramagnetic relaxation enhancement data for membrane protein structure determination by NMR.
Gottstein D, Reckel S, Dötsch V, Güntert P.
Structure. 2012 Jun 6;20(6):1019-27. doi: 10.1016/j.str.2012.03.010. Epub 2012 May 3.

Caspase-2 is an initiator caspase responsible for pore-forming toxin-mediated apoptosis.
Imre G, Heering J, Takeda AN, Husmann M, Thiede B, zu Heringdorf DM, Green DR, van der Goot FG, Sinha B, Dötsch V, Rajalingam K.
EMBO J. 2012 May 30;31(11):2615-28. doi: 10.1038/emboj.2012.93. Epub 2012 Apr 24.

Fast automated NMR spectroscopy of short-lived biological samples.
Tikole S, Jaravine V, Rogov VV, Rozenknop A, Schmöe K, Löhr F, Dötsch V, Güntert P.
Chembiochem. 2012 May 7;13(7):964-7. doi: 10.1002/cbic.201200044. Epub 2012 Apr 11.

A universal expression tag for structural and functional studies of proteins.
Rogov VV, Rozenknop A, Rogova NY, Löhr F, Tikole S, Jaravine V, Güntert P, Dikic I, Dötsch V.
Chembiochem. 2012 May 7;13(7):959-63. doi: 10.1002/cbic.201200045. Epub 2012 Mar 20.

A systematic approach to increase the efficiency of membrane protein production in cell-free expression systems.
Haberstock S, Roos C, Hoevels Y, Dötsch V, Schnapp G, Pautsch A, Bernhard F.
Protein Expr Purif. 2012 Apr;82(2):308-16. doi: 10.1016/j.pep.2012.01.018. Epub 2012 Feb 8.

In-cell solid-state NMR as a tool to study proteins in large complexes.
Reckel S, Lopez JJ, Löhr F, Glaubitz C, Dötsch V.
Chembiochem. 2012 Mar 5;13(4):534-7. doi: 10.1002/cbic.201100721. Epub 2012 Feb 1.

Combinatorial triple-selective labeling as a tool to assist membrane protein backbone resonance assignment.
Löhr F, Reckel S, Karbyshev M, Connolly PJ, Abdul-Manan N, Bernhard F, Moore JM, Dötsch V.
J Biomol NMR. 2012 Mar;52(3):197-210. doi: 10.1007/s10858-012-9601-1. Epub 2012 Jan 18.

Single-molecule force spectroscopy from nanodiscs: an assay to quantify folding, stability, and interactions of native membrane proteins.
Zocher M, Roos C, Wegmann S, Bosshart PD, Dötsch V, Bernhard F, Müller DJ.
ACS Nano. 2012 Jan 24;6(1):961-71. doi: 10.1021/nn204624p. Epub 2011 Dec 30.

Characterization of molecular interactions between ACP and halogenase domains in the Curacin A polyketide synthase.
Busche A, Gottstein D, Hein C, Ripin N, Pader I, Tufar P, Eisman EB, Gu L, Walsh CT, Sherman DH, Löhr F, Güntert P, Dötsch V.
ACS Chem Biol. 2012 Feb 17;7(2):378-86. doi: 10.1021/cb200352q. Epub 2011 Dec 15.



Solution NMR structure of proteorhodopsin.
Reckel S, Gottstein D, Stehle J, Löhr F, Verhoefen MK, Takeda M, Silvers R, Kainosho M, Glaubitz C, Wachtveitl J, Bernhard F, Schwalbe H, Güntert P, Dötsch V.
Angew Chem Int Ed Engl. 2011 Dec 9;50(50):11942-6. doi: 10.1002/anie.201105648. Epub 2011 Oct 27.

Systems for the cell-free synthesis of proteins.
Kai L, Roos C, Haberstock S, Proverbio D, Ma Y, Junge F, Karbyshev M, Dötsch V, Bernhard F.
Methods Mol Biol. 2012;800:201-25. doi: 10.1007/978-1-61779-349-3_14.

Preparative scale cell-free production and quality optimization of MraY homologues in different expression modes.
Ma Y, Münch D, Schneider T, Sahl HG, Bouhss A, Ghoshdastider U, Wang J, Dötsch V, Wang X, Bernhard F.
J Biol Chem. 2011 Nov 11;286(45):38844-53. doi: 10.1074/jbc.M111.301085. Epub 2011 Sep 20.

Cell-free expression and assembly of ATP synthase.
Matthies D, Haberstock S, Joos F, Dötsch V, Vonck J, Bernhard F, Meier T.
J Mol Biol. 2011 Oct 28;413(3):593-603. doi: 10.1016/j.jmb.2011.08.055. Epub 2011 Sep 10.

The large extracellular loop of organic cation transporter 1 influences substrate affinity and is pivotal for oligomerization.
Keller T, Egenberger B, Gorboulev V, Bernhard F, Uzelac Z, Gorbunov D, Wirth C, Koppatz S, Dötsch V, Hunte C, Sitte HH, Koepsell H.
J Biol Chem. 2011 Oct 28;286(43):37874-86. doi: 10.1074/jbc.M111.289330. Epub 2011 Sep 6.

Functional expression of the PorAH channel from Corynebacterium glutamicum in cell-free expression systems: implications for the role of the naturally occurring mycolic acid modification.
Rath P, Demange P, Saurel O, Tropis M, Daffé M, Dötsch V, Ghazi A, Bernhard F, Milon A.
J Biol Chem. 2011 Sep 16;286(37):32525-32. doi: 10.1074/jbc.M111.276956. Epub 2011 Jul 28.

Structural basis for tail-anchored membrane protein biogenesis by the Get3-receptor complex.
Stefer S, Reitz S, Wang F, Wild K, Pang YY, Schwarz D, Bomke J, Hein C, Löhr F, Bernhard F, Denic V, Dötsch V, Sinning I.
Science. 2011 Aug 5;333(6043):758-62. doi: 10.1126/science.1207125. Epub 2011 Jun 30.

Differential altered stability and transcriptional activity of ΔNp63 mutants in distinct ectodermal dysplasias.
Browne G, Cipollone R, Lena AM, Serra V, Zhou H, van Bokhoven H, Dötsch V, Merico D, Mantovani R, Terrinoni A, Knight RA, Candi E, Melino G.
J Cell Sci. 2011 Jul 1;124(Pt 13):2200-7. doi: 10.1242/jcs.079327. Epub 2011 Jun 7.

Improved accuracy in measuring one-bond and two-bond (15)N, (13)C (α) coupling constants in proteins by double-inphase/antiphase (DIPAP) spectroscopy.
Löhr F, Reckel S, Stefer S, Dötsch V, Schmidt JM.
J Biomol NMR. 2011 Jun;50(2):167-90. doi: 10.1007/s10858-011-9507-3. Epub 2011 Jun 7.

Characterization of the interaction of GABARAPL-1 with the LIR motif of NBR1.
Rozenknop A, Rogov VV, Rogova NY, Löhr F, Güntert P, Dikic I, Dötsch V.
J Mol Biol. 2011 Jul 15;410(3):477-87. doi: 10.1016/j.jmb.2011.05.003. Epub 2011 May 18.

Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth.
Wild P, Farhan H, McEwan DG, Wagner S, Rogov VV, Brady NR, Richter B, Korac J, Waidmann O, Choudhary C, Dötsch V, Bumann D, Dikic I.
Science. 2011 Jul 8;333(6039):228-33. doi: 10.1126/science.1205405. Epub 2011 May 26.

Mutation in SAM domain of TP63 is associated with nonsyndromic cleft lip and palate and cleft palate.
Kantaputra PN, Malaivijitnond S, Vieira AR, Heering J, Dötsch V, Khankasikum T, Sripathomsawat W.
Am J Med Genet A. 2011 Jun;155A(6):1432-6. doi: 10.1002/ajmg.a.34011. Epub 2011 May 12.

How to create a specific recognition for an unspecific interaction.
Dötsch V.
Structure. 2011 May 11;19(5):601-2. doi: 10.1016/j.str.2011.04.003.

Quality control in oocytes: domain-domain interactions regulate the activity of p63.
Deutsch GB, Zielonka EM, Coutandin D, Dötsch V.
Cell Cycle. 2011 Jun 15;10(12):1884-5. Epub 2011 Jun 15.

Long-range distance measurements on nucleic acids in cells by pulsed EPR spectroscopy.
Krstić I, Hänsel R, Romainczyk O, Engels JW, Dötsch V, Prisner TF.
Angew Chem Int Ed Engl. 2011 May 23;50(22):5070-4. doi: 10.1002/anie.201100886. Epub 2011 Apr 19.

Rapid identification of protein-protein interfaces for the construction of a complex model based on multiple unassigned signals by using time-sharing NMR measurements.
Kodama Y, Reese ML, Shimba N, Ono K, Kanamori E, Dötsch V, Noguchi S, Fukunishi Y, Suzuki E, Shimada I, Takahashi H.
J Struct Biol. 2011 Jun;174(3):434-42. doi: 10.1016/j.jsb.2011.04.001. Epub 2011 Apr 9.

Structural insights into Rcs phosphotransfer: the newly identified RcsD-ABL domain enhances interaction with the response regulator RcsB.
Schmöe K, Rogov VV, Rogova NY, Löhr F, Güntert P, Bernhard F, Dötsch V.
Structure. 2011 Apr 13;19(4):577-87. doi: 10.1016/j.str.2011.01.012.

A disulfide bridge network within the soluble periplasmic domain determines structure and function of the outer membrane protein RCSF.
Rogov VV, Rogova NY, Bernhard F, Löhr F, Dötsch V.
J Biol Chem. 2011 May 27;286(21):18775-83. doi: 10.1074/jbc.M111.230185. Epub 2011 Apr 6.

The parallel G-quadruplex structure of vertebrate telomeric repeat sequences is not the preferred folding topology under physiological conditions.
Hänsel R, Löhr F, Foldynová-Trantírková S, Bamberg E, Trantírek L, Dötsch V.
Nucleic Acids Res. 2011 Jul;39(13):5768-75. doi: 10.1093/nar/gkr174. Epub 2011 Mar 30.

DNA damage in oocytes induces a switch of the quality control factor TAp63α from dimer to tetramer.
Deutsch GB, Zielonka EM, Coutandin D, Weber TA, Schäfer B, Hannewald J, Luh LM, Durst FG, Ibrahim M, Hoffmann J, Niesen FH, Sentürk A, Kunkel H, Brutschy B, Schleiff E, Knapp S, Acker-Palmer A, Grez M, McKeon F, Dötsch V.
Cell. 2011 Feb 18;144(4):566-76. doi: 10.1016/j.cell.2011.01.013.

Phenotypic analysis of Arg227 mutations of TP63 with emphasis on dental phenotype and micturition difficulties in EEC syndrome.
Sripathomsawat W, Tanpaiboon P, Heering J, Dötsch V, Hennekam RC, Kantaputra P.
Am J Med Genet A. 2011 Jan;155A(1):228-32. doi: 10.1002/ajmg.a.33768.

2010 and earlier


Optimization of amino acid type-specific 13C and 15N labeling for the backbone assignment of membrane proteins by solution- and solid-state NMR with the UPLABEL algorithm.
Hefke F, Bagaria A, Reckel S, Ullrich SJ, Dötsch V, Glaubitz C, Güntert P.
J Biomol NMR. 2011 Feb;49(2):75-84. doi: 10.1007/s10858-010-9462-4. Epub 2010 Dec 18.

Preparative scale production of functional mouse aquaporin 4 using different cell-free expression modes.
Kai L, Kaldenhoff R, Lian J, Zhu X, Dötsch V, Bernhard F, Cen P, Xu Z.
PLoS One. 2010 Sep 24;5(9):e12972. doi: 10.1371/journal.pone.0012972.

NmerA of Tn501 mercuric ion reductase: structural modulation of the pKa values of the metal binding cysteine thiols.
Ledwidge R, Hong B, Dötsch V, Miller SM.
Biochemistry. 2010 Oct 19;49(41):8988-98. doi: 10.1021/bi100537f.

Tracing the protectors path from the germ line to the genome.
Coutandin D, Ou HD, Löhr F, Dötsch V.
Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15318-25. doi: 10.1073/pnas.1001069107. Epub 2010 Aug 9.

Advances in cell-free protein synthesis for the functional and structural analysis of membrane proteins.
Junge F, Haberstock S, Roos C, Stefer S, Proverbio D, Dötsch V, Bernhard F.
N Biotechnol. 2011 Apr 30;28(3):262-71. doi: 10.1016/j.nbt.2010.07.002. Epub 2010 Jul 15.

p63 and p73, the ancestors of p53.
Dötsch V, Bernassola F, Coutandin D, Candi E, Melino G.
Cold Spring Harb Perspect Biol. 2010 Sep;2(9):a004887. doi: 10.1101/cshperspect.a004887. Epub 2010 May 19. Review.

Modulation of G-protein coupled receptor sample quality by modified cell-free expression protocols: a case study of the human endothelin A receptor.
Junge F, Luh LM, Proverbio D, Schäfer B, Abele R, Beyermann M, Dötsch V, Bernhard F.
J Struct Biol. 2010 Oct;172(1):94-106. doi: 10.1016/j.jsb.2010.05.004. Epub 2010 May 9.

Structural investigation of the C-terminal catalytic fragment of presenilin 1.
Sobhanifar S, Schneider B, Löhr F, Gottstein D, Ikeya T, Mlynarczyk K, Pulawski W, Ghoshdastider U, Kolinski M, Filipek S, Güntert P, Bernhard F, Dötsch V.
Proc Natl Acad Sci U S A. 2010 May 25;107(21):9644-9. doi: 10.1073/pnas.1000778107. Epub 2010 May 5.

Strategies for the cell-free expression of membrane proteins.
Reckel S, Sobhanifar S, Durst F, Löhr F, Shirokov VA, Dötsch V, Bernhard F.
Methods Mol Biol. 2010;607:187-212. doi: 10.1007/978-1-60327-331-2_16.

Cell-free expression profiling of E. coli inner membrane proteins.
Schwarz D, Daley D, Beckhaus T, Dötsch V, Bernhard F.
Proteomics. 2010 May;10(9):1762-79. doi: 10.1002/pmic.200900485.

Membrane protein expression in cell-free systems.
Schneider B, Junge F, Shirokov VA, Durst F, Schwarz D, Dötsch V, Bernhard F.
Methods Mol Biol. 2010;601:165-86. doi: 10.1007/978-1-60761-344-2_11.

The C-terminus of p63 contains multiple regulatory elements with different functions.
Straub WE, Weber TA, Schäfer B, Candi E, Durst F, Ou HD, Rajalingam K, Melino G, Dötsch V.
Cell Death Dis. 2010;1:e5. doi: 10.1038/cddis.2009.1.

Nix is a selective autophagy receptor for mitochondrial clearance.
Novak I, Kirkin V, McEwan DG, Zhang J, Wild P, Rozenknop A, Rogov V, Löhr F, Popovic D, Occhipinti A, Reichert AS, Terzic J, Dötsch V, Ney PA, Dikic I.
EMBO Rep. 2010 Jan;11(1):45-51. doi: 10.1038/embor.2009.256. Epub 2009 Dec 11.

Ubiquitin linkages make a difference.
Dikic I, Dötsch V.
Nat Struct Mol Biol. 2009 Dec;16(12):1209-10. doi: 10.1038/nsmb1209-1209.

The molecular pharmacology and in vivo activity of 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS121), a dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.
Koeberle A, Rossi A, Zettl H, Pergola C, Dehm F, Bauer J, Greiner C, Reckel S, Hoernig C, Northoff H, Bernhard F, Dötsch V, Sautebin L, Schubert-Zsilavecz M, Werz O.
J Pharmacol Exp Ther. 2010 Mar;332(3):840-8. doi: 10.1124/jpet.109.160663. Epub 2009 Nov 24.

NMR studies reveal the role of biomembranes in modulating ligand binding and release by intracellular bile acid binding proteins.
Pedò M, Löhr F, D'Onofrio M, Assfalg M, Dötsch V, Molinari H.
J Mol Biol. 2009 Dec 18;394(5):852-63. doi: 10.1016/j.jmb.2009.10.014. Epub 2009 Oct 22.

Evaluation of parameters critical for observing nucleic acids inside living Xenopus laevis oocytes by in-cell NMR spectroscopy.
Hänsel R, Foldynová-Trantírková S, Löhr F, Buck J, Bongartz E, Bamberg E, Schwalbe H, Dötsch V, Trantírek L.
J Am Chem Soc. 2009 Nov 4;131(43):15761-8. doi: 10.1021/ja9052027.

Conformational stability and activity of p73 require a second helix in the tetramerization domain.
Coutandin D, Löhr F, Niesen FH, Ikeya T, Weber TA, Schäfer B, Zielonka EM, Bullock AN, Yang A, Güntert P, Knapp S, McKeon F, Ou HD, Dötsch V.
Cell Death Differ. 2009 Dec;16(12):1582-9. doi: 10.1038/cdd.2009.139. Epub 2009 Sep 18.

On track to tenure-track.
Dötsch V.
EMBO Rep. 2009 Sep;10(9):936-7. doi: 10.1038/embor.2009.190.

Cell-free expression and stable isotope labelling strategies for membrane proteins.
Sobhanifar S, Reckel S, Junge F, Schwarz D, Kai L, Karbyshev M, Löhr F, Bernhard F, Dötsch V.
J Biomol NMR. 2010 Jan;46(1):33-43. doi: 10.1007/s10858-009-9364-5. Epub 2009 Aug 13.

Segmental isotopic labeling of a central domain in a multidomain protein by protein trans-splicing using only one robust DnaE intein.
Busche AE, Aranko AS, Talebzadeh-Farooji M, Bernhard F, Dötsch V, Iwaï H.
Angew Chem Int Ed Engl. 2009;48(33):6128-31. doi: 10.1002/anie.200901488.

A cost-effective amino-acid-type selective isotope labeling of proteins expressed in Leishmania tarentolae.
Foldynová-Trantirková S, Matulová J, Dötsch V, Löhr F, Cirstea I, Alexandov K, Breitling R, Lukes J, Trantírek L.
J Biomol Struct Dyn. 2009 Jun;26(6):755-61.

Modulation of the Rcs-mediated signal transfer by conformational flexibility.
Rogov VV, Schmöe K, Löhr F, Rogova NY, Bernhard F, Dötsch V.
Biochem Soc Trans. 2008 Dec;36(Pt 6):1427-32. doi: 10.1042/BST0361427.

The better tag remains unseen.
Durst FG, Ou HD, Löhr F, Dötsch V, Straub WE.
J Am Chem Soc. 2008 Nov 12;130(45):14932-3. doi: 10.1021/ja806212j. Epub 2008 Oct 21.

Production of membrane proteins using cell-free expression systems.
Schwarz D, Dötsch V, Bernhard F.
Proteomics. 2008 Oct;8(19):3933-46. doi: 10.1002/pmic.200800171. Review.

Structural basis for the selectivity of the external thioesterase of the surfactin synthetase.
Koglin A, Löhr F, Bernhard F, Rogov VV, Frueh DP, Strieter ER, Mofid MR, Güntert P, Wagner G, Walsh CT, Marahiel MA, Dötsch V.
Nature. 2008 Aug 14;454(7206):907-11. doi: 10.1038/nature07161.

Transmembrane segment enhanced labeling as a tool for the backbone assignment of alpha-helical membrane proteins.
Reckel S, Sobhanifar S, Schneider B, Junge F, Schwarz D, Durst F, Löhr F, Güntert P, Bernhard F, Dötsch V.
Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8262-7. doi: 10.1073/pnas.0710843105. Epub 2008 Jun 11.

Large-scale production of functional membrane proteins.
Junge F, Schneider B, Reckel S, Schwarz D, Dötsch V, Bernhard F.
Cell Mol Life Sci. 2008 Jun;65(11):1729-55. doi: 10.1007/s00018-008-8067-5. Review.

Cell free expression and functional reconstitution of eukaryotic drug transporters.
Keller T, Schwarz D, Bernhard F, Dötsch V, Hunte C, Gorboulev V, Koepsell H.
Biochemistry. 2008 Apr 15;47(15):4552-64. doi: 10.1021/bi800060w. Epub 2008 Mar 25.

Ubiquitin binding mediates the NF-kappaB inhibitory potential of ABIN proteins.
Wagner S, Carpentier I, Rogov V, Kreike M, Ikeda F, Löhr F, Wu CJ, Ashwell JD, Dötsch V, Dikic I, Beyaert R.
Oncogene. 2008 Jun 12;27(26):3739-45. doi: 10.1038/sj.onc.1211042. Epub 2008 Jan 21.

Investigation of proteins in living bacteria with in-cell NMR experiments.
Dötsch V.
Top Curr Chem. 2008;273:203-14. doi: 10.1007/128_2007_21.

Preparative scale expression of membrane proteins in Escherichia coli-based continuous exchange cell-free systems.
Schwarz D, Junge F, Durst F, Frölich N, Schneider B, Reckel S, Sobhanifar S, Dötsch V, Bernhard F.
Nat Protoc. 2007;2(11):2945-57.

Reprint of "Cell-free production of G protein-coupled receptors for functional and structural studies" [J. Struct. Biol. 158 (2007) 482-493].
Klammt C, Schwarz D, Eifler N, Engel A, Piehler J, Haase W, Hahn S, Dötsch V, Bernhard F.
J Struct Biol. 2007 Aug;159(2):194-205.

Cell-free production of integral membrane proteins on a preparative scale.
Klammt C, Schwarz D, Dötsch V, Bernhard F.
Methods Mol Biol. 2007;375:57-78. Review.

Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes.
Ikeda F, Hecker CM, Rozenknop A, Nordmeier RD, Rogov V, Hofmann K, Akira S, Dötsch V, Dikic I.
EMBO J. 2007 Jul 25;26(14):3451-62. Epub 2007 Jun 28.

E3-independent monoubiquitination of ubiquitin-binding proteins.
Hoeller D, Hecker CM, Wagner S, Rogov V, Dötsch V, Dikic I.
Mol Cell. 2007 Jun 22;26(6):891-8.

Structural evolution of C-terminal domains in the p53 family.
Ou HD, Löhr F, Vogel V, Mäntele W, Dötsch V.
EMBO J. 2007 Jul 25;26(14):3463-73. Epub 2007 Jun 21.

Investigating macromolecules inside cultured and injected cells by in-cell NMR spectroscopy.
Serber Z, Selenko P, Hänsel R, Reckel S, Löhr F, Ferrell JE Jr, Wagner G, Dötsch V.
Nat Protoc. 2006;1(6):2701-9.

Cell-free production of G protein-coupled receptors for functional and structural studies.
Klammt C, Schwarz D, Eifler N, Engel A, Piehler J, Haase W, Hahn S, Dötsch V, Bernhard F.
J Struct Biol. 2007 Jun;158(3):482-93. Epub 2007 Jan 23.

Improved pulse sequences for sequence specific assignment of aromatic proton resonances in proteins.
Löhr F, Hänsel R, Rogov VV, Dötsch V.
J Biomol NMR. 2007 Mar;37(3):205-24. Epub 2007 Jan 20.

The guanylate kinase domain of the MAGUK PSD-95 binds dynamically to a conserved motif in MAP1a.
Reese ML, Dakoji S, Bredt DS, Dötsch V.
Nat Struct Mol Biol. 2007 Feb;14(2):155-63. Epub 2007 Jan 14.

NMR assignment of 1H, 13C and 15N resonances of the truncated Escherichia coli RcsC (700-949), including the phosphoreceiver domain.
Rogov VV, Löhr F, Rogova N, Klammt C, Koglin A, Bernhard F, Dötsch V.
J Biomol NMR. 2007 Jun;38(2):165. Epub 2006 Oct 12.

A new structural domain in the Escherichia coli RcsC hybrid sensor kinase connects histidine kinase and phosphoreceiver domains.
Rogov VV, Rogova NY, Bernhard F, Koglin A, Löhr F, Dötsch V.
J Mol Biol. 2006 Nov 17;364(1):68-79. Epub 2006 Jul 29.

NMR in the SPINE Structural Proteomics project.
Ab E, Atkinson AR, Banci L, Bertini I, Ciofi-Baffoni S, Brunner K, Diercks T, Dötsch V, Engelke F, Folkers GE, Griesinger C, Gronwald W, Günther U, Habeck M, de Jong RN, Kalbitzer HR, Kieffer B, Leeflang BR, Loss S, Luchinat C, Marquardsen T, Moskau D, Neidig KP, Nilges M, Piccioli M, Pierattelli R, Rieping W, Schippmann T, Schwalbe H, Travé G, Trenner J, Wöhnert J, Zweckstetter M, Kaptein R.
Acta Crystallogr D Biol Crystallogr. 2006 Oct;62(Pt 10):1150-61. Epub 2006 Sep 19. Review.

Preparative scale cell-free expression systems: new tools for the large scale preparation of integral membrane proteins for functional and structural studies.
Schwarz D, Klammt C, Koglin A, Löhr F, Schneider B, Dötsch V, Bernhard F.
Methods. 2007 Apr;41(4):355-69. Review.

Cell-free expression as an emerging technique for the large scale production of integral membrane protein.
Klammt C, Schwarz D, Löhr F, Schneider B, Dötsch V, Bernhard F.
FEBS J. 2006 Sep;273(18):4141-53. Epub 2006 Aug 23. Review.

Combination of cell-free expression and NMR spectroscopy as a new approach for structural investigation of membrane proteins.
Koglin A, Klammt C, Trbovic N, Schwarz D, Schneider B, Schäfer B, Löhr F, Bernhard F, Dötsch V.
Magn Reson Chem. 2006 Jul;44 Spec No:S17-23. Review.

NMR assignment of the L27 heterodimer from LIN-2 and LIN-7 scaffold proteins.
Petrosky KY, Löhr F, Dötsch V.
J Biomol NMR. 2006;36 Suppl 1:15.

Conformational switches modulate protein interactions in peptide antibiotic synthetases.
Koglin A, Mofid MR, Löhr F, Schäfer B, Rogov VV, Blum MM, Mittag T, Marahiel MA, Bernhard F, Dötsch V.
Science. 2006 Apr 14;312(5771):273-6.

One functional switch mediates reversible and irreversible inactivation of a herpesvirus protease.
Nomura AM, Marnett AB, Shimba N, Dötsch V, Craik CS.
Biochemistry. 2006 Mar 21;45(11):3572-9.

Actin binding to the central domain of WASP/Scar proteins plays a critical role in the activation of the Arp2/3 complex.
Kelly AE, Kranitz H, Dötsch V, Mullins RD.
J Biol Chem. 2006 Apr 14;281(15):10589-97. Epub 2005 Dec 23.

Evaluation of detergents for the soluble expression of alpha-helical and beta-barrel-type integral membrane proteins by a preparative scale individual cell-free expression system.
Klammt C, Schwarz D, Fendler K, Haase W, Dötsch V, Bernhard F.
FEBS J. 2005 Dec;272(23):6024-38.

Induced structure of a helical switch as a mechanism to regulate enzymatic activity.
Nomura AM, Marnett AB, Shimba N, Dötsch V, Craik CS.
Nat Struct Mol Biol. 2005 Nov;12(11):1019-20.

Triple-resonance methods for complete resonance assignment of aromatic protons and directly bound heteronuclei in histidine and tryptophan residues.
Löhr F, Rogov VV, Shi M, Bernhard F, Dötsch V.
J Biomol NMR. 2005 Aug;32(4):309-28.

Efficient strategy for the rapid backbone assignment of membrane proteins.
Trbovic N, Klammt C, Koglin A, Löhr F, Bernhard F, Dötsch V.
J Am Chem Soc. 2005 Oct 5;127(39):13504-5.

A general model for preferential hetero-oligomerization of LIN-2/7 domains: mechanism underlying directed assembly of supramolecular signaling complexes.
Petrosky KY, Ou HD, Löhr F, Dötsch V, Lim WA.
J Biol Chem. 2005 Nov 18;280(46):38528-36. Epub 2005 Sep 7.

In-cell NMR spectroscopy.
Reckel S, Löhr F, Dötsch V.
Chembiochem. 2005 Sep;6(9):1601-6. Review.

In-cell NMR spectroscopy.
Serber Z, Corsini L, Durst F, Dötsch V.
Methods Enzymol. 2005;394:17-41.

Optimization of 13C direct detection NMR methods.
Shimba N, Kovacs H, Stern AS, Nomura AM, Shimada I, Hoch JC, Craik CS, Dötsch V.
J Biomol NMR. 2004 Oct;30(2):175-9.

Solution structure of the Escherichia coli YojN histidine-phosphotransferase domain and its interaction with cognate phosphoryl receiver domains.
Rogov VV, Bernhard F, Löhr F, Dötsch V.
J Mol Biol. 2004 Oct 29;343(4):1035-48.

Assignment of (1)H, (13)C and (15)N resonances of the Escherichia coli YojN histidine-phosphotransferase (HPt) domain.
V Rogov V, Löhr F, Bernhard F, Dötsch V.
J Biomol NMR. 2004 Sep;30(1):103-4.

Methyl groups as probes for proteins and complexes in in-cell NMR experiments.
Serber Z, Straub W, Corsini L, Nomura AM, Shimba N, Craik CS, Ortiz de Montellano P, Dötsch V.
J Am Chem Soc. 2004 Jun 9;126(22):7119-25.

High level cell-free expression and specific labeling of integral membrane proteins.
Klammt C, Löhr F, Schäfer B, Haase W, Dötsch V, Rüterjans H, Glaubitz C, Bernhard F.
Eur J Biochem. 2004 Feb;271(3):568-80.

Fast mapping of protein-protein interfaces by NMR spectroscopy.
Reese ML, Dötsch V.
J Am Chem Soc. 2003 Nov 26;125(47):14250-1.
PMID: 14624553 [PubMed - indexed for MEDLINE]
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Unusual Rel-like architecture in the DNA-binding domain of the transcription factor NFATc.
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Salt-stabilized globular protein structure in 7 M aqueous urea solution.
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Water suppression by coherence selection with absorptive lineshape without loss in sensitivity.
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Interaction of urea with an unfolded protein. The DNA-binding domain of the 434-repressor.
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