Selected Publications
| 2021 | 2020 | 2019 | | | 2018 | | | 2017 | | | 2016 | | | 2015 | | | 2014 | | | 2013 | | | 2012 | | | 2011 | | | 2010 and earlier |
2021 |
| Demonstrating Ligandability of the LC3A and LC3B Adapter Interface. Hartmann M, Huber J, Kramer JS, Heering J, Pietsch L, Stark H, Odadzic D, Bischoff I, Fürst R, Schröder M, Akutsu M, Chaikuad A, Dötsch V, Knapp S, Biondi RM, Rogov VV, Proschak E. J Med Chem. 2021 Mar 26. doi: 10.1021/acs.jmedchem.0c01564. Online ahead of print. PMID: 33769048 |
| Characterization of a natural variant of human NDP52 and its functional consequences on mitophagy. Di Rita A, Angelini DF, Maiorino T, Caputo V, Cascella R, Kumar M, Tiberti M, Lambrughi M, Wesch N, Löhr F, Dötsch V, Carinci M, D'Acunzo P, Chiurchiù V, Papaleo E, Rogov VV, Giardina E, Battistini L, Strappazzon F. Cell Death Differ. 2021 Mar 15. doi: 10.1038/s41418-021-00766-3. Online ahead of print. PMID: 33723372 |
| The UBA domain of conjugating enzyme Ubc1/Ube2K facilitates assembly of K48/K63-branched ubiquitin chains. Pluska L, Jarosch E, Zauber H, Kniss A, Waltho A, Bagola K, von Delbrück M, Löhr F, Schulman BA, Selbach M, Dötsch V, Sommer T. EMBO J. 2021 Feb 12:e106094. doi: 10.15252/embj.2020106094. Online ahead of print. PMID: 33576509 |
| Isoform-Specific Roles of Mutant p63 in Human Diseases. Osterburg C, Osterburg S, Zhou H, Missero C, Dötsch V. Cancers (Basel). 2021 Jan 31;13(3):536. doi: 10.3390/cancers13030536. PMID: 33572532 Free PMC article. Review. |
| The p63 C-terminus is essential for murine oocyte integrity Lena AM, Rossi V, Osterburg S, Smirnov A, Osterburg C, Tuppi M, Cappello A, Amelio I, Dötsch V, De Felici M, Klinger FG, Annicchiarico-Petruzzelli M, Valensise H, Melino G, Candi E. Nat Commun. 2021 Jan 15;12(1):383. doi: 10.1038/s41467-020-20669-0. PMID: 33452256 |
2020 |
| DNA Damaged Induced Cell Death in Oocytes Gebel J, Tuppi M, Sänger N, Schumacher B, Dötsch V. Molecules. 2020 Dec 3;25(23):E5714. doi: 10.3390/molecules25235714. PMID: 33287328 Review. |
| Co-translational Insertion of Membrane Proteins into Preformed Nanodiscs Levin R, Koeck Z, Dötsch V, Bernhard F. J Vis Exp. 2020 Nov 19;(165). doi: 10.3791/61844. PMID: 33283784 |
| Membrane insertion mechanism and molecular assembly of the bacteriophage lysis toxin ΦX174-E Mezhyrova J, Martin J, Peetz O, Dötsch V, Morgner N, Ma Y, Bernhard F. FEBS J. 2020 Nov 27. doi: 10.1111/febs.15642. Online ahead of print. PMID: 33244868 |
| Ubiquitination in the ERAD Process. Lopata A, Kniss A, Löhr F, Rogov VV, Dötsch V. Int J Mol Sci. 2020 Jul 28;21(15):E5369. doi: 10.3390/ijms21155369. PMID: 32731622 Review. |
| Discovery of Protein-Protein Interaction Inhibitors by Integrating Protein Engineering and Chemical Screening Platforms. Maculins T, Garcia-Pardo J, Skenderovic A, Gebel J, Putyrski M, Vorobyov A, Busse P, Varga G, Kuzikov M, Zaliani A, Rahighi S, Schaeffer V, Parnham MJ, Sidhu SS, Ernst A, Dötsch V, Akutsu M, Dikic I. Cell Chem Biol. 2020 Jul 27:S2451-9456(20)30283-X. doi: 10.1016/j.chembiol.2020.07.010. Online ahead of print. PMID: 32726587 |
| p63 uses a switch-like mechanism to set the threshold for induction of apoptosis. Gebel J, Tuppi M, Chaikuad A, Hötte K, Schröder M, Schulz L, Löhr F, Gutfreund N, Finke F, Henrich E, Mezhyrova J, Lehnert R, Pampaloni F, Hummer G, Stelzer EHK, Knapp S, Dötsch V. Nat Chem Biol. 2020 Jul 27. doi: 10.1038/s41589-020-0600-3. Online ahead of print. PMID: 32719556 |
| Oxygen-dependent asparagine hydroxylation of the ubiquitin-associated (UBA) domain in Cezanne regulates ubiquitin binding. Mader J, Huber J, Bonn F, Doetsch V, Rogov VV, Bremm A. J Biol Chem. 2020 Jan 14. pii: jbc.RA119.010315. doi: 10.1074/jbc.RA119.010315. [Epub ahead of print] PMID: 31937588 [PubMed - as supplied by publisher] |
2019 |
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| Regulation of Phosphoribosyl-Linked Serine Ubiquitination by Deubiquitinases DupA and DupB. Shin D, Mukherjee R, Liu Y, Gonzalez A, Bonn F, Liu Y, Rogov VV, Heinz M, Stolz A, Hummer G, Dötsch V, Luo ZQ, Bhogaraju S, Dikic I. Mol Cell. 2019 Nov 5. pii: S1097-2765(19)30797-X. doi: 10.1016/j.molcel.2019.10.019. [Epub ahead of print] PMID: 31732457 [PubMed - as supplied by publisher] Free Article |
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| A TP63 mutation causes prominent alopecia with mild ectodermal dysplasia.A. Duchatelet S, Russo C, Osterburg C, Mallet S, Bole-Feysot C, Nitschké P, Richard MA, Dötsch V, Missero C, Nassif A, Hovnanian A. J Invest Dermatol. 2019 Nov 1. pii: S0022-202X(19)33376-7. doi: 10.1016/j.jid.2019.06.154. [Epub ahead of print] No abstract available. PMID: 31682841 [PubMed - as supplied by publisher] |
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| A Diversity of Selective Autophagy Receptors Determines the Specificity of the Autophagy Pathway. Kirkin V, Rogov VV. Mol Cell. 2019 Sep 21. pii: S1097-2765(19)30690-2. doi: 10.1016/j.molcel.2019.09.005. [Epub ahead of print] Review. PMID: 31585693 [PubMed - as supplied by publisher] |
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TA*p63 and GTAp63 achieve tighter transcriptional regulation in quality control by converting an inhibitory element into an additional transactivation domain. |
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Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites. |
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| An atypical LIR motif within UBA5 (ubiquitin like modifier activating enzyme 5) interacts with GABARAP proteins and mediates membrane localization of UBA5 Huber J, Obata M, Gruber J, Akutsu M, Löhr F, Rogova N, Güntert P, Dikic I, Kirkin V, Komatsu M, Dötsch V, Rogov VV Autophagy. 2019 Apr 16. doi: 10.1080/15548627.2019.1606637. [Epub ahead of print] PMID: 30990354 [PubMed - as supplied by publisher] |
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| Towards complete polypeptide backbone NH assignment via combinatorial labeling. Löhr F, Gebel J, Henrich E, Hein C, Dötsch V. J Magn Reson. 2019 Mar 29;302:50-63. doi: 10.1016/j.jmr.2019.03.010. [Epub ahead of print] PMID: 30959416 [PubMed - as supplied by publisher] |
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| Deletions and loss-of-function variants in TP63 associated with orofacial clefting. Khandelwal KD, van den Boogaard MH, Mehrem SL, Gebel J, Fagerberg C, van Beusekom E, van Binsbergen E, Topaloglu O, Steehouwer M, Gilissen C, Ishorst N, van Rooij IALM, Roeleveld N, Christensen K, Schoenaers J, Bergé S, Murray JC, Hens G, Devriendt K, Ludwig KU, Mangold E, Hoischen A, Zhou H, Dötsch V, Carels CEL, van Bokhoven H. Eur J Hum Genet. 2019 Mar 8. doi: 10.1038/s41431-019-0370-0. [Epub ahead of print] PMID: 30850703 [PubMed - as supplied by publisher] |
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| Cell cycle arrest in mitosis promotes interferon-induced necroptosis. Frank T, Tuppi M, Hugle M, Dötsch V, van Wijk SJL, Fulda S. Cell Death Differ. 2019 Feb 11. doi: 10.1038/s41418-019-0298-5. [Epub ahead of print] PMID: 30742091 [PubMed - as supplied by publisher] |
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| Synthetic Biology-Based Solution NMR Studies on Membrane Proteins in Lipid Environments. Henrich E, Löhr F, Mezhyrova J, Laguerre A, Bernhard F, Dötsch V. Methods Enzymol. 2019;614:143-185. doi: 10.1016/bs.mie.2018.08.019. Epub 2018 Dec 21. PMID: 30611423 |
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2018 |
| Structural and functional analysis of the GABARAP interaction motif (GIM). Rogov VV, Stolz A, Ravichandran AC, Rios-Szwed DO, Suzuki H, Kniss A, Löhr F, Wakatsuki S, Dötsch V, Dikic I, Dobson RC, McEwan DG. EMBO Rep. 2018 Dec;19(12). pii: e47268. doi: 10.15252/embr.201847268. No abstract available. |
| The soluble loop BC region guides, but not dictates, the assembly of the transmembrane cytochrome b6. Tome-Stangl L, Schaetzel C, Tenzer S, Bernhard F, Schneider D. PLoS One. 2017 Dec 14;12(12):e0189532. doi: 10.1371/journal.pone.0189532. eCollection 2017. PMID: 29240839 |
| Rat Organic Cation Transporter 1 Contains Three Binding Sites for Substrate 1-Methyl-4-phenylpyridinium per Monomer. Keller T, Gorboulev V, Mueller T, Dotsch V, Bernhard F, Koepsell H. Mol Pharmacol. 2018 Nov 8. pii: mol.118.113498. doi: 10.1124/mol.118.113498. [Epub ahead of print] PMID: 30409791 |
| Structural and functional insights into the interaction and targeting hub TMD0 of the polypeptide transporter TAPL. Bock C, Löhr F, Tumulka F, Reichel K, Würz J, Hummer G, Schäfer L, Tampé R, Joseph B, Bernhard F, Dötsch V, Abele R. Sci Rep. 2018 Oct 23;8(1):15662. doi: 10.1038/s41598-018-33841-w. PMID: 30353140 |
| Molecular Determinants for Ligand Selectivity of the Cell-Free Synthesized Human Endothelin B Receptor. Dong F, Rues RB, Kazemi S, Dötsch V, Bernhard F. J Mol Biol. 2018 Oct 18. pii: S0022-2836(18)30556-4. doi: 10.1016/j.jmb.2018.10.006. [Epub ahead of print] PMID: 30342934 |
| Lipid conversion by cell-free synthesized phospholipid methyltransferase Opi3 in defined nanodisc membranes supports in trans mechanism . Henrich E, Lőhr F, Pawlik G, Peetz O, Dötsch V, Morgner N, Kroon AI, Bernhard F. Biochemistry. 2018 Sep 18. doi: 10.1021/acs.biochem.8b00807. [Epub ahead of print] PMID: 30226041 |
| LILBID and nESI: Different Native Mass Spectrometry Techniques as Tools in Structural Biology. Peetz O, Hellwig N, Henrich E, Mezhyrova J, Dötsch V, Bernhard F, Morgner N. J Am Soc Mass Spectrom. 2018 Sep 17. doi: 10.1007/s13361-018-2061-4. [Epub ahead of print] PMID: 30225732 |
| HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα Di Rita A, Peschiaroli A, D Acunzo P, Strobbe D, Hu Z, Gruber J, Nygaard M, Lambrughi M, Melino G, Papaleo E, Dengjel J, El Alaoui S, Campanella M, Dötsch V, Rogov VV, Strappazzon F, Cecconi F. Nat Commun. 2018 Sep 14;9(1):3755. doi: 10.1038/s41467-018-05722-3. PMID: 30217973 |
| Regulation of the Activity in the p53 Family Depends on the Organization of the Transactivation Domain. Krauskopf K, Gebel J, Kazemi S, Tuppi M, Löhr F, Schäfer B, Koch J, Güntert P, Dötsch V, Kehrloesser S. Structure. 2018 Aug 7;26(8):1091-1100.e4. doi: 10.1016/j.str.2018.05.013. Epub 2018 Jun 28. PMID: 30099987 |
| Structural investigation of glycan recognition by the ERAD quality control lectin Yos9 Kniss A, Kazemi S, Löhr F, Berger M, Rogov VV, Güntert P, Sommer T, Jarosch E, Dötsch V. J Biomol NMR. 2018 Jul 31. doi: 10.1007/s10858-018-0201-6. [Epub ahead of print] PMID: 30066206 |
| Precursor-based selective methyl labelling of cell-free synthesized proteins Lazarova M, Lőhr F, Rues RB, Kleebach R, Dötsch V, Bernhard F. ACS Chem Biol. 2018 Jun 12. doi: 10.1021/acschembio.8b00338. [Epub ahead of print] PMID: 29894149 |
| Donated chemical probes for open science Müller S, Ackloo S, Arrowsmith CH, Bauser M, Baryza JL, Blagg J, Böttcher J, Bountra C, Brown PJ, Bunnage ME, Carter AJ, Damerell D, Dötsch V, Drewry DH, Edwards AM, Edwards J, Elkins JM, Fischer C, Frye SV, Gollner A, Grimshaw CE, IJzerman A, Hanke T, Hartung IV, Hitchcock S, Howe T, Hughes TV, Laufer S, Li VM, Liras S, Marsden BD, Matsui H, Mathias J, O'Hagan RC, Owen DR, Pande V, Rauh D, Rosenberg SH, Roth BL, Schneider NS, Scholten C, Singh Saikatendu K, Simeonov A, Takizawa M, Tse C, Thompson PR, Treiber DK, Viana AY, Wells CI, Willson TM, Zuercher WJ, Knapp S, Mueller-Fahrnow A. Elife. 2018 Apr 20;7. pii: e34311. doi: 10.7554/eLife.34311. PMID: 29676732 |
| CHK2 sets the stage for CK1 in oocyte quality control Kehrloesser S, Tuppi M, Dötsch V. Cell Death Differ. 2018 Apr 17. doi: 10.1038/s41418-018-0107-6. [Epub ahead of print] No abstract available. PMID: 29666471 |
| Structural Characterization of the Interaction of the Fibroblast Growth Factor Receptor with a Small Molecule Allosteric Inhibitor Kappert F, Sreeramulu S, Jonker HRA, Richter C, Rogov VV, Proschak E, Hargittay B, Saxena K, Schwalbe H. Chemistry. 2018 Apr 14. doi: 10.1002/chem.201801770. [Epub ahead of print] PMID: 29656465 |
| Protein labeling strategies for liquid-state NMR spectroscopy using cell-free synthesis Hoffmann B, Löhr F, Laguerre A, Bernhard F, Dötsch V. Prog Nucl Magn Reson Spectrosc. 2018 Apr;105:1-22. doi: 10.1016/j.pnmrs.2017.11.004. Epub 2017 Dec 7. Review. PMID: 29548364 |
| Oocyte DNA damage quality control requires consecutive interplay of CHK2 and CK1 to activate p63 Tuppi M, Kehrloesser S, Coutandin DW, Rossi V, Luh LM, Strubel A, Hötte K, Hoffmeister M, Schäfer B, De Oliveira T, Greten F, Stelzer EHK, Knapp S, De Felici M, Behrends C, Klinger FG, Dötsch V. Nat Struct Mol Biol. 2018 Feb 26. doi: 10.1038/s41594-018-0035-7. [Epub ahead of print] PMID: 29483652 |
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Systematic optimization of cell-free synthesized human endothelin B receptor folding. |
| Chain Assembly and Disassembly Processes Differently Affect the Conformational Space of Ubiquitin Chains. Kniss A, Schuetz D, Kazemi S, Pluska L, Spindler PE, Rogov VV, Husnjak K, Dikic I, Güntert P, Sommer T, Prisner TF, Dötsch V. Structure. 2018 Jan 17. pii: S0969-2126(17)30410-0. doi: 10.1016/j.str.2017.12.011. [Epub ahead of print] PMID:29358025 |
| Protein aggregation of the p63 transcription factor underlies severe skin fragility in AEC syndrome. Russo C, Osterburg C, Sirico A, Antonini D, Ambrosio R, Würz JM, Rinnenthal J, Ferniani M, Kehrloesser S, Schäfer B, Güntert P, Sinha S, Dötsch V, Missero C. Proc Natl Acad Sci U S A. 2018 Jan 16. pii: 201713773. doi: 10.1073/pnas.1713773115. [Epub ahead of print] PMID: 29339502 |
2017 |
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Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase. |
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Non-oncogenic roles of TAp73: from multiciliogenesis to metabolism. |
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Insights into co-translational membrane protein insertion by combined LILBID-mass spectrometry and NMR spectroscopy |
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The E. coli S30 lysate proteome: A prototype for cell-free protein production. |
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Control mechanisms in germ cells mediated by p53 family proteins. |
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Site-specific inhibition of the SUMO-conjugating enzyme Ubc9 selectively impairs SUMO chain formation. |
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The soluble loop BC guides, but not dictates, the assembly of the transmembrane cytochrome b6. |
| Insights into co-translational membrane protein insertion by combined LILBID-mass spectrometry and NMR spectroscopy. Peetz, O., Henrich, E., Laguerre, A., Löhr, F., Hein, C., Dötsch, V., Bernhard, F., and Morgner, N. (2017) Anal. Chem. 89: 12314-12318. doi: 10.1021/acs.analchem.7b03309. |
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Cell-free protein synthesis in micro compartments: building a minimal cell from biobricks. |
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Structural and functional analysis of the GABARAP interaction motif (GIM). |
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Membrane Protein Production in E. coli Lysates in Presence of Preassembled Nanodiscs. |
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From Gene to Function: Cell-free Electrophysiological and Optical Analysis of Ion Pumps in Nanodiscs. |
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Phosphorylation of the mitochondrial autophagy receptor Nix enhances its interaction with LC3 proteins. |
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Apoptosis inhibitor 5 is an endogenous inhibitor of caspase-2. |
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Methods for Studying Interactions Between Atg8/LC3/GABARAP and LIR-Containing Proteins. |
| Integral Membrane Proteins Can Be Crystallized Directly from Nanodiscs. M. Nikolaev, E. Round, I. Gushchin, V. Polovinkin, T. Balandin, P. Kuzmichev, V. Shevchenko, V. Borshchevskiy, A. Kuklin, A. Round, F. Bernhard, D. Willbold, G.Bueldt and V. Gordeliy(2017) Cryst. Growth Des. 17, 945-948. |
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Analyzing native membrane protein assembly in nanodiscs by combined non-covalent mass spectrometry and synthetic biology. |
2016 |
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Acceleration of protein backbone NMR assignment by combinatorial labeling: Application to a small molecule binding study. |
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Fluorescence-based ATG8 sensors monitor localization and function of LC3/GABARAP proteins. |
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The synaptic vesicle protein SV31 assembles into a dimer and transports Zn2. |
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Mechanism of TAp73 inhibition by ΔNp63 and structural basis of p63/p73 hetero-tetramerization. |
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From Nanodiscs to Isotropic Bicelles: A Procedure for Solution Nuclear Magnetic Resonance Studies of Detergent-Sensitive Integral Membrane Proteins. |
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Cell-Free Production of Membrane Proteins in Escherichia coli Lysates for Functional and Structural Studies. |
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Intrinsic aggregation propensity of the p63 and p73 TI domains correlates with p53R175H interaction and suggests further significance of aggregation events in the p53 family. |
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Combining In vitro Folding with Cell-Free Protein Synthesis for Membrane Protein Expression. |
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The CUE Domain of Cue1 Aligns Growing Ubiquitin Chains with Ubc7 for Rapid Elongation. |
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Co-translational formation and pharmacological characterization of beta1-adrenergic receptor/nanodisc complexes with different lipid environments. |
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Quality control in oocytes by p63 is based on a spring-loaded activation mechanism on the molecular and cellular level. |
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Structural Evolution and Dynamics of the p53 Proteins. |
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Structural and functional analysis of a novel interaction motif within UFM1-activating enzyme 5 (UBA5) required for binding to ubiquitin-like proteins and ufmylation. |
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Lipid Requirements for the Enzymatic Activity of MraY Translocases and in Vitro Reconstitution of the Lipid II Synthesis Pathway. |
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). |
2015 |
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Labeling of Membrane Proteins by Cell-Free Expression. |
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Structural investigations of the p53/p73 homologs from the tunicate species Ciona intestinalis reveal the sequence requirements for the formation of a tetramerization domain. |
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Probing metallo-β-lactamases with molecular fragments identified by consensus docking. |
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TECPR2 Cooperates with LC3C to Regulate COPII-Dependent ER Export. |
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Assembling a Correctly Folded and Functional Heptahelical Membrane Protein by Protein Trans-splicing. |
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Biosynthesis of membrane dependent proteins in insect cell lysates: identification of limiting parameters for folding and processing. |
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Structure and Biophysical Characterization of the S-Adenosylmethionine-dependent O-Methyltransferase PaMTH1, a Putative Enzyme Accumulating during Senescence of Podospora anserina. |
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An extended combinatorial 15N, 13Cα, and 13C' labeling approach to protein backbone resonance assignment. |
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Membrane protein production in Escherichia coli cell-free lysates. |
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Screening for lipid requirements of membrane proteins by combining cell-free expression with nanodiscs. |
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FAM96A is a novel pro-apoptotic tumor suppressor in gastrointestinal stromal tumors. |
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CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling. |
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Cell-free expression of G-protein-coupled receptors. |
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Co-translational stabilization of insoluble proteins in cell-free expression systems. |
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2014 |
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Time-shared experiments for efficient assignment of triple-selectively labeled proteins. |
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Functional interplay between MDM2, p63/p73 and mutant p53. |
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Cell-free expression of G-protein coupled receptors: new pipelines for challenging targets. |
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Stabilisation and characterisation of the isolated regulatory domain of human 5-lipoxygenase. |
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In-cell NMR and EPR spectroscopy of biomacromolecules. |
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Cell-free expression and in meso crystallisation of an integral membrane kinase for structure determination. |
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Crystal structure of a PCP/Sfp complex reveals the structural basis for carrier protein posttranslational modification. |
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Peak picking NMR spectral data using non-negative matrix factorization. |
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Interactions between autophagy receptors and ubiquitin-like proteins form the molecular basis for selective autophagy. |
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High-level cell-free production of membrane proteins with nanodiscs. |
2013 |
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SPLICEFINDER - a fast and easy screening method for active protein trans-splicing positions. |
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Conformational stabilization of the membrane embedded targeting domain of the lysosomal peptide transporter TAPL for solution NMR. |
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Molecular crowding drives active Pin1 into nonspecific complexes with endogenous proteins prior to substrate recognition. |
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How to switch a master switch. |
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Endoplasmic reticulum targeting and insertion of tail-anchored membrane proteins by the GET pathway. |
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Structural basis for phosphorylation-triggered autophagic clearance of Salmonella. |
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Functional properties of cell-free expressed human endothelin A and endothelin B receptors in artificial membrane environments. |
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Analysis of the oligomeric state and transactivation potential of TAp73α. |
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Artificial environments for the co-translational stabilization of cell-free expressed proteins. |
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High-resolution insight into G-overhang architecture. |
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Modified lipid and protein dynamics in nanodiscs. |
2012 |
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Characterization of the ground state dynamics of proteorhodopsin by NMR and optical spectroscopies. |
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A method for integrative structure determination of protein-protein complexes. |
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Cell-free expression of human glucosamine 6-phosphate N-acetyltransferase (HsGNA1) for inhibitor screening. |
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Characterization of co-translationally formed nanodisc complexes with small multidrug transporters, proteorhodopsin and with the E. coli MraY translocase. |
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Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer. |
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Investigation of quadruplex structure under physiological conditions using in-cell NMR. |
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Co-translational association of cell-free expressed membrane proteins with supplied lipid bilayers. |
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Requirements on paramagnetic relaxation enhancement data for membrane protein structure determination by NMR. |
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Caspase-2 is an initiator caspase responsible for pore-forming toxin-mediated apoptosis. |
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Fast automated NMR spectroscopy of short-lived biological samples. |
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A universal expression tag for structural and functional studies of proteins. |
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A systematic approach to increase the efficiency of membrane protein production in cell-free expression systems. |
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In-cell solid-state NMR as a tool to study proteins in large complexes. |
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Combinatorial triple-selective labeling as a tool to assist membrane protein backbone resonance assignment. |
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Single-molecule force spectroscopy from nanodiscs: an assay to quantify folding, stability, and interactions of native membrane proteins. |
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Characterization of molecular interactions between ACP and halogenase domains in the Curacin A polyketide synthase. |
2011 |
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Solution NMR structure of proteorhodopsin. |
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Systems for the cell-free synthesis of proteins. |
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Preparative scale cell-free production and quality optimization of MraY homologues in different expression modes. |
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Cell-free expression and assembly of ATP synthase. |
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The large extracellular loop of organic cation transporter 1 influences substrate affinity and is pivotal for oligomerization. |
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Functional expression of the PorAH channel from Corynebacterium glutamicum in cell-free expression systems: implications for the role of the naturally occurring mycolic acid modification. |
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Structural basis for tail-anchored membrane protein biogenesis by the Get3-receptor complex. |
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Differential altered stability and transcriptional activity of ΔNp63 mutants in distinct ectodermal dysplasias. |
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Improved accuracy in measuring one-bond and two-bond (15)N, (13)C (α) coupling constants in proteins by double-inphase/antiphase (DIPAP) spectroscopy. |
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Characterization of the interaction of GABARAPL-1 with the LIR motif of NBR1. |
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Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth. |
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Mutation in SAM domain of TP63 is associated with nonsyndromic cleft lip and palate and cleft palate. |
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How to create a specific recognition for an unspecific interaction. |
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Quality control in oocytes: domain-domain interactions regulate the activity of p63. |
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Long-range distance measurements on nucleic acids in cells by pulsed EPR spectroscopy. |
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Rapid identification of protein-protein interfaces for the construction of a complex model based on multiple unassigned signals by using time-sharing NMR measurements. |
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Structural insights into Rcs phosphotransfer: the newly identified RcsD-ABL domain enhances interaction with the response regulator RcsB. |
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A disulfide bridge network within the soluble periplasmic domain determines structure and function of the outer membrane protein RCSF. |
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The parallel G-quadruplex structure of vertebrate telomeric repeat sequences is not the preferred folding topology under physiological conditions. |
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DNA damage in oocytes induces a switch of the quality control factor TAp63α from dimer to tetramer. |
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Phenotypic analysis of Arg227 mutations of TP63 with emphasis on dental phenotype and micturition difficulties in EEC syndrome. |
2010 and earlier |
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Optimization of amino acid type-specific 13C and 15N labeling for the backbone assignment of membrane proteins by solution- and solid-state NMR with the UPLABEL algorithm. |
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Preparative scale production of functional mouse aquaporin 4 using different cell-free expression modes. |
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NmerA of Tn501 mercuric ion reductase: structural modulation of the pKa values of the metal binding cysteine thiols. |
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Tracing the protectors path from the germ line to the genome. |
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Advances in cell-free protein synthesis for the functional and structural analysis of membrane proteins. |
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p63 and p73, the ancestors of p53. |
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Modulation of G-protein coupled receptor sample quality by modified cell-free expression protocols: a case study of the human endothelin A receptor. |
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Structural investigation of the C-terminal catalytic fragment of presenilin 1. |
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Strategies for the cell-free expression of membrane proteins. |
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Cell-free expression profiling of E. coli inner membrane proteins. |
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Membrane protein expression in cell-free systems. |
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The C-terminus of p63 contains multiple regulatory elements with different functions. |
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Nix is a selective autophagy receptor for mitochondrial clearance. |
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Ubiquitin linkages make a difference. |
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The molecular pharmacology and in vivo activity of 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS121), a dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase. |
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NMR studies reveal the role of biomembranes in modulating ligand binding and release by intracellular bile acid binding proteins. |
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Evaluation of parameters critical for observing nucleic acids inside living Xenopus laevis oocytes by in-cell NMR spectroscopy. |
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Conformational stability and activity of p73 require a second helix in the tetramerization domain. |
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On track to tenure-track. |
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Cell-free expression and stable isotope labelling strategies for membrane proteins. |
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Segmental isotopic labeling of a central domain in a multidomain protein by protein trans-splicing using only one robust DnaE intein. |
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A cost-effective amino-acid-type selective isotope labeling of proteins expressed in Leishmania tarentolae. |
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Modulation of the Rcs-mediated signal transfer by conformational flexibility. |
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The better tag remains unseen. |
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Production of membrane proteins using cell-free expression systems. |
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Structural basis for the selectivity of the external thioesterase of the surfactin synthetase. |
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Transmembrane segment enhanced labeling as a tool for the backbone assignment of alpha-helical membrane proteins. |
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Large-scale production of functional membrane proteins. |
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Cell free expression and functional reconstitution of eukaryotic drug transporters. |
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Ubiquitin binding mediates the NF-kappaB inhibitory potential of ABIN proteins. |
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Investigation of proteins in living bacteria with in-cell NMR experiments. |
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Preparative scale expression of membrane proteins in Escherichia coli-based continuous exchange cell-free systems. |
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Reprint of "Cell-free production of G protein-coupled receptors for functional and structural studies" [J. Struct. Biol. 158 (2007) 482-493]. |
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Cell-free production of integral membrane proteins on a preparative scale. |
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Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes. |
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E3-independent monoubiquitination of ubiquitin-binding proteins. |
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Structural evolution of C-terminal domains in the p53 family. |
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Investigating macromolecules inside cultured and injected cells by in-cell NMR spectroscopy. |
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Cell-free production of G protein-coupled receptors for functional and structural studies. |
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Improved pulse sequences for sequence specific assignment of aromatic proton resonances in proteins. |
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The guanylate kinase domain of the MAGUK PSD-95 binds dynamically to a conserved motif in MAP1a. |
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NMR assignment of 1H, 13C and 15N resonances of the truncated Escherichia coli RcsC (700-949), including the phosphoreceiver domain. |
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A new structural domain in the Escherichia coli RcsC hybrid sensor kinase connects histidine kinase and phosphoreceiver domains. |
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NMR in the SPINE Structural Proteomics project. |
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Preparative scale cell-free expression systems: new tools for the large scale preparation of integral membrane proteins for functional and structural studies. |
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Cell-free expression as an emerging technique for the large scale production of integral membrane protein. |
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Combination of cell-free expression and NMR spectroscopy as a new approach for structural investigation of membrane proteins. |
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NMR assignment of the L27 heterodimer from LIN-2 and LIN-7 scaffold proteins. |
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Conformational switches modulate protein interactions in peptide antibiotic synthetases. |
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One functional switch mediates reversible and irreversible inactivation of a herpesvirus protease. |
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Actin binding to the central domain of WASP/Scar proteins plays a critical role in the activation of the Arp2/3 complex. |
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Evaluation of detergents for the soluble expression of alpha-helical and beta-barrel-type integral membrane proteins by a preparative scale individual cell-free expression system. |
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Induced structure of a helical switch as a mechanism to regulate enzymatic activity. |
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Triple-resonance methods for complete resonance assignment of aromatic protons and directly bound heteronuclei in histidine and tryptophan residues. |
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Efficient strategy for the rapid backbone assignment of membrane proteins. |
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A general model for preferential hetero-oligomerization of LIN-2/7 domains: mechanism underlying directed assembly of supramolecular signaling complexes. |
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In-cell NMR spectroscopy. |
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In-cell NMR spectroscopy. |
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Optimization of 13C direct detection NMR methods. |
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Solution structure of the Escherichia coli YojN histidine-phosphotransferase domain and its interaction with cognate phosphoryl receiver domains. |
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Assignment of (1)H, (13)C and (15)N resonances of the Escherichia coli YojN histidine-phosphotransferase (HPt) domain. |
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Methyl groups as probes for proteins and complexes in in-cell NMR experiments. |
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High level cell-free expression and specific labeling of integral membrane proteins. |
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Fast mapping of protein-protein interfaces by NMR spectroscopy. |
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Quantitative identification of the protonation state of histidines in vitro and in vivo. |
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Elimination of 13Calpha splitting in protein NMR spectra by deconvolution with maximum entropy reconstruction. |
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A C-terminal inhibitory domain controls the activity of p63 by an intramolecular mechanism. |
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Low-conductivity buffers for high-sensitivity NMR measurements. |
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Gain-of-function mutation in ADULT syndrome reveals the presence of a second transactivation domain in p63. |
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Carbon-detected NMR experiments to investigate structure and dynamics of biological macromolecules. |
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Efficient identification of amino acid types for fast protein backbone assignments. |
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In-cell NMR spectroscopy. |
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Evaluation of parameters critical to observing proteins inside living Escherichia coli by in-cell NMR spectroscopy. |
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Protein-DNA interactions. |
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High-resolution macromolecular NMR spectroscopy inside living cells. |
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Structural basis for the functional switch of the E. coli Ada protein. |
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The GYF domain is a novel structural fold that is involved in lymphoid signaling through proline-rich sequences. |
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Functional glycan-free adhesion domain of human cell surface receptor CD58: design, production and NMR studies. |
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New approaches to structure determination by NMR spectroscopy. |
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Solution structure of the core NFATC1/DNA complex. |
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Unusual Rel-like architecture in the DNA-binding domain of the transcription factor NFATc. |
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The role of protein-solvent interactions in protein unfolding. |
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Amino-acid-type identification for deuterated proteins with a beta-carbon-edited HNCOCACB experiment. |
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Editing for amino-acid type in CBCACONH experiments based on the 13C beta-13C gamma coupling. |
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Selective identification of threonine, valine, and isoleucine sequential connectivities with a TVI-CBCACONH experiment. |
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Amino-acid-type-selective triple-resonance experiments. |
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Exploring the role of the solvent in the denaturation of a protein: a molecular dynamics study of the DNA binding domain of the 434 repressor. |
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Salt-stabilized globular protein structure in 7 M aqueous urea solution. |
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Water suppression by coherence selection with absorptive lineshape without loss in sensitivity. |
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Interaction of urea with an unfolded protein. The DNA-binding domain of the 434-repressor. |
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