Original- und Übersichtsarbeiten 2006-2010

Anatomie I

2010

Baudrexel S, Nürnberger L, Rüb U, Seifried C, Klein JC, Deller T, Steinmetz H, Deichmann R, Hilker R (2010) Quantitative mapping of T1 and T2* discloses nigral and brainstem pathology in early Parkinson's disease. Neuroimage, 51: 512-520

Beck H, Raab S, Copanaki E, Heil M, Scholz A, Shibuya M, Deller T, Machein M, Plate KH (2010) VEGFR-1 signaling regulates the homing of bone marrow-derived cells in a mouse stroke model. J Neuropath Exp Neur, 69: 168-175

Bishay P, Schmidt H, Marian C, Häussler A, Wijnvoord N, Ziebell S, Metzner J, Koch M, Myrczek T, Bechmann I, Kuner R, Costigan M, Dehghani F, Geisslinger G, Tegeder I (2010) R-flurbiprofen reduces neuropathic pain in rodents by restoring endogenous cannabinoids. PLoS One, 5: e10628

Copanaki E, Chang S, Vlachos A, Tschäpe JA, Müller UC, Kögel D, Deller T (2010) sAPPalpha antagonizes dendritic degeneration and neuron death triggered by proteasomal stress. Mol Cell Neurosci, 44: 386-393

Elden AC, Kim HJ, Hart MP, Chen-Plotkin AS, Johnson BS, Fang X, Armakola M, Geser F, Greene R, Lu MM, Padmanabhan A, Clay-Falcone D, McCluskey L, Elman L, Juhr D, Gruber PJ, Rüb U, Auburger G, Trojanowski JQ, Lee VMY, Van Deerlin VM, Bonini NM, Gitler AD (2010) Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS. Nature, 466: 1069-75

Ghebremedhin E, Rosenberger A, Rüb U, Vuksic M, Berhe T, Bickeböller H, de Vos RAI, Thal DR, Deller T (2010) Inverse relationship between cerebrovascular lesions and severity of lewy body pathology in patients with lewy body diseases. J Neuropath Exp Neur, 69: 442-448

Grinberg LT, Rueb U, Alho ATdL, Heinsen H (2010) Brainstem pathology and non-motor symptoms in PD. J Neurol Sci, 289: 81-88

Hawkes CH, Del Tredici K, Braak H (2010) A timeline for Parkinson's disease. Parkinsonism Relat D, 16: 79-84

Jedlicka P, Deller T, Schwarzacher SW (2010) Computational modeling of GABA(A) receptor-mediated paired-pulse inhibition in the dentate gyrus. J Comput Neurosci, 29: 509-519

Kahles T, Kohnen A, Heumueller S, Rappert A, Bechmann I, Liebner S, Wittko IM, Neumann-Haefelin T, Steinmetz H, Schroeder K, Brandes RP (2010) NADPH Oxidase Nox1 contributes to ischemic injury in experimental stroke in mice. Neurobiol Dis, 40: 185-192

Krueger M, Bechmann I (2010) CNS pericytes: concepts, misconceptions, and a way out. GLIA, 58(1): 1-10

Ma B, Baj G, Tongiorgi E, Chao MV, Tanese N (2010) Localization of BDNF mRNA with the Huntington’s disease protein in rat brain.Mol Neurodegener, 5: 22

Menrad H, Werno C, Schmid T, Copanaki E, Deller T, Dehne N, Brüne B (2010) Roles of hypoxia-inducible factor-1alpha (HIF-1alpha) versus HIF-2alpha in the survival of hepatocellular tumor spheroids. Hepatology, 51: 2183-2192

Müller CM, Vlachos A, Deller T (2010) Calcium homeostasis of acutely denervated and lesioned dentate gyrus in organotypic entorhino-hippocampal co-cultures. Cell Calcium, 47: 242-252

Parlapani E, Schmitt A, Wirths O, Bauer M, Sommer C, Rueb U, Skowronek MH, Treutlein J, Petroianu GA, Rietschel M, Falkai P (2010) Gene expression of neuregulin-1 isoforms in different brain regions of elderly schizophrenia patients. World J Biol Psychia, 11(2 Pt 2): 243-250

Pukrop T, Dehghani F, Chuang HN, Lohaus R, Bayanga K, Heermann S, Regen T, Rossum DV, Klemm F, Schulz M, Siam L, Hoffmann A, Trümper L, Stadelmann C, Bechmann I, Hanisch UK, Binder C (2010) Microglia promote colonization of brain tissue by breast cancer cells in a Wnt-dependent way. Glia, 58: 1477-1489

Savas JN, Ma B, Deinhardt K, Culver BP, Restituito S, Wu L, Belasco JG, Chao MV, Tanese N (2010) A role for Huntington diseases protein in dendritic neural RNA. J Biol Chem, 285: 13142-13153

Segal M, Vlachos A, Korkotian E (2010) The spine apparatus, synaptopodin, and dendritic spine plasticity. Neuroscientist, 16: 125-131

Seidel K, den Dunnen WFA, Schultz C, Paulson H, Frank S, de Vos RA, Brunt ER, Deller T, Kampinga HH, Rüb U (2010) Axonal inclusions in spinocerebellar ataxia type 3. Acta Neuropathol, 120: 449-460

Seidel K, Schöls L, Nuber S, Petrasch-Parwez E, Gierga K, Wszolek Z, Dickson D, Gai WP, Bornemann A, Riess O, Rami A, Den Dunnen WFA, Deller T, Rüb U, Krüger R (2010) First appraisal of brain pathology owing to A30P mutant alpha-synuclein. Ann Neurol, 67: 684-689

Shimokawa N, Haglund K, Hölter SM, Grabbe C, Kirkin V, Koibuchi N, Schultz C, Rozman J, Hoeller D, Qiu CH, Londoño MB, Ikezawa J, Jedlicka P, Stein B, Schwarzacher SW, Wolfer DP, Ehrhardt N, Heuchel R, Nezis I, Brech A, Schmidt MHH, Fuchs H, Gailus-Durner V, Klingenspor M, Bogler O, Wurst W, Deller T, de Angelis MH, Dikic I (2010) CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice. Embo J, 29: 2421-2432

Thal DR, Papassotiropoulos A, Saido TC, Griffin WST, Mrak RE, Kölsch H, Tredici KD, Attems J, Ghebremedhin E (2010) Capillary cerebral amyloid angiopathy identifies a distinct APOE epsilon4-associated subtype of sporadic Alzheimer's disease. Acta Neuropathol, 120: 169-183

Unfried C, Burbach G, Korf HW, von Gall C (2010) Melatonin receptor 1-dependent gene expression in the mouse pars tuberalis as revealed by cDNA microarray analysis and in situ hybridization. J Pineal Res, 48: 148-156

2009

Bach P, Tschäpe JA, Kopietz F, Braun G, Baade JK, Wiederhold KH, Staufenbiel M, Prinz M, Deller T, Kalinke U, Buchholz CJ, Müller UC (2009) Vaccination with Abeta-displaying virus-like particles reduces soluble and insoluble cerebral Abeta and lowers plaque burden in APP transgenic mice. J Immunol, 182: 7613-7624

Bockhart V, Constantin CE, Häussler A, Wijnvoord N, Kanngiesser M, Myrczek T, Pickert G, Popp L, Sobotzik JM, Pasparakis M, Kuner R, Geisslinger G, Schultz C, Kress M, Tegeder I (2009) Inhibitor kappaB Kinase beta deficiency in primary nociceptive neurons increases TRP channel sensitivity. J Neurosci, 29: 12919-12929

Braak H, Del Tredici K (2009) Neuroanatomy and pathology of sporadic Parkinson's disease. Adv Anat Embryol Cel, 201:1-119

Detje CN, Meyer T, Schmidt H, Kreuz D, Rose JK, Bechmann I, Prinz M, Kalinke U (2009) Local type I IFN receptor signaling protects against virus spread within the central nervous system. J Immunol, 182(4): 2297-2304

Dickson DW, Braak H, Duda JE, Duyckaerts C, Gasser T, Halliday GM, Hardy J, Leverenz JB, Del Tredici K, Wszolek ZK, Litvan I (2009) Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria. Lancet Neurol, 8(12): 1150-1157

Frank S, Copanaki E, Burbach GJ, Müller UC, Deller T (2009) Differential regulation of toll-like receptor mRNAs in amyloid plaque-associated brain tissue of aged APP23 transgenic mice. Neurosci Lett, 453: 41-44

Ghebremedhin E, Del Tredici K, Langston JW, Braak H (2009) Diminished tyrosine hydroxylase immunoreactivity in the cardiac conduction system and myocardium in Parkinson's disease: an anatomical study. Acta Neuropathol, 117: 777-784

Gierga K, Schelhaas H, Brunt E, Seidel K, Scherzed W, Egensperger R, de Vos R, den Dunnen W, Ippel P, Petrasch-Parwez E, Deller T, Schöls L, Rüb U (2009) Spinocerebellar ataxia type 6 (SCA6): neurodegeneration goes beyond the known brain predilection sites. Neuropathol Appl Neurobiol, 35:515-527

Gispert S, Ricciardi F, Kurz A, Azizov M, Hoepken HH, Becker D, Voos W, Leuner K, Müller WE, Kudin AP, Kunz WS, Zimmermann A, Roeper J, Wenzel D, Jendrach M, García-Arencíbia M, Fernández-Ruiz J, Huber L, Rohrer H, Barrera M, Reichert AS, Rüb U, Chen A, Nussbaum RL, Auburger G (2009) Parkinson phenotype in aged PINK1-deficient mice is accompanied by progressive mitochondrial dysfunction in absence of neurodegeneration. Plos One, 4: e5777

Grinberg LT, Rüb U, Ferretti RE, Nitrini R, Farfel JM, Polichiso L, Gierga K, Jacob-Filho W, Heinsen H, Brazilian Brain Bank Study Group (2009) The dorsal raphe nucleus shows phospho-tau neurofibrillary changes before the transentorhinal region in Alzheimer's disease. A precocious onset? Neuropathol Appl Neurobiol, 35: 406-416

Hawkes CH, Del Tredici K, Braak H (2009) Parkinson's disease: the dual hit theory revisited. Ann N Y Acad Sci, 1170: 615-622

Jedlicka P, Papadopoulos T, Deller T, Betz H, Schwarzacher SW (2009) Increased network excitability and impaired induction of long-term potentiation in the dentate gyrus of collybistin-deficient mice in vivo. Mol Cell Neurosci, 41: 94-100

Jedlicka P, Schwarzacher SW, Winkels R, Kienzler F, Frotscher M, Bramham CR, Schultz C, Bas Orth C, Deller T (2009) Impairment of in vivo theta-burst long-term potentiation and network excitability in the dentate gyrus of synaptopodin-deficient mice lacking the spine apparatus and the cisternal organelle. Hippocampus, 19: 130-140

Kern A, Seidel K, Oelschläger HH (2009) The central vestibular complex in dolphins and humans: functional implications of Deiters' nucleus. Brain Behav Evol, 73: 102-10

Kienzler F, Norwood BA, Sloviter RS (2009) Hippocampal injury, atrophy, synaptic reorganization, and epileptogenesis after perforant pathway stimulation-induced status epilepticus in the mouse. J Comp Neurol, 515: 181-96

Meltendorf C, Burbach GJ, Ohrloff C, Ghebremedhin E, Deller T (2009) Intrastromal keratotomy with femtosecond laser avoids profibrotic TGF-beta1 induction. Invest Ophthalmol Vis Sci, 50: 3688-3695

Nelson PT, Braak H, Markesbery WR (2009) Neuropathology and cognitive impairment in Alzheimer disease: a complex but coherent relationship. J Neuropath Exp Neur, 68: 1-14

Peters I, Igbavboa U, Schütt T, Haidari S, Hartig U, Rosello X, Böttner S, Copanaki E, Deller T, Kögel D, Wood WG, Müller WE, Eckert GP (2009) The interaction of beta-amyloid protein with cellular membranes stimulates its own production. Biochim Biophys Acta, 1788: 964-972

Pfeffer M, Müller CM, Mordel J, Meissl H, Ansari N, Deller T, Korf HW, von Gall C (2009) The mammalian molecular clockwork controls rhythmic expression of its own input pathway components. J Neurosci, 29: 6114-6123

Poulopoulos A, Aramuni G, Meyer G, Soykan T, Hoon M, Papadopoulos T, Zhang M, Paarmann I, Fuchs C, Harvey K, Jedlicka P, Schwarzacher SW, Betz H, Harvey RJ, Brose N, Zhang W, Varoqueaux F (2009) Neuroligin 2 drives postsynaptic assembly at perisomatic inhibitory synapses through gephyrin and collybistin. Neuron, 63: 628-642

Rüb U, Heinsen H, Brunt ER, Landwehrmeyer B, Den Dunnen WF, Gierga K, Deller T (2009) The human premotor oculomotor brainstem system - can it help to understand oculomotor symptoms in Huntington's disease? Neuropathol Appl Neurobiol, 35: 4-15

Rüb U, Jen JC, Braak H, Deller T (2009) Functional neuroanatomy of the human premotor oculomotor brainstem nuclei: insights from postmortem and advanced in vivo imaging studies. Exp Brain Res, 35: 4-15

Seidel K, De Vos R, Derksen L, Bauer P, Riess O, den Dunnen W, Deller T, Hageman G, Rüb U (2009) Widespread thalamic and cerebellar degeneration in a patient with a complicated hereditary spastic paraplegia (HSP). Ann Anat, 191: 203-211

Sobotzik JM, Sie JM, Politi C, Del Turco D, Bennett V, Deller T, Schultz C (2009) AnkyrinG is required to maintain axo-dendritic polarity in vivo. Proc Natl Acad Sci U S A, 106(41): 17564-17569

Streit WJ, Braak H, Xue QS, Bechmann I (2009) Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer's disease. Acta Neuropathol, 118: 475-485

van Zwam M, Huizinga R, Melief MJ, Wierenga-Wolf AF, van Meurs M, Voerman JS, Biber KP, Boddeke HW, Höpken UE, Meisel C, Meisel A, Bechmann I, Hintzen RQ, 't Hart BA; Amor S, Laman JD, Boven LA (2009) Brain antigens in functionally distinct antigen-presenting cell populations in cervical lymph nodes in MS and EAE.J Mol Med, 87(3): 273-286

Vlachos A, Korkotian E, Schonfeld E, Copanaki E, Deller T, Segal M (2009) Synaptopodin regulates plasticity of dendritic spines in hippocampal neurons. J Neurosci, 29: 1017-1033

Winkels R, Jedlicka P, Weise FK, Schultz C, Deller T, Schwarzacher SW (2009) Reduced excitability in the dentate gyrus network of betaIV-spectrin mutant mice in vivo. Hippocampus, 19: 677-686

Zolles G, Wenzel D, Bildl W, Schulte U, Hofmann A, Müller CS, Thumfart JO, Vlachos A, Deller T, Pfeifer A, Fleischmann BK, Roeper J, Fakler B, Klöcker N (2009) Association with the auxiliary subunit PEX5R/Trip8b controls responsiveness of HCN channels to cAMP and adrenergic stimulation. Neuron, 62: 814-825

2008

Alafuzoff I, Arzberger T, Al-Sarraj S, Bodi I, Bogdanovic N, Braak H, Bugiani O, Del Tredici K, Ferrer I, Gelpi E, Giaccone G, Graeber MB, Ince P, Kamphorst W, King A, Korkolopoulou P, Kovács GG, Larionov S, Meyronet D, Monoranu C, Parchi P, Patsouris E, Roggendorf W, Seilhean D, Tagliavini F, Stadelmann C, Streichenberger N, Thal DR, Wharton SB, Kretzschmar H (2008) Staging of neurofibrillary pathology in Alzheimer's disease: a study of the BrainNet Europe Consortium. Brain Pathol 18: 484-496

Braak H, Del Tredici K (2008)Neue Sicht des kortiko-striato-thalamo-kortikalen Regelkreises bei M. Parkinson. Nervenarzt 79: 1440-1445

Braak H, Del Tredici K (2008) Cortico-basal ganglia-cortical circuitry in Parkinson's disease reconsidered. Exp Neurol 212: 226-229

Braak H, Del Tredici K (2008) Reply to "Controversies over the staging of alpha-synuclein pathology in Parkinson's disease". Acta Neuropathol 116: 129-131

Braak H, Del Tredici K (2008) Invited Article: Nervous system pathology in sporadic Parkinson disease. Neurology 70: 1916-1925

Del Tredici K, Braak H (2008) Neurofibrillary changes of the Alzheimer type in very elderly individuals: neither inevitable nor benign: Commentary on "No disease in the brain of a 115-year-old woman". Neurobiol Aging 29: 1133-1136

Färber K, Markworth S, Pannasch U, Nolte C, Prinz V, Kronenberg G, Gertz K, Endres M, Bechmann I, Enjyoji K, Robson SC, Kettenmann H (2008) The ectonucleotidase cd39/ENTPDase1 modulates purinergic-mediated microglial migration. Glia 56: 331-341

Frank S, Burbach GJ, Bonin M, Walter M, Streit W, Bechmann I, Deller T (2008) TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice. Glia 56: 1438-1447

Frisoni GB, Ganzola R, Canu E, Rüb U, Pizzini FB, Alessandrini F, Zoccatelli G, Beltramello A, Caltagirone C, Thompson PM (2008) Mapping local hippocampal changes in Alzheimer's disease and normal ageing with MRI at 3 Tesla. Brain, 131: 3266-3276

Hoche F, Seidel K, Brunt ER, Auburger G, Schöls L, Bürk K, de Vos RA, den Dunnen W, Bechmann I, Egensperger R, Van Broeckhoven C, Gierga K, Deller T, Rüb U (2008) Involvement of the auditory brainstem system in spinocerebellar ataxia type 2 (SCA2), type 3 (SCA3) and type 7 (SCA7). Neuropath Appl Neuro 34: 479-491

Jedlicka P, Vlachos A, Schwarzacher SW, Deller T (2008) A role for the spine apparatus in LTP and spatial learning. Behav Brain Res 192: 12-19

De Jong EK, de Haas AH, Brouwer N, van Weering HR, Hensens M, Bechmann I, Pratley P, Wesseling E, Boddeke HW, Biber K (2008) Expression of CXCL4 in microglia in vitro and in vivo and its possible signaling through CXCR3. J Neurochem 105: 1726-1736

Lastres-Becker I, Rüb U, Auburger G (2008) Spinocerebellar ataxia 2 (SCA2). Cerebellum 7: 115-124

Owens T,Bechmann I, Engelhardt B (2008) Perivascular spaces and the two steps to neuroinflammation. J Neuropath Exp Neur, 67: 1113-1121

Politi C, Del Turco D, Sie JM, Golinski PA, Tegeder I, Deller T, Schultz C (2008) Accumulation of phosphorylated IkappaBalpha and activated IKK in nodes of Ranvier. Neuropath Appl Neuro 34: 357-365

Prinz M, Schmidt H, Mildner A, Knobeloch KP, Hanisch UK, Raasch J, Merkler D, Detje C, Gutcher I, Mages J, Lang R, Martin R, Gold R, Becher B, Brück W, Kalinke U (2008) Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system. Immunity, 28: 675-686

Riess O, Rüb U, Pastore A, Bauer P, Schöls L (2008) SCA3: Neurological features, pathogenesis and animal models. Cerebellum 7: 125-137

Rami A, Bechmann I, Stehle JH (2008) Exploiting endogenous anti-apoptotic proteins for novel therapeutic strategies in cerebral ischemia. Prog Neurobiol 85: 273-296

Riess O, Rüb U, Pastore A, Bauer P, Schöls L (2008) SCA3: Neurological features, pathogenesis and animal models. Cerebellum 7: 125-137

Ruangkittisakul A, Schwarzacher SW, Secchia L, Ma Y, Bobocea N, Poon BY, Funk GD, Ballanyi K (2008) Generation of eupnea and sighs by a spatiochemically organized inspiratory network. J Neurosci 28: 2447-2458

Rüb U, Brunt ER, Seidel K, Gierga K, Mooy CM, Kettner M, Van Broeckhoven C, Bechmann I, La Spada AR, Schöls L, den Dunnen W, de Vos RA, Deller T (2008) Spinocerebellar ataxia type 7 (SCA7): widespread brain damage in an adult-onset patient with progressive visual impairments in comparison with an adult-onset patient without visual impairments. Neuropath Appl Neuro Apr 34: 155-168

Rüb U, Jen JC, Braak H, Deller T (2008) Functional neuroanatomy of the human premotor oculomotor brainstem nuclei: insights from postmortem and advanced in vivo imaging studies. Exp Brain Res 187: 167-180

Rüb U, Brunt ER, Deller T (2008) New insights into the pathoanatomy of spinocerebellar ataxia type 3 (Machado-Joseph disease). Curr Opin Neurol 21: 111-116

Schäfer R, Dehn D, Burbach GJ, Deller T (2008) Differential regulation of chondroitin sulfate proteoglycan mRNAs in the denervated rat fascia dentata after unilateral entorhinal cortex lesion. Neurosci Lett 439: 61-65

Schiesling C, Kieper N, Seidel K, Krüger R (2008) Review: Familial Parkinson's disease--genetics, clinical phenotype and neuropathology in relation to the common sporadic form of the disease. Neuropathol Appl Neurobiol 34: 255-271

Thal DR, Griffin WS, Braak H (2008) Parenchymal and vascular Abeta-deposition and its effects on the degeneration of neurons and cognition in Alzheimer's disease. J Cell Mol Med 12 5B: 1848-1862

Thal DR, Griffin WS, de Vos RA, Ghebremedhin E (2008) Cerebral amyloid angiopathy and its relationship to Alzheimer’s disease. Acta Neuropathol 115: 599-609

Utter S, Tamboli IY, Walter J, Upadhaya AR, Birkenmeier G, Pietrzik CU, Ghebremedhin E, Thal DR (2008) Cerebral small vessel disease-induced apolipoprotein E leakage is associated with Alzheimer disease and the accumulation of amyloid beta-protein in perivascular astrocytes. J Neuropath Exp Neur 67: 842-856

Vlachos A, Maggio N, Segal M (2008) Lack of correlation between synaptopodin expression and the ability to induce LTP in the rat dorsal and ventral hippocampus. Hippocampus 18: 1-4

Vuksic M, Del Turco D, Bas Orth C, Burbach GJ, Feng G, Müller CM, Schwarzacher SW, Deller T (2008) 3D-reconstruction and functional properties of GFP-positive and GFP-negative granule cells in the fascia dentata of the Thy1-GFP mouse. Hippocampus 18: 364-375

Wuerfel J, Haertle M, Waiczies H, Tysiak E, Bechmann I, Wernecke KD, Zipp F, Paul F (2008) Perivascular spaces--MRI marker of inflammatory activity in the brain? Brain 131: 2332-2340

van Zwam M, Huizinga R, Melief MJ, Wierenga-Wolf AF, van Meurs M, Voerman JS, Biber KP, Boddeke HW, Höpken UE, Meisel C, Meisel A, Bechmann I, Hintzen RQ, 't Hart BA, Amor S, Laman JD, Boven LA (2008)  Brain antigens in functionally distinct antigen-presenting cell populations in cervical lymph nodes in MS and EAE. J Mol Med. (published Online)

2007

Bas Orth C, Schultz C, Müller CM, Frotscher M, Deller T (2007) Loss of the cisternal organelle in the axon initial segment of cortical neurons in synaptopodin-deficient mice. J Comp Neuro 504: 441-449

Bechmann I, Galea I, Perry VH (2007) What is the blood-brain barrier (not)? Trends Immunol 28: 5-11

Boeve BF, Silber MH, Saper CB, Ferman TJ, Dickson DW, Parisi JE, Benarroch EE, Ahlskog JE, Smith GE; Caselli RC, Tippman-Peikert M, Olson EJ, Lin SC, Young T, Wszolek Z, Schenck CH, Mahowald MW, Castillo PR, Del Tredici K, Braak H (2007) Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease. Brain 130: 2770-2788

Braak H, Sastre M, Bohl JR, de Vos RA, Del Tredici K (2007) Parkinson's disease: lesions in dorsal horn layer I, involvement of parasympathetic and sympathetic pre- and postganglionic neurons. Acta Neuropathol 113: 421-429

Braak H, Sastre M, Del Tredici K (2007) Development of alpha-synuclein immunoreactive astrocytes in the forebrain parallels stages of intraneuronal pathology in sporadic Parkinson's disease. Acta Neuropathol 114: 231-241

Braun JS, Hoffmann O, Schickhaus M, Freyer D, Dagand E, Bermpohl D, Mitchell TJ, Bechmann I, Weber JR (2007) Pneumolysin causes neuronal cell death through mitochondrial damage. Infect Immun 75: 4245-54

Burbach GJ, Vlachos A, Ghebremedhin E, Turco DD, Coomaraswamy J, Staufenbiel M, Jucker M, Deller T (2007) Vessel ultrastructure in APP23 transgenic mice after passive anti-Abeta immunotherapy and subsequent intracerebral hemorrhage. Neurobiol Aging 28: 202-12

Copanaki E, Schurmann T, Eckert A, Leuner K, Muller WE, Prehn JH, Kogel D (2007) The amyloid precursor protein potentiates CHOP induction and cell death in response to ER Ca2+ depletion. Biochim Biophys Acta 1773: 157-165

Deller T, Del Turco D, Rappert A, Bechmann I (2007) Structural reorganization of the dentate gyrus following entorhinal denervation: species differences between rat and mouse. Prog Brain Res 163: 501-528

Deller T, Orth CB, Del Turco D, Vlachos A, Burbach GJ, Drakew A, Chabanis S, Korte M, Schwegler H, Haas CA, Frotscher M (2007) A role for synaptopodin and the spine apparatus in hippocampal synaptic plasticity. Ann Anat 189: 5-16

Del Turco D, Deller T (2007) Organotypic entorhino-hippocampal slice cultures--a tool to study the molecular and cellular regulation of axonal regeneration and collateral sprouting in vitro. Methods Mol Biol 399: 55-66

Galea I, Bechmann I, Perry VH (2007) What is immune privilege (not)? Trends Immunol 28: 12-8

Gao Q, Mezei G, Nie Y, Rao Y, Choi CS, Bechmann I, Leranth C, Toran-Allerand D, Priest CA, Roberts JL, Gao XB, Mobbs C, Shulman GI, Diano S, Horvath TL (2007) Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals. Nat Med 13: 89-94

Ghebremedhin E, Thal DR, Schultz C, Braak H, Deller T (2007) Homozygosity for the K variant of BCHE gene increases the risk for development of neurofibrillary pathology but not amyloid deposits at young ages. Acta Neuropathol 114: 359-63

Hawkes CH, Del Tredici K, Braak H (2007) Parkinson's disease: a dual-hit hypothesis. Neuropath Appl Neuro 33: 599-614

Hoepken HH, Gispert S, Morales B, Wingerter O, Del Turco D, Mülsch A, Nussbaum RL, Müller K, Dröse S, Brandt U, Deller T, Wirth B, Kudin AP, Kunz WS, Auburger G (2007) Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6. Neurobiol Dis 25: 401-411

Ivens S, Kaufer D, Flores LP, Bechmann I, Zumsteg D, Tomkins O, Seiffert E, Heinemann U, Friedman A (2007) TGF-beta receptor-mediated albumin uptake into astrocytes is involved in neocortical epileptogenesis. Brain 130: 535-547

Kwidzinski E, Bechmann I (2007) IDO expression in the brain: a double-edged sword. J Mol Med-Jmm 85: 1351-1359

Lastres-Becker I, Rüb U, Auburger G (2007) Spinocerebellar ataxia 2 (SCA2). Cerebellum, -: 1-10

Lehnardt S, Wennekamp J, Freyer D, Liedtke C, Krueger C, Nitsch R, Bechmann I, Weber JR, Henneke P (2007) TLR2 and caspase-8 are essential for group B Streptococcus-induced apoptosis in microglia. J Immunol 179: 6134-6143

Lipp M, Brandt C, Dehghani F, Kwidzinski E, Bechmann I (2007) PD-L1 (B7-H1) regulation in zones of axonal degeneration. Neurosci Lett 425: 156-161

Lleo A, Galea E, Sastre M (2007) Molecular targets of non-steroidal anti-inflammatory drugs in neurodegenerative diseases. Cell Mol Life Sci 64: 1403-1418

Meltendorf C, Burbach GJ, Bühren J, Bug R, Ohrloff C, Deller T (2007) Corneal femtosecond laser keratotomy results in isolated stromal injury and favorable wound-healing response. Invest Ophth Vis Sci, 48(5): 2068-75

Mutlu L, Brandt C, Kwidzinski E, Sawitzki B, Gimsa U, Mahlo J, Aktas O, Nitsch R, van Zwam M, Laman JD, Bechmann I (2007) Tolerogenic effect of fiber tract injury: reduced EAE severity following entorhinal cortex lesion. Exp Brain Res 178: 542-553

Riess O, Rüb U, Pastore A, Bauer P, Schöls L (2007) SCA3: Neurological features, pathogenesis and animal models. Cerebellum -: 1-13

Rüb U, Seidel K, Ozerden I, Gierga K, Brunt ER, Schöls L, de Vos RA, den Dunnen W, Schultz C, Auburger G, Deller T (2007) Consistent affection of the central somatosensory system in spinocerebellar ataxia type 2 and type 3 and its significance for clinical symptoms and rehabilitative therapy. Brain Res Rev 53: 235-249

Wulczyn FG, Smirnova L, Rybak A, Brandt C, Kwidzinski E, Ninnemann O, Strehle M, Seiler A, Schumacher S, Nitsch R (2007) Post-transcriptional regulation of the let-7 microRNA during neural cell specification. Faseb J 21: 415-426

2006

Ackermann K, Bux R, Rub U, Korf HW, Kauert G, Stehle JH (2006) Characterization of human melatonin synthesis using autoptic pineal tissue. Endocrinology 147: 3235-3242

Braak H, de Vos RA, Bohl J, Del Tredici K (2006) Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology. Neurosci Lett 396: 67-72

Braak H, Rub U, Schultz C, Del Tredici K (2006) Vulnerability of cortical neurons to Alzheimer's and Parkinson's diseases. J Alzheimers Dis 9: 35-44.

Braak H, Muller CM, Rub U, Ackermann H, Bratzke H, de Vos RA, Del Tredici K (2006) Pathology associated with sporadic Parkinson's disease--where does it end? J Neural Transm Suppl 89-97

Braak H, Alafuzoff I, Arzberger T, Kretzschmar H, Del Tredici K (2006) Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry. Acta Neuropathol 112: 389-404

Burk K, Daum I, Rub U (2006) Cognitive function in multiple system atrophy of the cerebellar type. Mov Disord 21: 772-776

Custer SK, Garden GA, Gill N, Rueb U, Libby RT, Schultz C, Guyenet SJ, Deller T, Westrum LE, Sopher BL, La Spada AR (2006) Bergmann glia expression of polyglutamine-expanded ataxin-7 produces neurodegeneration by impairing glutamate transport. Nat Neurosci 9: 1302-1311

Dehn D, Burbach GJ, Schafer R, Deller T (2006) NG2 upregulation in the denervated rat fascia dentata following unilateral entorhinal cortex lesion. Glia 53: 491-500

Deller T, Bas OC, Vlachos A, Merten T, Del Turco D, Dehn D, Mundel P, Frotscher M (2006) Plasticity of synaptopodin and the spine apparatus organelle in the rat fascia dentata following entorhinal cortex lesion. J Comp Neurol 499: 471-484

Deller T, Haas CA, Freiman TM, Phinney A, Jucker M, Frotscher M (2006) Lesion-induced axonal sprouting in the central nervous system. Adv Exp Med Biol 557: 101-121

Ghebremedhin E, Del Tredici K, Vuksic M, Rub U, Thal DR, Burbach GJ, Rosenberger A, Bickeboller H, Deller T, de Vos RA, Jansen Steur EN, Braak H (2006) Relationship of apolipoprotein E and age at onset to Parkinson disease neuropathology. J Neuropathol Exp Neurol 65: 116-123

Gunther S, Maroteaux L, Schwarzacher SW (2006) Endogenous 5-HT2B receptor activation regulates neonatal respiratory activity in vitro. J Neurobiol 66: 949-961

Haglund M, Passant U, Sjobeck M, Ghebremedhin E, Englund E (2006) Cerebral amyloid angiopathy and cortical microinfarcts as putative substrates of vascular dementia. Int J Geriatr Psychiatry 21: 681-687

John N, Krugel H, Frischknecht R, Smalla KH, Schultz C, Kreutz MR, Gundelfinger ED, Seidenbecher CI (2006) Brevican-containing perineuronal nets of extracellular matrix in dissociated hippocampal primary cultures. Mol Cell Neurosci 31: 774-784

Kienzler F, Jedlicka P, Vuksic M, Deller T, Schwarzacher SW (2006) Excitotoxic hippocampal neuron loss following sustained electrical stimulation of the perforant pathway in the mouse. Brain Res 1085: 195-198

Kogel D, Svensson B, Copanaki E, Anguissola S, Bonner C, Thurow N, Gudorf D, Hetschko H, Muller T, Peters M, Konig HG, Prehn JH (2006) Induction of transcription factor CEBP homology protein mediates hypoglycaemia-induced necrotic cell death in human neuroblastoma cells. J Neurochem 99: 952-964

Larionov S, Dedeck O, Birkenmeier G, Orantes M, Ghebremedhin E, Thal DR (2006) The intronic deletion polymorphism of the Alpha2- macroglobulin gene modulates the severity and extent of atherosclerosis in the circle of Willis. Neuropathol Appl Neurobiol 32: 451-454

Rub U, de Vos RA, Brunt ER, Sebesteny T, Schols L, Auburger G, Bohl J, Ghebremedhin E, Gierga K, Seidel K, den Dunnen W, Heinsen H, Paulson H, Deller T (2006) Spinocerebellar ataxia type 3 (SCA3): thalamic neurodegeneration occurs independently from thalamic ataxin-3 immunopositive neuronal intranuclear inclusions. Brain Pathol 16: 218-227

Schulte U, Thumfart JO, Klocker N, Sailer CA, Bildl W, Biniossek M, Dehn D, Deller T, Eble S, Abbass K, Wangler T, Knaus HG, Fakler B (2006) The epilepsy-linked Lgi1 protein assembles into presynaptic Kv1 channels and inhibits inactivation by Kvbeta1. Neuron 49: 697-706

Schultz C, Konig HG, Del Turco D, Politi C, Eckert GP, Ghebremedhin E, Prehn JH, Kogel D, Deller T (2006) Coincident enrichment of phosphorylated IkappaBalpha, activated IKK, and phosphorylated p65 in the axon initial segment of neurons. Mol Cell Neurosci 33: 68-80

Schwarzacher SW, Vuksic M, Haas CA, Burbach GJ, Sloviter RS, Deller T (2006) Neuronal hyperactivity induces astrocytic expression of neurocan in the adult rat hippocampus. Glia 53: 704-714

Sicotte NL, Salamon G, Shattuck DW, Hageman N, Rub U, Salamon N, Drain AE, Demer JL, Engle EC, Alger JR, Baloh RW, Deller T, Jen JC (2006) Diffusion tensor MRI shows abnormal brainstem crossing fibers associated with ROBO3 mutations. Neurology 67: 519-521

Stanke M, Duong CV, Pape M, Geissen M, Burbach G, Deller T, Gascan H, Otto C, Parlato R, Schutz G, Rohrer H (2006) Target-dependent specification of the neurotransmitter phenotype: cholinergic differentiation of sympathetic neurons is mediated in vivo by gp 130 signaling. Development 133: 141-150

Thal DR, Capetillo-Zarate E, Del Tredici K, Braak H (2006) The development of amyloid beta protein deposits in the aged brain. Sci Aging Knowledge Environ 2006: re1